Ehab Abdel-Latif

• Mansoura University

A series of novel dye-based D-π-A-type metal-free organic dyes was prepared via the Wittig reaction. Dyes SAS-1-5 containing triphenylamine (TPA) as a strong electron donor was linked with an aryl ring as a π-conjugation spacer, cyanoacetamide, 2-(phenylsulfonyl)acetonitrile, and thiazolidine as the electron acceptors. Herein, we confirmed the chem...

This study presents a systematic investigation of novel phenothiazine-based sensitizers (SR1–6) for dye-sensitized solar cells (DSSCs), both as individual sensitizers and in co-sensitization with ruthenium-based N-719 dye. The compounds exhibited notable spectral properties when adsorbed on TiO2, demonstrating significant bathochromic shifts and br...

The current research implies the synthesis of two novel organic co-sensitizers based on carbazole, which are referred to as MA-1 and MA-2. The performances of these sensitizers in dye-sensitized solar cells (DSSCs) were also studied. The molecular structures were designed using donor-π-acceptor (D-π-A) configurations, where 9-heptyl carbazole and 9...

Developing new pesticide led compounds to minimize the escalating resistance of agricultural pests which raised by the extensive use of agrochemicals is highly desirable. A series of novel heterocyclic tosyl esters was designed, synthesized, and characterized via different spectral analyses. The pesticidal potential of the thiazolidinone, thiazole,...

This study presents a significant advancement in tandem dye-sensitized solar cells (T-DSSCs) through the strategic synthesis of novel triazatruxene (TAT) sensitizers MS-1 and MS-2. These organic sensitizers demonstrate exceptional light-harvesting capacity and overall performance, pushing the boundaries of power conversion efficiency (PCE) in DSSCs...

Dye-sensitized solar cells (DSSCs) have emerged as a promising alternative for renewable energy conversion. The synthesis and characterization of the 2-acetonitrile-benzoxazole (BOA) sensitizer MSW-1–4 are presented along with their chemical structures. Four new organic dyes, MSW-1 through MSW-4, were synthesized using BOA as the main building bloc...

The chemicals formed from antipyrines are flexible organic building blocks that are employed in the development of pharmaceuticals. By diazotizing (4‐arylazo‐3‐hydroxy‐2‐thienyl) 4‐antipyrine ketones 1a, 1b and 1c and (4‐arylazo‐3‐methyl‐2‐thienyl) 4‐antipyrine ketones (2a, 2b and 2c) further replaced with six other coupling components, a broad spe...

In this study, a series of novel pyrazole-based compounds were synthesized starting from the precursor ethyl 3-(4-amino-1-phenyl-3-((4-sulfamoylphenyl)carbamoyl)-1H-pyrazol-5-yl)-3-oxopropanoate (2). Various synthetic routes were used to obtain pyrazolyl-pyrazolone 3, tricyclic dipyrazolopyridine 4a-c, thiazolylbipyrazoles 5 & 6, pyrazolo[4,3-b]pyr...

As natural capping reagents, flaxseed gel, caprylic/capric triglyceride, aloe vera, and propylene glycol were utilized in the synthesis of ZnO-NPs in the current study. The synthesized ZnO NPs structure was characterized by Transmission Electron Microscopy (TEM), Fourier Transform Infrared (FT-IR), and X-Ray Diffraction (XRD). The prepared ZnO-NPs...

In this study, we synthesized new series of 5-oxo-2-phenyl-4-(arylsulfamoyl)sulphenyl) hydrazono)-4,5-dihydro-1H-pyrrole-3-carboxylate hybrids 4a-f with the goal of overcoming sulfonamide resistance and identifying novel therapeutic candidates by chemical changes. The chemical structures of the synthesized hybrids were established over the spectros...

The objective of this study is to synthesize novel heterocyclic scaffolds containing a thiophene moiety using easily accessible acetoacetamide as a key syn-thon. The reaction of acetoacetamide with diazonium salts resulted in the formation of the corresponding thiophene derivatives 4a-c. Additionally, the reaction of acetoacetamide derivative 3 wit...

