Edward H. Shortliffe

Edward H. Shortliffe
Columbia University | CU · Biomedical Informatics Ph.D. Program

MD, PhD

About

395
Publications
156,023
Reads
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24,187
Citations
Citations since 2017
47 Research Items
4670 Citations
20172018201920202021202220230200400600800
20172018201920202021202220230200400600800
20172018201920202021202220230200400600800
20172018201920202021202220230200400600800
Additional affiliations
July 2013 - present
Weill Cornell Medical College
Position
  • Professor (Associate)
Description
  • Voluntary faculty position - teaching and advising role
July 2012 - present
Arizona State University
Position
  • Professor (Full)
Description
  • Professor in Department of Biomedical Informatics and Senor Advisor to the Executive Vice Provost in the College of Health Solutions
November 2009 - September 2011
University of Texas Health Science Center at Houston
Position
  • Professor
Description
  • Part-time position while working as President/CEO at AMIA

Publications

Publications (395)
Article
Full-text available
The evolution of the informatics field, now with a well-accepted and crucial role in modern biomedicine and health care delivery, is the result of creative research over seven decades. The success is due in part to recognition that, throughout the process, investigators have documented not only what they have done but what they have learned, stimul...
Chapter
The history of artificial intelligence in medicine (AIM) is intimately tied to the history of AI itself, since some of the earliest work in applied AI dealt with biomedicine. This chapter first provides a brief overview of the early history of AI, but then focuses on AI in medicine (and in human biology) and provides a summary of how the field has...
Chapter
In this concluding chapter, we reflect upon key themes that have recurred throughout this volume, and in some cases throughout the history of the field. Topics of discussion include the role of explainability and user insight in human/AI teams, the increasing recognition that both formal knowledge and deep learning may be required to address biomed...
Chapter
Systems that use AI methods in biomedical settings, like most medical interventions, need to demonstrate formally their value, safety, and efficacy. The world of health and health care has come to expect rigorous evaluations that will make the case for the use of new methods or innovations, just as it does for new devices, medications or other trea...
Chapter
Recent advances in computing power and the availability of large amounts of training data have spurred tremendous improvements in the accuracy with which computers can perform tasks that were once considered the exclusive province of human intelligence. In medicine and health, this has led to a rapid growth of interest in the potential of artificia...
Article
After 25 years of service to the American Medical Informatics Association (AMIA), Ms Karen Greenwood, the Executive Vice President and Chief Operating Officer, is leaving the organization. In this perspective, we reflect on her accomplishments and her effect on the organization and the field of informatics nationally and globally. We also express o...
Article
Full-text available
Among the many contributions of Donald A.B. Lindberg was his work on behalf of a variety or professional organizations in the field of biomedical and health informatics. These began during his early days at the University of Missouri and continued throughout his 30 years at the National Library of Medicine. This chapter summarizes that work, which...
Article
Full-text available
This overview summary of the Informatics Section of the book Transforming biomedical informatics and health information access: Don Lindberg and the U.S. National Library of Medicine illustrates how the NLM revolutionized the field of biomedical and health informatics during Lindberg’s term as NLM Director. Authors present a before-and-after perspe...
Article
Full-text available
Among the many contributions of Donald A.B. Lindberg was his work on behalf of a variety or professional organizations in the field of biomedical and health informatics. These began during his early days at the University of Missouri and continued throughout his 30 years at the National Library of Medicine. This chapter summarizes that work, which...
Article
Full-text available
This overview summary of the Informatics Section of the book Transforming biomedical informatics and health information access: Don Lindberg and the U.S. National Library of Medicine illustrates how the NLM revolutionized the field of biomedical and health informatics during Lindberg's term as NLM Director. Authors present a before-and-after perspe...
Chapter
The discipline of clinical informatics continues to evolve as it has for the past half-century. In the past decade, electronic health records (EHR) in inpatient care settings have become essentially ubiquitous in the United States. Clinical informaticians are now focused on optimizing EHRs and clinical decision support to improve healthcare quality...
