Edward Alexander

Edward Alexander
San Diego Mesa College · Chemistry

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21
Publications
331
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196
Citations

Publications

Publications (21)
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Full-text available
The Photochemical procedure for the synthesis and purification of 2-Phenyl-bicyclo[1.1.1.]pentanol-2
Conference Paper
Ascorbic acid (AA) is an essential nutrient and natural antioxidant. Studies have shown that AA inhibits the activity of the glycolytic enzymes r-Phosphofructokinase-1 (rPFK-1), and r-Lactate Dehydrogenase (rLDH). While (AA) is unstable under physiological conditions, its fatty acid derivatives are stable and can induce apoptosis in cancer cells. T...
Conference Paper
A number of research studies on fatty acid derivatives of Ascorbic Acid (AA) have yielded interesting results such as: antimetastatic action of certain cancers, and inhibition of r-Phosphofructokinase (PFK-1) which helps regulate glycolysis and the metabolism of glucose. Other studies have concluded that cancer cells have a greater survival depende...
Conference Paper
Ascorbic Acid (AA) is a natural antioxidant. In vitro studies have shown it to inhibit the activity of the glycolytic enzyme r-Lactose Dehydrogenase (rLDH) from rabbit muscle. While AA has been found to be unstable under physiological conditions, its fatty acid derivatives are stable and have been used in cancer chemotherapy studies. The goal of th...
Article
Bei der Behandlung mit Natriumamid erh?lt man aus 2-Benzoyl-2-phenyl-bicyclo(1,l,l)pentan (I) die Phenylverbindung (II) und Benzamid (III).
Article
Die Photolyse des Pyrimidins (I) in Benzol ergibt das Acetylderivat (II), für dessen Bildung eine Typ-II-Elirninierung verantwortlich ist, die durch die Triplett-Carbonylgruppe eingeleitet wird.
Article
Bei Bestrahlung des Pyrimidylketons (I) in benzolischer Lösung unter Stickstoff entstehen die Pyrimidinderivate (II) bis (IV).
Article
Das Bicyclopentanol (I) lagert sich bei 135°C zu einem 65 : 35-Gemisch der Ketone (II) und (III) um.
Article
Das aus dem entsprechenden Bicyclo[l,l ,l ]pentanol-(2) dargestellte p-Nitrobenzoat (I) wird der Solvolyse in Aceton/Wasser (60:40) bei verschiedenen Temperaturen (50-96°C) unterworden; dabei entstehen unter Umlagerung die Cyclopentene (II) (6% Ausbeute) und (III) (92%).
Article
The photolysis in benzene of cyclobutyl phenyl ketone has been found to afford four products. The structures have been assigned as 1-phenyl-4-penten-1-one, 2-hydroxy-2-phenylbicyclo[1.1.1]pentane, cyclobutylphenylcarbinol, and the pinacol of starting material. The formation of the keto olefin and the bicyclopentanol is considered to proceed through...
Article
The urethan derivative III derived from 2-hydroxy-2-phenylbicyclo[1.1.1]pentane was prepared by the irradiation of cyclobutyl phenyl ketone and subsequent reaction with p-bromophenyl isocyanate. Structure III crystallized in space group P21 with lattice parameters a = 11.476 Å, b = 13.013 Å, c = 5.209 Å, β = 96.74°. The structure was determined by...

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Projects (2)
Project
The goal of this research is to synthesize Fatty Acid esters of Vitamin C and to study their ability to inhibit the activity of Glycolytic Enzymes.