Herein, the constructing synthon 3‐oxobutanamidothiophene derivatives 2 a and 2 b were synthesized and utilized for building a wide variety of pyran, thiazole, pyrazole or pyrimidine ring heterocyclic compounds that can be used as anticancer medications. 3‐Oxobutanamidothiophene derivatives 2 a,b were coupled with 4‐substitutedphenyl diazonium chlo...

A new series of thiophene-based organic chromophores (4–7 a, b) has been developed through structural engineering of the electron donor (D) group, incorporating N,N-dimethylaminophenyl and morpholinophenyl, and acceptor moieties such as benzonitrile and flurobenzonitrile. Additionally, a π-linkage of phenylthiophene was inserted. The effects of var...

Two new dichlorophenylfurylnicotinamidine regioisomers and were prepared from the corresponding di chlorophenylfurylnicotinonitriles when treated with lithium bis(trimethylsilyl)amide and subsequent deprotection, then hydrogen chloride salt formation. Nicotinonitriles were prepared employing a Suzuki coupling conditions for 6-(5-bromofuran-2-yl)nic...

Various sets of thiazole, thiophene, and 2-pyridone ring structures containing a dimethylaniline component were synthesized. Substituted thiazoles 2–3 and thiophenes 5–7 were produced by reacting thiocarbamoyl compound 4 with α-halogenated reagents in diferent basic conditions. Also, a series of 2-pyridone derivatives 9a–f substituted with dimethyl...

The synthesized Zeolite A/ZnCl2 nanoparticles via the hydrothermal route were characterized using FTIR, XRD, and SEM/EDAX techniques. The characterized catalyst was used for the eco-friendly synthesis of 4,5-dihydro-pyrazole-1-carbothioamide derivatives. Under solvent-free conditions, a multi-component reaction between hydrazine, isothiocyanate, an...

New sets of functionalized thiazolidinone and thiadiazole derivatives were synthesized, and their cytotoxicity was evaluated on HepG2, MCF‐7, HTC‐116, and WI38 cells. The synthetic approach is based on the preparation of 4‐(4‐acetamidophenyl)thiosemicarbazide (4) and their thiosemicarbazones 5a‐e, which are converted to the corresponding thiazoldin...

The effectiveness of synthesized antipyrinyl‐imidazotriazole and its derivatives as inhibitors for the corrosion of copper alloy in 0.5 M H 2 SO 4 solution was tested using weight loss, electrochemical impedance spectroscopy (EIS) and potentiodyanmic polarization techniques. The generated results confirmed that the tested compounds have strong inhi...

The aim of this study involves the synthesis novel thiophene analogues that can be used as anticancer medications through a strategic multicomponent reaction connecting ethyl 4‐chloroacetoacetate (1), phenyl isothiocyanate, and a series of active methylene reagents, including ethyl acetoacetate (2), malononitrile, ethyl cyanoacetate, cyanoacetamide...

We report on the synthesis and characterization of six novel 2,2′-bithiophene-based organic compounds ( 3a–c and 5a–c ) that are designed to serve as co-sensitizers for dye-sensitized solar cells (DSSCs) based on TiO 2 . The compounds are linked to various donor and acceptor groups, and we confirm their chemical structures through spectral analyses...

A series of 2-(4-substituted-phenylimino)thiazolidin-4-one compounds was synthesized via heterocyclizing the corresponding N-aryl-2-chloroacetamides with ammonium thiocyanate. Their chemical structures were elucidated based on an extensive analysis of their spectroscopic data, including infrared, 1H NMR, 13C NMR, and mass analyses. The possible tau...

