Ekkehart Jenetzky

Witten/Herdecke University · Faculty of Health/School of Medicine

Introduction Today, accessing information on health issues is easier than ever. However, the flood of information can make decision-making difficult. Information can influence the intention for an action, yet the action often remains unpredictable. It is unclear if there is a relationship between the intention behavior gap and the wish for medical...

Hintergrund: Komplexe Fehlbildungen erfordern eine ressourcenintensive Versorgung. Vergütungsmuster der korrektiven Fehlbildungschirurgie wurden vor dem Hintergrund der Versorgungslandschaft bisher nicht analysiert. Methoden: Krankenhausabrechnungsdaten zu Korrekturoperationen von zehn ausgewählten komplexen Fehlbildungen von 2020–2022 wurden anal...

Objective In this observational study, we determined the distribution of mHealth applications (apps) in Germany using data from the FeverApp registry. Methods The registry data were processed to assess general monthly trends in app distribution, and a seasonal autoregressive integrated moving average model was decomposed to investigate time series...

Substudy of FeverApp Register: usage of a health app for parents (Ecological Momentary Assessment - EMA) and effects on consultation frequency in pediatric practices

Introduction Patients with acute ischemic stroke (AIS) and large-vessel occlusion are frequently transferred by emergency physicians (EPs) from primary to comprehensive stroke centers (CSC) for thrombectomy, particular when thrombolysed. Data on complications during such transfers are highly limited. Patients and methods Consecutive AIS patients t...

Background The selection of data elements is a decisive task within the development of a health registry. Having the right metadata is crucial for answering the particular research questions. Furthermore, the set of data elements determines the registries’ readiness of interoperability and data reusability to a major extent. Six health registries s...

Policymakers and practitioners are increasingly focused on achieving health equity and meeting the specific health needs of diverse populations, including vulnerable groups such as children. To address these challenges, the Fever App for Parents has emerged as a solution to guide parents through the complexities of managing fever in their children...

Introduction: As part of an exploratory and hypothesis-generating study, we developed the Sports Preference Questionnaire (SPOQ) to survey the athletic behavior of mentally ill children and adolescents, subjectively assessed physical fitness and perceived psychological effects of physical activity. Methods: In a department of child and adolescent...

In der kindlichen Entwicklungsphase bringen chronische Erkrankungen wie Diabetes mellitus Typ 1 (T1D) besondere Herausforderungen mit sich. Betroffene Kinder und Jugendliche sind mit zusätzlicher Musikerziehung möglicherweise besser in der Lage, sich diesen Herausforderungen zu stellen. Über den Zeitraum von 4 Jahren (2017–2020) wurden in einer mul...

Background Anorectal malformations (ARMs) are complex congenital anomalies. The corrective operation is demanding and schedulable. Based on complete national data, patterns of care have not been analyzed in Germany yet. Methods All cases with ARM were analyzed (1) at the time of birth and (2) during the hospital stay for the corrective operation, b...

Background: People with type 1 diabetes (t1d) are fasting with the intention to slow down or halt health deterioration or to improve their health condition.First promising results of research in this field are available. According to current fasting guidelines fasting is only recommended under medical supervision. Objectives: To survey the number o...

Background: The bladder exstrophy-epispadias complex (BEEC) is a spectrum of congenital abnormalities that involves the abdominal wall, the bony pelvis, the urinary tract, the external genitalia, and, in severe cases, the gastrointestinal tract as well. Methods: Herein, we performed an exome analysis of case-parent trios with cloacal exstrophy (...

Introduction Vaccinations are considered to have a large impact on disease control, hence a multitude of vaccines in infancy is recommended. Retrospective studies suggest a possible relation between timing, kind or number of vaccines given in the first year of life and the subsequent incidence of allergic diseases. It must be clarified whether a ca...

Objectives Mobile health applications could be means of educating and changing behaviours of their users. Their features and qualities determine the sustainability of use. The FeverApp with two main features of information and documentation is a research-based app. In this observational cohort study, to evaluate the influential predictors of use,...

Feedback of data quality measures to study sites is an established procedure in the management of registries. Comparisons of data quality between registries as a whole are missing. We implemented a cross-registry benchmarking of data quality within the field of health services research for six projects. Five (2020) and six (2021) quality indicators...

Febrile infections are common in childhood. Children can be infected with SARS-CoV-2, but their course is milder than in adults. So far, a comparison between febrile infections with a positive or negative Corona test with the Omicron variant is missing. The data used are from the FeverApp registry, which collects parent-reported data on febrile inf...

