Eimear Dolan

Eimear Dolan
University of São Paulo | USP · Hospital das Clínicas (FMUSP)

PhD

About

98
Publications
28,951
Reads
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1,424
Citations
Additional affiliations
August 2011 - February 2015
Robert Gordon University
Position
  • Lecturer

Publications

Publications (98)
Article
Full-text available
Background Circulating biomarkers are often used to investigate the bone response to an acute bout of exercise, but heterogeneity in factors such as study design, quality, selected biomarkers, and exercise and participant characteristics render it difficult to synthesize and evaluate available evidence. Objective The aim of this study was to quant...
Article
Full-text available
The energy costs of athletic training can be substantial, and deficits arising from costs unmet by adequate energy intake, leading to a state of low energy availability, may adversely impact athlete health and performance. Life history theory is a branch of evolutionary theory that recognizes that the way the body uses energy-and responds to low en...
Article
Objective To describe acute/postacute COVID-19 presentations in athletes. Design Systematic review and meta-analysis. Data sources The search was conducted in four databases (MEDLINE, EMBASE, SCOPUS, SPORTDiscus) and restricted to studies published from 2019 to 6 January 2022. Eligibility criteria for selecting studies Studies were required to (...
Article
Full-text available
Glucocorticoid (GC) therapy is a common treatment employed in rheumatic and autoimmune diseases due to its anti-inflammatory and immunosuppressive effects. However, GC therapy can also induce a number of adverse effects, including muscle and bone loss, hypertension, metabolic perturbations and increased visceral adiposity. We reviewed available evi...
Article
Full-text available
The purpose of this study was to investigate the time-course of decrements in physical performance following a pre-match warm-up in soccer players. Knowledge of this information could be used to inform re-warm-ups and pre-pitch entry practices of soccer substitutes. Data were collected over five sessions with 12 male youth professionals (15-17...
Article
Full-text available
Background Extracellular buffering supplements [sodium bicarbonate (SB), sodium citrate (SC), sodium/calcium lactate (SL/CL)] are ergogenic supplements, although questions remain about factors which may modify their effect. Objective To quantify the main effect of extracellular buffering agents on exercise outcomes, and to investigate the influenc...
Preprint
Full-text available
Circulating biomarkers are used to investigate the bone response to an acute bout of exercise, but heterogeneity in factors such as study design, quality, selected biomarkers and exercise and participant characteristics render it difficult to synthesize and evaluate available evidence. PURPOSE: To quantify the effects of an acute exercise bout on b...
Article
Energy is a finite resource that is competitively distributed among the body’s systems and biological processes. During times of scarcity, energetic “trade-offs” may arise if less energy is available than is required to optimally sustain all systems. More immediately essential functions are predicted to be prioritized, even if this necessitates the...
Article
Full-text available
Exercising women report three to six times more ACL tears than men, which happen, in the majority of cases, with a non-contact mechanism. This sex disparity has, in part, been attributed to the differences in reproductive hormone profiles between men and women. Many studies have shown that anterior knee (AK) laxity and the rate of non-contact ACL i...
Article
Freshwater turtles found in higher latitudes can experience extreme challenges to acid-base homeostasis while overwintering, due to a combination of cold temperatures along with the potential for environmental hypoxia. Histidine containing dipeptides (HCDs; carnosine, anserine and balenine) may facilitate pH regulation in response to these challeng...
Article
Large inter-individual variability is present in most health and performance interventions but little is known about the factors that underpin this variation. PURPOSE: To estimate the average group effect and intervention response variation from beta-alanine (BA) supplementation on high intensity cycling capacity. METHODS: Individual participant...
Article
Full-text available
There is growing evidence that supplementation with carnosine, or its rate-limiting precursor β-alanine, can ameliorate aspects of metabolic dysregulation that occur in diabetes and its related conditions. The purpose of this systematic review and meta-analysis was to evaluate the effect of carnosine or β-alanine supplementation on markers of glyce...
