Dusanka Kitic

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• Professor
• Professor at University of Nis

In the presented study, polyphenol profile, spasmolytic, antimicrobial and antioxidant properties of lyophilized Thymus serpyllum extracts were examined. The main phenolic acid in the extracts was rosmarinic acid, followed by salvianolic acid I, salvianolic acid K isomer and caffeic acid, whereas chlorogenic acid was detected only in traces; the do...

Red currant (Ribes rubrum L.) berries are rich in bioactive compounds and exhibit nutritive and protective features. This research examined the content of secondary metabolites of the red currant variety Redpoll lyophilized juice and waste extract and their antioxidative and spasmolytic effects. The flavonol and anthocyanin contents of the samples...

Red currants ( Ribes rubrum L.) belongs to Grossulariaceae family and the Ribes genus. They are sweet and sour, nutrient rich berries that have shown antioxidant, antibacterial, antiseptic, cardioprotective, and anti-inflammatory effects. The aim of this study was to determine the vitamin C content and antioxidant potential of juices from six varie...

The study aimed to investigate the protective effects of chokeberry fruit products and by-products against cisplatin-induced acute nephrotoxicity in rats. Potential mechanisms involving oxidative stress and inflammatory responses were examined through biochemical and histopathological analyses of kidney tissue. Chokeberry waste, along with the whol...

Antioxidant activity of hydrolate obtained from the aerial part of sweet basil Ocimum basilicm L. Ocimum basilicum is a well-known aromatic, medicinal, and culinary plant. The essential oils obtained through steam distillation from the leaves and flowering tops of sweet basil have antiseptic, antimicrobial, antioxidant, antiviral, and anti-inflamma...

This study aimed to evaluate the spasmolytic activity of an underground parts extract of Gentiana asclepiadea L. (Gentianaceae), assess its antioxidant and antimicrobial activities, and explore the impact of extract encapsulation on the aforementioned bioactivities. An extract encapsulated by spray drying with whey protein, pure extract, and pure w...

BACKGROUND Polyphenolic-rich chokeberry extracts and juice could provide health benefits in humans. Moreover, by-products after processing stand out as a potential new source of valuable compounds. OBJECTIVE The research aimed to evaluate in vitro bioactivity of chokeberry fruit extract, juice, and waste extract (material remaining after juice pro...

Morinda citrifolia L., commonly known as Noni, has a longstanding history in traditional medicine for treating various diseases. Recently, there has been an increased focus on exploring Noni extracts and phytoconstituents, particularly for their effectiveness against cancers such as lung, esophageal, liver, and breast cancer, and their potential in...

The roots of Gentiana lutea L. are utilized in the preparation of various beverages and herbal remedies, serving as a traditional remedy for gastrointestinal ailments. The spasmolytic activity that could substantiate the traditional use of G. lutea root had not been investigated. The main objective goal of the study was to determine the validity of...

The use of medicinal plant species and their products is widespread in the field of gastrointestinal and respiratory diseases. This study aimed to evaluate the traditional use of Salvia sclarea L., clary sage, finding the possible mechanisms of its spasmolytic and bronchodilator actions in in vitro conditions supported by molecular docking analysis...

Introduction. Homocysteine is an amino acid that is formed in the metabolism of methionine as the quantitatively most important metabolite. Its chemical structure has been known for 90 years and its biological roles are still being investigated. Under normal conditions, homocysteine is present in plasma at the concentration of 5 - 9 mmol/l. When th...

Aim. This study aimed to evaluate and quantify the antimicrobial activity of lyophilized fruit juice (BCLJ) and waste extract (BCLW) obtained from the black currant (Ribes nigrum L.) variety Čačanska crna. Materials and method. The study was conducted using four Gram (+) (Bacillus cereus, Listeria monocytogenes, Staphylococcus aureus, Enterococcus...

