Duygu Gülmez SevimErciyes Üniversitesi · Department of Ophthalmology
Duygu Gülmez Sevim
MD, Ophthalmologist, FICO, FEBO - phd candidate in molecular biology and genetics
About
68
Publications
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Introduction
Duygu Gülmez Sevim currently works at the Department of Ophthalmology, Erciyes University, Kayseri, Turkey.
Additional affiliations
December 2014 - present
June 2010 - November 2014
Publications
Publications (68)
Purpose
The aim of this study was to investigate the peripapillary choroidal vascular changes in thyroid orbitopathy (TO).
Methods
The study included 20 eyes of 10 patients with active TO (aTO), 30 eyes of 15 patients with inactive TO (inaTO) and 30 eyes of 30 healthy subjects. The peripapillary choroidal vascular change was assessed with peripapi...
Purpose
Behçet’s disease (BD) is an autoimmune chronic systemic inflammatory disease characterized by a versatile clinical spectrum. Growth arrest specific protein 6 (GAS6)/soluble AXL (sAXL) signaling pathway draws attention in the resolution of inflammation, and its deficiency is associated with chronic inflammatory, autoimmune diseases, as well...
Purpose
To determine the etiology and anatomic localization of uveitis, the frequency of intraocular pressure (IOP) elevation, and the type of secondary glaucoma and to assess the medical, surgical, and postoperative complications in adult and pediatric patients with acute or chronic uveitis.
Methods
A total of 307 eyes of 186 patients who were fol...
Objective
To evaluate the effect of adalimumab (ADA) on choroidal thickness (ChT) and choroidal vascularity index (CVI) in eyes with non-infectious uveitis (NIU).
Methods
Thirty-seven eyes with NIU including Behçet disease (BD), sarcoidosis, ankylosing spondylitis (AS), juvenile idiopathic arthritis and idiopathic arthritis, 38 eyes of non-uveitic...
Aim The aim of this study is to evaluate the demographic data, treatment efficacy, optical coherence tomography (OCT) results used for the diagnosis and follow-up of patients with pseudotumor cerebri syndrome (PCS) followed up in our pediatric neurology clinic between 2014 and 2019.
Methods: We included children aged <18 years with or without bila...
AIM: To compare superficial and deep vascular properties of optic discs between crowded discs and controls using optical coherence tomography angiography (OCT-A). METHODS: Thirty patients with crowded discs, and 47 control subjects were enrolled in the study. One eye of each individual was included and OCT-A scans of optic discs were obtained in a...
Purpose
The purpose of the study was to investigate the parapapillary choroidal microvasculature in thyroid eye disease (TED) using optical coherence tomography angiography (OCTA).
Methods
Only one eye of each subject was included in the study. Patients with TED and controls were included in the study. Participants were divided into three groups:...
A novel, algorithmic “naming-meshing” system was introduced for the distinction of hypopyon from pseudohypopyon to make an early diagnosis and prompt treatment of anterior chamber collection standardized to encompass all sediment characteristics. For this reason, a literature review of “hypopyon” and “pseudohypopyon” was conducted in MEDLINE/PubMed...
Purpose
To evaluate the efficacy and safety of adalimumab (ADA, Humira®) for treatment of non-infectious uveitis (NIU) refractory to conventional medications.
Methods
Anti-tumor necrosis factor-α naive patients with NIU unresponsive to conventional immunosuppressive treatment were treated with ADA. Most cases with NIU were related to ocular Behçet...
Objective:
To compare the intraocular pressure (IOP)-lowering effect of different types of surgery available in the literature using a network meta-analysis (NMA) based on a systematic review.
Methods:
PubMed and the Cochrane database were searched. Randomized clinical trials involving surgical interventions for high IOP for PAC (primary angle c...
Bilateral acute iris transillumination (BAIT) is characterized by abundant pigment discharge into the anterior chamber. Atonic pupil and severe intraocular pressure elevations may be observed. Generally, there is a viral upper respiratory tract infection or systemic fluoroquinolone usage before BAIT. Two cases with a recent history of Covid-19 pres...
Objective
To evaluate the effect of adalimumab (ADA) on choroidal thickness (ChT) and choroidal vascularity index (CVI) in eyes with non-infectious uveitis (NIU).
Methods
Thirty-seven eyes with NIU, 38 eyes of non-uveitic (NU) patients, and 40 control eyes were included. ADA was used for anti-TNF-naive adult (80mg) or pediatric (40mg) patients wit...
Large congenital lid colobomas are traditionally repaired using 1- or 2-step vascularized flap-graft combinations. However, visual axis occlusion for weeks is a severe problem in small children and recent reports suggest that the flap pedicle does not contribute to blood perfusion. A “one-step” substitute for large lid defects has recently been rep...
