Edward P Monnelly

Boston University | BU · Department of Psychiatry

Continuous antipsychotic treatment is important in schizophrenia, and studies have shown that rates of discontinuation are high. Some studies suggest that weight gain may lead schizophrenic patients to discontinue treatment, whereas other studies show smaller effects of weight gain on medication discontinuation, and some find weight gain associated...

Clinicians commonly use nonindicated (or "off-label") medications for the treatment of alcoholism, although there is no clear evidence to support this practice. Quetiapine and trazodone are 2 medications frequently used in this manner, especially to treat sleep disturbance associated with alcohol withdrawal. Using national administrative data from...

Quetiapine is an atypical antipsychotic that has sedative effects. In this retrospective study, indices of alcohol use were compared for alcohol-dependent subjects who either were (n = 30) or were not (n = 20) treated with quetiapine (25 to 200 mg nightly) for disturbed sleep. Indices examined included total days of abstinence, number of hospitaliz...

Increased aggressive behavior can occur in association with posttraumatic stress disorder (PTSD). This study tested the hypothesis that low-dose risperidone reduces aggression and other PTSD-related symptoms in combat veterans. Subjects were male combat veterans with PTSD who scored 20 or higher on cluster D (hyperarousal) of the Patient Checklist...

We examined personality traits (Sociability, Impulsivity, Neuroticism) as mediators of the effects of family history on alcohol outcomes. A sample of 485 men reported on family history of alcohol problems in 1973, completed the Eysenck Personality Inventory in 1976, and responded to a survey on alcohol use in 1982. Using structural equation modelin...

In a retrospective chart review, the quality of care given 531 hospitalized veterans during an index admission was examined to determine whether patient characteristics or aspects of treatment differed between 243 patients readmitted within 30 days of discharge and a control group of 288 patients not readmitted for at least six months. The stronges...

The present study was designed to test the hypothesis of "schizophrenic spectrum" disorders. The families of 60 process schizophrenics were systematically interviewed with structured interview forms, and evaluated for psychiatric illness according to strict diagnostic criteria. The interviewed persons were then separated into two groups for compara...

In 1971, McCabe et al.1 conducted a blind family study of a group consisting of 28 good-prognosis and 25 poor-prognosis schizophrenics. The results of that study showed that the families of poor-prognosis schizophrenics contained significantly more schizophrenia, neurosis, and overall illness, but significantly less affective disorder, than the fam...

60 poor prognosis schizophrenic probands and their first degree relatives were systematically interviewed blindly with regard to the subtypes of the probands. Comparisons were made between 32 paranoid probands and their families and 28 nonparanoid probands and their families. Besides definitional differences, paranoid probands had a later age of on...

This is the third in a series of investigations of social effectiveness defined by educational and occupational achievement among patients with primary affective disorder. As in previous studies, there is no evidence that patients with primary affective disorder differ significantly in social achievement from their own siblings. This study in an at...

The psychiatric consultations done in a children's hospital over an 11 month period were analyzed. Major reasons for referral included a symptom of unknown etiology (possibly psychosomatic), suspected depression, and behavior problems on the ward. Hysteria was the most common psychiatric disorder found on consultation; one third of the girls had th...