Edna Maria Vissoci Reiche

Edna Maria Vissoci Reiche
Universidade Estadual de Londrina | UEL · Centro de Ciências da Saúde (CCS)

Doctor
Professor of the Medicine School of Pontifical Catholic University of Paraná, Campus Londrina (PUCPR).

About

244
Publications
46,433
Reads
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4,495
Citations
Citations since 2017
97 Research Items
2659 Citations
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Introduction
I am working with autoimmune, inflammatory, and infeccious diseases in an attempt to identy a panel of biomarkers (clinical, imaging and laboratory) to help the diagnosis, as well to early predict the prognosis of these diseases.
Additional affiliations
February 2022 - August 2022
Pontifícia Universidade Católica do Paraná (PUC-PR) Campus Londrina
Position
  • Professor
Description
  • Teaching Basic Immunology to School of Medicine of PUCPR.
January 1980 - February 2021
Universidade Estadual de Londrina
Position
  • Head of Department
Description
  • Senior Professor of Posgraduate Program of Physiopathology and Clinical Laboratory and Program of Health Sciences in the Londrina State University. Experience in Clinical Immunology and Molecular Diagnosis.

Publications

Publications (244)
Article
Full-text available
The aim was to investigate the association between plasma levels of cellular adhesion molecules (CAMs) and risk factors, subtypes, severity and short-term mortality of acute ischemic stroke (IS), and to identify a panel of biomarkers to predict short-term mortality after IS. The prospective study evaluated 132 IS patients within 24 h of their hospi...
Preprint
Full-text available
Adverse childhood experiences (ACEs) have been associated with chronic health problems in adolescents and young adults. The aim of this study was to investigate in adolescents and young adults how lower quality of life, elevated perceived stress and ACEs could influence depression and anxiety symptoms, practice of physical activity, loss of control...
Article
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IntroductionThe main mechanisms in the physiopathology of migraine are cortical spreading depression and trigeminal activation with the release of CGRP. Neurogenic inflammation and neuroinflammation can exert an influence over both these mechanisms, but there are still a number of gaps in our understanding. Interleukin (IL)- 1β is a pro-inflammator...
Article
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IntroductionFew studies have been conducted into neurogenic inflammation and neuroinflammation in respect of migraine. However, evidence suggests that the immune system may exert an influence over trigeminal activation and cortical spreading depression in individuals suffering from migraine. The interleukin (IL)-18 is a pro-inflammatory cytokine an...
Preprint
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An association between ischemic stroke (IS) and acute renal injury (AKI) has been reported. The aim of the study was to evaluate the occurrence of AKI and the potential prognostic validity of a panel of clinical and laboratory biomarkers in predicting AKI and short-term mortality after the IS. A prospective and longitudinal study enrolled 95 patien...
Article
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The early stage of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, may be accompanied by high activity of the nucleotide-binding domain, leucine-rich repeat and pyrin domain-containing protein 3 (NLRP3) in ammasome and a cytokine storm. The aim of the study was to construct Machine Learning (ML) models that predict critical...
Preprint
Full-text available
The early stage of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, may be accompanied by high activity of the nucleotide-binding domain, leucine-rich repeat and pyrin domain-containing protein 3 (NLRP3) inflammasome and a cytokine storm. The aim of the study was to construct Machine Learning (ML) models that predict critical...
Article
Full-text available
Objective The aim of this study was to evaluate the association of -924 G>A (rs2232365) and -3279 C>A (rs3761548) FOXP3 variants with IBD susceptibility, clinical and endoscopic activity, and IL-10 and TGF-β1 plasma levels. Method The study included 110 IBD female patients, 60 with Ulcerative Colitis (UC) and 50 with Crohn's Disease (CD), and 154...
Preprint
The aim was to investigate the association between plasma levels of cellular adhesion molecules (CAMs) and risk factors, subtypes, severity and short-term mortality of acute ischemic stroke (IS), and to identify a panel of biomarkers to predict short-term mortality after IS. The prospective study evaluated 132 IS patients within 24 h of their hospi...
Article
Full-text available
Coronavirus disease 2019 (COVID-19) continues to spread globally despite the discovery of vaccines. Many people die due to COVID-19 as a result of catastrophic consequences, such as acute respiratory distress syndrome, pulmonary embolism, and disseminated intravascular coagulation caused by a cytokine storm. Immunopathology and immunogenetic resear...