Background:
To compare the optic disc capillary vascular status between crowded and normal optic discs using optical coherence tomography angiography (OCT-A).
Methods:
A total of 101 eyes were included in this cross-sectional, comparative study. Fifty-one eyes with crowded optic discs (Group 1) were compared with 50 eyes with normal discs (Group...
Background:
Coronavirus disease 2019 (Covid-19) has many different ocular manifestations. This study evaluates the effects of the disease and the steroid used in this disease on ocular structures.
Purpose:
To evaluate the effects of Covid-19 and the steroids used in the treatment of severe infection on ocular structures and choroidal thickness....
Purpose
The purpose of the study was to quantitatively measure the width of the retrobulbar optic nerve-sheath complex by computed tomography (CT) in glaucoma and evaluate its relationship with optic nerve changes and visual field loss parameters.
Methods
Sixty-six eyes of 33 patients with bilateral asymmetric glaucomatous optic nerve damage and 2...
Purpose
To assess the efficacy of adalimumab (ADA) on visual acuity (VA), ocular inflammation, vitreous haze and central macular thickness (CMT) in pediatric refractory non-infectious uveitis.
Methods
Thirty-one eyes of 16 pediatric patients with uveitis of various etiologies were treated with ADA. VA, intraocular active inflammatory cells, vitreo...
Purpose:
The aim of this paper was to evaluate the ring amplitudes in diabetic patients and to evaluate the effect of the risk factors for diabetic retinopathy on the ring amplitudes. We also aimed to investigate the success of ring amplitudes in classifying diabetic retinopathy.
Methods:
The study included 32 eyes of 32 diabetic patients withou...
A woman was admitted with complaints of severe watering and discharge in the right eye for 3 years. Lacrimal lavage revealed nasolacrimal ductus stenosis and the planning was Monoka stent intubation by using a Ritleng steel probe. We aimed to report for the first time the surgical manipulation of a fractured steel tip of a Ritleng probe within the...
Objective: In this study, it is aimed to evaluate the superficial peripapillary vascularization qualitatively and quantitatively in patients with acute nonarteritic anterior ischemic optic neuropathy (NAION) using optical coherence tomography angiography (OCT-A).
Methods: 11 patients with acute NAION diagnosis and 14 controls were evaluated retrosp...
Background
Diabetic retinopathy is characterized by microvascular, neural and glial cell damage. Optical coherence tomography angiography (OCTA) can detect subclinical microvasculopathy while multifocal electroretinography (mfERG) can detect subclinical local retinal dysfunction before onset of clinically observable retinopathy. Here, we investigat...
Introduction
Polyarteritis nodosa is a systemic vasculitis characterized by necrotizing inflammatory lesions affecting the middle and small arteries.
Case presentation
A 23-year-old male presented to our ophthalmology clinic with a 1-day history of sudden vision loss in his left eye. Posterior segment examination the left eye showed optic disc bor...
Objective: To investigate the effects of chronic obstructive pulmonary disease (COPD) in dry eye status in males and whether the hypoandrogenic status has any concomitant impact.
Methods: Eighty patients with stable COPD and individually matched healthy volunteers on the basis of body mass index (BMI), age, and sex were enrolled. Ocular surface tes...
Background and objectives:
This study shows the clinical data of 1-year follow-up of 8 patients with degenerative macular diseases who received suprachoroidal adipose tissue derived mesenchymal stem cell (ADMSC) implantation.
Methods and results:
This prospective, single-center, phase 1/2 study enrolled 8 eyes of 8 patients with degenerative mac...
Purpose: To translate the original 28-item Impact of Vision Impairment Profile into Turkish and to investigate its validity and reliability. Methods: Patients with no limitations to respond and affected by a chronic eye disease including retinitis pigmentosa (RP), age-related macular degeneration (ARMD) and diabetic macular edema which cause low vi...
This study includes one-year results of 14 patients with severe Retinitis Pigmentosa (RP) who had subretinal mesenchymal stem cell (ADMSC) implantation. The highest Visual Acuity (VA) in the study was 20/2000 and 7 of the patients had severe VA loss. The patients received subretinal ADMSCs after total vitrectomy. We observed no systemic complicatio...
The aim of this study was to evaluate the changes of the fi ndings in optical coherence tomography angiography (OCTA) of two cases with chronic central serous chorioretinopathy (CSCR) before and after photodynamic therapy (PDT). Retinal and choroidal vasculature changes of two cases diagnosed with chronic CSCR of whom the duration of the symptoms w...
Objectives:
To investigate the correlation between the clinical grading of the severity of meibomian gland dysfunction (MGD) and meibomian gland area (MGA) loss detected using Sirius meibography in the upper and lower eyelids and to correlate these parameters with dry eye signs and symptoms.
