Eduard Langenegger

Eduard Langenegger
Stellenbosch University | SUN · Department of Obstetrics and Gynaecology/ Maternal Medicine

Doctor of Philosophy

About

51
Publications
15,629
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1,219
Citations
Additional affiliations
July 2005 - June 2016
Stellenbosch University
Position
  • Head of Department

Publications

Publications (51)
Preprint
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Background Preeclampsia affects about 5% of pregnancies and is diagnosed by new onset of hypertension with end-organ dysfunction. It is hypothesized that systemic inflammation causes maternal vascular endothelial dysfunction and vascular injury. Objective To assess whether plasma concentrations of the circulating inflammatory proteins Interleukin-6...
Article
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Background. Few data are available on COVID-19 outcomes among pregnant women in sub-Saharan Africa (SSA), where high-risk comorbidities are prevalent. We investigated the impact of pregnancy on SARS-CoV-2 infection and of SARS-CoV-2 infection on pregnancy to generate evidence for health policy and clinical practice. Methods. We conducted a 6-countr...
Article
Full-text available
BACKGROUND: Few data are available on COVID-19 outcomes among pregnant women in sub-Saharan Africa (SSA), where high-risk comorbidities are prevalent. We investigated the impact of pregnancy on SARS-CoV-2 infection and of SARS-CoV-2 infection on pregnancy to generate evidence for health policy and clinical practice. METHODS: We conducted a 6-countr...
Article
Full-text available
Coronavirus disease 2019 (COVID-19) in pregnancy is associated with excess maternal and infant morbidity and mortality in both African and higher-resource settings. Furthermore, mounting evidence demonstrates the safety and efficacy of COVID-19 vaccination for pregnant women and infants. However, national guidelines in many African countries are eq...
Article
Full-text available
Background: Few data are available on COVID-19 outcomes among pregnant women in sub-Saharan Africa (SSA), where high-risk comorbidities are prevalent. We investigated the impact of pregnancy on SARS-CoV-2 infection and of SARS-CoV-2 infection on pregnancy to generate evidence for health policy and clinical practice. Methods: We conducted a 6-cou...
Article
Full-text available
Background and Objectives There are no tools to accurately predict who is at risk of developing neurological complications of preeclampsia and no objective methods to determine disease severity. We assessed whether plasma levels of the cerebral biomarkers neurofilament light (NfL), tau and glial fibrillary acidic protein (GFAP) could reflect diseas...
Article
Background Preeclampsia complicates approximately 5% of all pregnancies. When pulmonary edema occurs, it accounts for 50% of preeclampsia related mortality. Currently, there is no consensus on the degree to which left ventricular systolic dysfunction contributes to the development of pulmonary edema. Objectives To use cardiac MRI to detect subtle...
Article
Full-text available
BACKGROUND: The impact of SARS-CoV-2 infection in pregnant women living with HIV (PLHIV) has not been described previouslyOBJECTIVES: To describe the clinical presentation and outcomes of a cohort of women with high-risk pregnancies with confirmed COVID-19 to determine whether risk factors for disease severity and adverse outcomes of COVID-19 diffe...
Article
Full-text available
Cerebral complications in preeclampsia are leading causes of maternal mortality. Animal models suggest that an injured blood-brain barrier and neuroinflammation may be important but there is paucity of data from human studies. Therefore, we aimed to evaluate this in women with preeclampsia and eclampsia. We included women recruited to the South Afr...
Article
Full-text available
Objective To describe risk factors and outcomes of pregnant women infected with SARS‐CoV‐2 admitted to South African healthcare facilities. Methods A population‐based cohort study was conducted utilizing an amended International Obstetric Surveillance System protocol. Data on pregnant women with SARS‐CoV‐2 infection, hospitalized between April 14,...
Article
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Pre-eclampsia is a leading cause of maternal and perinatal morbidity and mortality. The burden of disease lies mainly in low-middle income countries. The aim of this project is to establish a pre-eclampsia biobank in South Africa to facilitate research in the field of pre-eclampsia with a focus on phenotyping severe disease.The approach of our biob...
Article
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In the African context, there is a paucity of data on SARS-CoV-2 infection and associated COVID-19 in pregnancy. Given the endemicity of infections such as malaria, HIV, and tuberculosis (TB) in sub-Saharan Africa (SSA), it is important to evaluate coinfections with SARS-CoV-2 and their impact on maternal/infant outcomes. Robust research is criti...
Article
Objective Human cases of acute profound hypoxic-ischemic (HI) injury (HII), in which the insult duration timed with precision had been identified, remains rare, and there is often uncertainty of the prior state of fetal health. Study Design A retrospective analysis of 10 medicolegal cases of neonatal encephalopathy-cerebral palsy survivors who sust...
Article
Full-text available
Background: The effect of neuraminidase inhibitor (NAI) treatment on length of stay (LoS) in patients hospitalized with influenza is unclear. Methods: We conducted a one-stage individual participant data (IPD) meta-analysis exploring the association between NAI treatment and LoS in patients hospitalized with 2009 influenza A(H1N1) virus (A[H1N1]...