Aromatic herbal drugs have been widely used in the treatment of many respiratory and gastrointestinal diseases as part of traditional medicine. Many recent studies have shown that plant species of the Lamiaceae family and their products express relaxant effects on the contractions of the isolated ileal and tracheal smooth muscle of experimental ani...

Prunus armeniaca L. (Rosaceae)-syn. Amygdalus armeniaca (L.) Dumort., Armeniaca armeniaca (L.) Huth, Armeniaca vulgaris Lam is commonly known as the apricot tree. The plant is thought to originate from the northern, north-western, and north-eastern provinces of China, although some data show that it may also come from Korea or Japan. The apricot fr...

In the present study, polyphenol extraction from Thymus serpyllum by-product (herbal dust) in microwave reactor was optimized through varying extraction time, ethanol concentration and solid-to-solvent ratio via determination of total polyphenol and flavonoid contents, and antioxidant activity, using response surface methodology and a central compo...

Headspace sampling is a fast, simple and economical way to prepare plant samples for analysis by gas chromatography. For the first time, the composition of the head space volatiles (HSV) of six Salvia species (S. verticillata, S. glutinosa, S. nemorosa, S. aethiopis, S. amplexicaulis and S. officinalis) in the flowering stage and two (S. glutinosa...

Birch leaves and bark are traditionally used for folk medicine for centuries. Numerous research focused on the chemical composition and biological effects of birch extracts. The main pharmacologically active compounds found in extracts are flavonoids, saponins, tannins, essential oil, and triterpenes. Different species, age of the plant, geographic...

This paper presents an analysis of the morphological and anatomical characteristics of the aboveground parts (herba) of clary sage (Salvia sclarea L.), with an emphasis on the investigation of its surface structures. After the procedure of the primary processing and drying of the plant material, it was determined that the composition of the crushed...

The term "phytopreparations" indicates products with active substances obtained from medicinal plants. Herbal medicines, extracts, essential oils, and isolated active principles are present in both cosmetology and dermatology. The new term, "cosmeceutical" refers to cosmetic preparations which also have therapeutic action. A review of relevant lite...

The researchers’ aims were to evaluate the effects of chokeberry juice in the treatment of burning mouth syndrome (BMS) and oral discomfort in menopausal women. The following validated scales and questionnaires were used before and after treatment: questionnaire used for selection of research participants with xerostomia, the xerostomia inventory,...

Willow gentian (Gentiana asclepiadea L., Gentianaceae) is a medicinal plant that is primarily used in the treatment of gastrointestinal and liver diseases in folk medicine. As a bitter raw material, it is also used in the food industry for liquors flavoring. In order to optimize the ultrasound-assisted extraction (UAE) of gentiopicroside, isovitexi...

The genus Viburnum (Adoxaceae, Dipsacales) is of scientific interest due to the chemical components and diverse biological activities found across species of the genus, which includes more than 230 species of evergreen, semievergreen, or deciduous shrubs and small trees. Although frequently used as an ornament, the Viburnum species show biological...

BACKGROUND Black currants are berries that attract attention due to the beneficial effects they possess. They are proven to be good antioxidants, anticancerogenic, cardio- and neuroprotective agents. OBJECTIVE The main objective of this research was to evaluate the differences in the flavonols composition, antioxidant and spasmolytic activity of j...

The ethanol extracts of selected Acinos Miller species were investigated in terms of chemical composition, antimicrobial and antioxidative activities. Qualitative and quantitative analyses of the extracts were performed using GC and GC-MS. Eighty-six constituents, accounting for 93.70-99.99% of the total composition of the extracts, were identified...

Chronic pelvic pain syndrome (CPPS) can be triggered by a various types of gynecological, gastrointestinal, urological, and musculoskeletal disorders. Recently, the role of the central nervous system has proven to be an integral part on the development of any chronic pain syndrome, including CPPS. However, owing to the complex and heterogeneous eti...