Article
Over a 31-year span as Director of the US National Library of Medicine (NLM), Donald A.B. Lindberg, MD, and his extraordinary NLM colleagues fundamentally changed the field of biomedical and health informatics—with a resulting impact on biomedicine that is much broader than its influence on any single subfield. This article provides substance to bo...
Chapter
This chapter provides fundamental background about the nature of clinical data and decision making, which will be required for understanding the field of biomedical informatics. It describes various types of clinical data, how clinical data are collected and used by medical professionals, and how they support medical practice and clinical research....
Chapter
Biomedical informatics continues to be an evolving field, constantly welcoming new cross-disciplinary connections. This chapter examines the general trends that are reflected in the past four editions of this book and how they have led to the trends in this edition. We provide our vision for the future, but also include seven authoritative guest co...
Chapter
This chapter introduces the field of biomedical informatics, explaining that it addresses underlying scientific issues (basic research) while also having major applied goals and an opportunity to transform life science research, health, and health care in positive ways. It acknowledges that the full potential of the field has not yet been realized...
Article
Every year, significant amounts of expensive injectable or infused drugs, distributed in single-dose vials, are discarded in the United States. This is due in part to the increasing number of drugs that are administered in variable doses based on a patient’s weight or body surface area. Sharing medication from single-dose vials among patients is ge...
Article
Full-text available
Objective IBM(R) Watson for Oncology (WfO) is a clinical decision-support system (CDSS) that provides evidence-informed therapeutic options to cancer-treating clinicians. A panel of experienced oncologists compared CDSS treatment options to treatment decisions made by clinicians to characterize the quality of CDSS therapeutic options and decisions...
Book
Full-text available
This 5th edition of this essential textbook continues to meet the growing demand of practitioners, researchers, educators, and students for a comprehensive introduction to key topics in biomedical informatics and the underlying scientific issues that sit at the intersection of biomedical science, patient care, public health and information technolo...
Article
Purpose: To examine the impact of a clinical decision support system (CDSS) on breast cancer treatment decisions and adherence to National Comprehensive Cancer Center (NCCN) guidelines. Patients and methods: A cross-sectional observational study was conducted involving 1,977 patients at high risk for recurrent or metastatic breast cancer from th...
Article
e14114 Background: Watson for Oncology (WfO) is an artificial intelligence-based clinical decision-support system which provides therapeutic options and associated scientific evidence to cancer-treating physicians. Oncologists at Bumrungrad International Hospital (BIH) have used WfO since 2015. We examined the association between concordance of WfO...
Article
95 Background: Watson for Oncology (WFO) is an artificial intelligence (AI) based clinical decision-support tool trained by Memorial Sloan Kettering. This retrospective observational study of breast, lung, colon and rectal cancer examined the concordance of treatment options provided by WFO to treatments selected by clinicians at Bumrungrad Interna...
Article
Full-text available
Background Comparison of options from clinical decision-support (CDS) systems and decisions made in practice may be biased towards the treating institution. In this retrospective study, bias was minimized by blinding evaluators to the source of treatment recommendations, either Watson for Oncology® (WFO®) or treatments patients received at Bumrungr...
Article
Purpose: The aim of the current study was to assess treatment concordance and adherence to National Comprehensive Cancer Network breast cancer treatment guidelines between oncologists and an artificial intelligence advisory tool. Patients and methods: Study cases of patients (N = 1,977) who were at high risk for recurrence or who had metastatic...
Article
6553 Background: Clinical decision-support systems (CDSS) such as Watson for Oncology (WFO) may reduce treatment variation in oncology, provided options offered by the system are at least as acceptable as expert, evidence-based options. Deviation from expert consensus in practice is not well documented. In this blinded study, WFO therapeutic option...
Article
A prospective blinded study of 1000 cases analyzing the role of artificial intelligence: Watson for oncology and change in decision making of a Multidisciplinary Tumor Board (MDT) from a tertiary care cancer center. S.P. Somashekhar, Martín-J. Sepúlveda, Edward H Shortliffe, Rohit Kumar C, Amit Rauthan, Poonam Patil, ... https://ascopubs.org/doi/a...