Background In the current work, we have utilized the reactivity of N-(4-acetylphenyl)-2-(4-formylphenoxy)acetamide for the synthesis of novel series of 1,2-dihydropyridines, arylidines, and hydrazides. Our strategies were prolonged for the synthesis of novel terthienylnicotinamidine hydrochloride salt through a Stille coupling reaction of 6-(5'-bro...

This investigation outlines the synthesis and design of four innovative organic dyes (MRS-1-4) as co-sensitizers for dye-sensitized solar cells (DSSCs), which are co-sensitized with the well-established Ru (II) dye N719. These new dyes incorporate an electron-rich furan unit attached with thiazole as auxiliary acceptors that linked into electron-wi...

The synthesis, description, and demonstration of dye-sensitive solar cell sensitizers containing bifuran/ biphenyl derivatives with cyanoacetic acid, barbiturate, thiobarbituric acid, and 4-carboxylcyanoacetamides have been reported. A photovoltaic performance measurement was conducted using the Ru(II) dye N3 as a reference to examine the effects o...

Several pyrazole-benzene sulfonamides were reported as human carbonic anhydrase inhibitors. In this research work, a design of Arylidine-extented 5-oxo-pyrazole benzenesulfonamides (4a-i), (8a-d) and (10a-e) were reported based on tail-approach design. Beside the reported synthetic procedures and confirmation by different analytical procedures, a D...

Synthetic strategy for the synthesis of thiophene 2-carboxamide derivatives substituted with hydroxyl, methyl and amino groups at position-3 was proposed. The strategy includes the cyclization of the precursor ethyl 2-arylazo-3-mercapto-3-(phenylamino)acrylate derivatives, 2-acetyl-2-arylazo-thioacetanilide derivatives and N-aryl-2-cyano-3-mercapto...

3-Amino-4,6-dimethylpyrazolopyridine was applied as a precursor for the synthesis of some new pyridopyrazolo-triazine and pyridopyrazolo-triazole derivatives through diazotization, followed by coupling with many 2-cyanoacetamide compounds, ethyl 3-(phenylamino)-3-thioxopropanoate, 3-oxo-N-phenylbutanethioamide, and α-bromo-ketone reagents [namely;...

The synthesized Zeolite A/ZnCl2 nanoparticles via the hydrothermal route were characterized using FTIR, XRD, and SEM/EDAX techniques. The characterized catalyst was used for the eco-friendly synthesis of 4,5-dihydro-pyrazole-1-carbothioamide derivatives. Under solvent-free conditions, a multi-component reaction between hydrazine, isothiocyanate, an...

A new series of pyridine, thiazole, and pyrazole analogues were synthesized. The pyridone analogues 4a-e were synthesized by treating N-aryl-2-cyano-3-(4-(diphenylamino)phenyl)acrylamides 3a-e with malononitrile. Many 4-arylidene-thiazolidin-5-one analogues 6a-d were obtained by Knoevenagel reactions of 4-(diphenylamino)benzaldehyde (1) with their...

Synthesis of metal-free organic sensitizers is a promising route for obtaining low-cost, high-efficiency sensitizers for dye-sensitized solar cells (DSSCs). We present the results of a comprehensive photovoltaic analysis of four carbazole organic sensitizers with a D-A architecture in this study. MES 1-4 have been developed and used as sensitizers...

A novel series of antipyrinyl thienyl ketones 4a-c, 7a-c, 10a-c, and 13a-b was chemically synthesized through the cyclocondensation of 4-chloroacetylantipyrine with various 2-substituted-thioacetanilide scaffolds, including 3-arylazo-4-mercapto-4-phenylamino-buten-2-ones, ethyl 2-arylazo-3-mercapto-3-phenylamino-acrylate, 2-cyano-3-mercapto-3-(phen...

A new series of metal-free organic dyes ( SM1-5 ) with dual anchors are synthesized for application in dye-sensitized solar cells (DSSC). Here, a simple triphenylamine (TPA) moiety serves as the electron donor, while di-cyanoacrylamide and di-thiazolidine-5-one units serve as the electron acceptors and anchoring groups. To understand the effect of...