Recent literature evidence indicates the potential use of chokeberry preparations in the prevention and treatment of some chronic noncommunicable diseases. The aim of the present study was to evaluate the effects of the three months oral chokeberry juice supplementation in type 2 diabetic patients, as well as its influence on hematological paramete...

Chokeberry (Aronia melanocarpa (Michx.) Elliott) has been traditionally used for centuries in the herbal medicine of the Native North Americans considering the numerous pharmacological activities. The aim of this research was to analyze the effects of the chokeberry juice on the cardiovascular activity, in order to authenticate the use of Aronia me...

BACKGROUND: Phytotherapy has an important role in the functional gastrointestinal and motility disorder prevention and treatment. OBJECTIVE: The aims of our study were to analyze the chemical composition and the antispasmodic activity of the dry black chokeberry ethanolic extract, waste extract and the juice in the isolated rat ileum. METHODS: The...

Herbal products have gained popularity, and they are often perceived as safe. The roles of the pharmacists and physicians are essential in the proper usage of those products. This study aimed to investigate the students of Faculty of Medicine in Niš about the use of herbal preparations and the differences between medicine, pharmacy and dentistry st...

Objective: The purpose of this study was to investigate the relaxative effects of black currant juice on the gastrointestinal smooth muscle in vitro. Materials and methods: Berries of black currant cultivar Ometa were used for preparation of juice used in this study. Spasmolytic activity of black currant juice was tested on rat ileum isolated fr...

Ethnopharmacological relevance: Salvia sclarea L., clary, is an aromatic plant traditionally used in folk medicine for the treatment of various diseases and conditions. Although it has been primarily used as a stomachic, there are data on traditional use of S. sclarea as an agent against gingivitis, stomatitis and aphthae. Aim of the study: The...

The aim of this study was to evaluate the effects of black currant (Ribes nigrum L. ‘Ben Sarek’) juice on the blood pressure and frequency of cardiac contractions, as well as vasomotor responses of rat aortic rings. Arterial blood pressure was measured directly from the carotid artery in the anaesthetized rabbits. The aortic rings were pre-contract...

Background/Aim. The fennel (Foeniculum vulgare Miller, Apiaceae) has a long history of use as traditional herb medicine due to its carminative properties. The study was aimed to investigate the effects of aqueous and methanol fennel stem extracts on intestinal activity. Methods. Relaxant activity of aqueous and methanol fennel stem extracts was eva...

Introduction. Commercially used chemical dental cleansers adversely affect mechanical properties of denture. Therefore, there is a need for finding an alternative which will not change the surface properties of material. Aim. This paper studied the effect of the herbal extract (Foeniculum vulgare Mill.) solution on the wetting and mechanical proper...

We present a case of a 33-year old man who complained of weakness, fever and decreased urinating. A personal history revealed a consumption of creatine, protein supplements, soft drinks containing caffeine and stevia, and extreme physical activity which included lifting of heavy weights. The patient developed anuria, uraemia, fatigue, rhabdomyolysi...

Background/aim: A considerable number of patients suffering from diabetes mellitus (DM) turn to self-medication using medicinal plants, preparations, and medicine. The aim of this study was to investigate self-medication using medicinal plants and the potential influence of health care professionals' advice or media information regarding the use of...

Anethum graveolens L. is a member of the Apiaceae family and more commonly known as dill. Dill has been used for gastrointestinal ailments such as flatulence, indigestion, stomach ache and colic. It has therapeutic effects such as mucosal protective, antisecretory, antimicrobial, antispasmodic, antihypercholesterolaemic and antihyperlipidaemic. The...

The aim of this study was to investigate whether green tea extract has beneficial effect on gentamicin-induced acute renal failure. The investigation was conducted on thirty-two Wistar rats divided into four groups of 8 animals each. Control (C) group received normal saline. GT group received green tea extract orally, 300mg/kg. GM group received ge...

