Ede Frecska

Ede Frecska
University of Debrecen · Psychiatry Clinic

M.D., Ph.D.

About

189
Publications
71,549
Reads
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3,009
Citations
Citations since 2016
47 Research Items
1008 Citations
2016201720182019202020212022050100150200
2016201720182019202020212022050100150200
2016201720182019202020212022050100150200
2016201720182019202020212022050100150200
Additional affiliations
January 2010 - present
University of Debrecen
Position
  • Head of Department
November 2007 - May 2009
Northport VA Medical Center
Position
  • Managing Director
July 2001 - December 2003
University of Florida
Position
  • Professor (Associate)

Publications

Publications (189)
Article
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Introduction After a long moratorium since the Controlled Substances Act was passed in 1970, there has been a resurgence of research on the potential therapeutic benefits of psychedelic (PE) compounds. It has been widely believed that the PE effect is a result of the interaction between the drug and the mindset of the patient (the “set”) with the e...
Article
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Ischemic eye diseases are major causes of vision impairment. Thus, potential retinoprotective effects of N'N-dimethyltryptamine (DMT) were investigated. To inhibit its rapid breakdown by monoamine-oxidase A (MAO-A) enzyme, DMT was co-administered with harmaline, a β-carboline in the Amazonian Ayahuasca brew. Using ligation, 60 min of ischemia was p...
Article
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Bél–agy tengelynek nevezzük az emésztőrendszer és a központi idegrendszer működése közötti funkcionális kapcsolatot. A humán mikrobiom ezen a területen is nagy áttörést hozott, és új perspektívába helyezte a migrén kóroktanának tényezőit is, amelyek ma a klinikai agykutatás és a farmakológia fontos kutatási területei. Jelen összefoglaló a környezet...
Article
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The vast majority of research on dimethyltryptamine (DMT) has targeted its psychotropic properties and serotonergic activity, with little focus on its effects beyond the nervous system and at other receptor sites. The recent discovery that DMT is an endogenous agonist of the sigma-1 receptor (sigmaR-1) may shed light on yet undiscovered physiologic...
Article
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A Covid-19-fertôzés vizsgálata kezdetben-amely leginkább az akut és viszonylag behatárolható idôtartamú szomatikus tüneteket jelentette-a pandémia terjedése folyamán kiterjedt az elhúzódó, szövôd-ményként értelmezhetô tünetekre is. Gyûlnek az adatok a keringést, légzést, véralvadást érintô, valamint a reumatoló-giai, a bôrgyógyászati, a szemészeti...
Article
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With the increasing attention to the health promoting activities of the bioactive compounds from some plants, many researchers are focusing on the biological potential and mechanisms of certain cultivated plant species. In this review, we survey the olive and almond based extracts specific phytoconstituents and their associated health promoting eff...
Article
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Dimethyltryptamine (DMT), an endogenous ligand of sigma-1 receptors (Sig-1Rs), acts against systemic hypoxia, but whether DMT may prevent cerebral ischemic injury is unexplored. Here global forebrain ischemia was created in anesthetized rats and aggravated with the induction of spreading depolarizations (SDs) and subsequent short hypoxia before rep...
Article
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The objective of this research is to identify the relationship between the neuropsychiatric symptoms (NPSs) of patients with major neurocognitive disorder (mNCD), their quality of life, illness intrusiveness and the caregiver’s burden. We assessed 131 patients with mNCD. Examination methods included WHO well-being index short version, illness intru...
Article
Full-text available
Discovery and development of the selective serotonin reuptake inhibitors mark a milestone in neuropharmacology. Drugs from this class alter the functioning of the serotonin system by the potentiation of serotonin through the negative allosteric modulation of its neuronal uptake by the human serotonin transporter. Selective serotonin reuptake inhibi...
Article
Background and purpose: N,N-dimethyltryptamine (DMT) is an endogenous ligand of the Sigma 1 receptor (Sig-1R) with documented in vitro cytoprotective properties against hypoxia. Our aim was to demonstrate the in vivo neuroprotective effect of DMT following ischemia-reperfusion injury in the rat brain. Methods: Transient middle cerebral occlusion...
