Edward J Stanek

Edward J Stanek
University of Massachusetts Amherst | UMass Amherst · Department of Public Health

About

167
Publications
9,410
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
6,949
Citations
Citations since 2017
6 Research Items
1696 Citations
2017201820192020202120222023050100150200250300
2017201820192020202120222023050100150200250300
2017201820192020202120222023050100150200250300
2017201820192020202120222023050100150200250300

Publications

Publications (167)
Article
Full-text available
We consider a finite population mixed model that accommodates response errors and show how to obtain optimal estimators of the finite population parameters in a pretest-posttest context. We illustrate the method with the estimation of the difference in gain between two interventions and consider a simulation study to compare the empirical version o...
Article
We develop best linear unbiased predictors (BLUP) of the latent values of labeled sample units selected from a finite population when there are two distinct sources of measurement error: endogenous, exogenous or both. Usual target parameters are the population mean, the latent values associated to a labeled unit or the latent value of the unit that...
Article
Objective: We determined the prevalence and correlates of cannabis use in Massachusetts after recreational use was passed, but before recreational cannabis stores opened. Method: A cross-sectional, population-based survey of Massachusetts adults, age 18 years or older, (n=3,022) was conducted in November–December, 2017. We estimated population-lev...
Article
Full-text available
Objectives Cigarette smoking, low physical activity, and sedentary behavior are modifiable risk factors for adverse pregnancy outcomes. However, only one study has evaluated predictors of these health risk behaviors among women at high risk for gestational diabetes mellitus (GDM). Therefore, our goal was to examine predictors of smoking, low physic...
Technical Report
Full-text available
In 2015, the first adult longitudinal cohort study of gambling and problem gambling was launched in Massachusetts. This report presents results from the first wave of the study with a focus on the establishment of the cohort and on the incidence of new cases of problem gambling since 2013/2014.
Article
Purpose: To examine the effect of a prenatal exercise intervention on gestational weight gain (GWG) and to update meta-analyses. Design: Randomized controlled trial and meta-analysis. Setting: Obstetrical practices in a Western Massachusetts hospital. Patients: We analyzed 241 ethnically diverse pregnant participants at high risk for gestati...
Article
Background: Exposure to bisphenol-A (BPA) and phthalates is highly prevalent. Prior studies have not assessed associations between urinary levels of BPA and phthalate metabolites and body composition. Methods: National Health and Nutrition Examination Survey (NHANES) data from 1999 to 2006 on adults aged ≥20 were analyzed by linear regression fo...
Article
Full-text available
The proportion of women entering pregnancy overweight or obese has been rising and, in turn, is associated with adverse maternal and fetal outcomes. Gestational weight gain (GWG) exceeding Institute of Medicine (IOM) guidelines further increases health risks and has been independently associated with postpartum weight retention. Hispanic women are...
Article
Full-text available
C-reactive protein (CRP) during pregnancy has been associated with adverse maternal outcomes such as preeclampsia and gestational diabetes mellitus. Randomized trials suggest that exercise programs may be associated with reductions in CRP in non-pregnant populations; however, such studies have not been conducted among pregnant women. The purpose of...
Article
To examine the effect of an individually tailored, motivationally matched prenatal exercise intervention on gestational diabetes mellitus (GDM) and other measures of glucose intolerance among ethnically diverse prenatal care patients at increased risk for GDM. The Behaviors Affecting Baby and You study randomized eligible women at a mean (standard...
Article
We use a finite population mixed model that accommodates response error in the survey variable of interest and auxiliary information to obtain optimal estimators of population parameters from data collected via simple random sampling. We illustrate the method with the estimation of a regression coefficient and conduct a simulation study to compare...
Article
Aims: To pilot the feasibility of a prenatal lifestyle intervention to modify physical activity and diet among pregnant overweight and obese Hispanic women, with the aim of reducing risk factors for gestational diabetes mellitus. Methods: Women were randomized either to a lifestyle intervention (n = 33, 48.5%), consisting of a culturally and lin...
Article
Objectives: We examined the impact of a prenatal exercise intervention on physical activity in 260 women at risk for gestational diabetes mellitus. Methods: We randomized participants in the Behaviors Affecting Baby and You (BABY) Study, which took place from 2007 to 2012, to either a 12-week individually tailored, motivationally matched exercis...
Article
Full-text available
We extend the random permutation model to obtain the best linear unbiased estimator of a finite population mean accounting for auxiliary variables under simple random sampling without replacement (SRS) or stratified SRS. The proposed method provides a systematic design-based justification for well-known results involving common estimators derived u...