The present paper investigated the quantities of total polyphenols, tannins, flavonoids, hydroxycinnamic derivatives, rosmarinic acid and thujone, as well as the antioxidant and antimicrobial activities in 12 S alvia verbenaca L. extracts. The sample, prepared with 80% methanol using ultrasound extraction (UE) contained the highest levels of total...

Ruta graveolens L. (rue) is an edible medicinal plant that is traditionally used in various countries. This study aimed to investigate and compare the phenolic content, antioxidant capacity, antibacterial and cytotoxic activities of the methanolic and ethanolic extracts of wild growing and cultured rue. The total phenolic content of the tested extr...

GC and GC/MS analyses of the methanol extracts obtained from the aerial parts of six Acinos Miller species from Serbia and Montenegro were performed. Seventy-four constituents, accounting for 84.9-99.0% of the total composition of the extracts, were identified. The common feature of the A. suaveolens, A. majoranifolius and A. alpinus methanol extra...

The present study investigates the chemical compositions of three Satureja montana L. ssp montana essential oils and correlates chemical variability with biological activities. GC/MS analysis showed that with an increase in altitude (100–500–800 m), a higher content of linalool, terpinen-4-ol and cis-sabinene hydrate was found, while the percentage...

In wide regions of the Balkan Peninsula, plant species of the genus Satureja L. (Lamiaceae) are traditionally used as natural preservatives for meat products, and as antimicrobial agents in phytotherapy of food borne diseases. The present study describes the antimicrobial activity of eight Satureja species essential oils against Salmonella enteriti...

Uvae ursi folium (Arctostaphylos uva ursi, Ericaceae) is the best known and most widely used herbal urinary antiseptic. In traditional medicine, other Ericaceae species are also used for the treatment of urinary tract infections. The present study investigates antimicrobial activity of five species of Ericaceae family native to the Balkan Peninsula...

Unlabelled: The aim of this article was to determine the chemical composition (anthocyanin and ascorbic acid contents, total phenols, and tannins), and the antioxidative, and antimicrobial activities of the juices and methanol extracts of 4 varieties-Tenah, Triton, Ben Sarek, and Ometa. The juices were made during 2008, 2009, and 2010 from the ber...

Fungi are an important group of microorganisms. They are studied due to their significant impact on the environment, industry and human health. In relation to biological aspects, biogeochemical cycling of elements, the world of nature would not be possible without the contribution of fungi as the primary decomposers of organic material. On the othe...

Arbutus unedo, Bruckentalia spiculifolia, Calluna vulgaris, Erica arborea and Erica carnea possess strong antioxidant activity and they are traditionally used for the treatment of various skin diseases. The present study investigated the total phenylpropanoid content, antioxidant properties and phenolic composition of dry leaf ethanol extracts of t...

Characterization by GC-FID and GC/MS analyses of the Stachys officinalis (L.) Trevis. essential oil obtained by hydrodistillation of the aerial parts allowed the identification of 190 components that represented 97.9% of the total oil content. The main constituents identified were germacrene D (19.9%), β-caryophyllene (14.1%), and α-humulene (7.5%)...

Flavonoids are biologically active polyphenolic compounds widely distributed in plants. More than 5000 individual flavonoids have been identified, which are classified into at least 10 subgroups according to their chemical structure. Flavonoids of 6 principal subgroups- flavonols, flavones, anthocyanidins, catechins, flavanones, and isoflavones- ar...

The acute negative inotropic and chronotropic effects of the commercial extract of ginkgo leaf (Gingium(®)) and ethanolic extracts of onion bulbs and celery root on spontaneous and noradrenalin-stimulated contractions of the Wistar rat atria were investigated. All analyzed extracts exerted negative inotropic effects on the isolated rat atria. Among...

Sideritis raeseri spp. raeseri Boiss & Heldr is a native plant from the Mediterranean region that is used due to its medicinal and culinary properties. The aim of this study was to evaluate the effects of ethanol extract of S. raeseri on the blood pressure, vascular and cardiac contractions. Arterial blood pressure was registered directly from the...