Article
Full-text available
Background Behavioural and psychological symptoms in dementia (BPSD) form an important sub-syndrome of dementia. We assessed the frequency and severity of BPSD in a random sample of Hungarian treatment-naïve dementia patients. Furthermore, we examined the relationship between cognitive symptoms and BPSD and the pattern of BPSD in specific types of...
Article
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Background: Micro-rheological relations of renal ischemia-reperfusion (I/R) have not been completely elucidated yet. Concerning anti-inflammatory agents, it is supposed that sigma-1 receptor agonist N,N-dimethyl-tryptamin (DMT) can be useful to reduce I/R injury. Objective: To investigate the micro-rheological and metabolic parameters, and the e...
Article
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During the last decade, the Human Microbiom Project resulted in several important discoveries regarding the role of the microbiota communities – with the central role of the gut flora – in maintaining physiological homeostasis. The increasing knowledgebase carries important consequences for mental health. From a psychiatrist’s perspective, the curr...
Article
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Background: Widespread protein aggregation occurs in the living system under stress or during aging, owing to disturbance of endoplasmic reticulum (ER) proteostasis. Many neurodegenerative diseases may have a common mechanism: the failure of protein homeostasis. Perturbation of ER results in unfolded protein response (UPR). Prolonged chronical UPR...
Presentation
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Presentation
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The presentation will illustrate how important are visionary experiences in shaping our culture, and emphasize that by the passing of time Western academic thinking has forgotten about their significance. The “Founding Fathers” of Western civilization (Pythagoras and Parmenides) had Eastern influences and they were fully aware of the creative power...
Article
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Concerns regarding the projected prevalence of Alzheimer’s disease (AD) over the next several decades have stimulated a need for the detection of AD in its earliest stages. A self-administered cognitive test (Test Your Memory, TYM) is designed as a short, cognitive screening tool for the detection of AD. Our aim was to validate the Hungarian versio...
Article
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Purpose: In contemporary phenomenology, Dieter Lohmar has suggested that the new task of phenomenological research is to analyze the “alternative representational systems” of fantasy. In line with this program, we propose that psychedelic experience could also be suitable subject to this project subsumed under the wider category of fantasy activity...
Chapter
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Presentation
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Előadásom címét Oswald Spengler monumentális történetfilozófiai műve (A Nyugat Alkonya) ihlette, tartalmát pedig az a sokakat zavarba ejtő kultúrtörténeti tény, hogy a nyugati gondolkodás kezdetét jelentő mű, Parmenidész munkája „A természetről” nem az általunk megszokott filozófiai traktátusok formájában volt megfogalmazva, hanem egy alvilági utaz...
Article
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Háttér és célkitűzések: A tanulmány célja a Schaefer és Olson (1981) által kidolgozott Personal Assessment of Intimacy in Relationships (PAIR) párkapcsolati kérdőív magyar változatának, a PAIR-H párkapcsolati kérdőívnek a pszichometriai vizsgálata. Módszer: A PAIR-H pár-kapcsolati kérdőív egy komplex kérdőívcsomagban került felvételre egy nagyobb,...
Article
Full-text available
Background and objectives. The subject of our research was to discover the correlation of neuropsychiatric symptoms of neurocognitive disorder patients to quality of life, illness intrusiveness, and deterioration of everyday activity and burden of relatives of patients. Methods: In our research we carried out neuropsychological examinations on deme...
Article
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Objective: In our case report we present the treatment of a female patient suffering from therapy resistant depression. This procedure is not in practice in Hungary at present, the aim of our work to reproduce the findigs of international studies in domestic circumstances. Matter: Major depression is a common, chronic and severe mental disorder, wi...
Article
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The central element of the traditional Amazonian shamanic rituals, ayahuasca has raised increasing scientific interest during the last few decades. A vast body of lay anecdotes refer to weaker-stronger therapeutic effects, yet rigorous scientific research is scarce. The trauma processing effect of ayahuasca has been underpinned by neuroimaging find...
Article
Full-text available
Ayahuasca is a brew made of two admixture plants containing dimethyltryptamine (DMT) and β-carbolines (harmine and tetrahydroharmine). The indigenous groups of the Amazonas basin have been using it for centuries as an ethnomedical substance in healing and spiritual-religious rituals. During the last two decades the brew has raised increased scienti...
