
Edward MullinsImperial College London | Imperial · Institute of Reproductive and Developmental Biology
Edward Mullins
PhD MRCOG
About
49
Publications
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Introduction
NIHR Academic Clinical Lecturer, Imperial College and Queen Charlotte's hospital, Editor-in-Chief, Chief Medical Officer's annual report into Women's Health, PhD in fetal and maternal medicine. Interests in public health and lifecourse epidemiology.
Current projects:
-Prevention of recurrent GDM through dietary supplements before and during pregnancy
-TRUFFLE 2 study - optimal management of late onset FGR
-Health in pregnancy: using home monitoring to profile women's PA and health during and after pregnancy
-Pre-conception intervention to reduce hypertension in pregnancy
-Using an app to improve perinatal mental health care and outcomes
Additional affiliations
Position
- Researcher
August 2007 - present
Publications
Publications (49)
Fetal growth restriction (FGR) is a major complication of pregnancy with unknown etiology which results in marked fetal, neonatal and long-term morbidity, and mortality. FGR is likely to result from suboptimal placental implantation and perturbed immunological interactions. The diagnostic criteria for FGR vary between studies and the condition ofte...
Fetal growth restriction (FGR) is an important and poorly understood condition of pregnancy, which results in significant fetal, neonatal and long-term morbidity and mortality. The aetiology of FGR is unknown and is likely to result from sub-optimal placental implantation and feto-maternal immunological interaction. The diagnostic criteria for FGR...
Objective:
To investigate the use of the fetal cerebroumbilical ratio to predict intrapartum compromise in appropriately grown fetuses.
Study design:
A prospective observational study set at Queen Charlotte's and Chelsea hospital, London, UK. Fetal biometry and Doppler resistance indices were measured in 400 women immediately before established...
The majority of intrapartum fetal hypoxia occurs in uncomplicated pregnancies. Current intrapartum monitoring techniques have not resulted in a reduction in the incidence of cerebral palsy in term neonates. We report the development of a composite risk score to allow risk stratification of normal pregnancies before labor.
Six hundred one women were...
Objective
Prepregnancy optimization of cardiovascular function may reduce the risk of pre-eclampsia. We aimed to assess the feasibility and effect of preconception cardiovascular monitoring, exercise, and beetroot juice on cardiovascular parameters in women planning to conceive.
Design and method
Prospective single-site, open-label, randomized con...
Introduction
Despite a growing body of research on the risks of SARS-CoV-2 infection during pregnancy, there is continued controversy given heterogeneity in the quality and design of published studies.
Methods
We screened ongoing studies in our sequential, prospective meta-analysis. We pooled individual participant data to estimate the absolute an...
Introduction
The aim of this survey was to evaluate the current practice in respect of diagnosis and management of fetal growth restriction among obstetricians in different countries.
Material and methods
An e‐questionnaire was sent via REDCap with “click thru” links in emails and newsletters to obstetric practitioners in different countries and s...
Objectives:
Current antenatal care largely relies on widely spaced appointments, hence only a fraction of the pregnancy period is subject to monitoring. Continuous monitoring of physiological parameters could represent a paradigm shift in obstetric care. Here, we analyse the data from daily home monitoring in pregnancy and consider the implication...
Condensed abstract:
To ascertain whether remote multimodality cardiovascular monitoring of health in pregnancy is feasible, 24 participants were asked to daily monitor body weight, heart rate, blood pressure, activity levels, and sleep patterns. Study participants took on average 4.3 (standard deviation = 2.20) home recordings of each modality per...
Introduction
Following the detection of fetal growth restriction, there is no consensus about the criteria that should trigger delivery in the late preterm period. The consequences of inappropriate early or late delivery are potentially important yet practice varies widely around the world, with abnormal findings from fetal heart rate monitoring in...
Key content
Continuing financial constraints on the UK’s National Health Service means the need for clinicians to provide high‐quality care in a cost‐effective way has never been greater.
While the medical education system equips doctors with skills to provide safe clinical care, it should also provide an understanding of healthcare costs and cost‐...
Objective:
Few large cohort studies have reported data on maternal, fetal, perinatal and neonatal outcomes associated with SARS-CoV-2 infection in pregnancy. We report the outcome of infected pregnancies from a collaboration formed early during the pandemic between the investigators of two registries, the UK and global Pregnancy and Neonatal outco...
Objectives:
Person-to-person spread of COVID-19 in the UK has now been confirmed. There are limited case series reporting the impact on women affected by coronavirus during pregnancy. In women affected by severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS), the case fatality rate appeared higher in those affected i...
BACKGROUND Person to person spread of COIVD-19 in the UK has now been confirmed. There are limited case series reporting the impact on women affected by coronaviruses (CoV) during pregnancy. In women affected by SARS and MERS, the case fatality rate appeared higher in women affected in pregnancy compared with non-pregnant women. We conducted a rapi...
The UK government missed an opportunity for global leadership on child obesity. Now it’s time to commit, say Mark Hanson and colleagues
The UK government published its report Childhood Obesity: a Plan for Action , after a protracted delay, on 18 August 2016, when parliament was in recess and the nation was focused on the success of Team GB at the...
https://www.uk.elsevierhealth.com/kumar-and-clarks-clinical-medicine-9780702066016.html?gclid=Cj0KCQiA7IDiBRCLARIsABIPohj40CcRuVtDDrtjv5TvQDJ7pu4gbJi6W6uwGbz785rgOX13bxvveMUaAqHaEALw_wcB#panel1
To establish whether the finding of perihepatic adhesions (PHAs) at laparoscopy for ectopic pregnancy (EP) is associated with poor perioperative and reproductive outcomes.