Preprint
Full-text available
Objective: The aim was to evaluate the association between the MTHFR 677C>T (rs1801133) variant with susceptibility and severity of peripheral arterial occlusive disease (PAOD) and levels of homocysteine (Hcy). Subject and Methods: A case-control study enrolled 157 patients with PAOD and unrelated 113 controls. The severity and anatomoradiological...
Article
Full-text available
In coronavirus disease (COVID-19), the nucleotide-binding domain, leucine-rich repeat and pyrin domain-containing protein 3 (NLRP3) inflammasome is activated in response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Acute infections are accompanied by a sickness symptom complex (SSC) which is highly conserved and protec...
Preprint
Full-text available
Objective/Design: A case-control study aims to evaluate the frequency of the IL36G C>T (rs13392494) and the IL36G A>G (rs7584409) variants and their association with susceptibility, joint involvement and severity of psoriasis (PsO). Subjects and Methods: The study included 154 patients with PsO and 154 controls from Brazilian population. The IL36G...
Preprint
Full-text available
Psoriasis (PsO) is a chronic, immune-mediated, inflammatory and polygenic dermatosis and may be associated with psoriatic arthritis (PsA). Interleukin 36 (IL-36) has important role in to make the interaction between the innate and adaptive immune response. Variants in genes encoding cytokines can modulate the susceptibility as well as the severity...
Preprint
Full-text available
Objective and design: A case-control study evaluated the association of the IL36G C>T (rs13392494) and the IL36G A>G (rs7584409) variants with susceptibility, joint involvement and severity of psoriasis (PsO). Material: 154 PsO patients and 154 controls were included. The Classification Criteria for Psoriatic Arthritis and the Psoriasis Area and Se...
Preprint
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Peripheral arterial occlusive disease (PAOD) is characterized by atherosclerotic lesions involving non-cardiac and non-cerebral arteries and disturbances in the axial vessels and at the microcirculatory level, which may lead to critical ischemia of lower limbs. Conflicting results have been reported about the role of the MTHFR 677 C > G (rs1801133)...
Article
Full-text available
Some clinical, imaging, and laboratory biomarkers have been identified as predictors of prognosis of acute ischemic stroke (IS). The aim of this study was to evaluate the prognostic validity of a combination of clinical, imaging, and laboratory biomarkers in predicting 1-year mortality of IS. We evaluated 103 patients with IS within 24 h of their h...
Article
Full-text available
In coronavirus disease (COVID-19), the nucleotide-binding domain, leucine-rich repeat and pyrin domain-containing protein 3 (NLRP3) inflammasome is activated in response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Acute infections are accompanied by a sickness symptom complex (SSC) which is highly conserved and protec...
Preprint
Full-text available
Coronavirus disease 2019 (COVID-19) continues to spread globally despite the discovery of vaccines. Many people die due to COVID-19 as a result of catastrophic consequences, such as acute respiratory distress syndrome, pulmonary embolism, and disseminated intravascular coagulation caused by a cytokine storm. Immunopathology and immunogenetic resear...
Article
Full-text available
This study used established biomarkers of death from ischemic stroke (IS) versus stroke survival to perform network, enrichment, and annotation analyses. Protein-protein interaction (PPI) network analysis revealed that the backbone of the highly connective network of IS death consisted of IL6, ALB, TNF, SERPINE1, VWF, VCAM1, TGFB1, and SELE. Cluste...
Article
Full-text available
Acute ischemic stroke (IS) is one of the leading causes of morbidity, functional disability and mortality worldwide. The objective was to evaluate IS risk factors and imaging variables as predictors of short-term disability and mortality in IS. Consecutive 106 IS patients were enrolled. We examined the accuracy of IS severity using the National Ins...
Preprint
Full-text available
Background: In COVID-19, the NLRP3 inflammasome is activated in response to SARS-CoV-2 infection. Acute infections are accompanied by a sickness symptom complex (SSC) which is a highly conserved symptom complex that protects against infections and hyperinflammation. Aims: To examine the associations of COVID-19, SSC and the NLPR3 rs10157379 T>C and...
Preprint
Full-text available
We investigated whether the MTHFR 677C>T (rs1801133) variant and plasma homocysteine and folate are associated with multiple sclerosis (MS), disability, disability progression, and inflammatory biomarkers. We included 163 MS patients categorized using the Expanded Disability Status Scale (EDSS) as mild (EDSS<3) and moderate/high (EDSS≥3) disability...
