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Introduction
Current institution
Additional affiliations
September 2018 - present
October 2012 - present
Publications
Publications (65)
Background
This Consensus Workshop dealt with diagnostic methodologies in the context of surveillance, screening, assessment of stage and grade, prognosis, monitoring and prediction of periodontal status. Several elements provided the impetus for the workshop, including the limited quality of available research on diagnostic tests, the rapid develo...
Aim
This randomised controlled trial (RCT) with a 3‐year follow‐up was aimed at assessing the clinical and radiographic outcomes of implants with either a hybrid or moderately rough macro‐surface design placed in patients with a history of periodontitis.
Material and Methods
Forty periodontitis subjects with a stable periodontal condition were inc...
Aim
To investigate the effect of periodontal therapy on endothelial function of subjects with periodontitis in stages III or IV and established cardiovascular disease.
Materials and methods
A triple-blinded, parallel groups, randomized clinical trial of 6 months duration, on patients with history of coronary heart disease and periodontitis in stag...
DENTAL IMPLANTS HAVE CONSISTENTLY shown high survival rates in partially and
fully edentulous cases. Nevertheless, treatment with dental implants nowadays could only
be considered complete if the patient's aesthetic demands are met. One of the most critical
anatomical issues in achieving aesthetics and harmony around single-tooth implants is the
pr...
Aim
To assess the correlation between micro‐computed tomography (micro‐CT) and linear morphometric measurements in terms of mandibular bone levels in a modified experimental periodontitis model in rodents to study the mechanisms of association between periodontal destruction and neuroinflammation.
Methods
The proposed in vivo experimental periodon...
The role of the oral microbiome in mental health has recently been appreciated within the proposed oral-brain axis. This study examined the structure and composition of the salivary microbiome in a large-scale population-based cohort of individuals reporting mental health symptoms (n = 306) compared to mentally healthy controls (n = 164) using 16S...
Aims
Periodontitis and cardiovascular diseases (CVD) are highly prevalent non‐communicable diseases, sharing an inflammatory pathogenesis and common risk factors. The objective of the present research is to assess the association between periodontitis and cardiovascular disease risk in a representative sample of the Spanish‐employed population.
Me...
Aim
To evaluate the effectiveness of a flapless surgical approach in the treatment of peri‐implantitis and to explore the factors influencing its outcome.
Materials and Methods
The present retrospective study evaluated patients with at least one implant diagnosed with peri‐implantitis and treated with a flapless surgical access, with or without sy...
Existe una estrecha relación entre la periodontitis y la diabetes. La atención a las patologías bucales en general se realiza fuera del Sistema Nacional de Salud. Sin embargo, la diabetes tiene una gran influencia en cómo evolucionarán algunas de estas patologías, como la periodontitis, y en las complicaciones que puedan presentarse. La diabetes no...
Aim
To evaluate the cross‐sectional association between severe periodontitis and diabetes mellitus (DM), in a representative sample of Spanish population.
Materials and Methods
The di@bet.es epidemiological study is a population‐based cohort study aimed to determine the prevalence and incidence of DM in the adult population of Spain. The at‐risk s...
Aim:
The aim of this systematic review was to evaluate the efficacy of patient-performed or administered adjunctive measures to non-surgical peri-implantitis therapy in terms of probing depth (PD) and/or bleeding on probing (BoP) reductions.
Materials and methods:
Randomized and controlled clinical trials with at least 6 months of follow-up were...
Bone augmentation procedures aim to regenerate the deficient alveolar ridge to properly place dental implants that are completely surrounded by bone. However, these are invasive and technically demanding surgeries that are not free of either complications or treatment errors. Careful patient selection and preparation is a mandatory process to reduc...
Vertical ridge augmentation techniques have been advocated to enable restoring function and esthetics by means of implant‐supported rehabilitation. There are three major modalities. The first is guided bone regeneration, based on the principle of compartmentalization by means of using a barrier membrane, which has been demonstrated to be technicall...
Vertical ridge augmentation is one of the most challenging procedures in implant dentistry because of the advanced skills required by the operator and the fact that bone augmentation is aimed outside the bony contour, in an environment of reduced blood supply. What is more, the flap management required to ensure soft tissue closure frequently leads...
Aim:
To explore the potential mechanisms of neuroinflammation (microglia, blood-brain barrier [BBB] permeability, and the sphingosine-1-phosphate [S1P] pathways) resulting from the association between periodontitis and depression in rats.
