Edward Suarez Moreira Bahnson

Edward Suarez Moreira Bahnson
University of North Carolina at Chapel Hill | UNC · Department of Cell Biology and Physiology

PhD

About

87
Publications
23,523
Reads
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784
Citations
Introduction
Edward Suarez Moreira Bahnson currently works at the Department of Cell biology and Physiology, University of North Carolina at Chapel Hill. Edward does research in vascular biology and redox-based therapeutics. Their current project is 'Cell-Mediated Targeted Redox Intervention for the Prevention of Restenosis in the Injured Vasculature.'
Additional affiliations
August 2016 - present
University of North Carolina at Chapel Hill
Position
  • Professor (Assistant)
March 2016 - July 2016
Northwestern University
Position
  • Research Assistant Professor
February 2015 - June 2016
Hebrew Theological College
Position
  • Instructor
Description
  • I developed and taught a 4 credit-hour Organic Chemistry Course with lectures and lab.
Education
January 2004 - May 2010
Kent State University
Field of study
  • Biomedical Sciences
March 1994 - November 2002
Universidad de la República de Uruguay
Field of study
  • Biochemistry

Publications

Publications (87)
Article
Aims Assessment of preclinical models of vascular disease is paramount in the successful translation of novel treatments. The results of these models have traditionally relied on two-dimensional (2D) histological methodologies. Light sheet fluorescence microscopy (LSFM) is an imaging platform that allows for three-dimensional (3D) visualization of...
Conference Paper
Background Atherosclerosis remains the leading cause of death and disability worldwide. Atherosclerosis is treated by revascularization procedures that often fail due to neointimal hyperplasia (NH). NH results from vascular smooth muscle cell (VSMC) migration and proliferation from the media into the intima. Overproduction of reactive species drive...
Article
Full-text available
Aims: Cardiovascular interventions continue to fail as a result of arterial restenosis secondary to neointimal hyperplasia. We sought to develop and evaluate a systemically delivered nanostructure targeted to the site of arterial injury to prevent neointimal hyperplasia. Nanostructures were based on self-assembling biodegradable molecules known as...
Article
Interactions between Staphylococcus aureus and the host immune system can have significant impacts on antibiotic efficacy, suggesting that targeting and modulating the immune response to S. aureus infection may improve antibiotic efficacy and improve infection outcome. As we've previously shown, high levels of reactive oxygen species (ROS), associa...
Article
Atherosclerotic disease is the leading cause of death world-wide with few novel therapies available despite the ongoing health burden. Redox dysfunction is a well-established driver of atherosclerotic progression; however, the...
Article
Full-text available
Vitamin B12 (B12) is an essential co-factor for two enzymes in mammalian metabolism and can also act as a mimetic of superoxide dismutase (SOD) converting superoxide (O2 •−) to hydrogen peroxide (H2O2). High oral dose B12 decreases renal O2 •− and post-ischemia/reperfusion injury in mice and protects against damage induced by hypoxia/reperfusion in...
Preprint
Atherosclerotic disease is the leading cause of death world-wide with few novel therapies available despite the ongoing health burden. Redox dysfunction is a well-established driver of atherosclerotic progression; however, the clinical translation of redox-based therapies is lacking. One of the challenges facing redox-based therapies is their targe...
Article
Staphylococcus aureus is a leading human pathogen that frequently causes chronic and relapsing infections. Antibiotic tolerant persister cells contribute to frequent antibiotic failure in patients. Macrophages represent an important niche during S. aureus bacteremia and recent work has identified a role for oxidative burst in the formation of antib...
Preprint
Full-text available
Staphylococcus aureus is a leading human pathogen that frequently causes chronic and relapsing infections. Antibiotic tolerant persister cells contribute to frequent antibiotic failure in patients. Macrophages represent an important niche during S. aureus bacteremia and recent work has identified a role for oxidative burst in the formation of antib...
Article
Full-text available
Selective delivery of nuclear factor erythroid 2-related factor 2 (Nrf2) activators to the injured vasculature at the time of vascular surgical intervention has the potential to attenuate oxidative stress and decrease vascular smooth muscle cell (VSMC) hyperproliferation and migration towards the inner vessel wall. To this end, we developed a nanof...
Article
Background Studies have shown poorer health outcomes for people who identify as sexual and/or gender minority (LGBTQ+) compared to heterosexual peers. Our goal was to establish baseline levels of LGBTQ Ally Identity Measure (AIM) scores: (1) Knowledge and Skills, (2) Openness and Support, and (3) Awareness of Oppression of the LGBTQ+ in surgical tr...
Article
Full-text available
Atherosclerosis remains a leading cause of death and disability around the world and a major driver of health care spending. Nanomaterials have gained widespread attention due to their promising potential for clinical translation and use. We have developed a collagen-targeted peptide amphiphile (PA)-based nanofiber for the prevention of neointimal...