Plant species Satureja kitaibelii Wierzb. ex Heuff. is used as a spice and as a natural preservative for food and herbal tea, owing to its characteristic scent and flavor as well as high antimicrobial activity. In the present study, the antimicrobial activity of isolated essential oil of S. kitaibelii was tested against a panel of 30 pathogenic mic...

Sideritis raeseri spp. raeseri Boiss. & Heldr., known as "mountain tea," has been widely used in the Mediterranean region as a spice and in folk medicine as a very popular decoction because of its anti-inflammatory, carminative, analgesic, antitussive, stomachic, and antimicrobial properties. The study was aimed to investigate the effects of an eth...

The acute effect of ethanol extracts ginkgo (Ginkgo biloba L.), garlic (Allium sativum L.), and onion (Allium cepa L.) on arterial blood pressure (BP), and heart rate (HR) in anesthetized normotensive rats was examined and compared. Arterial BP was registered in the left carotid artery. The data showed that intravenous administration of the extract...

Arbutus unedo leaf is used traditionally for gastrointestinal complaints. Ethanol extracts from Arbutus unedo collected in both Montenegro (AuM) and Greece (AuG) were found to decrease the ileal basal tonus, with AuG producing a significantly higher (p < 0.05) reduction in contractile response to acetylcholine. AuM and AuG relaxed 80 mM K(+) induce...

A 39-year-old female presented to the nephrology clinic emergency department with a complaint of muscle weakness and stomach pain. A detailed personal history revealed ingestion of 50–100 g herbal products which contained licorice, every day for 8 weeks to treat sterility. The herbal product was studied and determined to contain ‘licorice’ containi...

The genus Acinos Miller (Lamiaceae) is represented by five species in the flora of Serbia. Acinos graveolens (syn. Thymus graveolens M. Bieb., Calamintha graveolens (M.B.) Benth, Satureia graveolens (M.B.) Stoj. et Stef.) is an annual species that was recently recorded in southern Serbia. In taxonomy A. graveolens is related to the West Mediterrane...

Using plants in therapy originates from far past. The skill of treating with plants has been developed in all nations and is now preserved, more or less, as traditional or popular therapy, commonly named popular medicine. Valeriana officinalis, which has been successfully used in traditional therapy, is accepted and represents an important medicina...

The acute negative inotropic and chronotrophic effects of aqueous and alcoholic garlic extracts (Allium sativum L.) on spontaneous and adrenalin-stimulated contractions of the Wistar rat atria were investigated. The addition of garlic extracts to isolated rat atria evoked negative inotropic and chronotropic effects. Ethanolic garlic extract exerts...

Introduction: Parsley (Petroselinum crispum) is used in the traditional herbal medicine to treat intestinal disorders. The aim of this study was to examine the effect of aqueous and ethanol extracts of parsley on spontaneous and acetylcholine induced contractions on isolated rat ileum. Material and methods: Wistar albino rats (250-300 g) were us...

Helichrysum plicatum (Turkish Helichrysum) has been used in folk medicine for the treatment of gastric and hepatic disorders. The aim of the present study was to examine the relaxant activity of an extract of H. plicatum flowers on isolated rat ileum. Segments of ileum of rats were suspended in an organ bath. Cumulative concentrations of H. plicatu...

In this study we present the effects of aqueous and ethanol extracts of celery (Apium graveolens L., Apiaceae) investigated on the mean blood pressure of anaesthetized rabbits and contractility of isolated atria of the rats. In our experiments were used rabbits and Wistar albino rats. The effects of extracts (0.5-15 mg/kg) on blood pressure were re...

A hydro-distilled oil of Satureja hortensis L. was investigated for its antimicrobial activity against a panel of 11 bacterial and three fungal strains. The antimicrobial activity was determined using the disk-diffusion and broth microdilution methods. The essential oil of S. hortensis L. showed significant activity against a wide spectrum of Gram...

