Eibhlís M O'Connor

Eibhlís M O'Connor
University of Limerick | UL · Department of Life Sciences

PhD Nutritional Sciences

About

58
Publications
13,792
Reads
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3,394
Citations
Citations since 2017
30 Research Items
2484 Citations
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20172018201920202021202220230100200300400500
20172018201920202021202220230100200300400500
Additional affiliations
January 2013 - present
University of Limerick
Position
  • Lecturer in Human Nutrition
January 2013 - September 2016
University of Limerick
Position
  • Lecturer
January 2012 - December 2012
University College Cork
Position
  • Junior Lecturer
Education
October 2004 - February 2009
University College Cork
Field of study
  • Vitamin K and Nutritional Status in Healthy Adolescents and Adult Crohn's Disease patients: Implications for Bone Health

Publications

Publications (58)
Article
Background The Mediterranean diet (Medi-diet) has proven benefits for healthy ageing but isn’t the habitual diet of most middle-aged or older adults in Ireland; there can be accessibility and tolerability issues with high amounts of fresh fruit and vegetables. Providing key Medi-diet nutrients in a food product is a novel approach to this challenge...
Article
Full-text available
Scope: Gut microbiota alterations are associated with obesity and type 2 diabetes. Yeast β-glucans are potential modulators of the innate immune-metabolic response, by impacting glucose, lipid and cholesterol homeostasis. We examined whether yeast β-glucan interacts differentially with either an obese healthy or obese diabetic gut microbiome, to i...
Article
Full-text available
The use of mobile applications for dietary purposes has dramatically increased along with the consistent development of mobile technology. Assessing diet quality as a dietary pattern or an indicator across key food groups in comparison to those recommended by dietary guidelines is useful for identifying optimal nutrient intake. This systematic revi...
Chapter
Iron, zinc, copper, manganese, molybdenum, cobalt, and possibly, chromium are essential trace metals for humans. Zinc, in particular, is vital for many physiological processes that regulate endocrine and immune functions and control healthy brain development and activity. However, currently, it is estimated that 20 percent of the human population i...
Article
Full-text available
The colonic microbiome has been implicated in the pathogenesis of colorectal cancer (CRC) and intestinal microbiome alterations are not confined to the tumour. Since data on whether the microbiome normalises or remains altered after resection of CRC are conflicting, we studied the colonic microbiota of patients after resection of CRC. We profiled t...
Article
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Dietary fibre has long been established as a nutritionally important, health-promoting food ingredient. Modern dietary practices have seen a significant reduction in fibre consumption compared with ancestral habits. This is related to the emergence of low-fibre “Western diets” associated with industrialised nations, and is linked to an increased pr...
Article
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Background and Aims Atherosclerotic calcification is a powerful predictor of cardiovascular disease. This study aims to determine whether circulating levels of a local/systemic calcification inhibitor or a marker of bone formation correlate with measures of coronary or extracoronary calcification. Methods and Results Clinical computed tomography (...
Article
Full-text available
In professional rugby, sports-related concussion (SRC) remains the most frequent time loss injury. Therefore, accurately diagnosing SRC and monitoring player recovery, through a multi-modal assessment process, is critical to SRC management. In this protocol study, we aim to assess SRC over multiple time points post-injury to determine the value of...
Conference Paper
Full-text available
The rupture of atherosclerotic plaques is the prerequisite for adverse cardiovascular events. Calcification morphology plays a critical role in plaque stability, therefore accurate calcification classification is essential for favourable patient management. Blood biomarkers may be a worthwhile approach to stratify patients based on calcification ph...
Article
Purpose: The Joint Action Malnutrition in the Elderly (MaNuEL) Knowledge Hub was established to extend scientific knowledge, strengthen evidence-based practice, build a sustainable, transnational network of experts and harmonize research and clinical practice in the field of protein-energy malnutrition in older persons. This paper aims to summariz...
Article
Full-text available
Background: Vitamin K has multiple important physiological roles, including blood coagulation and beneficial effects on myelin integrity in the brain. Some intestinal microbes possess the genes to produce vitamin K in the form of menaquinone (MK). MK appears in higher concentration in tissues, such as the brain, particularly MK4, than the dietary...
Article
Full-text available
Background There are complex interactions between aging, frailty, diet, and the gut microbiota; modulation of the gut microbiota by diet could lead to healthier aging. The purpose of this study was to test the effect of diets differing in sugar, fat, and fiber content upon the gut microbiota of mice humanized with microbiota from healthy or frail o...
Article
Prebiotics may improve ageing-related dysbiosis. Milk is a source of nutrients including oligosaccharides whose prebiotic potential remains largely unexplored. We used a murine model to explore the effect of milk products on high diversity and lower diversity faecal microbiota from healthy and frail elderly subjects, respectively. Mice were treated...
Article
Full-text available
Background & aims: Malnutrition in older adults results in significant personal, social, and economic burden. To combat this complex, multifactorial issue, evidence-based knowledge is needed on the modifiable determinants of malnutrition. Systematic reviews of prospective studies are lacking in this area; therefore, the aim of this systematic revi...
Article
Full-text available
Studies have shown associations between reduced vitamin K status and poor cognitive function. However, despite this apparent link, direct studies measuring cognitive function, vitamin K status and inflammation are lacking. In the current study, The ELDERMET cohort was investigated to identify associations between cognition, vitamin K status and inf...
Article
Background & aims: Malnutrition is widespread among older people and related to poor outcome. Reported prevalences vary widely, also because of different diagnostic criteria used. This study aimed to describe prevalences in several populations of older persons in different settings using harmonized definitions. Methods: Available studies within...
Article
Older adults are at increased risk of malnutrition which is associated with poorer health, quality of life, and worse disease outcomes. This study identifies predictors of incident malnutrition using data from a sub-sample (n=1,841) of The Irish Longitudinal Study on Ageing (TILDA). Participants were excluded if they were <65 years, missing BMI dat...