Article
Full-text available
Background Multiple therapeutic properties have been attributed to Cannabis sativa. However, further research is required to unveil the medicinal potential of Cannabis and the relationship between biological activity and chemical profile. Objectives The primary objective of this study was to characterize the chemical profile and antioxidant proper...
Preprint
Full-text available
Atherosclerotic vascular disease is the leading cause of death world-wide with few novel therapies available in spite of the ongoing health burden. Oxidative stress is a well-established driver of atherosclerotic progression; however the clinical translation of redox-based therapies is lacking. One of the challenges facing redox-based therapies is...
Article
Full-text available
Purpose of Review Diabetes is a common and prevalent medical condition as it affects many lives around the globe. Specifically, type-2 diabetes (T2D) is characterized by chronic systemic inflammation alongside hyperglycemia and insulin resistance in the body, which can result in atherosclerotic legion formation in the arteries and thus progression...
Article
Full-text available
Renal ischemia/reperfusion injury (IRI) is a leading cause of acute kidney injury (AKI), a potentially fatal syndrome characterized by a rapid decline in kidney function. Excess production of superoxide contributes to the injury. We hypothesized that oral administration of a high dose of vitamin B12 (B12 - cyanocobalamin), which possesses a superox...
Preprint
Full-text available
Aims: Assessment of preclinical models of vascular disease are paramount in the successful translation of novel treatments. The results of these models have traditionally relied on 2-D histological methodologies. Light sheet fluorescence microscopy (LSFM) is an imaging platform that allows for 3-D visualization of whole organs and tissues. In this...
Article
Full-text available
Purpose of Review Cardiovascular disease (CVD) involves a broad range of clinical manifestations resulting from a dysfunctional vascular system. Overproduction of reactive oxygen and nitrogen species is causally implicated in the severity of vascular dysfunction and CVD. Antioxidant therapy is an attractive avenue for treatment of CVD-associated pa...
Article
Full-text available
Engulfment and cell motility protein 1 (ELMO1) is part of a guanine nucleotide exchange factor for Ras-related C3 botulinum toxin substrate (Rac), and ELMO1 polymorphisms were identified to be associated with diabetic nephropathy in genome-wide association studies. We generated a set of Akita Ins2C96Y diabetic mice having 5 graded cardiac mRNA leve...
Article
Full-text available
Nanomedicine is a promising, noninvasive approach to reduce atherosclerotic plaque burden. However, drug delivery is limited without the ability of nanocarriers to sense and respond to the diseased microenvironment. In this study, we developed nanomaterials from peptide amphiphiles (PAs) that respond to the increased levels of matrix metalloprotein...
Conference Paper
Cardiovascular disease and atherosclerosis are devastating diseases in the modern world. Diabetes is a common comorbidity that accelerates progression of atherosclerosis. There is much need for a small animal model to recapitulate the human condition. Serum biomarkers are useful to confirm disease diagnosis, monitor progression and prognosis. We kn...
Article
Overproduction of reactive species, or failure to maintain their levels within the physiological range, results in cellular redox dysfunction. In turn, redox dysfunction is at the molecular basis of disease etiology and progression. Accordingly, antioxidant intervention to restore redox homeostasis has been pursued as a therapeutic strategy. Redox-...
Article
Full-text available
Erratum: In pages 900 and 901 of the article published in ACS Nano 2016, 10(1):899-909, the sequence of the RLM of the peptide amphiphile RLM was erroneously given as RLMTQDCLQQRSK. The correct sequence should be RLMTQDCLQQSRK.
Article
Full-text available
Atherosclerosis remains the number one cause of death and disability worldwide. Atherosclerosis is treated byrevascularization procedures to restore bloodflow to distal tissue, but these procedures often fail due to rest-enosis secondary to neointimal hyperplasia. Diabetes mellitus is a metabolic disorder that accelerates bothatherosclerosis develo...
Conference Paper
Atherosclerosis, remains the leading cause of death and disability in Western countries. Current therapeutic modalities for the treatment of arterial disease include balloon angioplasty and stenting. However, the success rate of these procedures is limited due to the development of arterial restenosis secondary to neointimal hyperplasia. Redox inte...
Article
Full-text available
Reactive oxygen and nitrogen species are indispensable in cellular physiology and signaling. Overproduction of these reactive species or failure to maintain their levels within the physiological range results in cellular redox dysfunction, often termed cellular oxidative stress. Redox dysfunction in turn is at the molecular basis of disease etiolog...
Article
Full-text available
Peripheral arterial disease is a leading cause of morbidity and mortality. The most commonly utilized prosthetic material for peripheral bypass grafting is expanded polytetrafluoroethylene (ePTFE) yet it continues to exhibit poor performance from restenosis due to neointimal hyperplasia, especially in femoral distal bypass procedures. Recently, we...