Herein, we present a thorough photovoltaic investigation of four triphenylamine organic sensitizers with D–π–A configurations and compare their photovoltaic performances to the conventional ruthenium-based sensitizer N719. SFA-5–8 are synthesized and utilized as sensitizers for dye-sensitized solar cell (DSSC) applications. The effects of the donor...

p-Fluorophenacyl chloride (1) was used as a building block for the preparation of new tetra-substituted thiophene derivatives. The basic-catalyzed reaction of 1 with various thiocarbamoyl compounds such as 2-acetyl-2-substituted-thioacetanilides 2a,b, 3-arylazo-4-mercapto-4-phenylamino-buten-2-ones 5a–c, ethyl 2-arylazo-3-mercapto-3-phenylamino-acr...

Novel dyes F1-3 based on bichalcophene-pyrimidine-2,4,6-trione derivatives with dual anchoring were developed, synthesized, and evaluated as sensitizers and co-sensitizers for dye-sensitized solar cells (DSSCs). F1 displayed the best DSSC performance (η, PCE = 4.41%) and the highest photovoltaic parameters, which were as follows: current density, J...

A novel series of benzothiazolopyridine derivatives was synthesized via interaction of -2- (benzothiazol-2-yl)-3-(4-chlorophenyl)acrylonitrile (2) with a diverse of commercially available reagents (indandione, thiobarbituric acid, and malononitrile). Moreover, a novel group of benzothiazole linked substituted 1,2,3-triazole derivatives were synthes...

The design and synthesis of eight novel carbazole-based acrylamide derivatives (M1-4) and 2-pyridone-based dyes (M5-8) for dye-sensitized solar cell (DSSC) purposes are discussed in this article. Due to superior delocalization of electrons over the π-conjugated molecules when a cyanoacrylamide moiety is incorporated in the chemical structure, M1-4...

Two novel bithienyl fluorobenzamidine derivatives namely, 4-([2,2′:5′,2′′-terthiophen]-5-yl)-2-fluorobenzamidine hydrochloride salt (MA-1615), 5′-(4-amidino-3-fluorophenyl)-[2,2′-bithiophene]-5-carboxamidine dihydrochloride salt (MA-1740) were synthesized, characterized and their corrosion inhibition properties were evaluated by electrochemical met...

We have synthesized a new class of carbazole-based cyanoacetanilides (5a-c) and carbazole based-thiazolidine derivatives (7a and 7b). These compounds were prepared from 9-hexylcarbazole by employing a multistep synthetic strategy and their structural elucidation was confirmed by the combination of standard spectroscopic methods such as FT-IR, ¹H NM...

A number of interesting N-(4-chlorophenyl)-2-phenoxyacetamide derivatives were synthesized through interaction of N-(4-chlorophenyl)-2-(4-formylphenoxy)acetamide (1) with cyanoacetamide derivatives 2a-e, hydrazine derivatives, activated nitriles and acetophenone to yield novel acrylamide, hydrazone, acrylonitrile and chalcone derivatives, respectiv...

Four novels (N-benzothiazolyl)-cyanoacetamide-based metal-free dyes SA17-20 with D-π-A architecture were designed and synthesized as co-sensitizers for HD-2 for dye-sensitized solar cells (DSSCs). They contain strong donating moieties of trimethoxybenzene and N,N-dimethylaniline conjugated with the nitrile function of cyanoacetamide part (NHCOCH2CN...

New phthalonitrile derivatives formed from reactions of 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) were considered as the key intermediates for the synthesis of new phthalocyanines. Moreover, new phthalonitrile derivatives 2, 5, 9, 10, 15 and 16 reacted with 1,4-diazabicyclo[2.2.2]octane (DBO) or hydroquinone to afford the corresponding new ph...