The FeverApp registry is an ambulant ecological momentary assessment (EMA) model registry focusing on research of fever in children. Verification of EMA reliability is a challenge, due to absence of other source data. To ensure the reliability of EMA data, 973 families were invited to reassess their documentation in a survey. The survey contained q...

Background: Registries are important in rare disease research. The Anorectal Malformation Network (ARM-Net) registry is a well-established European patient registry collecting demographic, clinical, and functional outcome data. We assessed the quality of this registry through review of the structure, data elements, collected data, and user experie...

Background Echocardiography is highly relevant in patients with ischemic stroke or TIA. Utilization of routine echocardiographic examinations [transthoracic (TTE) or transesophageal (TEE)] on stroke units remains however unknown. To representatively examine echocardiographic rates on stroke units in Germany and to evaluate structural factors that m...

Zusammenfassung Hintergrund Fieber gilt als wichtige Abwehrreaktion des Körpers bei Infekten und spielt im Kindesalter eine große Rolle. Unter Eltern sind immer noch Angst und Unsicherheit im Umgang mit Fieber weit verbreitet. Als Aufklärungsinstrument für Eltern können Informationsbroschüren zum Wissen und Umgang mit Fieber im Kindesalter dienen....

Classic bladder exstrophy represents the most severe end of all human congenital anomalies of the kidney and urinary tract and is associated with bladder cancer susceptibility. Previous genetic studies identified one locus to be involved in classic bladder exstrophy, but were limited to a restrict number of cohort. Here we show the largest classic...

Parents' confidence regarding their children's fever is a key factor in its management and there is still unnecessary anxiety and associated antipyretic overuse. The FeverApp application collects naturalistic real-time data on febrile infections and educates parents on fever management. Logistic regression examined the associations between (1) pare...

Background: The FeverApp registry uses ecological momentary assessment (EMA) to collect parental data on pediatric fever for scientific research. The mobile app FeverApp educates parents on safe fever management and serves as a fever diary. Objective: The focus of this study was to evaluate the completeness and concordance of the EMA-based Fever...

Anorectal malformations (ARM) represent a spectrum of rare malformations originating from a perturbated development of the embryonic hindgut. Approximately 60% occur as a part of a defined genetic syndrome or within the spectrum of additional congenital anomalies. Rare copy number variations (CNVs) have been associated with both syndromic and non-s...

Background Fever in children is a major problem in pediatric oncology. Usual management leads to immediate antibiotic and antipyretic therapy, although there is consensus that antipyretic therapy should not be utilized with the sole aim of reducing body temperature. Increased body temperature during fever appears to be an effective modifier in term...

SummaryIntroduction: Quality of care for immi-grants and their direct descendants (I/DDpatients) with diabetes is unsatisfactory.Causes include socioeconomic status,language deficits, and cultural influences.Poorer quality of care may also affecthealth-related quality of life (HRQOL) in chil-dren and adolescents (C/A patients) withtype 1 diabetes m...

In the past, an anteriorly located anus was often misdiagnosed and treated as an anorectal malformation (ARM) with a perineal fistula (PF). The paper aims to define the criteria for a normal anus, an anterior anus (AA) as an anatomic variant, and milder types of ARM such as congenital anal stenosis (CAS) and PF. An extensive literature search was p...

Observational research benefits from a rich methodological foundation of registry development and operation published in international and national guidelines. Metadata management is an essential part of registry implementation based on concepts of data elements and value sets. The metadata from six German registries revealed vastly divergent inter...

Background Fever in children is a major problem in pediatric oncology. Usual management leads to immediate antibiotic and antipyretic therapy, although there is consensus that antipyretic therapy should not be utilized to reduce body temperature. Increased body temperature during fever appears to be an effective modifier in terms of viral replicati...

Background: The acronym VATER/VACTERL association describes the combination of at least three component features (CFs): vertebral defects (V), anorectal malformations (ARM) (A), cardiac defects (C), tracheoesophageal fistula with or without esophageal atresia (TE), renal malformations (R), and limb defects (L). Individuals presenting two CFs have...

Im Rahmen einer Machbarkeitsstudie zum Fasten von Typ 1 Diabetiker:innen mit 29 Teilnehmer:innen, die die Studie beendet haben, wurde neben der Machbarkeit und Sicherheit unter anderem auch das allgemeine Befinden mit dem WHO-5-Fragebogen ermittelt. Dieses verbesserte sich von 54 (±4.4) zu 68.8 (±15; P = 0.01) nach dem Fasten 1. Ebenfalls erfolgte...