Article
In January 2002, the first biological control program was implemented on the Galapagos Islands with the release of the Australian coccinellid Rodolia cardinalis Mulsant to control the invasive cottony cushion scale, Icerya purchasi Maskell. This was the first time that Galapagos authorities had approved the introduction of a biological control agen...
Article
We address the problem of selecting the best linear unbiased predictor (BLUP) of the latent value (e.g., serum glucose fasting level) of sample subjects with heteroskedastic measurement errors. Using a simple example, we compare the usual mixed model BLUP to a similar predictor based on a mixed model framed in a finite population (FPMM) setup with...
Article
Full-text available
The objective of this investigation is to describe the associations of number of eating episodes and proportion of meals eaten away from home with total serum cholesterol. Data from 499 participants, recruited from a health maintenance organization in central Massachusetts, aged 20-70, were used for this analysis. Dietary information and total bloo...
Article
Exposure to chemicals from ingestion of contaminated soil may be an important pathway with potential health consequences for children. A key parameter used in assessing this exposure is the quantity of soil ingested, with estimates based on four short longitudinal mass-balance soil ingestion studies among children. The estimates use trace elements...
Article
Physical activity during pregnancy is associated with reduced risk of adverse maternal and fetal outcomes. However, the majority of pregnant women are inactive and interventions designed to increase exercise during pregnancy are sparse. We evaluated the feasibility and preliminary efficacy of an exercise intervention among a diverse sample of pregn...
Article
Ingestion of soil by young children may be an important source of exposure to environmental contaminants. Estimates of soil ingestion have been made by several studies using trace elements in a mass-balance approach, but differ substantially between studies and trace elements. We conduct a meta-analysis of four major mass-balance soil ingestion stu...
Article
We develop a design-based prediction approach to estimate the finite population mean in a simple setting where some responses are missing. The approach is based on indicator sampling random variables that operate on labeled units (subjects). We define missing data mechanisms that may depend on a subject, or on a selection (such as when the study de...
Article
Mixed models may be defined with or without reference to sampling, and can be used to predict realized random effects, as when estimating the latent values of study subjects measured with response error. When the model is specified without reference to sampling, a simple mixed model includes two random variables, one stemming from an exchangeable d...
Article
This study assessed the occurrence of hormetic dose responses from three previously published data sets [1-3] with 825 chemicals in three Ames assay tester strains (i.e., TA97, TA98, TA100) with and without the S9 fraction, using a five dose protocol and semi-log dose spacing. Ninety-five (95) (11.5%) chemicals satisfied the multiple a priori entry...
Article
This article assesses the response below a toxicological threshold for 1888 antibacterial agents in Escherichia coli, using 11 concentrations with twofold concentration spacing in a high-throughput study. The data set had important strengths such as low variability in the control (2%-3% SD), a repeat measure of all wells, and a built-in replication...
Article
Full-text available
High through-put studies commonly use automated systems with 96-well plates in which multiple chemicals are tested at multiple doses using log-2 dose increments after a suitable incubation period. There are typically multiple (ranging from five to eleven) doses on each chemical, and occasionally plate replications of the dose-response studies. The...
Article
The present study was undertaken to ascertain the extent to which mental health professionals still assign etiological responsibility to parents, and to identify relationships between these beliefs and differences in professionals' theoretical orientations, preferred approaches to working with parents of children with mental health problems, demogr...
Article
Full-text available
Bioavailability of arsenic (As) from ingested soil is estimated in a two-period experimental study involving 11 subjects/period. In the first period, a 7-day mass-balance study measured As in food/beverages, urine, and stool to estimate bioavailability of As in food and beverages. Food/beverage As bioavailability (percentage ingested that is not in...
Article
Full-text available
Women diagnosed with gestational diabetes mellitus (GDM) are at substantially increased risk of developing type 2 diabetes and obesity, currently at epidemic rates in the United States. GDM, therefore, identifies a population of women at high risk of developing type 2 diabetes and provides an opportunity to intervene before the development of this...
Article
Full-text available
Plantas banqueras con Aphidius colemani Viereck fueron probadas en invernaderos en los estados de Massachusetts y Nueva York para el control del áfido del algodón, Aphis gossypii Glover, y el áfido verde del durazno, Myzus persicae (Sulzer) sobre 2 cultivos de flores de la primavera, violetas (Viola tricolor hortensis) y margaritas (hibrido de Argy...