Twelve new thienylbenzamidines and their analogues 4 a–i, 7, and 12 a, b were synthesized and their anti‐proliferative activity was evaluated against 60 cancer cell lines. The tested compounds showed potent anticancer activity against most cancer cell lines with median growth inhibition (GI50)<2 μM. Leukemia and renal cancer cell lines were the mos...

A series of new 6,8-dichloro-imidazo[1,2-a]pyridine derivatives incorporating pyridine, thiazole, and pyrazole ring systems was synthesized. The synthetic strategy of imidazopyridinyl-pyridine hybrids 2 and 3 involves one pot reaction of the precursor 3-acetyl-6,8-dichloro-2-methylimidazo[1,2-a] pyridine (1) with aldehydes, malononitrile, and/or et...

The chemical performance of 5‐bromo‐2‐(bromoacetyl)‐thiophene (1) was tested towards the reaction with numerous bi‐nucleophilic reagents (namely; 2‐aminobenzothiazoles, 2‐aminothiazole, 2‐aminotetrazole, 2‐aminotriazole, 2‐aminopyridines, 2‐aminobenzimidazole and o‐phenylenediamine). Therefore, a series of bridged nitrogen heterocycles bearing thio...

The chloroacetamide derivative, 1 , was used as a versatile precursor for the synthesis of various types of N ‐aryl‐2‐(benzothiazol‐2‐ylthio)acetamide derivatives. The reaction of 1 with 2‐mercaptobenzothiazole followed by condensation reaction of the produced sulfide with phenylhydrazine, 2‐cyanoacetohydrazide, and/or thiosemicarbazide furnished t...

The synthesis of six novel 2-cyanoacetanilide-derived metal-free organic dyes, named SA11-16, containing 4-dimethylaminophenyl, 4-anisyl or 2,4,5-trimethoxyphenyl as electron donating moieties, and carboxyl (–COOH) or nitro (–NO2) groups as anchoring moieties was reported along with their optical properties, theoretical geometrical studies and spec...

A simple synthesis for a series of chloropyridine derivatives incorporating heterocyclic hybrids has been accomplished. The key reaction involving employment of 5‐chloro‐2‐(cyanoacetamido)pyridines 3 in the synthesis of chloropyridinyl‐pyridone, chloropyridinyl‐pyrazole, chloropyridinyl‐thiazole and chloropyridinyl‐thiophene hybrids. The newly synt...

The photophysical and electrochemical properties of new-targeted 2-cyanoacetanilide-based dyes are illustrated. The new cyanoacetanilides SA7-10 were synthesized and employed as co-sensitizers in DSSCs. The chemical structures of these 2-cyanoacetanilides differ according to the substituent at benzene ring (-H, -Me, -OMe and -NEt2) keeping the same...

Treatment of ethyl 2-((3-cyano-4,6-dimethylpyridin-2-yl)thio)acetate (4) with hydrazine hydrate furnished 2-((3-cyano-4,6-dimethylpyridin-2-yl)thio)-acetohydrazide (5) which underwent condensation with five benzaldehydes to afford the corresponding N'-arylidene-2-((3-cyano-4,6-dimethylpyridin-2-yl)thio)acetohydrazides 6a-e. The reaction of hydrazid...

The synthesis of various N-aryl 2-chloroacetamides has been described through chloroacetylation of the corresponding aryl amine. The chemical reactivity of N-aryl 2-chloroacetamides is attributed to the easy replacement of its chlorine atom by nucleophiles (namely; oxygen, nitrogen and/or sulfur). Furthermore, this nucleophilic substitution may acc...

The synthesis of various N-aryl 2-chloroacetamides has been described through chloroacetylation of the corresponding aryl amine. The chemical reactivity of N-aryl 2-chloroacetamides is attributed to the easy replacement of its chlorine atom by nucleophiles (namely; oxygen, nitrogen and/or sulfur). Furthermore, this nucleophilic substitution may acc...