Preprint
Full-text available
We investigated whether the MTHFR 677C>T (rs1801133) variant and plasma homocysteine and folate are associated with multiple sclerosis (MS), disability, disability progression, and inflammatory biomarkers. We included 163 MS patients categorized using the Expanded Disability Status Scale (EDSS) as mild (EDSS<3) and moderate/high (EDSS≥3) disability...
Preprint
Full-text available
We investigated whether the MTHFR 677C>T (rs1801133) variant and plasma homocysteine and folate are associated with multiple sclerosis (MS), disability, disability progression, and inflammatory biomarkers. We included 163 MS patients categorized using the Expanded Disability Status Scale (EDSS) as mild (EDSS<3) and moderate/high (EDSS≥3) disability...
Preprint
Full-text available
Background: In COVID-19, the NLRP3 inflammasome is activated in response to SARS-CoV-2 infection. Acute infections are accompanied by a sickness symptom complex (SSC) which is a highly conserved symptom complex that protects against infections and hyperinflammation. Aims: To examine the associations of COVID-19, SSC and the NLPR3 rs10157379 T>C and...
Article
Full-text available
The aim of this study was to evaluate the association of the +869 T > C (rs1800470) and −509 C > T (rs1800469) TGFB1 variants, individually or in haplotypes structure, with susceptibility, autoantibodies, disease activity, and TGF-β1 plasma levels in patients with systemic lupus erythematosus (SLE). The study included 203 patients with SLE and 165...
Preprint
Full-text available
The aim of this study was to evaluate the association between the MTHFR 677C > T (rs1801133) genetic variant with susceptibility and severity of peripheral arterial occlusive disease (PAOD) and with serum levels of homocysteine (Hcy). This case-control study enrolled 157 patients with PAOD attended at University Hospital of Londrina, and unrelated...
Preprint
Full-text available
This study used established biomarkers of death due to ischemic stroke (IS) and performed network, enrichment, and annotation analysis. Protein-protein interaction (PPI) network analysis revealed that the backbone of the highly connective network of IS death consisted of IL6, ALB, TNF, SERPINE1, VWF, VCAM1, TGFB1, and SELE. Cluster analysis reveale...
Preprint
This study used established biomarkers of death due to ischemic stroke (IS) and performed network, enrichment, and annotation analysis. Protein-protein interaction (PPI) network analysis revealed that the backbone of the highly connective network of IS death consisted of IL6, ALB, TNF, SERPINE1, VWF, VCAM1, TGFB1, and SELE. Cluster analysis reveale...
Article
Full-text available
To evaluate the association between TGFB1 + 869 T > C (rs1800470) and TGFB1-509 C > T (rs1800469) variants with susceptibility for rheumatoid arthritis (RA), disease activity, presence of rheumatoid factor (RF), anti-cyclic citrullinated peptide (anti-CCP) and TGF-β1 plasma levels. A total of 262 patients with RA and 168 control individuals were te...
Article
Background : Studies have demonstrated that the gut microbiota of patients with rheumatoid arthritis (RA) is different from that of healthy individuals and could influence inflammation and oxidative stress. Objective : to evaluate the effects of a mixture of probiotics supplementation in cytokine plasma levels, inflammatory biomarkers, oxidative/n...
Article
Full-text available
The aim of this study was to evaluate the association of rs2232365 (-924 G > A) and rs3761548 (-3279 C > A) FOXP3 variants with systemic lupus erythematosus (SLE) susceptibility, TGF-β1 plasma levels, autoantibodies, and LN nephritis, and SLE disease activity index (SLEDAI). The study included 196 SLE female patients and 157 female controls. FOXP3...
Article
Full-text available
Purpose The aim of the present study was to evaluate the IL6 −174 G>C (rs1800795) and −572 G>C (rs1800796) genetic variants and their association with inflammatory bowel diseases (IBDs), disease activity, and response to TNF-α inhibitors. Methods The study included 178 patients with IBD and 224 healthy controls. Among the IBD patients, 66 of them...
Article
Full-text available
Introduction: Lowered thiol or sulfhydryl (-SH) groups and glutathione (GSH) metabolism may be associated with prostate cancer (PCa) and benign prostatic hyperplasia (BPH). The main objectives of this study were to systematically review and meta-analyze the evidence on the associations among-SH groups, GSH, GSH peroxidase (GPx), GSH reductase (GR)...