Article
Full-text available
Cross-sectional studies have reported seasonal variation in high-sensitivity C-reactive protein (hsCRP). However, longitudinal data are lacking. We collected data on diet, physical activity, psychosocial factors, physiology, and anthropometric measurements from 534 healthy adults (mean age 48 years, 48.5% women, 87% white) at quarterly intervals ov...
Article
Full-text available
Quantitative features of dose responses were analyzed for 2,189 candidate anticancer agents in 13 strains of yeast (Saccharomyces cerevisiae). The agents represent a diverse class of chemical compounds including mustards, other alkylating agents, and antimetabolites, inter alia. Previous analyses have shown that the responses below the toxic thresh...
Article
Prediction of random effects is an important problem with expanding applications. In the simplest context, the problem corresponds to prediction of the latent value (the mean) of a realized cluster selected via two-stage sampling. Recently, Stanek and Singer (JASA, 2004) developed best linear unbiased predictors (BLUP) under a finite population mix...
Article
This study evaluated characteristics of the concentration-response relationships of chemicals from the U.S. National Cancer Institute (NCI) Yeast Anticancer Drug Screen database with respect to the threshold and the hormetic dose-response models. The database reported concentration-response studies of 2189 chemicals from a broad range of chemical c...
Article
Full-text available
This study examined the relation between quality of dietary carbohydrate intake, as measured by glycemic index (GI) and glycemic load (GL), and serum high-sensitivity C-reactive protein (hs-CRP) levels. During a 1-y observational study, data were collected at baseline and at each quarter thereafter. GI and GL were calculated from multiple 24-h diet...
Article
To investigate the effect of diet alone (D), exercise alone (E), and a combination of diet and exercise (DE) on body weight, body composition, energy intake, blood pressure, serum lipid and leptin levels, and fitness levels in mildly obese sedentary women and men. The three interventions were compared in a randomized longitudinal study design. The...
Article
Predictors of random effects are usually based on the popular mixed effects model developed under the assumption that the sample is obtained from a conceptual infinite population; such predictors are employed even when the actual population is finite. Two alternatives that incorporate the finite nature of the population are obtained from the superp...
Article
Full-text available
Adjustment for covariates (also called auxiliary variables in survey sampling literature) is commonly applied in health surveys to reduce the variances of the prevalence estimators. In theory, adjusted prevalence estimators are more accurate when variance components are known. In practice, variance components needed to achieve the adjustment are un...
Chapter
The main objective in a group randomized trial is a comparison between treatments. Often, interest exists in the expected response for a particular group receiving a treatment. As a random sample of groups is included in the trial, the parameter for such a group is represented as a random effect. In this context, predicting the expected response fo...
Article
Full-text available
The National Toxicology Program (NTP) and the National Institute of Environmental Health Sciences (NIEHS) established the NTP Center for the Evaluation of Risks to Human Reproduction (CERHR) in June 1998. The purpose of CERHR is to provide timely, unbiased, scientifically sound evaluations of human and experimental evidence for adverse effects on r...
Article
We recently reported results of an analysis of a large National Cancer Institute (NCI) database on effects of chemicals in yeast, concluding that dose-response relationships in the low-dose range are more compatible with a hormetic dose-response model than a threshold model (Calabrese et al., 2006). Crump suggests that our interpretation may be inc...
Article
Full-text available
Which dose-response model best explains low-dose responses is a critical issue in toxicology, pharmacology, and risk assessment. The present paper utilized the U.S. National Cancer Institute yeast screening database that contains 56,914 dose-response studies representing the replicated effects of 2189 chemically diverse possible antitumor drugs on...
Article
We report results from a replication in second and third generation female mice of accelerated time to puberty associated with low Pb exposure levels . Mice in the 2nd generation study are offspring of mice from the initial study; the 3rd generation mice are offspring from mice in the 2nd generation study. For each generation the time to puberty on...
Article
Full-text available
High sensitivity C-reactive protein (CRP) is a marker of acute inflammation recently recognized as an independent predictor of future cardiovascular disease and diabetes. The identification of modifiable factors, such as diet, that influence serum CRP concentrations may provide the means for reducing the risk of these diseases. Data on longitudinal...
Article
To carry out a community-based research approach to determine the most effective educational interventions to reduce smoking among African-American smokers. The intervention included preparation of the community, planning and developing a model of change, and developing a community-based intervention. The study population consisted of 2,544 randoml...
