Ehsan Misaghi

Ehsan Misaghi
University of Alberta | UAlberta

MSc

About

8
Publications
17,582
Reads
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34
Citations
Introduction
I'm currently an MD/PhD (Genetics) student at the University of Alberta. My research revolves around understanding the role of planar cell polarity in development, using zebrafish as a model organism. My prior research has been on neuroimaging and neurological correlates of speech and language, stuttering, epilepsy and stroke.
Additional affiliations
December 2018 - August 2019
University of Alberta
Position
  • Lab Coordinator
January 2017 - December 2018
University of Alberta
Position
  • Project Manager
September 2014 - December 2016
University of Alberta
Position
  • Research Assistant
Education
August 2019 - June 2027
University of Alberta
Field of study
  • Medicine and Molecular Biology & Genetics
September 2014 - August 2016
University of Alberta
Field of study
  • Neuroscience
September 2010 - July 2014
Amirkabir University of Technology
Field of study
  • Biomedical Engineering

Publications

Publications (8)
Article
Background: Walking while talking (WWT) is a dual-task (cognitive and motor) performance test that has not yet been validated in older adults with lower-limb amputation (LLA). WWT is composed of two sections: WWT-simple (walking while reciting every letter of the alphabet) and WWT-complex (walking while reciting every other letter of the alphabet)...
Article
Background: Older adults with lower-limb amputations (LLAs) often experience lack of confidence and poor balance, which limits their mobility. There are few validated measures for assessing these outcomes in the LLA population. Objectives: To assess the validity of the Life Space Assessment (LSA) and the Physical Activity Scale for the Elderly (...
Article
Background The impact of perihematoma edema in Intracerebral Hemorrhage (ICH) on white matter integrity is uncertain. Fractional Anisotropy (FA), as measured with Diffusion Tensor Imaging (DTI), can be used to assess white matter microstructure. We tested the hypotheses that sections of the Corticospinal Tract (CST) passing through perihematoma ede...
Article
Cover legend: The cover image is based on the Rapid Communication Curved Multiplanar Reformatting Provides Improved Visualization of Hippocampal Anatomy by Donald William Gross et al, https://doi.org/10.1002/hipo.23177. Cover image © Donald W Gross Images.
Article
Full-text available
Objective: Neuropathological studies indicate that hippocampal sclerosis (HS) consists of three subtypes (ILAE types 1-3 HS). However, HS subtypes currently can only be diagnosed by pathological analysis of hippocampal tissue resected during epilepsy surgery or at autopsy. In vivo diagnosis of HS subtypes holds potential to improve our understandi...
Article
Full-text available
There is a growing body of literature studying changes in hippocampal subfields in a variety of different neurological conditions, but this work has mainly focused on the hippocampal body given challenges in visualization of hippocampal anatomy in the head and tail when sectioned in the typical coronal image plane. Curved multiplanar reformatting (...
Article
Stuttering is a neurodevelopmental speech disorder with a phenotype characterized by speech sound repetitions, prolongations and silent blocks during speech production. Developmental stuttering affects 1% of the population and 5% of children. Neuroanatomical abnormalities in the major white matter tracts, including the arcuate fasciculus, corpus ca...
Article
Background: Perihematoma edema in intracerebral hemorrhage (ICH) is thought to be associated with tissue injury. Fractional Anisotropy (FA), as measured with Diffusion Tensor Imaging (DTI), can be used to assess white matter integrity. We tested the hypotheses that sections of the Corticospinal Tract (CST) passing directly through edema would 1) ha...

Questions

Questions (3)
Question
Hi everyone,
I'm fairly new to DKI tractography. I have used ExploreDTI for DTI tractography before and I know a few software packages that work well for DTI, but I wanted to use specific software packages for DKI tractography. I have used DKE to estimate the tensor and it works fine for that aspect, but unfortunately, the tractography module does not work well. I was wondering if anyone here has used any software packages that are specifically designed for DKI tractography (or are at least capable of doing that, especially resolving the crossing fibers issues, etc.) and they have got reasonable outputs. I'd appreciate if you can introduce me some of those packages.
Thanks a lot,
Ehsan
Question
The p-value for correlation (e.g. Pearson's r) means how significant is the difference between the obtained Pearson's r and the number 0 (no correlation). There is a p-value associated with the ICC (intraclass correlation coefficient), too. Do we have to report it? What does that mean? And what do we have to do if it's greater than .05? What would be a typical statement to report ICC in a scientific manner?
Thanks in anticipation,
Ehsan
Question
I am aware of the study "Hofer and Frahm, 2006" that used adults as the subjects. Using the definition of that study in diffusion images of children does not yield satisfactory results, e.g. when defining the splenium as the posterior 1/4 of the CC width, most of the time we get some fibers that look like the fibers of the body of the CC along with occipital and temporal projections of the splenium. Do you know any studies suggesting a delineation of the CC parts in children?

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Projects

Projects (2)
Project
The goal of this project is to determine disrupted connections in the brains of people with Juvenile Myoclonic Epilepsy (JME) using a novel neuroimaging technique, diffusion kurtosis imaging (DKE).