Article
Full-text available
Purpose Lowered thiol (-SH) groups and glutathione (GSH) metabolism may be associated with prostate cancer (PCa) and benign prostatic hyperplasia (BPH). The objectives of this study were to systematically review and meta-analyze the associations among -SH groups, GSH, GSH peroxidase (GPx), GSH reductase (GR), and GSH transferase (GST) and PCa/BPH....
Article
Full-text available
Immune-inflammatory, metabolic, oxidative, and nitrosative stress (IMO&NS) pathways and, consequently, neurotoxicity are involved in acute ischemic stroke (IS). The simultaneous assessment of multiple IMO&NS biomarkers may be useful to predict IS and its prognosis. The aim of this study was to identify the IMO&NS biomarkers, which predict short-ter...
Article
Background The association between subclinical atherosclerosis with traditional cardiovascular disease (CVD) risk factors, inflammatory and metabolic biomarkers has been demonstrated in worldwide and Brazilian human immunodeficiency virus type 1 (HIV-1)- infected individuals. However, the association of subclinical atherosclerosis with these aforem...
Article
Full-text available
Oxidative stress (OS) is associated with the onset of prostate cancer (PCa). The aims of this study are to examine whether OS biomarkers may be employed as external validating criteria for the diagnosis PCa. This case-control study recruited 204 subjects, 73 patients with PCa, 67 patients with benign prostate hyperplasia (BPH), and 64 healthy contr...
Preprint
Full-text available
Introduction: Lowered thiol or sulfhydryl (-SH) groups and glutathione (GSH) metabolism may be associated with prostate cancer (PCa) and benign prostatic hyperplasia (BPH). The main objectives of this study were to systematically review and meta-analyze the evidence on the associations among-SH groups, GSH, GSH peroxidase (GPx), GSH reductase (GR)...
Preprint
Full-text available
Introduction: Lowered thiol or sulfhydryl (-SH) groups and glutathione (GSH) metabolism may be associated with prostate cancer (PCa) and benign prostatic hyperplasia (BPH). The main objectives of this study were to systematically review and meta-analyze the evidence on the associations among -SH groups, GSH, GSH peroxidase (GPx), GSH reductase (GR)...
Article
Full-text available
Psoriasis is chronic, immune-mediated, inflammatory disease with a multifactorial etiology that affects the skin tissue and causes the appearance of dry and scaly lesions of anywhere on the body. The study of the pathophysiology of psoriasis reveals a network of immune cells that, together with their cytokines, initiates a chronic inflammatory resp...
Article
Full-text available
An imbalance of inflammatory/anti-inflammatory and oxidant/antioxidant molecules has been implicated in the demyelination and axonal damage in multiple sclerosis (MS). The current study aimed to evaluate the plasma levels of tumor necrosis factor (TNF)-α, soluble TNF receptor (sTNFR)1, sTNFR2, adiponectin, hydroperoxides, advanced oxidation protein...
Article
Full-text available
An association between prolactinemia with disability, clinical forms, and sex of patients with multiple sclerosis (MS) remains unclear. The aim of this study was to evaluate the association of prolactin with clinical forms and accumulating disability over time in patients with MS. A longitudinal study was carried out with 101 patients with relapsin...
Article
Full-text available
The objective of this study is to delineate the cellular adhesion molecule (CAM) profile and plasminogen activator inhibitor type 1 (PAI-1), and their association with metabolic syndrome (MetS) and carbohydrate metabolism biomarkers in psoriasis patients with mild and moderate severity. Sixty-seven patients with psoriasis as well as 102 healthy sub...
Article
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The original version of this article unfortunately contained a mistake. Camila Cataldi de Alcantara was not listed among the authors. The corrected author group should be:
Article
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Background The association between tumor necrosis factor (TNF)-α, soluble TNF receptor (sTNFR)1 and sTNFR2 with clinical characteristics of multiple sclerosis (MS) remains unclear. Objective To examine whether TNF-α, sTNFR1 and sTNFR2 are associated with MS diagnosis, disability, disability progression and clinical forms of MS. Materials and subj...
Article
The objective of this study was to evaluate the role of immune-inflammatory, metabolic, hormonal, and oxidative stress biomarkers in disability progression (DP) and clinical forms of multiple sclerosis (MS). The study evaluated 140 MS patients at admission (T0), and eight (T8) and 16 months (T16) later. The Expanded Disability Status Score (EDSS) a...