Article
Hilkens et al. (1) raise an interesting question - should low bone mass in elite road-cyclists be treated? We believe the extent of low bone mass should determine if direct treatment is warranted. Although cyclists may have lower bone mass than other groups (1), their T-scores generally reside toward the lower end of population norms and many don’t...
Article
Full-text available
Background: The Physical Activity Readiness Questionnaire for Everyone (PAR-Q+) is the international standard for pre-participation risk stratification and screening. In order to provide a practical and valid screening tool to facilitate safe engagement in physical activity and fitness assessments for the Brazilian population, this study aimed to t...
Article
This study investigated the effect of beta-alanine supplementation on short-duration sprints and final 4-km simulated uphill cycling time-trial performance during a comprehensive and novel exercise protocol representative of the demands of road-race cycling, and determined if changes were related to increases in muscle carnosine content. Seventeen...
Article
Currently, little is known about the extent of interindividual variability in response to beta-alanine (BA) supplementation, nor what proportion of said variability can be attributed to external factors or to the intervention itself (intervention response). To investigate this, individual participant data on the effect of BA supplementation on a hi...
Poster
Purpose: To estimate the proportion of the ergogenic effect that could be explained by placebo with well-known effective ergogenic aids including caffeine and buffers by meta-analysing data from studies containing both placebo and non-placebo control sessions. Methods: MedLine, Embase and SPORTDiscus were used to identify articles using relevant te...
Preprint
Full-text available
Freshwater turtles found in higher latitudes can experience extreme challenges to acid-base homeostasis while overwintering, due to a combination of cold temperatures along with the potential for environmental hypoxia. Histidine containing dipeptides (HCDs; carnosine, anserine and balenine) may facilitate pH regulation in response to these challeng...
Poster
Background: Expectation of ingesting buffering and caffeine supplements, but having ingested placebo, can improve exercise performance in double-blind placebo-controlled studies. We determined the placebo effects associated with caffeine and buffering supplements with specific focus on factors modifying the size of these effects, including exercise...
Article
Full-text available
Commercial saturation divers are exposed to unique environmental conditions and are required to conduct work activity underwater. Consequently, divers' physiological status is shown to be perturbed and therefore, appropriate strategies and guidance are required to manage the stress and adaptive response. This study aimed to evaluate the daily energ...
Article
Purpose: Women’s professional cycling has grown in popularity, and this increase is also apparent in Brazil, which has increased its female cycling calendar in recent years. The aim of this observational study was to (1) determine training and competition loads of a top-level Brazilian female cycling team, (2) evaluate nutrition and clinical health...
Article
Introduction: Placebos are used as a control treatment that is meant to be indistinguishable from the active intervention. However, where substantive placebo effects may occur, studies that do not include a nonplacebo control arm may underestimate the overall effect of the intervention (active plus placebo components). This study aimed to determine...
Article
Sodium bicarbonate (SB) is considered an effective ergogenic supplement for improving high-intensity exercise capacity and performance, although recent data suggests that women may be less amenable to its ergogenic effects than men. Currently, an apparent paucity of data on women means no consensus exists on whether women benefit from SB supplement...
Chapter
Creatine is one of the most popular supplements worldwide, and it is frequently used by both athletic and nonathletic populations to improve power, strength, muscle mass, and performance. However, new uses for creatine are emerging, as it seems to have therapeutic effects in a wide variety of clinical conditions, such as insulin insensitivity, canc...
Article
Health coaching has emerged as a potential supporting tool for health professionals to overcome behavioral barriers, but its efficacy in weight management remains unclear. We conducted a systematic review and meta-analysis to synthesize and evaluate the quality of evidence supporting the use of self-reported health coaching for weight loss. Seven e...
Article
Full-text available
Background Bone is a plastic tissue that is responsive to its physical environment. As a result, exercise interventions represent a potential means to influence the bone. However, little is currently known about how various exercise and participant characteristics interact to influence bone metabolism. Acute, controlled, interventions provide an in...