Article
Full-text available
Introduction: Artificial Intelligence in Medicine (AIM) research is now 50 years old, having made great progress that has tracked the corresponding evolution of computer science, hardware technology, communications, and biomedicine. Characterized as being in its “adolescence” at an international meeting in 1991, and as “coming of age” at another me...
Preprint
Full-text available
The pursuit of increased efficiency and quality of clinical care based on the analysis of workflow has seen the introduction of several modern technologies into medical environments. Electronic health records (EHRs) remain central to analysis of workflow, owing to their wide-ranging impact on clinical processes. The two most common interventions to...
Article
The pursuit of increased efficiency and quality of clinical care based on the analysis of workflow has seen the introduction of several modern technologies into medical environments. Electronic health records (EHRs) remain central to analysis of workflow, owing to their wide-ranging impact on clinical processes. The two most common interventions to...
Article
Full-text available
Clinicians and researchers have long envisioned the day when computers could assist with difficult decisions in complex clinical situations. The first article on this subject appeared in the scientific literature about 60 years ago,¹ and the notion of computer-based clinical decision support has subsequently been a dominant topic for informatics re...
Article
Full-text available
Background: Breast cancer oncologists are challenged to personalize care with rapidly changing scientific evidence, drug approvals, and treatment guidelines. Artificial intelligence (AI) clinical decision-support systems (CDSSs) have the potential to help address this challenge. We report here the results of examining the level of agreement (conco...
Article
This article offers suggested guidelines for graduate students who are embarking on informatics doctoral studies and anticipating the dissertation research and its documentation. Much of the guidance is pertinent for writing dissertations in other disciplines as well. The messages are largely directed at doctoral students, but some elements are als...
Article
Context: Strategic planning in population health and public health practice often uses single indicators of success or, when using multiple indicators, provides no mechanism for coherently combining the assessments. Cost-effectiveness analysis, the most complex strategic planning tool commonly applied in public health, uses only a single metric to...
Article
A fundamental challenge in the field of clinical decision support is to determine what characteristics of systems make them effective in supporting particular types of clinical decisions. However, we lack such a theory of decision support itself and a model to describe clinical decisions and the systems to support them. This article outlines such a...
Chapter
Clinical informatics has evolved over the last 50 years, along with computing and communications technology and with our healthcare system and its financing. In the last decade a new profession has emerged, with formal curricula for trainees and certification examinations for physicians who work in the discipline. In the coming years, new certifica...
Article
Full-text available
Given the complexities of current clinical practice environments, strategies to reduce clinical error must appreciate that error detection and recovery are integral to the function of complex cognitive systems. In this review, while acknowledging that error elimination is an attractive notion, we use evidence to show that enhancing error detection...
Chapter
The increasingly complex informatics technology that evolved since 1950 created a new domain of knowledge and a new professional discipline. In this chapter we discuss the foundations and evolution of the field of medical informatics, focusing on the role of publications, professional organizations, government, and industry in promoting the field’s...
Chapter
After reading this chapter, you should know the answers to these questions:
Article
Full-text available
Reconfiguring our health delivery sector to provide safe and effective care, improve health, and simultaneously reduce costs requires both efficient, high quality medical services and community‐wide population health and prevention activities, supported by the immediate availability of comprehensive electronic patient information. 1 Given the vario...
Article
Full-text available
The IMIA Yearbook editorial team asked five internationally renowned biomedical informaticians to respond to Prof. Haux's editorial. This paper summarizes their thoughts and responses. Contributions are ordered alphabetically by the contributor's last name. All authors provided an equal contribution to this manuscript.
Article
Full-text available
Only a few years ago, the mention of informatics in clinical circles generated questions regarding the rigor or relevance of the field. With the expanding interest and investment in health information technology by hospitals, health systems, and practitioners, however, interest in and acceptance of clinical informatics has increased substantially....
Article
Full-text available
Introduction: This article is part of a Focus Theme of METHODS of Information in Medicine on Health Record Banking. Background: In late summer 2010, an organization was formed in greater Phoenix, Arizona (USA), to introduce a health record bank (HRB) in that community. The effort was initiated after market research and was aimed at engaging 200,...