Article
Full-text available
Patients at risk of organ dysfunction or with established organ dysfunction should be referred to central or tertiary‐level hospitals. However, even in central hospitals, intensive care unit (ICU) beds are often unavailable, which may contribute to maternal deaths. One pragmatic solution is to establish obstetric critical care units (OCCUs) in the...
Article
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Objective: To investigate the outcomes of critically ill obstetric patients managed in a obstetric critical care unit in South Africa. Methods: Patients with severe maternal morbidity managed in the labor ward of Tygerberg Hospital were studied over three months before the establishment of the obstetrician-led obstetric critical care unit. One y...
Article
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Unrepaired cyanotic heart disease is considered a high-risk lesion owing to the consequent increase in maternal and fetal complications. In the presence of pulmonary hypertension, maternal mortality approaching 50% has been reported, and pregnancy is therefore considered contraindicated. We present a case of a 32-year-old woman presenting at 34 wee...
Article
Introduction Acute pulmonary oedema remains a life threatening complication of pre-eclampsia. The systolic left ventricular function in patients with pre-eclampsia and pulmonary oedema is not clear. Hypothesis We hypothesise that pulmonary oedema complicating pre-eclampsia is associated with the presence of a higher incidence of LV systolic dysfun...
Article
Objective The aim of this study was to compare the accuracy of non-invasive blood pressure measurements in the brachial artery based on systolic occlusion pressures to brachial intra-arterial blood pressure measurements in patients with severe pre-eclampsia. Methods A prospective descriptive cross sectional study was conducted in the Obstetrics Cr...
Article
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Background: The impact of neuraminidase inhibitors (NAIs) on Influenza-related pneumonia (IRP) is not established. Our objective was to investigate the association between NAI treatment and IRP incidence and outcomes in patients hospitalised with A(H1N1)pdm09 virus infection. Methods: A worldwide meta-analysis of individual participant data (IPD...
Data
Figure S1. Date of admission of 29 512 patients hospitalized with A(H1N1)pdm09 infection (by month). Table S1. PRIDE study Investigators. Table S2. Minimum dataset requirement. Table S3. Standardised dataset – data dictionary with definitions used in this analysis. Table S4. Comparison of hospitalised patients included in analysis compared with...
Article
Full-text available
BACKGROUND: The impact of neuraminidase inhibitors (NAIs) on influenza‐related pneumonia (IRP) is not established. Our objective was to investigate the association between NAI treatment and IRP incidence and outcomes in patients hospitalised with A(H1N1)pdm09 virus infection. METHODS: A worldwide meta‐analysis of individual participant data from 20...
Thesis
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SUMMARY Life-threatening complications during pregnancy and childbirth may develop unexpectedly and can rapidly progress to organ failure and even death. Survival depends on quality emergency obstetric and critical care management. The limited critical care resources in South Africa often lead to maternal deaths that are potentially preventable. T...
Article
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Neuraminidase inhibitors were widely used during the 2009/10 influenza A H1N1 pandemic, but evidence for their effectiveness in reducing mortality is uncertain. We did a meta-analysis of individual participant data to investigate the association between use of neuraminidase inhibitors and mortality in patients admitted to hospital with pandemic inf...
Article
Full-text available
Summary Background Neuraminidase inhibitors were widely used during the 2009–10 influenza A H1N1 pandemic, but evidence for their effectiveness in reducing mortality is uncertain. We did a meta-analysis of individual participant data to investigate the association between use of neuraminidase inhibitors and mortality in patients admitted to hospita...
Article
Full-text available
To compare the accuracy of two non-invasive methods of blood-pressure measurement with intra-arterial measurement in women with pre-eclampsia and acute severe hypertension. This descriptive, cross-sectional study prospectively enrolled 23 women with pre-eclampsia and acute severe hypertension for continuous intra-arterial blood-pressure monitoring....
Chapter
Full-text available
Preface Aim: to provide relevant evidence based practical information and guidelines for all grades of health worker at all levels of care who manage women with postpartum haemorrhage. This monograph arises from the deliberations of the National Committee on Confidential Enquiries into Maternal Deaths (NCCEMD) on how best to minimise maternal death...
Article
Full-text available
To compare oral misoprostol with dinoprostone for induction of labor and their effects on the fetal heart rate patterns. In a randomized controlled trial, 200 patients received either misoprostol 50 mug orally for every 4 h, or dinoprostone 0.5 mg intracervically for every 6 h. Cardiotocographic recordings, in 10-min windows 30, 60, and 80 min afte...

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