Article
Factors associated with malnutrition in long-term care versus community dwelling older Irish adults - Volume 77 Issue OCE3 - M. Kelly, H. Purtill, M. Grace, S. Leahy, P.W. O'Toole, E. O'Herlihy, E.M. O'Connor
Article
Objectives To identify determinants of incident malnutrition in community‐dwelling older adults. Design Meta‐analysis of 6 community‐based longitudinal datasets with follow‐up of 1 to 3 years. Setting Datasets from MaNuEL (MalNutrition in the Elderly) partners were included: 3 studies from Germany and 1 each from Ireland, the Netherlands, and New...
Article
Full-text available
Specific patient cohorts are at increased risk of vascular calcification. Functional matrix-gla protein (MGP), a tissue-derived vitamin K dependent protein, is reported to be an important inhibitor of vascular calcification and may have clinical potential to modify the progression of vascular calcification through regulation of functional MGP fract...
Article
Full-text available
In order to tackle the increasing problem of malnutrition (i.e. protein-energy malnutrition) in the older population, the Joint Action Malnutrition in the Elderly (MaNuEL) Knowledge Hub has been recently launched as part of the Strategic Research Agenda of the Joint Programming Initiative (JPI) A Healthy Diet for a Healthy Life (HDHL). This paper i...
Article
Full-text available
The role of vitamin K in the body has long been associated with blood clotting and coagulation. In more recent times, its role in a range of physiological processes has been described including the regulation of bone and soft tissue calcification, cell growth and proliferation, cognition, inflammation, various oxidative processes and fertility, whe...
Article
Full-text available
In order to tackle the increasing problem of malnutrition (i.e. protein-energy malnutrition) in the older population, the Joint Action Malnutrition in the Elderly (MaNuEL) Knowledge Hub has been recently launched as part of the Strategic Research Agenda of the Joint Programming Initiative (JPI) A Healthy Diet for a Healthy Life (HDHL). This paper i...
Article
Full-text available
With modern medicine and an awareness of healthy lifestyle practices, people are living longer and generally healthier lives than their ancestors. These successes of modern medicine have resulted in an increasing proportion of elderly in society. Research groups around the world have investigated the contribution of gut microbial communities to hum...
Article
Although epidemiological findings support a role for vitamin K status in the improvement of bone indices in adult patients with Crohn's disease (CD), this needs to be confirmed in double-blind, randomised controlled trials (RCT) with phylloquinone (vitamin K1). By conducting two RCT, the present study aimed to first establish whether supplementatio...
Article
Full-text available
Purpose: Ageing is associated with loss of cognitive function and an increased risk of dementia which is expected to place growing demands on health and long-term care providers. Among multiple causative factors, evidence suggests that cognitive impairment in older subjects may be influenced by diet. The objective of this study was to examine the...
Article
Objectives: To assess the dietary intakes of Irish community-dwelling elderly individuals, participating in the ELDERMET project. Design: Cross-sectional study. Setting: Cork city and county region of southern Ireland. Participants: Two hundred and eight (94 males, 114 females) community-dwelling subjects aged 64-93 yrs. Measurements: Diet...
Article
Full-text available
Alterations in intestinal microbiota composition and function have been linked to conditions including functional gastrointestinal disorders, obesity and diabetes. The gut microbiome encodes metabolic capability in excess of that encoded by the human genome, and bacterially produced enzymes are important for releasing nutrients from complex dietary...
Article
The objective of this review is to outline the contribution of the gut microbiota to nutritional status and to highlight the mechanisms by which this can occur. Historically, research linking intestinal bacteria with nutritional status focused on the degradation of indigestible food components by bacterial enzymes and metabolites. Of late, emerging...
Article
Full-text available
Alterations in intestinal microbiota composition are associated with several chronic conditions, including obesity and inflammatory diseases. The microbiota of older people displays greater inter-individual variation than that of younger adults. Here we show that the faecal microbiota composition from 178 elderly subjects formed groups, correlating...
Article
Full-text available
Fish-oil consumption is inversely correlated with depression and cognition decline in healthy Irish elderly adults - Volume 71 Issue OCE2 - E. M. O'Connor, S. E. Power, G. F. Fitzgerald, P. W. O'Toole
Article
Full-text available
The proportion of citizens older than 65 years of age in Western populations is increasing. It is therefore important to investigate the fundamental role of diet in the prevention of age-associated chronic disease (1). In addition, gender differences in food consumption and nutrient intakes are well recognised (2) , and need to be further explored...
Article
Full-text available
The effect of vitamin K1 supplementation for 12 months on bone mineral density and indices of vitamin K status and bone turnover in adult Crohn's disease patients - Volume 70 Issue OCE3 - E. M. O'Connor, G. Grealy, J. McCarthy, A. Desmond, O. Craig, F. Shanahan, K. D. Cashman
Article
Full-text available
There is some evidence for a nutritional interaction between vitamin D and vitamin K status. We have recently reported that serum percentage undercarboxylated osteocalcin (%ucOC; a marker of vitamin K status) was inversely correlated with serum 25-hydroxyvitamin D (25(OH)D) concentration (reflective of vitamin D status) in healthy Danish girls (age...
Article
Full-text available
The effect of short-term phylloquinone supplementation on indices of vitamin K status and bone turnover in adult patients with Crohn's disease - Volume 68 Issue OCE3 - E. M. O'Connor, G. Grealy, J. McCarthy, A. Desmond, F. Shanahan, K. D. Cashman
Article
The findings of a number of cross-sectional studies suggest benefits of high phylloquinone (vitamin K(1)) intake on bone health in later life. Until recently these observational data were supported by the findings of an intervention study that showed a protective role for vitamin K(1) (together with calcium, magnesium, zinc, and vitamin D(3)) on bo...
Article
Full-text available
Dietary intakes and body composition in adult patients with long-standing Crohn's disease currently in remission - Volume 67 Issue OCE7 - E. M. O'Connor, F. Shanahan, K. D. Cashman
Article
Full-text available
Recent cross-sectional data suggest that better vitamin K status in young girls (aged 3-16 years) is associated with decreased bone turnover, even though it is not associated with bone mineral content (BMC). The objective of the present study was to investigate the relationship between serum percentage of undercarboxylated osteocalcin (%ucOC), as a...

