Ehsan Moazen Zadeh

Ehsan Moazen Zadeh
Icahn School of Medicine at Mount Sinai | MSSM · Department of Psychiatry

MD MSc

About

35
Publications
6,748
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544
Citations
Citations since 2016
33 Research Items
541 Citations
2016201720182019202020212022020406080100120
2016201720182019202020212022020406080100120
2016201720182019202020212022020406080100120
2016201720182019202020212022020406080100120
Introduction
I graduated with a MD from Iran University of Medical Sciences in 2016, and with an MSc from the University of British Columbia in 2019. My research interests are neuroimaging and neuropharmacology of psychiatric disorders. Currently, I am focused on RCTs of opioid use disorder.

Publications

Publications (35)
Article
Full-text available
Background: Black-White differences are shown in psychosocial and medical correlates of depressive symptoms and major depressive disorder (MDD). The current longitudinal study compared Blacks and Whites for the association between baseline depressive symptoms and subsequent risk of MDD after 15 years. Methods: Data were obtained from the America...
Article
Aim: To test if opium tincture (OT) was non-inferior to methadone in retaining participants in opioid agonist treatment (OAT). Design: A phase III, multicentre, parallel group, non-inferiority, double-blind randomized controlled trial with an allocation ratio of 1:1. Participants were provided treatment and followed for a period of 85 days. Set...
Article
Full-text available
Introduction Opium tincture (OT) is widely used for opioid substitution treatment (OST) in Iran. Objectives To determine if OT is a safe and effective medication for OST. Methods Opium Trial was a multicenter, double‐blind, noninferiority randomized controlled trial, with 204 participants with opioid dependence in Iran. Participants were then ran...
Article
Background: There is a knowledge gap in systematic reviews on the impact of opioid agonist treatments on mental health. Objectives: We compared mental health outcomes between different opioid agonist treatments and placebo/waitlist, and between the different opioids themselves. Methods: This meta-analysis of randomized clinical trials (RCTs) was pr...
Article
Full-text available
Background There is a growing body of evidence regarding eHealth interventions that target substance use disorders. Development and funding decisions in this area have been challenging, due to a lack of understanding of what parts of an intervention work in which context. Objective We conducted a realist review of the literature on electronic cogn...
Article
Full-text available
Cannabidiol (CBD) is gaining considerable attention in the research community with promising results in a variety of neuropsychiatric conditions. In particular, there are replicated findings for the therapeutic effects of CBD on psychotic and anxiety symptoms as well as substance use disorders, all of which are highly prevalent in patients who pres...
Article
Early intervention approaches are built on the premise of preventing disability, burden, and cognitive sequelae caused by bipolar disorder. The objective of this systematic review was to characterise the effectiveness of all the available psychological and pharmacological treatments for early intervention in people at high risk of developing bipola...
Preprint
Full-text available
Objective: There is a dearth of high-quality systematic evidence on the impact of opioid substitution medi-cations on mental health. We compared mental health outcomes between opioid medications and place-bo/waitlist, and between different opioids. Methods: This systematic review and meta-analysis of randomized clinical trials (RCTs) was pre-regist...
Article
Full-text available
Background: When planning interventions aimed at preventing suicide, it is important to consider how socioeconomic and cultural factors may affect suicide rates. There has been variability in the accuracy of recording suicide deaths, leading to varying levels of underestimation. Social, cultural and religious elements affect whether deaths resulti...
Preprint
BACKGROUND There is a growing body of evidence on eHealth interventions that are targeting substance use disorders. Development and decision-making in eHealth has been challenging due to the lack of understanding of how programs work effectively. OBJECTIVE We conducted a realist review on literature of Electronic Health Cognitive-behavioural Thera...
Article
Introduction and objectives Vortioxetine, a novel antidepressant, may be an interesting candidate for adjunctive therapy of schizophrenia. Our primary objective was to investigate the effect of vortioxetine on negative symptoms, with the assessment of positive, general psychopathology and total symptoms as our secondary goal. Methods This was an e...
Article
Full-text available
Background: Duloxetine and pregabalin are among the most widely used medications in the treatment of patients with fibromyalgia syndrome (FM). Objectives: To add to the very few lines of evidence that exist on the comparative safety and efficacy of these two medications. Methods: In this open-label randomized clinical trial, outpatient women,...
Article
Objectives This is the first study to compare the safety and efficacy of opium tincture (OT) with methadone for treatment of opioid use disorder. Methods In this multicenter, double‐blind, noninferiority controlled trial, a stratified sample of 204 participants with opioid use disorder were recruited from community outreach, drop‐in centers, and t...
Article
Full-text available
Background:: Riluzole is a glutamate regulator and effective in treatment of neuropsychiatric conditions. Aims:: We assessed riluzole for treatment of methamphetamine dependence. Methods:: In this randomized, double-blind, placebo-controlled clinical trial, male outpatients with methamphetamine dependence who were 18-65 years old received eith...
Article
Full-text available
Objective: Saffron was found efficient and safe in treatment of neuropsychiatric disorders, in particular depression. We compared the efficacy of saffron with duloxetine in treatment of patients with fibromyalgia. Materials and Methods: In this double-blind parallel-group clinical trial, outpatients with fibromyalgia were randomized to receive eith...
Article
We investigated the association between exposure to chemical warfare and chronic mental/physical conditions. This was a secondary analysis of data from a case–control study on Iranian male veterans. Participants with neuropsychiatric disorders other than depressive/anxiety disorders, anatomical defects, or malignancies were excluded. Compared to no...
Article
Full-text available