Background and purpose: In acute stroke patients, plasma concentrations of direct oral anticoagulants (DOAC) at hospital admission only poorly mirror DOAC exposure or the coagulation status at the time of the event. Here, we evaluated whether DOAC exposure and DOAC plasma concentration at the time of transient ischemic attacks (TIA) and ischemic s...

Esophageal atresia with or without tracheoesophageal fistula (EA/TEF) is the most common congenital malformation of the upper digestive tract. This study represents the first genome-wide association study (GWAS) to identify risk loci for EA/TEF. We used an European case-control sample comprising 764 EA/TEF patients and 5,778 controls and observed g...

The FAIR Guiding Principles do not address the quality of data and metadata. Therefore, data collections could be FAIR but useless. In a funding initiative of registries for health services research, trueness of data received special attention. Completeness in the definition of recall was selected to represent this dimension in a cross-registry ben...

Zusammenfassung Ziel der Studie Die Machbarkeit und Modellhaftigkeit eines App-basierten Eltern-Registers ist aufzuzeigen. Methodik Die FeverApp als interaktives Erfassungsinstrument und die zugrundeliegende Datenstruktur des Registers werden vorgestellt. Die bisherigen Rekrutierungsbemühungen werden veranschaulicht und die Temperaturverteilung, so...

Introduction: The prevalence of rare diseases is very important for health care research. According to the European Surveillance of Congenital Anomalies (EUROCAT) registers, the live prevalence for exstrophy and/or epispadias (grades 1–3) is reported with 1:23,255 (95% CI: 1:26,316; 1:20,000). A Europe-wide prevalence evaluation based on reports fr...

Objectives Fever is a common symptom among children. Parental lack of knowledge about fever could cause anxiety and lead to unnecessary measures to subside fever. There is little evidence about German parents’ knowledge and their fever management. Design A cross-sectional study using a paper-based questionnaire. Setting 16 kindergartens in Saarbr...

Both DSM-5 and ICD-11 have provided weight cut-offs and severity specifiers for the diagnosis of anorexia nervosa (AN) in childhood, adolescence and adulthood. The aims of the current study focusing on inpatients aged < 19 years were to assess (1) the relationship between age and body mass index (BMI; kg/m2), BMI-centiles, BMI-standard deviation sc...

Introduction: Chronic kidney disease is common in patients with acute ischemic stroke. We investigated whether chronic kidney disease has an impact on anticoagulation treatment recommendations after ischemic stroke or transient ischemic attack (TIA) related with atrial fibrillation (AF). Materials and methods: We extracted treatment-related data...

Background Evidence for periconceptional or prenatal environmental risk factors for the development of congenital diaphragmatic hernia (CDH) is still scarce. Here, in a case-control study we investigated potential environmental risk factors in 199 CDH patients compared to 597 healthy control newborns. Methods The following data was collected: time...

Background and Purpose: Clinical outcome and mortality after endovascular thrombectomy (EVT) in patients with ischemic stroke are commonly assessed after 3 months. In patients with acute kidney injury (AKI), unfavorable results for 3-month mortality have been reported. However, data on the in-hospital mortality after EVT in this population are spar...

The FeverApp Registry is a model registry focusing on pediatric fever using a mobile app to collect data and present recommendations. The recorded interactions can clarify the relationship between user documentation and user information. This initial evaluation regarding features of participants and usage intensity of educational video, information...

Zusammenfassung Hintergrund Bei Kindern- und Jugendlichen häufen sich Narrative über Beschwerden durch das Tragen eines Mund-Nasen-Schutzes (Maske). Weltweit existiert bisher kein Register für mögliche Nebenwirkungen von Masken. Methode Im Rahmen des www.Co-Ki.de Multi-Studienkomplexes wurde ein Online-Register aufgebaut, im dem Eltern, Ärzt*inne...

Aims/Hypothesis: Intermittent as well as prolonged fasting are receiving considerable attention and appear favorable in conditions like the metabolic syndrome, type 2 diabetes, rheumatic diseases and others. Fasting for people with type 1 diabetes (T1D) is generally considered too risky. However, the ability and possibility to change from carbohydr...