Methods:
One hundred thirty eyes of 130 volunteer pati...
Purpose: To evaluate optical coherence tomography (OCT) and multifocal electroretinogram (mfERG) fi ndings in patients with central serous chorioretinopathy (CSC) Methods: Sixty-two eyes of 31 patients with unilateral treatment naive CSC were included in the study. All subjects underwent complete ophthalmologic examination including best-corrected...
Retinal ven tıkanıklığı (RVT) en sık görülen retinal vasküler hastalıklardan biridir. Makula ödemi (MÖ) ise RVT' de azalmış görme keskinliğinin en önemli nedenidir. MÖ, kan-retina bariyerinin bozulması sonucunda gelişen damar dışına sıvı kaçışına bağlı oluşur ve retinal kalınlıkta belirgin artışa yol açar. Fundus floresein anjiografi (FFA) ve optik...
Purpose
To define the alterations in retinal vessel diameter in Parkinson’s disease (PD) by optical coherence tomography (OCT).
Methods
This is a case-control study including 41 eyes of 41 patients with diagnosis of PD and 35 eyes of 35 age- and sex-matched control subjects. All subjects underwent complete neurological and ophthalmological examina...
Purpose:
There have been ongoing clinical trials of therapeutic agents in Huntington's disease (HD) which requires development of reliable biomarkers of disease progression. There have been studies in the literature with conflicting results on the involvement of retina in HD, and up to date there is not a study evaluating the single retinal layers...
Objective: To compare the peripapillary retinal nerve fiber layer (pRNFL) thickness and macular volume in patients with multiple sclerosis (MS), neuromyelitis optica spectrum disorders (NMOSD) and healthy controls.
Materials and Methods: This study used spectral domain optical coherence tomography (SD-OCT) to measure pRNFL and the volume of retinal...
This prospective clinical case series aimed to investigate the safety and efficacy of suprachoroidal adipose tissue-derived mesenchymal stem cell (ADMSC) implantation in patients with dry-type age-related macular degeneration (AMD) and Stargardt's macular dystrophy (SMD). This study included four patients with advanced-stage dry-type AMD and four p...
Objectives
To assess the effects of anti-vascular endothelial growth factor (VEGF) drugs on retinal pigment epithelium cell culture.
Materials and Methods
Aflibercept (0.5 mg/mL), bevacizumab (0.3125 mg/mL), and ranibizumab (0.125 mg/mL) were applied to retinal pigment epithelium cell cultures isolated from the enucleated eyes of New Zealand white...
A 53-year-old woman with hemiparesis and poor dexterity, underwent cosmetic blepharopigmentation on the both upper eyelids in the dermatology clinic of a private hospital. She was not asked for any information on her medical history and no informed consent was obtained and the procedure was performed without any protective ocular shields. The patie...
Purpose: To evaluate pain scores of patients during intravitreal (IV) afl ibercept versus ranibizumab injections.
Materials and Methods: In this interventional study, 88 eyes of 88 patients who received IV anti-vascular endothelial growth factor (anti- VEGF) therapy were included. Fourty three patients received IV 2.0 mg/0.05 ml afl ibercept inject...
Purpose: Evaluation of the relationship between macular optical coherence tomography (OCT) parameters with visual functions in patients with retinitis pigmentosa (RP).
Materials and Methods: Demographic data and parameters of spectral domain-OCT of patients with RP whom applied to our clinic were evaluated retrospectively. One hundred and fi fty-th...
A 69-year-old female with unilateral proptosis for 1 year presented at our ophthalmology clinic. She had degenerative myopia
and a history of low vision for several years. A radiographic imaging revealed a right orbital mass causing bone lysis and invading
the intracranial space. Total resection of the mass was performed, and the findings of a hist...
A 25-year-old woman underwent diode laser application on the both upper eyelids in the dermatology department of a private hospital to obtain a cosmetic healing of the reddish look on her eyelids without any protective lenses. The patient experienced severe uveitis, atonic pupils, raised intraocular pressure, and increased sensitivity to light in h...
Purpose:
To evaluate the effect of fluorescein angiography on retinal vessel diameter with Optical Coherence Tomography (OCT).
Methods:
In this cross-sectional study, a total of 81 eyes of 81 patients who were performed fluorescein angiography (FA) procedure were included. Retinal vessels were examined with the Spectral-domain OCT at baseline an...
To assess the correlation between functional and anatomical evaluations with multifocal electroretinography (mfERG) and spectral-domain optical coherence tomography (SD-OCT) in patients with Parkinson’s disease (PD). This cross-sectional study involved 116 eyes of 58 patients with PD and 30 age- and sex-matched control subjects. All study participa...