PurposeDue to concerns regarding the side effects of hormone therapy, many studies have focused on the development of non-hormonal agents for treatment of hot flashes. The aim of this study was to evaluate the efficacy and safety of saffron (stigma of Crocus sativus) in treatment of major depressive disorder associated with post-menopausal hot flas...
Article
Objectives Red yeast rice (RYR) has demonstrated neuroprotective effects in animal studies. The aim of this study was to access the efficacy of RYR for treatment of depression in patients with recent history of percutaneous coronary intervention. Design This was a 6-week double-blind placebo-controlled randomized clinical trial. Setting Participa...
Article
Objectives: Cognitive decline, depression, and anxiety are among the major concerns in patients undergoing coronary artery bypass grafting (CABG). Crocus sativus L. (saffron) seems to be a promising candidate for treatment of these conditions. Design: In this 12-week, randomized, double-blind, placebo-controlled clinical trial, men and women wit...
Article
We assessed the efficacy of pexacerfont, a CRF1 antagonist, for the treatment of withdrawal symptoms. In this randomized, double-blind, placebo-controlled clinical trial, male patients with amphetamine or opioid dependence, on the basis of the Diagnostic and Statistical Manual of Mental Disorders, 4th ed., Text Revision (DSM-IV-TR), in the age rang...
Article
Objectives: Providing novel treatments for autism has been a subject of long-standing research. Based on etiopathological findings, we aim at assessing potential therapeutic effects of statins, here simvastatin, on autism symptoms for the first time. Methods: In this randomized, double-blind, placebo-controlled, parallel-group 10-week clinical t...
Article
There have been few studies of pregnenolone therapy in schizophrenia and those that exist have been subject to several critical limitations, thus yielding inconsistent results. We attempted to assess the therapeutic effect of pregnenolone in a patient sample as homogeneous as possible. In this randomized double-blind clinical trial, 82 female inpat...
Article
Full-text available
Background Despite the existing knowledge regarding the negative mental health consequences of perceived racial discrimination, very few researchers have used a longitudinal design with long-term follow-up periods to explore gender differences in this association over time. Objective The current longitudinal study aimed to investigate gender diffe...
Article
Objective: Veterans of war affected by posttraumatic stress disorder (PTSD) are at increased risk for cardiovascular diseases. We aimed to compare brachial and central blood pressures between veterans with PTSD and controls. Method: In this case-control study on veterans of Iran–Iraq war, 50 veterans with PTSD and 50 veterans as controls were selec...
Article
FROM: Barnes TR, Leeson VC, Paton C, et al . Antidepressant Controlled Trial For Negative Symptoms In Schizophrenia (ACTIONS): a double-blind, placebo-controlled, randomised clinical trial. Health Technol Assess 2016;20:1–46. Persistent negative symptoms which do not respond to antipsychotic regimens are experienced by 15–20% of patients with schi...
Article
We investigated the effects of simvastatin adjunctive therapy on the negative symptoms of schizophrenia. In this double-blind trial, inpatients with chronic schizophrenia were clinically stabilized on a constant dose of risperidone for at least 4 weeks before the study and were then randomized to receive risperidone (4-6 mg/day) plus either simvast...
Article
Full-text available
Background: The Center for Epidemiologic Studies Depression (CES-D) scale is one of the most widely used tools to measure depressive symptoms in epidemiological studies. Given the importance of cross-racial measurement equivalence of CES-D scale for research, we performed confirmatory factor analysis of 12 - item CES-D in a nationally representati...
Conference Paper
Full-text available
Background: Among the military personnel especially veterans of war, those affected by post traumatic stress disorder (PTSD) are at increased risk for cardiovascular diseases. We aimed to assess blood pressure measures as well as other cardiovascular risk factors such as depression in this population. Methods: In this case-control study, 50 veteran...
Article
Full-text available
Background The degree by which depressive symptoms and clinical depression reflect each other may vary across populations. The present study compared Blacks and Whites for the magnitude of the cross-sectional associations between various domains of depressive symptoms and endorsement of clinical disorders of depression. Methods Data came from the N...
Article
Full-text available
Purpose: Despite the well-established association between baseline depressive symptoms and risk of all cause-mortality, limited information exists on racial differences in the residual effects of baseline depressive symptoms above and beyond socioeconomic status (SES) and physical health on this link. The current study compared Blacks and Whites f...
Article
Full-text available
Introduction: N-methyl-D-aspartate receptor subunits antibody (NR2-ab) is a sensitive marker of ischemic brain damage in clinical circumstances, such as cerebrovascular accidents. We aimed to assess the value of serum NR2-ab in predicting the post-cardiopulmonary resuscitation (CPR) survival. Methods: In this cohort study, we examined serum NR2-...
Article
Serotonin transporter gene linked polymorphic region, also called 5HTTLPR, is a candidate in the genetics of bipolar disorder; however, the results of previous association studies are inconsistent. Several explanations have been proposed for that inconsistency; among them are the existing differences both in the genetic basis of bipolar disorder su...

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Projects

Projects (2)
Project
Prevent addiction Harm reduction in addiction Medical and non medical intervention in addiction Psychological health
Project
As shown in more than 200 papers, marginalized people gain less health from the very same socioeconomic resources than mainstream populations. In the US, Blacks, Hispanics, Native Americans, Asian Americans, and LGBTs are at a relative disadvantage compared to mainstream populations regarding the protective effects of education, income, employment, and marital status on a wide range of health outcomes. This phenomenon also holds for marginalized Whites who live in poor conditions. So it is not the behaviors of a particular group that result in disparities. It is social marginalization, broadly defined. Here is a summary: https://www.youtube.com/watch?v=I0TQ-FXmADI&t=1723s