Article
Full-text available
Background Diabetes is a major public health issue and there is a need to develop low-cost, novel interventions to prevent or reduce disease progression. Growing evidence shows that supplementation with carnosine, or its rate-limiting precursor β-alanine, can ameliorate aspects of the metabolic dysregulation that occurs in diabetes. There is, howev...
Article
Full-text available
Background Concentrations of endogenous sex hormones fluctuate across the menstrual cycle (MC), which could have implications for exercise performance in women. At present, data are conflicting, with no consensus on whether exercise performance is affected by MC phase.Objective To determine the effects of the MC on exercise performance and provide...
Article
Full-text available
Background Oral contraceptive pills (OCPs) are double agents, which downregulate endogenous concentrations of oestradiol and progesterone whilst simultaneously providing daily supplementation of exogenous oestrogen and progestin during the OCP-taking days. This altered hormonal milieu differs significantly from that of eumenorrheic women and might...
Article
Full-text available
Beta-alanine (BA) supplementation increases muscle carnosine content (MCarn), and has many proven, and purported, ergogenic, and therapeutic benefits. Currently, many questions on the nature of the MCarn response to supplementation are open, and the response to these has considerable potential to enhance the efficacy and application of this supplem...
Preprint
Full-text available
Women’s professional cycling has grown exponentially in popularity in the past years and it has been no different in Brazil. In 2019 the first Brazilian female cycling team achieved UCI ranking status. Nonetheless, there is a paucity of data regarding the seasonal demands that these athletes encounter. This semi-observational study monitored 5 athl...
Preprint
Full-text available
Beta-alanine (BA) supplementation increases muscle carnosine content (MCarn), and is ergogenic in many situations. Currently, many questions on the nature of the Mcarn response to supplementation are open, and the response to these has considerable potential to enhance the efficacy and applications of this supplementation strategy. Objective To co...
Article
Bone (re)modelling markers can help determine how bone responds to different types, intensities and durations of exercise. They might also help predict those at risk of bone injury. We synthesised evidence on the acute and chronic bone metabolic responses to exercise, along with how nutritional factors can moderate this response. Recommendations to...
Article
Full-text available
Sarcopenia is characterized by a loss of muscle mass, quality, and function, and negatively impacts health, functionality, and quality of life for numerous populations, particularly older adults. Creatine is an endogenously produced metabolite, which has the theoretical potential to counteract many of the morphological and metabolic parameters unde...
Article
Our aim was to investigate the prevalence of symptoms related to eating disorders, disordered eating and body image perception, and attitudes toward eating in a group of elite male artistic gymnastics. Seventeen athletes took part in this quali-quantitative, cross-sectional study. Presence of eating disorders symptoms, and body image perception and...
Article
Full-text available
Carnosine is an abundant histidine-containing dipeptide in human skeletal muscle and formed by beta-alanine and L-histidine. It performs various physiological roles during exercise and has attracted strong interest in recent years with numerous investigations focused on increasing its intramuscular content to optimize its potential ergogenic benefi...
Conference Paper
Full-text available
Purpose: Professional women's road cycling is growing in popularity and increasing in terms of numbers of participants and competitions, and in 2016 the Women's World Tour was established. Female World Tour cyclists can cover between 13 000 and 18 000 km in training and competition each year, including up to 65 competition days (Sanders et al., 201...
Conference Paper
Full-text available
Purpose: Professional female cyclists undertake intense training, and the demands of this training must be met by adequate nutritional intake. This is particularly relevant for professional teams who train and compete all year round, as they can cover up to 18 000 km (Sanders et al., 2019). Energy availability (EA) refers to the amount of energy av...
Conference Paper
Full-text available
Purpose: Prevalence of dietary supplement use by athletes has been widely investigated, with prevalence in Brazil ranging from 37% to 98% (Nabuco et al., 2016). The American College of Sports Medicine categorises supplements as sports foods, medical supplements, specific performance supplements and others (Thomas et al., 2016). However, not all sup...