Background: Narratives about complaints in children and adolescents caused by wearing a mask are accumulating. There is, to date, no registry for side effects of masks. Methods: At the University of Witten/Herdecke an online registry has been set up where parents, doctors, pedagogues and others can enter their observations. On 20.10.2020, 363 docto...

Background: Narratives about complaints in children and adolescents caused by wearing a mask are accumulating. There is, to date, no registry for side effects of masks. Methods: In the context of the www.co-ki.de multi-study-complex an online registry has been set up where parents, doctors, pedagogues and others can enter their observations. On 20....

Zusammenfassung Hintergrund In Deutschland werden über 80 % der Kinder und Jugendlichen von niedergelassenen Kinder- und Jugendärztinnen und -ärzten (KJÄ) betreut. Diese haben eine spezifische Perspektive auf die COVID-19-Pandemie. Methode Zentrale Onlineerfassung von Fallzahlen, individuellen Fallbeschreibungen und Beobachtungen zu Infektion und...

Background: Fever is one of the most common symptoms of pediatric consultations and its mismanagement is a health care burden. Guidelines on fever management are incoherent and data on fever management are still missing. This study protocol describes an app-based registry to evaluate the fever management of parents. Objective: The primary object...

Aim: Male patients with anorectal malformations (ARM) are classified according to presence and level of the recto-urinary fistula. This is traditionally established by a preoperative high-pressure distal colostogram that may be variably interpreted by different surgeons. The aim of this study was to evaluate the inter- and intraobserver variation i...

Aims/Hypothesis: Intermittent as well as prolonged fasting are receiving considerable attention and appear favorable in conditions like the metabolic syndrome, type 2 diabetes, rheumatic diseases and others. Fasting for people with type 1 diabetes is generally considered too risky. However, the ability and possibility to change from carbohydrate to...

Aims/Hypothesis: Intermittent as well as prolonged fasting are receiving considerable attention and appear favorable in conditions like the metabolic syndrome, type 2 diabetes, rheumatic diseases and others. Fasting for people with type 1 diabetes is generally considered too risky. However, the ability and possibility to change from carbohydrate to...

Previous studies in developing Xenopus and zebrafish reported that the phosphate transporter slc20a1a is expressed in pronephric kidneys. The recent identification of SLC20A1 as a monoallelic candidate gene for cloacal exstrophy further suggests its involvement in the urinary tract and urorectal development. However, little is known of the function...

Introduction Esophageal atresia with or without tracheoesophageal fistula (EA/TEF) occurs approximately 1 in 3.500 live births representing the most common malformation of the upper digestive tract. Only half a century ago, EA/TEF was fatal among affected newborns suggesting that the steady birth prevalence might in parts be due to mutational de no...

Introduction: To evaluate the impact of reconstructive strategies and post-operative management on short- and long-term surgical outcome and complications of classical bladder exstrophy (CBE) patients' comprehensive data of the multicenter German-wide Network for Congenital Uro-Rectal malformations (CURE-Net) were analyzed. Methods: Descriptive ana...

Objective: Nocturnal enuresis (NE), daytime urinary incontinence (DUI), and fecal incontinence (FI) are common disorders in childhood and are frequently accompanied by comorbid psychiatric disorders. Despite a high association between urinary and fecal incontinence with psychiatric and neurodevelopmental disorders, research on comorbidity between...

Purpose Conflicts of interest can impede both research and medical treatment. The European Reference Networks require their members to deal with financial and non-financial conflicts according to an explicit protocol. In a literature review, we identified relevant interests in paediatric surgery, and drafted such a policy. Methods We conducted a P...

Purpose Since pediatric surgeons aim to follow their patients with anorectal malformations (ARM) into adulthood the aim of this study was to investigate how pediatric surgeons deal with sexual issues related to ARM. Methods In 2018, a questionnaire was developed by the working group “Follow-up and sexuality” of the ARM-Net consortium and sent to a...

Introduction Anorectal malformations (ARM) are rare congenital malformations, resulting from disturbed hindgut development. A genetic etiology has been suggested, but evidence for the involvement of specific genes is scarce. We evaluated the contribution of rare and low-frequency coding variants in ARM etiology, assuming a multifactorial model. Me...

bold<>italic /italic<>/bold< Renal dysfunction (RD) is overall associated with unfavorable functional outcome and higher risk of mortality after acute ischemic stroke. Associations between RD and outcome in patients with acute vertebrobasilar stroke treated with thrombectomy have not been evaluated so far. >bold<>italic /italic<>/bold< Consecutive...