Egon Perilli

Egon Perilli
Flinders University · College of Science & Engineering

PhD Bioengineering, MSc Physics
Assoc Prof in Biomedical Engineering. Supervisor and instrument leader, micro-CT imaging lab

About

91
Publications
16,302
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1,966
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Introduction
2D and 3D quantitative imaging of bone structure and biomaterials combined with biomechanical testing. The main research is in osteoporosis and osteoarthritis. State of the art micro-CT imaging, in vitro and in vivo, of bone samples and entire bone segments, on human tissue and animal models. These techniques are used to determine bone structure at micro and macro level, density and morphometry. The mechanical strength of the bone is determined via experimental testing, for investigating the relationships between bone structure and mechanics. The application of digital volume correlation (DVC) on the images enables to compute displacements and strains, useful to validate finite element predictions. President (2018-2021) of the Australian & New Zealand Orthopaedic Research Society (ANZORS).
Additional affiliations
February 2012 - present
Flinders University
Position
  • Topic Coordinator and Topic Lecturer: Medical Physics, Biomaterials, Biomedical Instrumentation, Bone Biomechanics
September 2011 - April 2020
Flinders University
Position
  • Lecturer
January 2009 - present
The University of Adelaide
Position
  • Lecturer
Education
January 2003 - April 2006
University of Bologna
Field of study
  • Bioengineering
December 1994 - October 2001
University of Bologna
Field of study
  • Physics

Publications

Publications (91)
Article
Full-text available
Purpose: In the literature, inter-vertebral MRI signal intensity changes (Modic changes) were associated with corresponding histological observations on endplate biopsies. However, tissue-level studies were limited. No quantitative histomorphometric study on bone biopsies has yet been conducted for Modic changes. The aim of this study was to charac...
Article
Full-text available
Three-dimensional (3D) characterization of cortical porosity, most of which is under 100 µm in diameter, is usually confined to measurements made in 3–4 mm diameter cylinders of bone. We used micro-computed tomography (micro-CT) scanning of entire transaxial cross sections of human proximal femoral shafts (30–35 mm diameter) to quantify regional va...
Article
Full-text available
Tibial subchondral bone plays an important role in knee osteoarthritis (OA). Microarchitectural characterization of subchondral bone plate (SBP), underlying subchondral trabecular bone (STB) and relationships in microarchitecture between these compartments, however, is limited. The aim of this study was to characterize the spatial distribution of S...
Article
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Time-elapsed micro-computed-tomography (μCT) imaging allows studying bone micromechanics. However, no study has yet performed time-elapsed μCT imaging of human femoral neck fractures. We developed a protocol for time-elapsed synchrotron μCT imaging of the microstructure in the entire proximal femur, while inducing clinically-relevant femoral neck f...
Article
Biomechanical factors (e.g. joint loading) have a significant role in the progression of osteoarthritis (OA). However, some relationships between in vivo joint loading indices and tibial cartilage thickness are conflicting. This study investigated relationships between pre-operative in vivo external knee joint moments, joint alignment and regional...
Article
Full-text available
This study aimed to improve the overall fatigue properties of WAAM-produced SDSS by changing the interpass temperatures. Micro-computed tomography was used to quantitatively characterise the internal defects, such as porosity, in large-volume WAAM-fabricated SDSS materials. An increase in the interpass temperature led to a reduction in the ferrite...
Article
Postoperative weight bearing has the potential to generate fragmental motion of surgically repaired tibial plateau fractures (TPFs), which may contribute to loss of fracture reduction. The effect of loading on the internal distribution of fragmentary displacements is currently unknown. The aim of this study was to determine the internal displacemen...
Article
Primary stability of press-fit tibial trays is achieved by introducing an interference fit between bone and implant. The internal cancellous bone strains induced during this process and during loading have yet to be quantified experimentally. Advancements in large-gantry micro-CT imaging and digital volume correlation (DVC) allow quantification of...
Article
Solar receivers are an integral part of a concentrated solar power plant and commonly utilise tubular structures to absorb solar energy and transfer the heat into a heat transfer fluid. These systems often contain dissimilar materials joined through welds which are exposed to cyclic temperatures, which can be a locus of failure. A systematic forens...
Article
Full-text available
Introduction A characterization of the internal bone microstructure of the radial head could provide a better understanding of commonly occurring fracture patterns frequently involving the (antero)lateral quadrant, for which a clear explanation is still lacking. The aim of this study is to describe the radial head bone microstructure using micro-co...