Materials and methods:
This pre-clinical in vivo experimental study used Wistar rats, in which experimental...
Aim:
To evaluate 1) if periodontitis has an influence on the prevalence/incidence of respiratory diseases [chronic obstructive pulmonary disease (COPD), asthma, community-acquired pneumonia (CAP), obstructive sleep apnoea (OSA), and COVID-19)], and 2) which is the impact of periodontal therapy on the onset or progression of respiratory diseases....
Peri‐implantitis is a plaque‐associated pathologic condition occurring in tissues around dental implants, clinically characterized by increased peri‐implant probing pocket depth and progressive loss of supporting bone. Consequently, to arrest further disease progression and to increase the chance to obtain re‐osseointegration, surgical reconstructi...
Aim:
To evaluate outcome measures and methods of assessment in clinical studies on bone augmentation/preservation procedures for the placement of dental implants.
Materials and methods:
A systematic search was performed on three databases from January 2011 to April 2021 to identify clinical studies reporting on any type of bone augmentation/pres...
Aim:
To evaluate outcome measures and methods of assessment in clinical studies on bone augmentation/preservation procedures for the placement of dental implants.
Materials and methods:
A systematic search was performed on three databases from January 2011 to April 2021 to identify clinical studies reporting on any type of bone augmentation/pres...
Objectives:
To assess the literature on (i) the relevance of the presence of a minimum dimension of keratinized peri-implant mucosa (KPIM) to maintain the health and stability of peri-implant tissues, and; (ii) the surgical interventions and grafting materials used for augmenting the dimensions of the KPIM when there is a minimal amount or absence...
Objectives:
The aim of this systematic review was to evaluate the efficacy of soft tissue substitutes compared to autogenous gingival grafts in surgical procedures aimed at increasing the width of keratinized mucosa (KM) around dental implants.
Materials and methods:
Two focused questions were developed: PICOS #1) "What is the efficacy of surgic...
La diabetes mellitus y la hipertensión arterial son responsables
de una morbimortalidad muy importante, constituyendo un problema mayor
de salud pública. A su enorme prevalencia se
une el desconocimiento
de su enfermedad en prácticamente la mitad
de los pacientes que las padecen. La prevención
es, sin duda, la mejor manera de abordar estos problema...
Aim
To evaluate the radiological, clinical and microbiological outcomes of implants with a hybrid surface macro-design in patients with history of periodontitis.
Material and Methods
The study was designed as a 12-month, parallel-arm, randomized controlled trial where patients with history of treated periodontitis in need of dental implants for si...
Aim
The aim was to evaluate the efficacy and effectiveness of tooth-supported fixed prostheses in partially edentulous patients with stage IV periodontitis.
Material and Methods
Randomized and controlled clinical trials (RCTs and CCTs) and prospective/retrospective cohort studies or case series were searched in three databases. Survival rate of ab...
Aim
The aim of this study was to evaluate the efficacy of a xenogeneic collagen matrix to augment the width of keratinized mucosa (KM), concomitantly to the surgical treatment of peri-implantitis, when compared to the use of an autologous soft tissue graft.
Material and Methods
In this 12-month parallel-arm randomized controlled clinical trial, pa...
Background
Nonsurgical treatment, resective surgery, reconstructive surgery, or combined approaches have been proposed for the treatment of peri-implantitis, with variable results.
Purpose
To evaluate the 1-year clinical and radiographic outcomes following combined resective and reconstructive surgical treatment with topical piperacillin/tazobacta...
Objectives
To study whether there is an association between caries and periodontitis in a representative sample from employed Spanish adults.
Materials and methods
This cross-sectional study is part of a wide epidemiological survey (WORALTH, Workers’ ORAL healTH). Oral examination was carried out in 5130 dentate subjects. Periodontal status was as...
Objective:
There is a need to develop easy-to-use tools to screen periodontal condition in daily practice. This study aimed to evaluate the FDI World Dental Federation "Chairside Guide" (FDI-CG) developed by the Task Team of the FDI Global Periodontal Health Project (GPHP) as a potential tool for screening.
Methods:
Databases from 3 centres in G...
Aim
To analyse, through a preclinical in vivo model, the possible mechanisms linking depression and periodontitis at behavioural, microbiological and molecular levels.
