Eitan Kaplan

Eitan Kaplan
Seattle Children’s Research Institute · Center for Integrative Brain Research

PhD

About

7
Publications
600
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202
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Introduction
Skills and Expertise

Publications

Publications (7)
Article
Full-text available
Primary visual cortex (V1) is the locus of numerous forms of experience-dependent plasticity. Restricting visual stimulation to one eye at a time has revealed that many such forms of plasticity are eye-specific, indicating that synaptic modification occurs prior to binocular integration of thalamocortical inputs. A common feature of these forms of...
Thesis
The roles played by cortical inhibitory neurons in experience-dependent plasticity and learning are not well understood. Here we evaluate the participation of parvalbumin-expressing (PV+) GABAergic neurons in two forms of experience-dependent modification of primary visual cortex (V1) in adult mice: ocular dominance (OD) plasticity resulting from m...
Article
Full-text available
A feature of early postnatal neocortical development is a transient peak in signaling via metabotropic glutamate receptor 5 (mGluR5). In visual cortex, this change coincides with increased sensitivity of excitatory synapses to monocular deprivation (MD). However, loss of visual responsiveness after MD occurs via mechanisms revealed by the study of...
Article
Familiarity with stimuli that bring neither reward nor punishment, manifested through behavioral habituation, enables organisms to detect novelty and devote cognition to important elements of the environment. Here we describe in mice a form of long-term behavioral habituation to visual grating stimuli that is selective for stimulus orientation. Ori...
Conference Paper
Background: Fragile X (FX) is a single-gene disorder associated with autism. Fragile X is caused by a mutation in the Fmr1 gene, leading to a lack of production of its protein product, Fragile X mental retardation protein (FMRP). FMRP normally acts as an inhibitor of protein synthesis at the synapse, and the lack of FMRP leads to increased protein...
Article
Pre-mutation CGG repeat expansions (55-200 CGG repeats; pre-CGG) within the fragile-X mental retardation 1 (FMR1) gene cause fragile-X-associated tremor/ataxia syndrome in humans. Defects in neuronal morphology, early migration, and electrophysiological activity have been described despite appreciable expression of fragile-X mental retardation prot...

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