Edwin Emilio Valdivia Malqui

• Doctor of Philosophy
• Hannover Medical School

Immune rejection remains the major obstacle to long-term survival of allogeneic lung transplants. The expression of major histocompatibility complex molecules and minor histocompatibility antigens triggers allogeneic immune responses that can lead to allograft rejection. Transplant outcomes therefore depend on long-term immunosuppression, which is...

Xenotransplantation reemerged as a promising alternative to conventional transplantation enlarging the available organ pool. However, success of xenotransplantation depends on the design and selection of specific genetic modifications and on the development of robust assays allowing for a precise assessment of tissue-specific immune responses. Neve...

Patients with kidney failure depend on transplantation as the only curative option. Xenotransplantation re-emerged as a promising alternative to enlarge the available organ pool. However, the success of xenotransplantation depends on the design and selection of specific genetic modifications and on the development of robust assays allowing for a pr...

Limbal stem cell (LSC) transplantation is the only efficient treatment for patients affected by LSC deficiency (LSCD). Allogeneic LSC transplantation is one of the most successful alternative for patients with bilateral LSCD. Nevertheless, the high variability of the human leukocyte antigens (HLA) remains a relevant obstacle to long-term allogeneic...

Genetic engineering is a promising tool to repair genetic disorders, improve graft function or to reduce immune responses towards the allografts. Ex vivo organ perfusion systems have the potential to mitigate ischemic-reperfusion injury, prolong preservation time or even rescue organ function. We aim to combine both technologies to develop a modula...

Xenotransplantation may become the highly desired solution to close the gap between the availability of donated organs and number of patients on the waiting list. In recent years, enormous progress has been made in the development of genetically engineered donor pigs. The introduced genetic modifications showed to be efficient in prolonging xenogra...

Xenotransplantation of pancreatic islets offers a promising alternative to overcome the shortage of allogeneic donors. Despite significant advances, either immune rejection or oxygen supply in immune protected encapsulated islets remain major bottlenecks for clinical application. To decrease xenogeneic immune responses, we generated tissue engineer...

Organ gene therapy represents a promising tool to correct diseases or improve graft survival after transplantation. Polymorphic variation of the major histocompatibility complex (MHC) antigens remains a major obstacle to long-term graft survival after transplantation. Previously, we demonstrated that MHC-silenced cells are protected against allogen...

p class="normal"> Introducción: El gen de fusión BCR-ABL1 está presente en al menos la cuarta parte de pacientes adultos con leucemia linfoblástica aguda de células B. Su detección determina la viabilidad del tratamiento con inhibidores de tirosina quinasas (TKIs) que se controla mediante la cuantificación de transcritos de BCR-ABL1 . Algunos pacie...