Materials and methods
Periodontitis (P) was induced in Wistar:Han rats (oral gavages with Porphyromonas gingivalis and Fusobacterium nucleatum) during 12 weeks, followed by a 3‐week...
Aim
To evaluate the efficacy of different screening protocols for undiagnosed hyperglycaemia in a Research Network of Dental Clinics coordinated by the Spanish Society of Periodontology (SEPA).
Material and Methods
A total of 1143 patients were included in the study. Participants filled a questionnaire considering diabetes risk factors (FINDRISC)...
Introduction
Evidence of an association between periodontitis and MetS (metabolic syndrome) remains controversial. The objective of this study is to evaluate the association between periodontitis and MetS in a cross‐sectional population survey.
Material and Methods
WORALTH (Workers’ ORAL healTH) Study is a cross‐sectional survey, conducted on a re...
Aim
This randomized controlled trial aimed to assess the efficacy of a two‐stage crown lengthening intervention (SCL) in the aesthetic zone compared with a one‐stage crown lengthening procedure (CCL).
Materials and methods
Thirty subjects were randomly assigned to either SCL (n = 15) or CCL (n = 15) groups. SCL consisted of full‐thickness flaps fo...
Aim
There are no nationally‐representative epidemiological data available reporting on the different recession types according to the 2018 classification system or focusing on the aesthetic zone.
The aims of this cross‐sectional study were: i) to provide estimates on the prevalence, severity and extent of mid‐buccal GRs according to the 2018 classi...
Aims:
To determine the impact of periodontal treatment on systemic markers of inflammation in patients with metabolic syndrome (MetS) and periodontitis.
Material and methods:
In this parallel-arm, double blind, randomized controlled clinical trial, 63 patients with MetS and severe periodontitis were randomly assigned to receive intensive periodo...
Background
Although there is evidence of positive effect of periodontal therapy on systemic inflammation, this response is highly variable among subjects. It was the aim of this clinical investigation to determine the impact of periodontal treatment on systemic markers of inflammation in patients with metabolic syndrome (MetS) and periodontitis.
M...
Aim:
This systematic review aimed to answer the following focused questions: 1) "In patients with periodontitis, how effective are access flaps (AFs) as compared to subgingival debridement in attaining probing depth (PD) reduction?"; 2) "In patients with periodontitis, does the type of AF impact PD reduction?".
Material and methods:
Randomized c...
Background and objective:
Use of self-reported questionnaires in Dentistry may be useful to estimate the prevalence of periodontitis in epidemiological studies. This study aims to assess the accuracy of self-reporting for predicting the prevalence of periodontitis in a Spanish population participating in a diabetes incidence study.
Materials and...
Objective
To examine the association between periodontitis, diabetes, and prediabetes, assessed by fasting plasma glucose (FPG).
Materials and methods
Workers’ Oral Health Study is a cross-sectional survey conducted on a representative sample of the Spanish employed population including 5154 participants (59.5% men, aged 16–65). Examination of per...
Prebiotics and probiotics may have a role in the prevention and treatment of relevant oral diseases and conditions, including dental caries, periodontal and peri-implant diseases and halitosis. Prebiotics and probiotics may be associated with higher numbers or activity of “beneficial” bacterial species, thus controlling microbiological deleterious...
Background and aims:
To review the regenerative technologies used in bone regeneration: bone grafts, barrier membranes, bioactive factors and cell therapies.
Material and methods:
Four background review publications served to elaborate this consensus report.
Results and conclusions:
Biomaterials used as bone grafts must meet specific requireme...
Aim
Reports regarding prevalence of peri‐implant diseases show widely varying prevalence rates, which can be explained partially by variable diagnostic criteria adopted. Furthermore, several different factors have been associated with peri‐implant diseases. Hence, the aim of this cross‐sectional study is to i) determine the prevalence, extent and s...
periodontitis
in the adult USA population, with data from the 2011–2012 National Health and
Nutrition Examination Survey (NHANES) cycle.
Material and Methods: A subset of 3017 subjects aged >30 years, with >14 teeth
present and having received a periodontal examination in addition to data collected
on cardio‐metabolic risk measures (smoking habit,...
Abstract
Aim: To develop and validate a predictive model for moderate‐to‐severe periodontitis
in the adult USA population, with data from the 2011–2012 National Health and
Nutrition Examination Survey (NHANES) cycle.