Book
Full-text available
The world of biomedical research and health care has changed remarkably in the 25 years since the first edition of this book was undertaken. So too has the world of computing and communications and thus the underlying scientific issues that sit at the intersections among biomedical science, patient care, public health, and information technology. I...
Chapter
Full-text available
Decision making is an inherent part of everything that health professionals do, and accordingly it is not surprising that cognitive science has relevance throughout all of patient care, health promotion, and disease prevention. Even the procedural specialties that depend on manual dexterity or similar skills, such as surgery, intrinsically depend o...
Article
The International Medical Informatics Association (IMIA) biomedical informatics educational recommendations of 2010 provided an excellent guide for institutions across the world in updating their curricula or establishing new programs. IMIA subsequently decided to offer an accreditation process, guided by the earlier recommendations, to assess exis...
Article
Full-text available
"Once upon a time, several engineers, biologists and clinicians realized that a lot of information in biomedicine was partitioned into 'silos' that do not intercommunicate. These silos were a side effect of the existence of different disciplines required to, for example, develop new drugs. The engineers decided to dispose of the silos, and to put t...
Article
Full-text available
The promise of health information technology (HIT) is comprehensive electronic patient records when and where needed, leading to improved quality of care at reduced cost. However, physician experience and other available evidence suggest that this promise is largely unfulfilled.Comprehensive records require more than having every physician and hosp...
Article
Full-text available
In the past decades we have witnessed several large-scale national efforts and pilot projects around the globe targeted at developing health information exchange and making available a patient-centric, comprehensive and longitudinal health record to the clinicians at the point of care. However, despite these endeavors, the health information landsc...
Article
Full-text available
Academic biomedical informatics has achieved great successes through research contributions over several decades, now reflected in a thriving commercial marketplace for electronic health records and other informatics tools. That very success, coupled with changes in the ability of governments to support research at past levels, is forcing a reconsi...
Article
Full-text available
The AMIA biomedical informatics (BMI) core competencies have been designed to support and guide graduate education in BMI, the core scientific discipline underlying the breadth of the field's research, practice, and education. The core definition of BMI adopted by AMIA specifies that BMI is 'the interdisciplinary field that studies and pursues the...
Article
Full-text available
AMIA has been the home for informatics professionals for 22 years, and has undergone a remarkable evolution during that time. Its autumn meeting continues to be a vibrant setting for the best in informatics science and practice, building on a tradition that started with SCAMC (the Symposium on Computer Applications in Medical Care) in 1977. Its jou...
Book
The Centers for Medicare and Medicaid Services (CMS) is the agency in the Department of Health and Human Services responsible for providing health coverage for seniors and people with disabilities, for limited-income individuals and families, and for children--totaling almost 100 million beneficiaries. The agency's core mission was established more...
Article
Full-text available
To reflect on the history, status, and future trends of decision support in health and biomedical informatics. To highlight the new challenges posed by the complexity and diversity of genomic and clinical domains. To examine the emerging paradigms for supporting cost-effective, personalized decision making. A group of international experts in healt...
Technical Report
Full-text available
The Centers for Medicare and Medicaid Services (CMS) was originally chartered in 1965 to provide prompt payment of provider claims for the purpose of ensuring that certain elderly and vulnerable groups would receive timely and effective medical treatment. Critical to the agency’s work is its information technology (IT) infrastructure. In the past 4...
Article
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Shortly after Don Detmer joined AMIA as its first full-time professional president and CEO, he became aware of the growing demand among clinical informaticians for a process by which they could be credentialed to show their competence and accomplishments in the field. Such credentialing would require consensus on the design and content of training...
Article
Full-text available
As I discussed in a recent president's column,1 the roots of AMIA's founding and early identity were largely academic, with an emphasis on informatics and computer science research, both basic and applied. Yet, with the passage of time, yesterday's research has evolved into standard approaches and tools. Today's clinical computing products often re...