Chapter
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Article
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N,N-dimethyltryptamine (DMT) is a potent endogenous hallucinogen present in the brain of humans and other mammals. Despite extensive research, its physiological role remains largely unknown. Recently, DMT has been found to activate the sigma-1 receptor (Sig-1R), an intracellular chaperone fulfilling an interface role between the endoplasmic reticul...
Data
The effect of Sig-1R inhibition on the DMT-mediated cell survival of human iPSC-derived cortical neurons, moMACs and moDCs in hypoxia. Specific Sig-1R blocking was performed by using the highly selective Sig-1R antagonist BD1063 dihydrochloride at working concentrations of 1–100 μM. Cellular survival was monitored similarly to Figures 2, 4. Cells w...
Data
DMT does not influence the hypoxia-modulated expression of the ER-stress sensor ATF6 in human primary cells. (A) Prior to their placement into hypoxia chamber (0.5% O2), cells were treated with 50 μM DMT (+DMT) or left non-treated (ctrl). Protein level expression of ATF6 was evaluated by Western blotting after 6 h of hypoxia treatment (6 h) in comp...
Article
Full-text available
Ayahuasca is a brew made of two admixture plants containing dimethyltryptamine (DMT) and b-carbolines (harmine and tetrahydroharmine). The indigenous groups of the Amazonas basin have been using it for centuries as an ethnomedical substance in healing and spiritual-religious rituals. During the last two decades the brew has raised increased scienti...
Article
Full-text available
Az ayahuasca egy többféle növényi komponensből álló főzet, melynek fő hatóanyagai a DMT és a harmin. Régmúlt időktől fogva nyújt segítséget az Amazonas-menti népek testi, lelki, társadalmi és spirituális problémáinak megoldásában. Az utóbbi évtizedekben egyre nagyobb laikus és tudományos érdeklődés mutatkozik a szer terápiás célú felhasználása irán...
Article
Full-text available
Healing methods based on the altered states of consciousness common to spiritual or shamanic traditions escape neuroscientific explanations based on classical physics and classical cognition–denoted here as ‘perceptual-cognitive’ (characteristic of the ordinary state of consciousness) information processing. A second foundation of knowledge–named a...
Presentation
Full-text available
Ayahuasca is an Amazonian psychoactive brew of two main components. Its active agents are β-carboline and tryptamine derivatives. As a sacrament, ayahuasca is still a central element of many healing ceremonies in the Amazon Basin and its ritual consumption has become common among the mestizo populations of South America. Ayahuasca use amongst the i...
Article
Full-text available
Ayahuasca is an Amazonian psychoactive brew of two main components. Its active agents are β-carboline and tryptamine derivatives. As a sacrament, ayahuasca is still a central element of many healing ceremonies in the Amazon Basin and its ritual consumption has become common among the mestizo populations of South America. Ayahuasca use amongst the i...
Article
Full-text available
According to the WHO fact sheet depression is a common mental disorder affecting 350 million people of all ages worldwide. Transcranial Magnetic Stimulation (TMS) is a technique which allows the investigator to stimulate and study cortical functions in healthy subjects and patients suffering from various mental and neurological disorders. In the ea...
Article
Full-text available
In lack of professional research and appropriate concepts our scientific knowledge of psychedelic agents is limited. According to the long-held official view these drugs are entirely harmful and have no medical use. However, a recent surge of clinical and pharmacological studies in the field indicates that many psychedelic-like agents have therapeu...
Presentation
Full-text available
A two-input model of human information processing with the corresponding biological interfaces is proposed in the presentation. It is argued that dual aspects of nature generally are reflected in the way we relate to it, and may appear on the different levels humans make representation of the environment. Evidence from neurosciences for two quite d...
Conference Paper
Full-text available
Background: The orphan receptor sigma-1 is a transmembrane chaperone protein expressed in both the central nervous system and in immune cells. It has been shown to regulate neuronal differentiation, cell survival, and mediates anti-inflammatory responses and immunosuppressive effects in murine in vivo models. The hallucinogenic N,N-dimethyltryptami...
Presentation
Full-text available
Recent research suggests that a variety of lifestyle - especially dietary - changes influencing the integrity of gastrointestinal function may be driving at least some portion of the increased prevalence of illnesses of civilization, including neuropsychiatric problems, such as autism, attention-deficit-hyperactivity disorder, major depression, obs...
