Elaine Linda Lee

Elaine Linda Lee
Boston University | BU · Department of Medical Sciences and Education

PhD

About

13
Publications
3,709
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
227
Citations
Introduction
Elaine L. Lee currently works as the Grant Strategist at the Boston University School of Medicine, and has transitioned into research on teaching methods and metrics for scientific writing as an Assistant Professor at the Department of Medical Sciences and Education, Boston University. Previously, Elaine was a Postdoctoral Fellow at the Department of Biomedical Engineering, Boston University, and her research focused on cardiovascular tissue engineering and biomaterials.
Additional affiliations
February 2017 - September 2019
Boston University
Position
  • Professor (Assistant)
December 2005 - July 2006
Texas Heart Institute
Position
  • Research Assistant
Description
  • Designed system to visualize fluid flow problems in ventricles supported with different left ventricular assist devices. Characterized ventricular flow under varying design conditions in assist devices.
August 2005 - December 2005
Rice University
Position
  • Research Assistant
Description
  • Investigated heterogeneous expression of valvular interstitial cell markers in normal porcine mitral valve tissue. Found some valve cells express higher contractile marker concentrations than in other regions.
Education
July 2006 - January 2012
Case Western Reserve University
Field of study
  • Biomedical Engineering
August 2002 - May 2006
Rice University
Field of study
  • Bioengineering

Publications

Publications (13)
Article
Cell therapy treatment of post-myocardial infarction patients aims to regenerate tissue to improve function and prevent scarring. Although scaffold-free cell sheets offer an attractive solution, the monolayers are limited currently in their integrity as the individual layers do not cyclically stretch and cannot match the mechanical force transducti...
Article
Cells implanted after injury may remodel undesirably with improper mechanical stimulation from surrounding tissue. Proper conditioning of tissue engineered constructs before implantation can lead to suitable tissue architectures, along with an extracellular matrix (ECM) environment that more closely mimics native tissue. Additionally, cell implanta...
Article
Little is known about flow patterns in ventricles supported by continuous flow left ventricular assist devices (LVADs), and valuable information can be obtained with simple flow visualization experiments. We describe the application of several experimental techniques for the in vitro study of ventricular flow patterns (e.g., unsteadiness, vortical...
Article
Full-text available
Because various regions of the mitral valve contain distinctive extracellular matrix enabling the tissues to withstand diverse mechanical environments, we investigated phenotype and matrix production of porcine valvular interstitial cells (VICs) from different regions. VICswere isolated from the chordae (MCh), the center of the anterior leaflet (Al...
Article
Extracellular matrix changes occur in many heart valve pathologies. For example, myxomatous mitral valves are reported to contain excess proteoglycans and hyaluronan. However, it is unknown which specific proteoglycans are altered in myxomatous valves. Because proteoglycans perform varied functions in connective tissues, this study was designed to...
Article
Full-text available
Current cell sheet-based blood vessels lack biomimetic structure and require excessively long culture times that may compromise smooth muscle cell phenotype. We modified a commercially available product for uniaxial cell sheet conditioning with thermoresponsive copolymers. Thus, culture of detachable conditioned cell sheets is shortened while retai...
Article
Complex hierarchical organization is a hallmark of tissues and their subsequent integration into organs. A major challenge in tissue engineering is to generate arrays of cells with defined structural organization that display appropriate functional properties. Given what is known about cellular responses to physiochemical cues from the surrounding...
Article
Disrupted hierarchical structure in blood vessels following cardiovascular injury may contribute to maladaptive remodeling and lead to changes in mechanical properties. Cell-based tissue-engineered constructs that mimic native structures can actively adapt to guide remodeling, growth, and self-maintenance at the injury site. Cell sheet engineering...
Chapter
This chapter reviews the current techniques for bio-inspired cardiovascular materials. It talks about tissue engineering tools for imparting hierarchical structures into cardiovascular tissue constructs using scaffolds, bioreactors and biomolecules, and manipulations to cell sources, as well as methods of scaffold-less tissue engineering. Tissue en...
Conference Paper
Cells implanted following injury may remodel undesirably with improper mechanical stimulation from surrounding tissue. Proper cell conditioning in vitro before implantation can lead to extracellular matrix (ECM) growth that more closely mimics native tissue, and scaffolds are often used to promote ECM growth. However, because of adverse effects (eg...

Network

Cited By