Article
Full-text available
Tourism as well as international business travel creates health risks for individuals and populations both in host societies and home countries. One strategy to reduce health-related risks to travelers is to provide travelers and relevant caregivers timely, ongoing access to their own health information. Many websites offer health advice for travel...
Article
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Darlene LeMay Pearson Vian, 78, of Palo Alto, California passed away on February 9, 2011. Ms Vian worked at the Stanford University Medical School for over 37 years. She was Secretary of the Faculty Senate for nearly 10 years. She was … Correspondence to Brian P McCune, Cyladian Technology Consulting, 825 Oak Grove Avenue, Suite D101, Menlo Park,...
Article
Full-text available
In my inaugural column in January 2011, I described the recent efforts by AMIA to assess its current and future roles, and the ways in which we are perceived by our members and by external groups. Insights from formal and informal surveys have led to a number of changes, including our new logo and branding, our new website, and our explicit efforts...
Article
Full-text available
Although informatics is often viewed externally as a new discipline, the field has a rich history that dates back at least to the 1960s, with a well-known seminal paper appearing even earlier.1 AMIA itself was created in the late 1980s when three separate informatics organizations, with overlapping interests, saw the value in combining their missio...
Article
The explosive growth of biomedical complexity calls for a shift in the paradigm of medical decision making-from a focus on the power of an individual brain to the collective power of systems of brains. This shift alters professional roles and requires biomedical informatics and information technology (IT) infrastructure. The authors illustrate this...
Conference Paper
There is a growing appreciation that information technology is no longer an option but a necessity in the management of clinical and health information. This imperative has increasingly led to questions regarding the field of biomedical informatics (BMI) and its relationship to health information technology. Emerging in the 1960s from an academic b...
Article
Full-text available
Federal legislation (Health Information Technology for Economic and Clinical Health (HITECH) Act) has provided funds to support an unprecedented increase in health information technology (HIT) adoption for healthcare provider organizations and professionals throughout the U.S. While recognizing the promise that widespread HIT adoption and meaningfu...
Article
Full-text available
Article
When I first meet with preclinical medical students, I make a point of asking them what they believe will receive the greatest focus of their attention once they are in clinical practice. The most common response, not surprisingly, is patients, and yet it is clear to experienced practitioners that the correct answer is information—in the service of...
Conference Paper
Full-text available
Biomedical informatics is featured prominently in the planned funding for health information technology that is included in the administration’s economic stimulus plan. In this talk, Dr. Shortliffe will share his vision on the interface between public health and biomedical informatics, illuminate shining examples of public health informatics in pra...
Article
During the last two decades, biomedical informatics (BMI) has become a critical component in biomedical research and health care delivery, as evidenced by two recent phenomena. One, as discussed in the article by Bernstam and colleagues in this issue, has been the introduction of Clinical and Translational Science Awards. Perhaps even more importan...
Article
Full-text available
1. Introduction This is a remarkably exciting time to be involved professionally in the field of medical informatics. The underlying scientific principles are beginning to be identified and defined, educators are increasingly acknowledging the importance of the field for physicians of the present and future, and the technology itself is growing at...
Article
Don E. Detmer has served as President and Chief Executive Officer of the American Medical Informatics Association (AMIA) for the past five years, helping to set a course for the organization and demonstrating remarkable leadership as AMIA has evolved into a vibrant and influential professional association. On the occasion of Dr. Detmer's retirement...
Article
We describe and evaluate a framework, the Medical Database Adaptor (MEIDA), for linking knowledge-based medical decision-support systems (MDSSs) to multiple clinical databases, using standard medical schemata and vocabularies. Our solution involves a ...
Article
The American College of Medical Informatics is an honorary society established to recognize those who have made sustained contributions to the field. Its highest award, for lifetime achievement and contributions to the discipline now known more inclusively as biomedical informatics, is the Morris F Collen Award. Dr. Collen's own efforts as a pionee...
Article
Theoretical and methodological advances in the cognitive and learning sciences can greatly inform curriculum and instruction in biomedicine and also educational programs in biomedical informatics. It does so by addressing issues such as the processes related to comprehension of medical information, clinical problem-solving and decision-making, and...

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