Published papers considering composition, antimicrobial and antioxidant activity of Acinos Miller species were reviewed. Main volatile constituents are pulegone, menthone and germacrene D. Alcoholic and water extracts contain a number of flavonoids. Reported chemical composition suggest potential use of Acinos species as phyto-therapeutic and food...

Essential oil of Satureja hortensis L. was analyzed by GC and GC/MS and tested by a broth micro-well dilution method for activity against multiresistant clinical isolates of pathogenic bacteria from 10 different genera: Klebsiella, Escherichia, Proteus, Staphylococcus, Streptococcus, Pseudomonas, Enterococcus, Enterobacter, Citrobacter and Acinetob...

In this paper we present the results of studying the effects of the essential oil of Calamintha glandulosa Silic (EOCG) on the isolated rat ileum. C. glandulosa Silic has been used in folk medicine as an antispasmodic. EOCG (0.003-1 mg/ml) inhibited spontaneous contraction of the ileum (EC50 of 210.48 +/- 9.12 microg/ml). The calcium channel blocki...

An oil of Calamintha nepeta (L.) Savi ssp. nepeta var. subisodonda (Borb.) Hayek obtained by hydrodistillation was analyzed by GC and GC/MS. Eleven constituents were identified (96.5%). The main constituents in the oil were pulegone (75.5%), piperitenone oxide (6.0%), menthone (5.3%) and menthol (4.3%). The microbial activity of the oil was screene...

The hydrodistilled essential oil of Acinos arvensis (Lam.) Dandy was analysed by GC and GC/MS. Thirty constituents representing 83.8% of the oil were identified, of which germacrene D (47.0%) was the major component. Furthermore, β-bourbonene (7.7%), caryophyllene oxide (3.2%) and β-caryophyllene (3.0%) were noted as additional significant constituen...

An oil of Calamintha nepeta (L.) Savi ssp. glandulosa (Req.) P. W. Ball obtained by hydrodistillation was analyzed by GC and GC/MS and 36 constituents were identified (98.4%). The main constituents in the oil were pulegone (37.5%), menthone (17,6%), piperitenone (15.0%) and piperitone (10.2%).The antimicrobial activity of the oil was screened again...

The oil of Acinos hungaricus (Simonkai) Silic (Lamiaceae) obtained after water distillation was subjected to GC and GC/M S analysis and 37 constituents were identified (84.3%). The main constituents in the oil were caryophyllene oxide (16.8%), geraniol (9.7%), β-bourbonene (5.7%) and globulol (5.6%).

The essential oil of Calamintha vardarensis (Lamiaceae) obtained after water distillation was subjected to GC and GC/MS analysis and 30 constituents were identified (98.9%). The main constituents in the oil were menthone (48.3%), pulegone (34.8%) and cis-piperitone oxide (7.4%).

The volatile constituents of Calamintha sylvatica Bromf. subs. sylvatica in the different development stages (pre-blossom, full blossom and post-blossom) have been analysed using GC and GC–MS. Thirty-three constituents were identified. The most representative compound in all stages was cis-piperitone oxide (66.6–74.6%). Copyright © 2001 John Wiley...

The content and composition of fatty acids and alkanes of Satureja adamovicii Silic and Satureja fukarekii Silic were analized by GC. It was found that unsaturated acids prevailed and that the major components were palmitic, oleic, linoleic and linolenic acids. The hydrocarbon fractions of pentane extracts were shown to consist of the alkane homolo...

Hydrocarbon fractions of hexane extracts of Micromeria thymifolia (Scop.) Fritsch and Micromeria albanica (Griseb. ex. K. Malý) Šilić were investigated. Non-branched, saturated, aliphatic hydrocarbons (C17 to C34) were identified by GLC with triacontane and dotriacontane being the prevailing compounds. It was also observed that the relation between...