The design, synthesis and photovoltaic performance of metal-free 2-cyanoacetanilide based organic dyes, SA1-6 have been reported as sensitizers / co-sensitizers in dye sensitized solar cells (DSSCs). All dyes possess the thermodynamic requirements to be applied in DSSCs. The DFT and TD-DFT calculations were completed using Guassian09 package softwa...

Several novel pyrazolotriazine azo scaffolds were synthesized by the diazotization of 4-aminoacetanilide and coupling with 3-Aminocrotonitrile and then refluxed with hydrazine hydrate to furnish 4-(4-acetamidophenylazo)-3-amino-5-methyl-1H-pyrazol. The later scaffolds was diazotized and coupled with active methylene compounds namely; (malononitile,...

A new series of pyrazole derivatives was prepared in this work, including pyrazolopyrimidines, pyrazolotriazines, pyrazolylthienopyridines, and 2-(pyrazolylamino)thiazol-4-ones, utilizing 3-amino-5-methyl-1H-pyrazole as a synthetic precursor. Their in vitro anticancer activity was tested on hepatocellular carcinoma cell line, HepG2. The results rev...

Chemical reactivity of amino group that connected with the para position of acetanilide moiety (p-aminoacetanilide) attained more attention in chemistry. In this review article, we report the chemistry of p-aminoacetanilide and its utilization in the synthesis of azo compounds, pyrrole, imidazole, thiazole and various heterocycles of biological imp...

2‐Cyanoacetamido‐thiazole (1) was employed as a key for the construction of 6‐cyano‐7‐oxo‐7H‐thiazolo[3,2‐a]pyrimidine (4) which underwent reaction with hydrazine, malononitrile, ethyl cyanoacetate, and/or various 1,3‐bi‐nuclophilic reagents furnished the corresponding tri‐heterocyclic and tetra‐heterocyclic ring systems 5–12. In addition, the reac...

3-Amino-5-bromo-4,6-dimethyl-1H-pyrazolo[3,4-b]pyridine (2) was utilized as a precursor for the construction of new polyheterocyclic ring systems. It reacted with 4-substituted arylidene malononitriles and/or ethyl acetoacetate to furnish the corresponding pyrido[2',3':3,4]pyrazolo[1,5-a]pyrimidine derivatives 4a–c and 6, respectively. Diazotizatio...

Newly synthesized 1,2,3‐benzotriazine‐4‐one derivatives substituted at position‐3 were characterized by various analytical and spectral techniques. The in vitro antitumor activity was evaluated against three different cell lines (liver cells cancer, colorectal cancer, and breast cancer), where compounds 7b, 15, and 25 showed strong antitumor activi...

A series of some new heterocyclic scaffolds containing thiazole moiety was synthesized through the reaction of 2-chloroacetamidothiazole (1) with various types of nucleophiles, namely ethylthioglycolate, 2-mercaptobenzothiazole, 2-mercaptobenzoxazole, malononitrile, salicylaldehyde, ammonium thiocyanate, and 3-cyano-4,6-dimethyl-5-phenylazopyridin-...

The aim of this study involves the synthesis of novel heterocyclic scaffolds containing acetanilide moiety from the readily accessible 2-substituted-2-(4-acetamidophenylhydrazono)-thioacetanilides, which underwent reaction with various alpha-halogenated reagents (namely: bromoacetone, phenacyl bromide, ethyl bromoacetate and chloroacetonitrile) aff...

A series of some novel 4‐(N‐substituted amino)‐acetanilide scaffolds was synthesized through the nucleophilic substitution reactions of the highly versatile N‐(4‐acetamidophenyl)‐2‐chloroacetamide (3) with various types of nucleophilic reagents such as benzothiazole‐2‐thiol, ethyl 2‐mercaptoacetate, 4,6‐dimethyl‐2‐mercapto‐nicotinonitrile, various...

