El Mahmoudi Nada

El Mahmoudi Nada
Aix-Marseille Université | AMU

PhD student

About

12
Publications
1,022
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41
Citations

Publications

Publications (12)
Article
Full-text available
Unilateral vestibular lesions induce a vestibular syndrome, which recovers over time due to vestibular compensation. The therapeutic effect of L-Thyroxine (L-T4) on vestibular compensation was investigated by behavioral testing and immunohistochemical analysis in a rat model of unilateral vestibular neurectomy (UVN). We demonstrated that a short-te...
Article
Full-text available
Acute peripheral vestibulopathy leads to a cascade of symptoms involving balance and gait disorders that are particularly disabling for vestibular patients. Vestibular rehabilitation protocols have proven to be effective in improving vestibular compensation in clinical practice. Yet, the underlying neurobiological correlates remain unknown. The aim...
Article
Full-text available
Background Due to their anti-inflammatory action, corticosteroids are the reference treatment for brain injuries and many inflammatory diseases. However, the benefits of acute corticotherapy are now being questioned, particularly in the case of acute peripheral vestibulopathies (APV), characterized by a vestibular syndrome composed of sustained spi...
Preprint
Unilateral vestibular lesions induce a vestibular syndrome, which recovers over time due to vestibular compensation. The therapeutic effect of L-Thyroxine (L-T4) on vestibular compensation was investigated by behavioral testing and immunohistochemical analysis in a rat model of unilateral vestibular neurectomy (UVN). We demonstrated that an acute L...
Preprint
Full-text available
Background : Due to their anti-inflammatory action, corticosteroids are the reference treatment for brain injuries and many inflammatory diseases. However, the benefits of acute corticotherapy are now being questioned, particularly in the case of acute peripheral vestibulopathies (APV), characterized by a vestibular syndrome composed of sustained s...
Article
We previously revealed adult reactive neurogenesis in deafferented vestibular nuclei following unilateral vestibular neurectomy (UVN) in the feline model. We recently replicated the same surgery in a rodent model and aimed to elucidate the origin and fate of newly generated cells following UVN. We used specific markers of cell proliferation, glial...
Article
Full-text available
Vestibular pathologies are difficult to diagnose. Existing devices make it possible to quantify and follow the evolution of posturo-locomotor symptoms following vestibular loss in static conditions. However, today, there are no diagnostic tools allowing the quantitative and spontaneous analysis of these symptoms in dynamic situations. With this in...
Article
Full-text available
The vestibular system plays a crucial role in maintaining postural balance. Unilateral vestibular lesions result in a typical syndrome characterized by postural imbalance, altered locomotor patterns and gaze stabilization, as well as cognitive and neurovegetative disorders. One of the main difficulties encountered in the development of new anti-ver...
Article
Full-text available
Introduction La névrite vestibulaire (NV) est une vestibulopathie périphérique unilatérale aiguë. Elle représente environ 7 % des patients consultant pour des vertiges et se caractérise par un syndrome vestibulaire composé de vertiges, d’un nystagmus oculaire spontané, de troubles posturo-locomoteurs et de symptômes végétatifs. Ces troubles dispara...
Article
Full-text available
Introduction Diagnostiquer une pathologie vestibulaire reste toujours difficile. Les dispositifs existants permettent de quantifier et suivre l’évolution des symptômes posturo-locomoteurs en condition statique. Cependant, aujourd’hui il n’existe pas d’outils diagnostiques permettant l’analyse quantitative de ces symptômes dans une situation dynamiq...
Article
Introduction Unilateral vestibular lesion results in a typical syndrome characterized by postural imbalance, alteration of locomotion and gaze stabilization as well as cognitive and neurovegetative disorders. One of the main difficulties encountered in the development of new anti-vertigo drugs is the lack of sensitivity in the evaluation of this sy...