Background:
Differentiating Parkinson disease (PD) from progressive supranuclear palsy (PSP) can be challenging early in the clinical course. The aim of our study was to see if specific retinal changes could serve as a distinguishing feature.
Methods:
We used spectral domain optical coherence tomography (SD-OCT) with automatic segmentation to me...
Introduction: Usage of stem cells in the treatment of retinal diseases is a fairly new and popular topic in ophthalmology. Embryonic and bone marrow derived stem cells are currently being used for treatment. Age-related macular degeneration (AMD), Stargardt's macular dystrophy, and retinitis pigmentosa (RP) are common encountered retinal diseases c...
Purpose:
To compare corneal wetting performances of different dispersive ophthalmic viscosurgical devices.
Methods:
Three different types of dispersive ophthalmic viscosurgical devices, hydroxypropyl methylcellulose %2 (HPMC), sodium hyaluronate %3-sodium chondroitin sulphate %4 (HACS), and sodium hyaluronate %3 (HA), were applied on corneal sur...
AIM: To evaluate the retinal vessel diameters in patients with migraine by optical coherence tomography (OCT).
METHODS: In this cross-sectional study, 124 eyes of 62 patients with a diagnosis of unilateral migraine during attack-free period and 42 age- and sex-matched control subjects were included. Migraine patients were divided into the ≤2 migrai...
The XEN implantation is an ab interno technique of minimally invasive (or microincisional) glaucoma surgery (MIGS). It is a gelatin stent under investigation that would be implanted via a clear corneal incision without conjunctival dissection. Three 6.0mm long implants, each with an internal diameter for varying levels of Intraocular Pressure (IOP)...
A 2-year-old boy with a history of food allergy presented with severe edema and erythema, excoriations and honey-colored crusting on both lower eyelids, and erythematous rash on his perioral region. An evaluation for micronutrient deficiencies revealed low plasma zinc level. The patient was started on a regimen of zinc supplementation, and at 4 wee...
Background:
To investigate the effects of commonly used intravitreal anti-vascular endothelial growth factor (anti-VEGF) antibodies on proliferation index and viability of mesenchymal stem cells derived from ciliary body and limbus (CB-MSC and LMSC).
Methods:
CB-MSCs and LMSCs were isolated from newborn rats' eyes, and they were expanded in medi...
To investigate the status of insulin resistance, metabolic syndrome, dyslipidemia, and serum adiponectin levels in patients with uveal melanoma and choroidal nevus were investigated. Our study included 86 patients with uveal melanoma, 38 patients with choroidal nevus, and 86 controls. Uveal melanomas were classified as small, medium, and large on t...
The Evaluation Of Adherence To Treatment In Glaucoma Patients
Learning Effect In Automated Perimetry Vissual Field Test At Glaucoma Patients
To describe the clinical findings of a patient with tyrosinemia type I with noncompliance to a protein-restricted diet, treated with 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione (NTBC).
Clinical findings at the initial examination and after strict compliance to a protein-restricted diet after 4 weeks follow-up are described in a patien...
To evaluate the prognostic value of metal-metal contact during nasolacrimal duct (NLD) probing in patients with simple membranous versus complex congenital NLD obstructions (CNLDO).
Retrospective case series.
Infants diagnosed with CNLDO.
Seventy-nine eyes of 70 infants with CNLDO who underwent probing were recruited. Metal-metal contact was sought...
Obstructive sleep apnea (OSA) is a serious disorder characterized with repeated episodes of upper airway obstruction during sleep, resulting in nocturnal hypoxemia and hypercapnia which leads to many systemic and also ocular complications. Various eye disorders reported to be associated with OSA. Floppy eyelid syndrome (FES), cornea disorders, glau...
Limbal stem cell deficiency (LSCD) is a complex ocular condition with difficulty in corneal epithelialization, persistent ep-ithelial defects, corneal neovascularization, and corneal conjunctivalization. The reason underlying this condition could be either primary or secondary. Chemical and thermal burns, Stevens-Johnson syndrome, ocular cicatricia...
Introduction: This study aimed to evaluate the relationship between commonly observed
ocular conditions in older aged population, arcus senilis and exfoliation syndrome and to evaluate
their association with systemic vascular disease.
Materials and Method: Seventy-five patients with arcus senilis (Group 1) and 75 patients
without arcus senilis (Gro...
To investigate and report the clinical characteristics at initial presentation in patients who had Duane Syndrome, especially binocular vision and functional amblyopia.
The medical files of patients with Duane's syndrome were reviewed. The main outcome measures of the study were the initial clinical characteristics including amblyopia and associate...