Article
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Background The megalichthyids are one of several clades of extinct tetrapodomorph fish that lived throughout the Devonian–Permian periods. They are advanced “osteolepidid-grade” fishes that lived in freshwater swamp and lake environments, with some taxa growing to very large sizes. They bear cosmine-covered bones and a large premaxillary tusk that...
Article
Induction of severe inflammatory arthritis in the collagen antibody-induced arthritis (CAIA) murine model causes extensive joint damage and pain-like behavior compromising analysis. While mild models are less severe, their reduced, variable penetrance makes assessment of treatment efficacy difficult. This study aimed to compare macroscopic and micr...
Article
Full-text available
Introduction The three-dimensional (3D) microstructure of the cortical and trabecular bone of the proximal ulna has not yet been described by means of high-resolution 3D imaging. An improved characterization can provide a better understanding of their relative contribution to resist impact load. The aim of this study is to describe the proximal uln...
Article
The objectives of this study were to (1) develop a semi‐automated method to obtain lesion volume and bone mineral density in terms of Hounsfield Units from pelvic computed tomography (CT) scans in three regions of interest, and (2) assess accuracy and reliability of the method based on cadaveric CT scans. Image artefacts due to metal implants reduc...
Article
Full-text available
Observations of elastic instability of trabecular bone cores supported the analysis of cortical thickness for predicting bone fragility of the hip in people over 60 years of age. Here, we falsified the hypothesis that elastic instability causes minimal energy fracture by analyzing, with a micrometric resolution, the deformation and fracture behavio...
Article
This preliminary study quantified tibia cartilage thickness (Cart.Th), subchondral bone plate thickness (SBPl.Th) and subchondral trabecular bone (STB) micro-architecture in subjects with varus-or valgus-malaligned knees diagnosed with end-stage knee osteoarthritis (OA) and compared them to controls (non-OA). Tibial plateaus from 25 subjects with k...
Article
Full-text available
We hypothesize that variations of body anthro-pometry, conjointly with the bone strength, determine the risk of hip fracture. To test the hypothesis, we compared, in a simulated sideways fall, the hip impact energy to the energy needed to fracture the femur. Ten femurs from elderly donors were tested using a novel drop-tower protocol for replicatin...
Article
The aim of this study was to investigate if the distribution of subchondral volumetric bone mineral density (vBMD) from peripheral quantitative computed tomography (pQCT) is related to estimates of knee joint loads calculated during walking gait in healthy young people. We recruited 19 young (age 18-40 years) healthy people with no self-reported kn...
Article
Full-text available
Rheumatoid arthritis is characterised by a chronic inflammatory response resulting in destruction of the joint and significant pain. Although a range of treatments are available to control disease activity in RA, bone destruction and joint pain exist despite suppression of inflammation. This study is aimed at assessing the effects of parthenolide (...
Article
Full-text available
Aim The aim of this study is to describe the trabecular bone microstructure of the radial head, using high-resolution three-dimensional micro-computed tomography (micro-CT). Background In radial head fractures, the anterolateral quadrant is found most frequently involved. Several hypotheses about the influence of the trauma mechanism and gross bon...
Conference Paper
Full-text available
It happens too often that when we try to combine the best of two worlds we hit a wall: experts (and geeks..) in one discipline cannot (and refuse to) understand the other. Biologists are not really used (or don’t really want) to hear about force, stress and strain; mechanical engineers usually not about cellular biology and gene expression. OK, not...
Article
Primary press-fit fixation of femoral knee prostheses is obtained thanks to the inside dimensions of the implant being undersized with respect to the bone cuts created intra-operatively, dictated by a press-fit specified by the implant design. However, during prostheses press-fit implantation, high compressive and shear stresses at the implant-bone...
Conference Paper
Full-text available
INTRODUCTION During prostheses press-fit implantation, high compressive and shear stresses at the implant-bone interface are generated. Permanent bone damage occurs [1], but the extent remains unknown. The aim of this study is to quantify, using high-resolution peripheral quantitative computed tomography (HR-pQCT) and Digital Volume Correlation (DV...