Conference Paper
Background Diabetes Mellitus (DM) accelerates the rate of atherosclerosis development. Balloon angioplasty is a common surgical intervention for the treatment of atherosclerotic disease. However, angioplasty often fails due to restenosis secondary to neointimal hyperplasia. Chronic inflammation and redox dysfunction in DM leads to higher restenosis...
Conference Paper
Introduction Patients with Diabetes Mellitus have a higher risk of developing peripheral arterial and cardiovascular disease, which is partially attributed to inflammation, increased reactive oxygen species, and endothelial cell dysfunction. Nrf2 (NF-E2-related factor 2) plays a key role in protecting against environmental stress by inducing expres...
Article
Full-text available
Background: Periadventitial delivery of nitric oxide (NO) inhibits neointimal hyperplasia; however, the effect of periadventitial adipose tissue on the efficacy of NO at inhibiting neointimal hyperplasia has not been studied. The aim of our study was to assess the effect of NO in the presence and absence of periadventitial adipose tissue. We hypot...
Article
Non-compressible torso hemorrhage is a leading cause of mortality in civilian and battlefield trauma. We sought to develop an i.v.-injectable, tissue factor (TF)-targeted nanotherapy to stop hemorrhage. Tissue factor was chosen as a target because it is only exposed to the intravascular space upon vessel disruption. Peptide amphiphile (PA) monomers...
Article
Vascular interventions are associated with high failure rates from restenosis secondary to negative remodeling and neointimal hyperplasia. Periadventitial delivery of nitric oxide (•NO) inhibits neointimal hyperplasia, preserving lumen patency. With the development of new localized delivery vehicles, •NO-based therapies remain a promising therapeut...
Conference Paper
Introduction Vascular interventions are associated with high failure rates from restenosis secondary to negative remodeling and neointimal hyperplasia. Periadventitial delivery of nitric oxide ("NO) donors inhibits neointimal hyperplasia, preserving lumen patency. With the development of new localized delivery vehicles, "NO-based therapies remain a...
Article
Targeting of vascular intervention by systemically delivered supramolecular nanofibers after balloon angioplasty is described. Tracking of self-assembling peptide amphiphiles using fluorescence shows selective binding to the site of vascular intervention. Cylindrical nanostructures are observed to target the site of arterial injury, while spherical...
Article
Full-text available
Background: Nitric oxide ((•)NO) is more effective at inhibiting neointimal hyperplasia following arterial injury in male versus female rodents, though the etiology is unclear. Given that superoxide (O2(•-)) regulates cellular proliferation, and (•)NO regulates superoxide dismutase-1 (SOD-1) in the vasculature, we hypothesized that (•)NO different...
Data
Verification of the sex of male and female vascular smooth muscle cells (VSMC) using polymerase chain reaction (PCR). Presence of secondary bands in male samples (arrow) denotes positive verification of Y-chromosome. Lane 1: 100 bp ladder, Lane 2: Male (100 ng template DNA), Lane 3: Male (200 ng template DNA), Lane 4: female (100 ng template DNA),...
Conference Paper
Vascular interventions continue to fail from restenosis secondary to neointimal hyperplasia. We developed a novel, systemically delivered, targeted therapy that will prevent restenosis following all cardiovascular interventions, using a highly customizable peptide amphiphile (PA). Targeting was accomplished by conjugation with a unique collagen-bin...
Patent
Provided herein are compositions and methods for targeted drug delivery to prevent restenosis in the cardiovascular system. In particular, provided herein are nanoscale delivery vehicles for drugs that prevent proliferation and neointimal hyperplasia
Chapter
Full-text available
Cell culture is an invaluable tool for the experimental researcher. It allows for greater variable control and faster hypothesis testing, and it is cheaper than animal models. A thorough understanding of both the theory behind cell culture experiments and the techniques involved is paramount for a successful research career. In this chapter we cove...
Article
Introduction: Novel therapies capable of directly targeting and regressing atherosclerotic plaques would provide tremendous benefit to patients with atherosclerotic cardiovascular disease. Molecular imaging studies have shown the feasibility of targeting vascular adhesion molecule (VCAM-1) for non-invasive atherosclerosis imaging. Histidine contain...
Article
S-nitrosothiols (SNO) release nitric oxide (NO) through interaction with ascorbic acid (AA). However, little is known about their combined effect in the vasculature. The aim of this study was to investigate the effect of AA on SNO-mediated NO release, proliferation, cell cycle progression, cell death, and oxidative stress in vascular cells. Vascula...
Article
Superoxide (O(2)(•-)) is implicated in inflammatory states including arteriosclerosis and ischemia-reperfusion injury. Cobalamin (Cbl) supplementation is beneficial for treating many inflammatory diseases and also provides protection in oxidative-stress-associated pathologies. Reduced Cbl reacts with O(2)(•-) at rates approaching that of superoxide...