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Projects (2)
Project
The objective of GOGREEN ROUTES is to position European cities as world ambassadors of urban sustainability. Our inspirational approach shifts the focus of NBS towards the co-benefits to multidimensional health-termed 360-Health. GOGREEN ROUTES transdisciplinary consortium will pioneer a unique approach augmenting NBS, urban design with the goal of fostering a positive human-nature relationship, flourishing nature connectedness and promoting citizen engagement through digital, educational and behavioural innovation. GOGREEN ROUTES components focus on nature-based enterprise (GROW), sustainable physical activity (MOVE), digital, cultural (FEEL) and knowledge innovation (KNOW). GOGREEN ROUTES fosters mental health and well-being by optimising human-nature interactions for all citizens. These innovations will increase the uptake and acceptability of NBS across “Cultivating Cities” (Burgas, Lahti, Limerick, Tallinn, Umea & Versailles), “Seed Cities” (Munich, Murcia region & Malta) and a “Cross-Pollination Network: (Beijing, Mexico, & Tblisi). An urban well-being lab, based on the living lab methodology will couple participatory approaches with the Big Data analyses. To advance knowledge, best practice and dissemination GOGREEN ROUTES will cluster with H2020 projects including those involving our partners (e.g. proGIreg, bluehealth2020, Connecting Nature). In addition, linking all open-sourced data to the OPPLA and Think Nature Hubs, delivering online resource (e.g. Urban 360-Health Toolkit, MOOC’s) and empowering citizens in an iterative process of co-creation will ensure perpetuation beyond the end of the project. This novel approach, coupled with the high capacity of the consortium, makes GOGREEN ROUTES an exciting prospect. This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 869764.
Project