A retrospective cohort study was undertaken of all cases of EP managed surgically at a teaching hospital in northeast London in 2003-2013. Data for symptoms, reproductive history...
Counselling women where severe growth abnormalities are detected early in the pregnancy is often difficult due to a paucity of outcome data of this specific subset of early onset disease. This study therefore aimed to assess the outcome of pregnancies where an estimated fetal weight less than the third centile were detected prior to 24 weeks gestat...
Pregnancy complications, particularly those associated with placental dysfunction, occur more frequently in primiparous than multiparous women. This difference may be a consequence of improved trophoblastic invasion, and as a result improved placental function in multiparous pregnancy. Placental dysfunction in cases of fetal growth restriction may...
Background
The incidence of cerebral palsy in term infants has not changed over the last 30 years. Current intrapartum monitoring techniques are limited by their inherent poor specificity. Changes in fetal haemodynamics in the term fetus, similar to those seen in fetal growth restriction, have been associated with an increased risk of subsequent in...
To investigate the distribution of umbilical venous flow rates, measured in early labour, in a cohort of normal term pregnancies, and to establish the relationship between umbilical venous flow and subsequent intra-partum outcome.
Five hundred and eighty nine women with uncomplicated, term, singleton pregnancies, were recruited to this prospective...
Introduction Umbilical cord arterial blood samples are taken routinely following delivery at many obstetric units in the UK. Whilst the pH of cord blood has been extensively investigated, other parameters have not. In this study we compared several parameters in cord blood between infants born by different modes of delivery.
Methods Umbilical arter...
Introduction Up to 63% of cases of intra-partum hypoxia occur in pregnancies with no antenatal risk factors. Identification before labour of these antenatally normal fetuses at risk of intra-partum hypoxia would enable a more targeted approach to intra-partum care.
Methods Five hundred and eleven women with uncomplicated, term, singleton pregnancie...
Background
The incidence of several adverse pregnancy outcomes including fetal growth restriction are higher in pregnancies where the fetus is male, leading to suggestions that placental insufficiency is more common in these fetuses. Placental insufficiency associated with fetal growth restriction may be identified by multi-vessel Doppler assessmen...
Birthweight is known to be an important independent prognostic factor for morbidity and mortality of pre-term infants. However, little is known regarding the effect of birthweight on an infants' ability to tolerate labour. We set out to compare birthweights in term infants born by spontaneous vaginal delivery and those born by emergency caesarean s...
The majority of infants that become distressed in labour have had a normal antenatal course. Currently there is no way of identifying infants at high risk of intra-partum problems. The fetal cerebro-umbilical ratio has been suggested as a marker of placental function and has been shown to be significantly lower in growth restricted infants. We inve...
Introduction A number of studies have reported that ‘sparing’ or redistribution occurs in various vascular beds in IUGR. We took a global approach to assessing this redistribution using VBF.
Method Women booking at Queen Charlotte's & Chelsea Hospital were recruited. Serial scans for growth, vessel diameter (VD) and power Doppler studies of the asc...
Introduction IUGR is associated with oligohydramnios. We investigated fetal RA parameters in normal and IUGR pregnancies and their correlation with amniotic fluid index (AFI).
Method Women booking at Queen Charlotte's & Chelsea Hospital were recruited. Serial scans for growth, vessel diameter (VD) and power Doppler of the RA were performed at 24, 2...
Advanced maternal age may be associated with adverse maternal and perinatal outcomes in singleton pregnancies. It is unclear whether a similar association exists for dichorionic twins. This objective of this study was to ascertain whether advanced maternal age was associated with increased perinatal morbidity and mortality in a 15 year retrospectiv...
IntroductionDouble embryo transfer is used in a majority of in vitro fertilization and ICSI treatment cycles in the UK, and commonly results in DCDA twin pregnancies. Compared to spontaneous conception, assisted reproductive therapy (ART) has been associated with poorer outcomes in singleton pregnancies.1 Comparative outcomes for DCDA pregnancies h...
IntroductionAbsent end diastolic flow (AEDF) results from obliteration of around 60% of placental circulation and represents a major pathological sign in fetal management.Methods
Retrospective cohort study of maternity database. Maternal demographics, scan to delivery interval, umbilical artery flow, fetal and neonatal outcomes were recorded. Fetoc...
IntroductionFetal suprarenal masses are diagnosed incidentally on antenatal ultrasound. Differential diagnosis includes adrenal haemorrhage, neuroblastoma of the adrenal medulla, adrenocortical adenoma and pulmonary sequestration. Post-natal follow-up and characterisation is necessary to determine appropriate management.12Method
Cases were identifi...
Objective
To investigate perinatal outcomes of fetal echogenic bowel (FEB).
Methods
This is a retrospective observational study of FEB cases referred between January 2005 and December 2010. Data was obtained from Fetal Medicine, Obstetric, Neonatal Databases.
Results
There were 139 cases, mean gestation 21⁺⁵ (15⁺¹–35⁺⁵) weeks. 53 (38%) had fetal...