Article
This paper explores the effects of aging on femoral neck (FN) anatomy in a study of women aged 20-90 years in relation to implications for FN fracture propensity in buckling. Five hundred and four participants were scanned by Quantitative Computed Tomography and analyzed using Quantitative Computed Tomography Pro BIT (Mindways). FN cross-section wa...
Article
Full-text available
Objective: To study, in end-stage knee osteoarthritis (OA) patients, relationships between indices of in vivo dynamic knee joint loads obtained pre-operatively using gait analysis, static knee alignment, and the subchondral trabecular bone (STB) microarchitecture of their excised tibial plateau quantified with 3D micro-CT. Design: Twenty-five kn...
Article
We investigated if time between injury and surgery affects cancellous bone properties in patients suffering tibial plateau fractures (TPF), in terms of structural integrity and gene expression controlling bone loss. A cohort of 29 TPF, operated 1‐17 days post‐injury, had biopsies from the fracture and an equivalent contralateral limb site, at surge...
Research
Full-text available
Images were obtained at the Australian Synchrotron (Martelli and Perilli, 2015). The original pixel size is 29.31 microns whereas the pixel size in the images displayed here is 119 microns (4x). Also visible at https://youtu.be/lApwsm9DMpI
Article
Full-text available
Objectives: To (1) stratify patient subgroups according to their distinct walking gait patterns in end-stage knee osteoarthritis (OA); (2) compare measures of joint loading and proximal tibia subchondral trabecular bone (STB) microarchitecture among these gait subgroups. Design: Twenty-five knee OA patients undergoing total knee arthroplasty had p...
Article
This study aimed at assessing the feasibility of a discrete algebraic reconstruction technique (DART) to be used in in vivo small animal bone studies. The advantage of discrete tomography is the possibility to reduce the amount of X-ray projection images, which makes scans faster and implies also a significant reduction of radiation dose, without c...
Article
Full-text available
Objective: To investigate the effect of caffeic acid phenethyl ester (CAPE) on local and systemic inflammation and bone loss in collagen antibody-induced arthritis (CAIA) mice. Methods: Four groups of mice (n = 8 per group) were allocated; control, CAPE (1 mg/kg), CAIA and CAIA + CAPE (1 mg/kg). Local inflammation and bone loss were evaluated us...
Article
Osteoporosis and related bone fractures are an increasing global burden in our ageing society. Areal bone mineral density assessed through dual energy X-ray absorptiometry (DEXA), the clinically accepted and most used method, is not sufficient to assess fracture risk individually. Finite element (FE) modelling has shown improvements in prediction o...
Chapter
The lunate is the keystone of the wrist, and the primary pathological structure of Kienböck’s avascular necrosis. The normal lunate has a thin single layer of proximal subchondral bone plate, which is at risk of fracture, which does occur in Kienböck’s disease. There are spanning trabeculae between the proximal and thick distal subchondral bone pla...
Article
Kienböck disease is a condition that typically occurs in the “at-risk” patient, in the “at-risk” aspect of the proximal condyle of the “at-risk” lunate. In the active male, repetitive loading causes the stress fracture that commences in the single layer proximal subchondral bone plate. The lunate fracture commences at the point the lunate cantileve...
Article
Kienböck disease is a condition that typically occurs in the “at-risk” patient, in the “at-risk” aspect of the proximal condyle of the “at-risk” lunate. In the active male, repetitive loading causes the stress fracture that commences in the single layer proximal subchondral bone plate. The lunate fracture commences at the point the lunate cantileve...
Article
A major complication of silicone breast implants is the formation of a capsule around the implant known as capsular contracture which results in the distortion of the implant. Recently, a mouse model for studying capsular contracture was examined using micro-computed tomography (micro-CT), however, only qualitative changes were reported. The aim of...
Article
Full-text available
Objective: To investigate the effect of Embelin, an inhibitor of X-Linked Inhibitor of Apoptosis Protein (XIAP), on inflammation and bone erosion in a collagen antibody induced arthritis (CAIA) in mice. Methods: Four groups of mice (n = 6 per group) were allocated: CAIA untreated mice, CAIA treated with Prednisolone (10 mg/kg/day), CAIA treated...
Article
The study aimed to determine the effects of parthenolide (PAR) on bone volume (BV) and bone surface resorption as assessed by live-animal microcomputed tomography (µCT) and possible osteocyte death as indicated by empty lacunae histologically in polyethylene (PE) particle-induced calvarial osteolysis in mice. Baseline µCT scans were conducted 7 day...
