Edgar Cristancho

Edgar Cristancho
National University of Colombia | UNAL · Departamento de Biología (Bogotá)

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21
Publications
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188
Citations

Publications

Publications (21)
Article
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La afinidad de la hemoglobina (Hb) por oxigeno (O2) es un factor importante que influye en el transporte de este gas, especialmente en hipoxia y en diferentes enfermedades como anemia o fibrosis quística. En la medición de la afinidad se usa la determinación de la curva de disociación Hb:O2. El método presentado para establecer la curva de disociac...
Article
Full-text available
In Caucasians and Native Americans living at altitude, hemoglobin mass is increased in spite of erythropoietin concentrations ([Epo]) not markedly differing from sea level values. We hypothesized that a nocturnal decrease of arterial oxygen saturation (SaO2) causes a temporary rise of [Epo] not detected by morning measurements. SaO2 (continuous, fi...
Article
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p class="p1"> Antecedentes. La investigación sobre los efectos de la exposición a la altura sobre la eritropoyesis y el metabolismo de hierro ha permitido conocer el comportamiento y las adaptaciones que se presentan en poblaciones residentes o expuestas a diversas alturas sobre el nivel del mar. Objetivo. El presente artículo de revisión tiene com...
Article
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INTRODUCTION the development of this research is base on the growing interest in understanding the adaptations to chronic hipoxia mainly in the range of intermediate altitudes (1 500-3 000 m.s.n.m) and the need to establish parameters of normality in the variables [Hb], Hct and SO2 for diagnostic and characterization of the population purposes. OB...
Article
Erythropoietin Epo is the key hormone in the process of erythropoiesis and, therefore, essential for acclimation to altitude. Although circadian variation in Epo levels has been reported before, the results are often contradictory. Here, we tested the hypothesis that Epo levels follow a circadian variation and that such variation depends on gender...
Article
Full-text available
Iron deficiency is commonly diagnosed by serum ferritin [sFer] determination, iron deficiency anaemia from reduced mean cellular volume (MCV). [sFer] shows a high variance if inflammation or liver dysfunction are present. Athletes often present with hypoferritinaemia. This study was designed to evaluate the relation of total body haemoglobin mass (...
Article
Full-text available
The sex and age effect on the capacity to detect slight facial changes in a pair of photographs was evaluated in a group of people. Each pair of photographs was displayed during 1.5 s. Two treatments were used; with and without training. The former consisted of a pair of photographs that were exhibited to the person before the test like an example...
Article
Because of lacking ventilatory stimulation by sex hormones in postmenopausal women (PW), one might expect a lowered arterial oxygen saturation (S(O(2))) in hypoxia and therefore a stronger erythropoietic reaction than in young women (YW). Nine untrained (UTRPW) and 11 trained (TRPW) postmenopausal altitude residents (2600 m) were compared to 16 unt...
Article
Full-text available
Because of lacking ventilatory stimulation by sex hormones in postmenopausal women (PW), one might expect a lowered arterial oxygen saturation (S(O(2))) in hypoxia and therefore a stronger erythropoietic reaction than in young women (YW). Nine untrained (UTRPW) and 11 trained (TRPW) postmenopausal altitude residents (2600 m) were compared to 16 unt...
Article
Full-text available
A reliable and cost-effective screening test for erythropoietin (EPO) doping is still unavailable. Thus a new approach by estimating mean red blood cell (RBC) age by means of erythrocyte aspartate aminotransferase activity (eAST) was developed. We investigated 201 women and 169 men residing at low altitude for peak oxygen uptake, EPO, and eAST. Add...
Article
Full-text available
Color perception represents a major adaptive advantage which has been given by evolutionary pathways. It is such an important mechanism of biological signaling, a source of information from the environment. There are external factors other than those related with physiological processes influencing such perception, like sex and gender, due to the p...
Article
La percepción del color constituye una de las ventajas de adaptación proporcionadas por el desarrollo evolutivo. Es uno de los mecanismos más importantes de señalización biológica y una auténtica fuente por medio de la cual los organismos obtienen información acerca del entorno. Existen factores como la edad y el sexo, ajenos al propio mecanismo fi...
Article
Since the observation that mechanical stress causes red blood cell (RBC) destruction, foot-strike hemolysis has been used to explain sports anemia and RBC rejuvenation in athletes. Recently gained knowledge questions the importance of mechanical RBC trauma on RBC hemolysis in athletes. Male athletes (N = 90) and untrained male controls (N = 58) wer...
Article
Total hemoglobin mass has not been systematically investigated in females at altitude. We measured this quantity (CO-rebreathing method) as well as peak oxygen uptake in 54 young women (age 22.5 +/- 0.6 SE years) with differing physical fitness living in Bogota (2600 m) and compared the results with those of 19 subjects from 964 m in Colombia and 7...
Article
Full-text available
Three methods of preparation of red blood cell concentrate for erythrocyte aspartate aminotransferase measurement were compared: (1) filtration of whole blood through a cellulose column (n = 36); (2) washing of whole blood and aspiration of buffy coat after centrifugation (n = 48); (3) optimized method with washing without aspiration of buffy coat...

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Projects

Projects (2)
Archived project
This project identified the possibility to use intraerythrocytic enzymes as indirect markers for Erythropoietin doping.