A series of new thiazole-containing heterocyclic scaffolds was synthesized based on the reaction of 2cyanoacetamidothiazole (1) with various types of nucleophilic reagents. Thus, its base-catalyzed reaction with phenyl isothiocyanate followed by subsequent treatment of the thiocarbamoyl intermediate with various α-halogenated reagents furnished the...

2-(Antipyrinyl)-2-oxoethyl 4-aminobenzoate (3) has been diazotized by the action of nitrous acid (HCl and NaNO2) and coupled with various methylene components (namely; ethyl cyanoacetate, malononitrile, acetylacetone and ethyl acetoacetate) to furnish the corresponding 2-oxo-2-(4-antipyrinyl)ethyl 4-(hydrazinyl)-benzoates 5a-d. Heating of 5d with h...

Purpose This paper aimed to synthesise some new selenium-containing pyrazole, thiazole and thiophene dyestuffs and investigate their application in dyeing polyester fabrics. Design/methodology/approach 4,4′-Diselanediyl-bis-(2-methoxyaniline) was diazotized by acetic acid/sodium nitrite and coupled with active methylene components such as malononi...

A novel series of organic compounds containing azothiophene moiety have been synthesized. The thin films of these dyes have been prepared using a spin coating technique. The structure formation of the films has been studied using Fourier transform infrared, field emission scanning electron microscope and X-ray diffraction patterns. The synthetized...

Two derivatives of 3-amino-4-arylazo-1-phenylpyrazol-5-one have been used for dyeing un-irradiated and irradiated polyester and nylon fabrics using different absorbed doses of Co-60 gamma irradiation to study the effect of radiation treatment on the color strength of dyed fabrics. The data color report is used for the evaluation of un-irradiated an...

Benzoylacetone has been reacted with phenyl isothiocyanate to afford two different thiocarbamoyl derivatives (α-phenylthiocarbamoyl benzoylacetone and benzoyl thioacetanilide) depending upon the base used to perform the reaction. Several new 2-substituted-4-sulfamoylphenylazo-thiophene and/or thiazole derivatives were synthesized by heterocyclizati...

3-Methyl-1-thiocarbamoyl-2-pyrazolin-5-one has been utilized as a core for the synthesis of some 1-(thiazol-2-yl)-pyrazolin-5-one derivatives through diazo-coupling reaction and/or Knoevenagel condensation followed by heterocyclization with some α-halogenated reagents such as bromoacetone, phenacyl bromide, and ethyl bromoacetate. Base prompted add...

A new series of pyrazolo[3,4-d]pyrimidine-3-carbonitrile and pyrazolo[3,4-b]pyridine-3-carbonitrile derivatives was synthesized by the reaction of 5-amino-1-tosyl-1H-pyrazole-3,4-dicarbonitrile as a key starting material with various electrophilic and nucleophilic reagents. All the newly synthesized compounds were structurally confirmed by various...

A new derivatives of functionally 4,6-dimethyl-2-substituted-nicotinonitrile derivatives 4, 6, 7, 8 and 9 were synthesized through condensation reaction of the key compound 2-((4-acetylphenyl)amino)-4,6-dimethylnicotinonitrile (3) with thiosemicarbazide followed by cyclization of the produced thiosemicarbazone with various α-halogenated carbonyl re...

In an attempt to find a new class of antioxidants and corrosion inhibitors, a series of 5-anilino-4-(4-hydroxyphenylazo)-3-methyl-2-substituted-thiophene derivatives were prepared via the reaction of 2-acetyl-2-(4-hydroxyphenylhydrazono)-thioacetanilide (3) with appropriate a-halogenated carbonyl reagents namely, chloroacetone, phenacyl bromide, et...

A new series of 4-substituted-2-pyrazolin-5-one-1-carbothioamide derivatives 5, 7, 9, 10, 11 and 12 was synthesized through the reaction of 3-methyl-2-pyrazolin-5-one-1-carbothioamide (2) as a core compound with various electrophilic reagents. The structures of the newly synthesized compounds were confirmed by IR, 1H NMR, MS and elemental analysis....