Ekaterina Sigitova

Charles University in Prague | CUNI · Department of Psychiatry (1. LF)

Exact pathophysiological mechanisms of bipolar disorder have not been sufficiently clarified. We review the evidence of mitochondrial dysfunctions on the relation between both disease and pharmacotherapy. Mitochondria provide most of the energy production in cells; they are involved in decreased antioxidant defenses, increased lipid peroxidation, a...

The most common mood disorders are major depressive disorders and bipolar disorders. The pathophysiology of bipolar disorder is complex, multifactorial, and not fully understood. Creation of new hypotheses in the field gives impetus for studies and searching new biomarkers of the bipolar disorder. Conversely, new biomarkers facilitate not only diag...