Article
Full-text available
Particle-induced bone loss by osteoclasts is a common cause of aseptic loosening around implants. This study investigates whether caffeic acid phenethyl ester (CAPE), a potent and specific inhibitor of nuclear factor of activated T cells, cytoplasmic, calcineurin-dependent 1 and nuclear factor kappa B, at a low dose reduces bone resorption in a mur...
Article
Full-text available
In rodent models of inflammatory arthritis, bone erosion has been non-invasively assessed by micro-computed tomography (micro-CT). However, non-invasive assessments of paw swelling (oedema) are still based on clinical grading by visual evaluation, or measurements by callipers, not always reliable for the tiny mouse paws. The aim of this work is to...
Conference Paper
Full-text available
INTRODUCTION Nano-computed tomography (nano-CT) enables the investigation of bone structure at nano-meter level in 3D [1]. However, because of the small specimen dimensions in nano- CT, 500 μm or below, the specimen preparation is crucial [2]. As part of an ongoing study, we present a nano-CT examination of human trabecular bone using a laboratory...
Article
Full-text available
Kienböck's disease is idiopathic osteonecrosis of the lunate, leading to its fracture and collapse. This study compares internal and external bone micro-architecture of normal and fractured lunates (Kienböck's), by using high-resolution three-dimensional (3D) micro-computed tomography (micro-CT) on the whole bone of the two lunate types, and histol...
Article
Measurement of areal bone mineral density (aBMD) in intravertebral subregions may increase the diagnostic sensitivity of dual-energy X-ray absorptiometry (DXA)-derived parameters for vertebral fragility. This study investigated whether DXA-derived bone parameters in vertebral subregions were better predictors of vertebral bone strength in specimens...
Article
The molecular networks controlling bone homeostasis are not fully understood. The common evolution of bone and adaptive immunity encourages to investigate shared regulatory circuits. MHC Class II Transactivator (CIITA) is a master transcriptional co-activator believed to be exclusively dedicated for antigen presentation. CIITA is expressed in osteo...
Article
During insertion of a cancellous bone screw, the torque level reaches a plateau, at the engagement of all the screw threads prior to the screw head contact. This plateau torque (TPlateau) was found to be a good predictor of the insertion failure torque (stripping) and also exhibited strong positive correlations with areal bone mineral density (aBMD...
Article
Full-text available
http://link.springer.com/article/10.1007/s00264-013-1989-z
Article
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Bisphosphonates are considered potential disease modifying osteoarthritis (OA) agents. The present study investigated the efficacy of pre-emptive, early, and delayed alendronate (ALN) treatment initiation on subchondral trabecular bone and cartilage in low-dose monosodium iodoacetate (MIA)-induced knee osteoarthritis (OA) in rats. Male rats receive...
Article
Full-text available
Micro-CT systems are available that facilitate ex vivo examinations of human specimens as big as entire vertebrae, with spatial resolutions in the 10-micrometer range. This opens a new way for looking at entire bones in 3D. Accurate description of the internal microarchitecture of the entire organ can be obtained, at spatial resolutions previously...
Article
Full-text available
Osteoarthritis (OA) is a complex, multifactorial joint disease affecting both the cartilage and the subchondral bone. Animal models of OA aid in the understanding of the pathogenesis of OA and testing suitable drugs for OA treatment. In this study we characterized the temporal changes in the tibial subchondral bone architecture in a rat model of lo...
Article
Full-text available
Although a strong relationship exists between areal bone mineral density (aBMD) derived from dual-energy X-ray absorptiometry (DXA) and bone strength, the predictive validity of aBMD for osteoporotic vertebral fractures remains suboptimal. The diagnostic sensitivity of DXA may be improved by assessing aBMD within vertebral subregions, rather than r...
Article
CHARACTERISATION OF TEMPORAL SUBCHONDRAL BONE CHANGES IN A RAT MODEL OF LOW-DOSE MONOSODIUM IODOACETATE INDUCED OSTEOARTHRITIS: AN IN VIVO MICRO-CT STUDY G. Mohan1,2, E. Perilli1,2, J. Kuliwaba1,2, I. Parkinson1,2, J. Humphries1,2, N. Fazzalari1,2. 1Bone and Joint Res. Lab., Surgical Pathology, SA Pathology and Hanson Inst., Adelaide, SA, Australia...