Article
Western flower thrips, Frankliniella occidentalis (Pergande), is the principal insect pest of spring flower crops grown in the northeastern United States for use as bedding plants. Neoseiulus (=Amblyseius) cucumeris (Oudemans) is a predacious mite reared commercially that is recommended for control of western flower thrips in various vegetable and...
Article
This review proposes that the emerging acceptance of the hormetic dose-response model in toxicology and pharmacology has the potential to significantly change important aspects of drug development. Two situations where the hormesis concept may affect drug development are considered: one in which low-dose stimulation may represent an adverse/unwante...
Article
We assessed the reproducibility of measurements of plasma hormone and binding protein levels in umbilical cord blood collected from 30 male and female babies. They were delivered as singleton births from full-term pregnancies (gestational age >or= 37 weeks) in a cord blood donation programme. We assayed three plasma replicates from each cord blood...
Article
A number of studies have documented that Pb exerts immunotoxic effects on T lymphocytes. In studies designed to explore this general response over a broad dose range, female Swiss mice were administered six different diets containing Pb acetate 1 day after mating. During lactation, the mothers received the same feed given during pregnancy, and the...
Chapter
The main objective in a group randomized trial is a comparison between treatments. Often, there is interest in the expected response for a particular group receiving a treatment. Since a random sample of groups is included in the trial, the parameter for such a group is represented as a random effect. In this context, predicting the expected respon...
Article
Full-text available
We consider a well-known controversy that stems from the use of two mixed models for the analysis of balanced experimental data with a fixed and a random factor. It essentially originates in the different statistics developed from such models for testing that the variance parameter associated to the random factor is null. The corresponding hypothes...
Article
Full-text available
The primary objective of this study was to describe eating patterns (e.g., breakfast, lunch, dinner, snacking, number of eating episodes, temporal patterns of eating across the 24-hour day, and the frequency of eating out) in a healthy U.S. population in order to provide a basis for future studies on the association between eating patterns and dise...
Article
Female Swiss mice typically display signs of puberty at about 33-37 days of age. In the present investigation (96 female mice tested in 8 Pb exposure levels, n=12 per exposure level), the time to puberty onset was markedly influenced by exposure to dietary lead. While modest increases in blood lead concentrations from a normal background of 2-3 to...
Article
We consider a probability model where the design-based approach to inference under simple random sampling of a finite population encompasses a simple random permutation super-population model. The model consists of an expanded set of random variables following a random permutation probability distribution that keeps track of both the units’ labels...
Article
A variety of studies have noted seasonal variation in blood lipid levels. Although the mechanism for this phenomenon is not clear, such variation could result in larger numbers of people being diagnosed as having hypercholesterolemia during the winter. We conducted a longitudinal study of seasonal variation in lipid levels in 517 healthy volunteers...
Article
Full-text available
In many situations there is interest in parameters (e.g., mean) associated with the response distribution of individual clusters in a finite clustered population. We develop predictors of such parameters using a two-stage sampling probability model with response error. The probability model stems directly from finite population sampling without add...
Article
We develop a design-based prediction approach to estimate the finite population mean in a simple setting where some responses are missing. The approach is based on indicator sampling random variables that operate on labeled units (subjects). The missing data mechanism may depend on the subject, or on a selection (such as when the sample is assigned...
Article
Full-text available
Some studies have suggested that eating patterns, which describe eating frequency, the temporal distribution of eating events across the day, breakfast skipping, and the frequency of eating meals away from home, may be related to obesity. Data from the Seasonal Variation of Blood Cholesterol Study (1994-1998) were used to evaluate the relation betw...
Article
Hormesis is an adaptive response, commonly characterized by a biphasic dose-response that can be either directly induced, or the result of compensatory biological processes following an initial disruption in homeostasis [Calabrese and Baldwin, Hum. Exp.Toxicol., 21 (2002), 91]. Low and environmentally relevant levels of dietary cadmium significantl...
Article
The effect of lead (Pb) ingestion on hematological parameters in male and female Swiss mice was assessed. Eight different doses of Pb were administered through preparation of different feeds. The levels of Pb in the diet were designed to provide exposure below (0.6 to <2.0 microg/dl) and above (>2.0-13 microg/dl) normal background. One litter of mi...
Article
A current model of family-centered practice emphasizes empowerment of parents, an approach that brings together a strengths perspective, a constructivist emphasis on consumer voices, and knowledge derived from neuroscience of the last two decades. This study explored the extent to which a national random sample of National Association of Social Wor...
