E. Karpun

E. Karpun
Zaporozhye State Medical University | ZSMU · Department of Pharmacy

Master of Chemistry
Teaching Assistant, Researcher Ph.D. student; Senior Lab Technician - GC/MS at Zaporizhzhia State Medical University

About

18
Publications
1,648
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18
Citations
Citations since 2016
18 Research Items
16 Citations
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20162017201820192020202120220246810
20162017201820192020202120220246810

Publications

Publications (18)
Article
Full-text available
Citation: Karpun Ye, Parchenko V, Fotina T, Demianenko D, Fotin A, Nahornyi V, Nahorna N (2021) The investigation of antimicro-bial activity of some s-substituted bis-1,2,4-triazole-3-thiones. Pharmacia 68(4): 797-804. https://doi. Abstract New S-substituted 4-alkyl-5-((3-(pyridin-4-yl)-1H-1,2,4-triazole-5-yl)thio)methyl)-4H-1,2,4-triazole-3-thiol...
Article
Full-text available
New S-substituted 4-alkyl-5-((3-(pyridin-4-yl)-1H-1,2,4-triazole-5-yl)thio)methyl)-4H-1,2,4-triazole-3-thiol derivatives have been designed, synthesized and studied their antimicrobial activity on 11 standard Gram-positive and Gram-negative microorganism strains. Their spectral and physicochemical parameters were established using modern comprehens...
Article
The derivatives of 1,2,4-triazole are of the great scientific interest in the fields of pharmaceutics, agricultural chemistry, and construction The production of Trifuzol-Neo has already been launched, and it is now commercially available. Compounds based on 1,2,4-triazole may also be useful in veterinary practice due to their antiviral activity. T...
Article
Full-text available
The derivatives of 1,2,4-triazole are of the great scientific interest in the fields of pharmaceutics, agricultural chemistry, and construction The production of Trifuzol-Neo has already been launched, and it is now commercially available. Compounds based on 1,2,4-triazole may also be useful in veterinary practice due to their antiviral activity. T...
Article
Full-text available
The aim of the work. 1,2,4-triazole derivatives possess a wide range of pharmacological activity, so they are used for the development of drugs and active pharmaceutical ingredients. Due to the reactivity of 1,2,4-triazoles there are many options for their further structural modification on different reaction centers. Therefore, the aim of the work...
Article
Underground Valerian roots (Vаlеrіаnае radix) are officinal raw materials. More than 1000 compounds were detected in Valeriana officinalis L. s.l., of which no less than 500 natural substances of organic and inorganic origin were identified, among them – carbohydrates, amino acids, lipids, vitamins, enzymes, phenolic compounds, essential oil, irido...
Article
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The genus Salvia L. has more than 900 species distributed throughout the globe. 21 species are growing in Ukraine. All species of this genus have essential oils. Salvia officinalis and Salvia sclarea have been used in the culture and are widely used in medical practice. The chemical composition of other species of sage and the possibility of their...
Article
Full-text available
Hypoxia is a discrepancy between the required energy of the cell in the mitochondrial oxidative phosphorylation system. The immediate cause of the deficiency is a decrease in the oxygen concentration in the mitochondria. Today there is a huge demand for the development of new anti-hypoxic drugs. t is known that 1,2,4-triazole compounds can have ant...
Article
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The aim of the work was the chromato-mas-spectroscopic studyof the chemical composition of Tanacetum corymbosum (L.) Sch. Bip. and the identification of further prospects for the use of raw materials of this plant in medical and pharmaceutical practice. Materials and methods. The object of the study was the grass of Tanacetum corymbosum (L.) Sch....
Article
Full-text available
2020.-Т. 13, №1(32) Оригінальні дослідження Оriginal research Молекулярний докінг і біодоступність S-алкіл похідних 5-(3-флуорофеніл)-, 5-(5-бромофуран-2-іл)-та 5-(((3-(піридин-4-іл)-1H-1,2,4-тріазол-5-іл)тіо)метил)-4-метил-4H-1,2,4-тріазолів in silico методами Запорізький державний медичний університет, Україна A-концепція та дизайн дослідження; B...
Article
Full-text available
A combination of two rings of 1,2,4-triazole with the formation of new hybrids, bis-1,2,4-triazoles, with various functional groups and pharmacophores may comprise a promising class of the biologically active compounds. Alkaline phosphatases belong to a broad family of enzymes, ectonucleotidases, which are responsible for the dephosphorylation of n...
Article
Full-text available
2 Полтавська державна аграрна академія, Україна A-концепція та дизайн дослідження; B-збір даних; C-аналіз та інтерпретація даних; D-написання статті; E-редагування статті; F-остаточне затвердження статті Мета роботи-розробити ВЕРХ-МС методику визначення піперидиній 2-((5-(фуран-2-іл)-4-феніл-4H-1,2,4-тріазол-3-іл)тіо)ацетату у молоці та дослідити н...
Article
Full-text available
An important characteristic of chemical compounds is their biological activity, since its presence may be the basis for the use of the substance for therapeutic purposes, or, conversely, limit the possibilities of its practical application due to the occurrence of side and toxic effects. Computer evaluation of the spectrum of biological activity ma...

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