Article
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The connection between mood and sleep disorders is highly complex and can be studied and interpreted in many respects. Epidemiologic data show that the co-occurrence of the two disorders is quite frequent. Thus an approach regarding them as a unit promotes biological psychiatric research by revealing new pathophysiological and therapeutic conclusio...
Article
Full-text available
The orphan receptor sigma-1 (sigmar-1) is a transmembrane chaperone protein expressed in both the central nervous system and in immune cells. It has been shown to regulate neuronal differentiation and cell survival, and mediates anti-inflammatory responses and immunosuppression in murine in vivo models. Since the details of these findings have not...
Conference Paper
Background: Neuropsychiatric diseases have recently been attributed to chronic inflammation in the central nervous system, and correlation between gene polymorphisms of innate immune receptors and the frequency of late onset of Alzheimer's disease (AD) has also been shown. Ligation of murine maternal Toll-like receptors (TLRs) and RIG-I-like recept...
Article
Full-text available
Catatonia was first described in the 19th century as a syndrome with motor, affective and behavioral symptoms. During the 20th century it was rather regarded as a rare motoric manifestation of schizophrenia and that classification has almost resulted in the disappearance of catatonia among patients outside of the schizophrenia spectrum. With the in...
Article
Full-text available
Az N,N-dimetiltriptamin (DMT) növényi eredetű szerotoninerg hallucinogén. A DMT-vel kapcsolatos eddigi kísérletek a pszichotrop/pszichedelikus hatásra fókuszáltak. Egy új felfedezés, miszerint a DMT a szigma1-receptor endogén ligandja, fényt vethet a szer egyéb biológiai funkcióira. A tanulmányban áttekintjük a szigma1-receptor ligandjainak a cellu...
Article
Full-text available
N,N-dimethyltryptamine (DMT) is classified as a naturally occurring serotonergic hallucinogen of plant origin. It has also been found in animal tissues and regarded as an endogenous trace amine transmitter. The vast majority of research on DMT has targeted its psychotropic/psychedelic properties with less focus on its effects beyond the nervous sys...
Article
Full-text available
N,N-dimethyltryptamine (DMT) is classified as a naturally occurring serotonergic hallucinogen of plant origin. It has also been found in animal tissues and regarded as an endogenous trace amine transmitter. The vast majority of research on DMT has targeted its psychotropic/psychedelic properties with less focus on its effects beyond the nervous sys...
Article
Full-text available
Aims: Studies have demonstrated neuropsychological deficits across a variety of cognitive domains in patients with major depressive disorder (MDD) during acute episode. However, limited data are available concerning whether these abnormalities persist in the remission phase. Methods: In the present study CANTAB (Cambridge Automated Neuropsycholog...
Article
Full-text available
Introduction: The spreading of "designer drugs" resulted in the appearance of "similar yet different" substances, the chemical structure of which are modified so regularly, which makes their research very difficult. We came across one of these substances, MDPV, while on night duty before it was mentioned in research papers. Our own research explor...
Article
Full-text available
There has been a growing interest in and urge for the incorporation of spirituality within the framework of contemporary medicine. Crisis in health care is a worldwide phenomenon, which may indicate the need for a paradigm shift. The recommended bio-psycho-socio-spiritual model of medicine is the extension of the current biopsychosocial paradigm by...
Article
Full-text available
A two-input model of human information processing with the corresponding biological interfaces is proposed in this essay. It is argued that dual aspects of nature generally are reflected in the way we relate to it, and may appear on the different levels humans make representation of the environment. Evidence from neurosciences for two quite distinc...
Article
Full-text available
Ayahuasca, which originates from the Amazon Basin, is a psychoactive brew of two components. Its active agents are betacarboline and tryptamine derivatives. Near the spring of the Amazon River this brew is still a central component of many healing and tribal rituals. During the past few decades, the substance has become known among both laymen and...
Article
Full-text available
Rationale: There is a shortage of studies analyzing the time course of recurrent episodes and comparing effectiveness of long-term treatments in bipolar disorder. 'Number needed to treat' (NNT) analyses have been proven to be useful for clinically meaningful comparisons, but results vary considerably among studies. The survival curves of different...
Article
Full-text available
This article reviews the role of the first and second generation antipsychotics in the long-term treatment of schizophrenia. The different forms of course, the relationship between maintenance treatment and relapse rates, the influence of depot antipsychotics and adherence on the outcome, and other predictive factors will be addressed in the paper....