Article
Full-text available
β-Alanine supplementation is one of the world's most commonly used sports supplements, and its use as a nutritional strategy in other populations is ever-increasing, due to evidence of pleiotropic ergogenic and therapeutic benefits. Despite its widespread use, there is only limited understanding of potential adverse effects. To address this, a syst...
Article
Histidine containing dipeptides (HCDs: carnosine, anserine and balenine) have numerous therapeutic and ergogenic properties, but there is a lack of consensus on the mechanistic pathways through which they function. Potential roles include intracellular buffering, neutralisation of reactive species, and calcium regulation. Comparative investigations...
Article
Full-text available
β-Alanine (BA) supplementation may be ergogenic during high-intensity exercise, primarily due to the buffering of hydrogen cations, although the effects of beta-alanine supplementation on strength endurance are equivocal. The aim of the study was to determine the effects of 4 weeks of beta-alanine supplementation on skeletal muscle endurance using...
Article
Full-text available
Histidine containing dipeptides (HCDs) have numerous ergogenic and therapeutic properties, but their primary role in skeletal muscle remains unclear. Potential functions include pH regulation, protection against reactive oxygen/nitrogen species, or Ca2+ regulation. In recognition of the challenge of isolating physiological processes in-vivo, we emp...
Article
Bone health is determined by the rate of accrual in early life, followed by the rate of age-associated bone loss. Dietary protein intake might have a role in bone health across both of these phases via pleiotropic mechanistic pathways. Herein we summarise the pathways through which protein may exert either a positive or negative influence on bone....
Article
Full-text available
The ergogenic and therapeutic effects of increasing muscle creatine by supplementation are well-recognized. It appears that similar benefits to brain function and cognitive processing may also be achieved with creatine supplementation, however research in this area is more limited, and important knowledge gaps remain. The purpose of this review is...
Article
Full-text available
The concept of personalised nutrition and exercise prescription represents a topical and exciting progression for the discipline given the large inter-individual variability that exists in response to virtually all performance and health related interventions. Appropriate interpretation of intervention-based data from an individual or group of indi...
Article
Full-text available
Purpose: The present review critically evaluates existing literature on the effects of short- and long-term low energy availability (EA) on bone metabolism and health in physically active individuals. Methods: We reviewed the literature on the short-term effects of low EA on markers of bone metabolism and the long-term effects of low EA on outco...
Article
Context: The scientific literature shows conflicting evidence about the relationship between adiposity and bone mass in overweight and obese populations. Objective: The aim of this review was to quantify the correlation between adipose mass (absolute and relative) and bone mineral density (BMD) in overweight and obese populations. Data Sources: Thr...
Article
Objectives: To investigate the effects of an exercise referral scheme (ERS) aligned to the UK best practice guidelines on a range of outcomes including those associated with key health concerns of the Scottish population. Study design: A longitudinal design with data collection at three time points (baseline, midway and post) during a 12-week ER...
Article
This study aimed to assess the effect of extreme environmental exposure during an operational saturation dive on airway inflammation (exhaled nitric oxide (FeNo)), components of fitness (flexibility and aerobic capacity) and blood haematological variables. Six saturation divers, who undertook a 26 ± 0.5 day operational saturation dive were recruite...
Article
Full-text available
Objectives: The purpose of this study was to assess whether relatively simple interventions including self monitoring of heart rate and the use of targeted sprints for those with the lowest relative HR values (%HRmax) could be used to increase exercise intensity during small sided games (SSGs) in soccer. A secondary aim of the study was to assess t...
Article
Objective To conduct a systematic review and meta-analysis of the evidence on the effects of β-alanine supplementation on exercise capacity and performance. Design This study was designed in accordance with PRISMA guidelines. A 3-level mixed effects model was employed to model effect sizes and account for dependencies within data. Data sources 3...