Article
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O objetivo do trabalho foi avaliar fatores sociodemográficos e laboratoriais dos pacientes infectados pelo HIV em uso de terapia antirretroviral (TARV) associados ao Índice de Desenvolvimento Humano Municipal (IDHM). O estudo envolveu 4.900 pacientes de 116 municípios do Paraná, atendidos no período de 2012 a 2015. Os pacientes foram divididos em t...
Article
Full-text available
Objective The aim of this study was to evaluate the association between rs3761548 FOXP3 (-3279 C > A) variant and multiple sclerosis (MS), disability, disability progression, as well as transforming growth factor (TGF)-β1 and interleukin (IL)-10 plasma levels in MS patients. Methods and subjects The study included 170 MS patients and 182 controls....
Article
Full-text available
The aim of this study was to evaluate the immune-inflammatory, metabolic, and nitro-oxidative stress (IM&NO) biomarkers as predictors of disability in multiple sclerosis (MS) patients. A total of 122 patients with MS were included; their disability was evaluated using the Expanded Disability Status Scale (EDSS) and IM&NO biomarkers were evaluated i...
Article
Full-text available
Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease of multifactorial origin. Studies have shown that trace elements such as zinc and copper may help maintain optimum function of the immune system and metabolism, while toxic metals such as lead may increase systemic autoimmunity. The current study aimed to assess the rel...
Article
Full-text available
Introduction: Anemic patients with chronic kidney disease (CKD) can be divided into anemic patients without or with functional iron deficiency (FID). The increase in the number of cases of hemosiderosis in patients on hemodialysis (HD) attributed to excessive intravenous iron replacement has called for the investigation of the factors involved in...
Article
Full-text available
The TNF-β +252 A>G (rs909253) polymorphism has been associated with a risk of development of rheumatoid arthritis (RA) and could influence plasma tumor necrosis factor alpha (TNF-α) levels. The aim of the present study was to evaluate the association between the TNF-β +252 A>G polymorphism with plasma TNF-α levels, the presence of autoantibodies, a...
Article
Metals are involved in different pathophysiological mechanisms associated with neurodegenerative diseases (NDDs), including Alzheimer's disease (AD), Parkinson's disease (PD) and multiple sclerosis (MS). The aim of this study was to review the effects of the essential metals zinc (Zn), copper (Cu), manganese (Mn) and iron (Fe) on the central nervou...
Article
Full-text available
Objective The objectives of this study were to delineate the pro and anti-inflammatory cytokine profiles of psoriasis and cytokine profile models that externally validate the diagnosis. Subjects and Methods This study recruited 70 patients with psoriasis and 76 healthy controls. Cytokine profiles were evaluated, including pro-inflammatory M1 (IL-1...
Article
Full-text available
The aim of the study was to define new immune-inflammatory, oxidative stress and biochemical biomarkers, which predict mortality within a period of 3 months after acute ischemic stroke (AIS). We recruited 176 healthy volunteers and 145 AIS patients, categorized as AIS survivors and non-survivors, and measured interleukin (IL)-6, high sensitivity C-...
Article
Full-text available
Objective The objectives of this study were to delineate the pro and anti-inflammatory cytokine profiles of psoriasis and cytokine profile models that externally validate the diagnosis. Subjects and Methods This study recruited 70 patients with psoriasis and 76 healthy controls. Cytokine profiles were evaluated, including pro-inflammatory M1 (IL-1...
Article
Full-text available
Background Despite the advances in therapy, the occurrence of drug-resistant human immunodeficiency virus type 1 (HIV-1) is a major obstacle to successful treatment. This study aimed to characterize the genetic diversity and to determine the prevalence of transmitted drug resistance mutations (TDRM) between individuals recently or chronically diagn...
Article
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The cascade of care for people living with HIV infection (PLHIV) describes steps in diagnosis, linkage and retention in care, as well as the provision and success of combination antiretroviral therapy (cART). The aim of this study was to evaluate the rates regarding the retention in care, on cART, and suppressed viral load for PLHIV attended at a B...
Article
Full-text available
Rheumatoid arthritis (RA) is a chronic inflammatory and systemic disease characterized by endothelial activation. The main objective of this study was to verify the profile of cell adhesion molecules (CAM) in RA patients, and the influence of metabolic syndrome (MetS) and drugs used in the treatment of RA in this profile. A second objective was to...