Article
Previously published studies indicate that hepatotoxicity is associated with high blood lead (Pb) levels in animal models and humans. The present investigation evaluated the effects of in vivo Pb exposure via drinking water on mouse hepatocyte survival in vitro when blood Pb concentrations reflected those seen in children in urban and rural setting...
Article
ABSTRACT C02ed05v1.doc 5/7/02 8:42 AM (formerly c01ed37.doc),2
Article
Full-text available
The authors examined sources of variance in self-reported physical activity in a cohort of healthy adults ( n &equals; 580) from Worcester, Massachusetts (the Seasonal Variation of Blood Cholesterol Study, 1994–1998). Fifteen 24-hour physical activity recalls of total, occupational, and nonoccupational activity (metabolic equivalent-hours&sol;day)...
Article
Increased concentrations of high-sensitivity C-reactive protein (hs-CRP), a marker of systemic inflammation, are associated with increased risk for coronary heart disease. Because of its relationship to inflammation, hs-CRP has considerable biologic variation. This study was carried out to characterize CRP variation and to compare it to another ris...
Article
Full-text available
Monte Carlo environmental risk assessment requires estimates of the exposure distributions. An exposure of principal concern is often soil ingestion among children. We estimate the long-term (annual) average soil ingestion exposure distribution using daily soil ingestion estimates from children who participated in a mass-balance study at Anaconda,...
Article
Full-text available
Soil ingestion estimates from mass balance soil ingestion studies can be used in Monte Carlo Risk assessment. We develop and describe a simulation model based on four mass balance soil ingestion studies that enables food ingestion, soil ingestion, and transit time to be mimicked. We use the simulation to evaluate potential biases that exist in curr...
Article
Full-text available
The authors examined seasonal variation in physical activity in longitudinal analyses of 580 healthy adults from Worcester, Massachusetts (the Seasonal Variation of Blood Cholesterol Study, 1994-1998). Three 24-hour physical activity recalls administered five times during 12 months of follow-up were used to estimate household, occupational, leisure...
Article
Full-text available
A common analysis objective is estimation of a realized random effect. The parameter underlying such an effect is usually defined as an average response of a realized unit, such as a cluster mean, domain mean, small area mean, or subject effect. The effects are called random effects since their occurrence is the result of some (actual or assumed) r...
Article
Ingestion of contaminated soil by children may result in significant exposure to toxic substances at contaminated sites. Estimates of such exposure are based on extrapolation of short-term-exposure estimates to longer time periods. This article provides daily estimates of soil ingestion on 64 children between the ages of 1 and 4 residing at a Super...
Article
This paper evaluated three measures of physical activity employed in the Seasonal Variation of Blood Cholesterol Study (Seasons), and it had two objectives: 1) To examine the laboratory validity of the Actillume activity monitor, and 2) To examine the relative validity of three 24-h physical activity recalls (24HR) in quantifying short-term physica...
Article
Full-text available
Assessments of cortisol levels in saliva have been widely used by both researchers and clinicians as an index of adrenal functioning. Quarterly measurements of morning and evening cortisol levels were determined in a longitudinal study of 147 participants (72 women and 75 men) followed for 1 year each. The analysis of salivary cortisol revealed no...
Article
Measures of biologic and behavioural variables on a patient often estimate longer term latent values, with the two connected by a simple response error model. For example, a subject's measured total cholesterol is an estimate (equal to the best linear unbiased estimate (BLUE)) of a subject's latent total cholesterol. With known (or estimated) varia...
Article
This investigation assessed the effect of soil particle size on soil ingestion estimates of children residing at a superfund site. Earlier research indicated that wide intertracer variability in soil ingestion estimates are based on soil concentrations with a soil particle size of 0 to 2 µm was markedly reduced when the estimates were based on soil...
Article
This investigation assessed the effect of soil particle size on soil ingestion estimates of children residing at a superfund site. Earlier research indicated that wide intertracer variability in soil ingestion estimates are based on soil concentrations with a soil particle size of 0 to 2 µm was markedly reduced when the estimates were based on soil...
Article
Full-text available
To evaluate the effectiveness of a training program for physician-delivered nutrition counseling, alone and in combination with an office-support program, on dietary fat intake, weight, and blood low-density lipoprotein cholesterol levels in patients with hyperlipidemia. Forty-five primary care internists at the Fallon Community Health Plan, a cent...