Material and Methods: A subset of 3017 subjects aged >30 years, with >14 teeth
present and having received a periodontal examination...
revisión de la literatura 30 eldentistamoderno marzo 2019 IMPLANTOLOGÍA Introducción La rehabilitación de paciente edéntulos parcia-les o totales mediante prótesis implanto-soporta-das se ha convertido en una práctica habitual en las últimas décadas (1). Sin embargo, determina-das condiciones locales de las crestas edéntulas podrían ser desfavorabl...
Objectives
To compare clinical performance of a novel resorbable non‐cross‐linked collagen membrane, creos xenoprotect (CXP), with a reference membrane (BG) for guided bone regeneration (GBR) at dehisced single implant sites.
Materials and Methods
This randomized controlled trial included patients with simultaneous implant placement and GBR at deh...
AIM:
The primary aim of this systematic review was to evaluate the effect of various techniques used for vertical ridge augmentation on clinical vertical bone gain.
MATERIAL AND METHODS:
A protocol was developed to answer the following focused question: "In patients with vertical alveolar ridge deficiencies, how effective are different augmentation...
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
Appendix S1. CONSORT 2010 checklist of information to include when reporting a randomised trial.
Non-resolving inflammation is a central pathologic component of obesity, insulin resistance, type 2 diabetes and associated morbidities. The resultant hyperglycemia is deleterious to the normal function of many organs and its control significantly improves survival and quality of life for patients with diabetes. Macrophages play critical roles in b...
Interim study results have shown that the new resorbable collagen membrane facilitates bone augmentation in dehiscence defects similarly to the reference membrane. At definitive prosthetic placement, patients reported high functional and esthetic satisfaction, as well as a higher quality-of-life compared to pre-treatment. These findings further sup...
Aim:
To evaluate the efficacy of a probiotic combination in the treatment of gingivitis and to assess its impact on the subgingival microbiota.
Material and methods:
A placebo-controlled clinical trial was conducted in gingivitis subjects during 6 weeks. Test treatment consisted on the administration of two oral tablets per day containing the pr...
Periodontal diseases and dental caries are the most common diseases of humans and the main cause of tooth loss. Both diseases can lead to nutritional compromise and negative impacts upon self-esteem and quality of life. As complex chronic diseases, they share common risk factors, such as a requirement for a pathogenic plaque biofilm, yet they exhib...
Objective:
To compare clinical performance of a new resorbable non-cross-linked collagen membrane, creos xenoprotect (CXP), with a reference membrane (BG) for guided bone regeneration at dehisced implant sites.
Materials and methods:
This randomized controlled clinical trial enrolled patients with expected dehiscence defects following implant pl...
Objective:
This systematic review aimed to evaluate the scientific evidence on the efficacy of desensitizing mouthwashes for the treatment of dentin hypersensitivity (DH) and root sensitivity (RS).
Material and methods:
A thorough search in MEDLINE, PubMed and Cochrane Plus Library was conducted up to February 2015. Randomized clinical trials, p...
Objective:
To compare the effect of two newly formulated chlorhexidine (CHX) and cetylpyridinium chloride (CPC) mouthrinses after scaling and root planing (SRP) in terms of clinical, microbiological, patient-based variables and adverse events, with a positive control with the same active components, already marketed and tested.
Methods:
A pilot,...
The effect of probiotics in the prevention and treatment of several chronic systemic diseases is well documented. Traditionally, probiotics have been associated with gut health, but recently, there has been an increasing interest in their use within the field of dentistry for the management of different oral diseases such as caries, periodontal dis...
Unlabelled:
Periodontitis is a ubiquitous and irreversible inflammatory condition and represents a significant public health burden. Severe periodontitis affects over 11% of adults, is a major cause of tooth loss impacting negatively upon speech, nutrition, quality of life and self-esteem, and has systemic inflammatory consequences. Periodontitis...
To investigate the effects of an orally administered probiotic on the oral microbiota.
A placebo-controlled, parallel study was conducted in 40 gingivitis subjects during 8 weeks. Treatment consisted on the administration of a daily tablet, either containing Lactobacillus reuteri or placebo. Unstimulated saliva and subgingival samples were collecte...
Objective: To assess the microbiological effets of commercially prepared probiotic tablets containing two strains of Lactobacillus reuteri in patients with gingivitis. Methods: The study was a doubled-blind, placebo-controlled, cross-over, prospective, randomized clinical trial in patients with gingivitis. After supragingival prophylaxis participan...
