D.S.P. Cardoso

D.S.P. Cardoso
University of Lisbon | UL · iMED.UL

PhD in Medicinal Chemistry

About

25
Publications
9,440
Reads
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452
Citations
Introduction
David was born in Lisbon, Portugal, in 1989. Graduated in chemical engineering received his MSc Degree in 2012, which thesis was about development of laboratory scale antibiotics making use of analytical methods. David was working from 2013 to 2016 on several issues related with electrochemistry field such as functional materials for electrolytic hydrogen production, development of electrodes for fuel cells and electrolyzers. David started his PhD in 2016 towards Medicinal Chemistry area focused on obtaining novel compounds from a Mozambican plant for tackling multidrug resistance.
Additional affiliations
November 2016 - present
University of Lisbon
Position
  • PhD Student
Description
  • PhD main subject: "Plant derived compounds for targeting multidrug resistance in cancer"
July 2013 - October 2016
Technical University of Lisbon
Position
  • Researcher
Education
September 2007 - November 2012
Technical University of Lisbon
Field of study
  • Chemical Engeneering

Publications

Publications (25)
Article
Full-text available
Nickel–dysprosium (Ni–Dy) and nickel–samarium (Ni–Sm) alloys with 5 and 10 at% of rare earth metal were prepared by arc melting and by induction furnace melting, respectively. The alloys microstructure, morphology and chemical composition were inspected by scanning electron microscopy and energy dispersive X-ray analysis; phases crystal structure a...
Article
Hydrogen peroxide (H2O2) is being actively investigated as an oxidant for direct borohydride fuel cells. Herein, platinum-rare earth (RE = Sm, Dy, Ho) alloys are prepared by arc melting and their activity for hydrogen peroxide reduction reaction (HPRR) is studied in alkaline media. Cyclic voltammetry and chronoamperometry measurements show that Pt–...
Article
Organic electrosynthesis has received great attention as a powerful green tool for synthesis, affording less waste production, less chemicals spent, and often fewer reaction steps than conventional methods. Functional group interconversion and C-C bond generation by imposition of a proper electrode potential is what lies behind organic electrosynth...
Article
Aiming at generating a series of monoterpene indole alkaloids with enhanced multidrug resistance (MDR) reversing activity in cancer, two major epimeric alkaloids isolated from Tabernaemontana elegans, tabernaemontanine (1) and dregamine (2), were derivatized by alkylation of the indole nitrogen. Twenty-six new derivatives (3–28) were prepared by re...
Article
Full-text available
Multidrug resistance (MDR) in cancer is one of the main limitations for chemotherapy success. Numerous mechanisms are behind the MDR phenomenon wherein the overexpression of the ATP-binding cassette (ABC) transporter proteins P-glycoprotein (P-gp), breast cancer resistance protein (BCRP) and multidrug resistance protein 1 (MRP1) is highlighted as a...
Article
Hydrogen peroxide (H2O2), a reactive oxygen species, is an excellent alternative to oxygen as an oxidant for direct liquid fuel cells (DLFCs). To overcome problems related to scarcity and high cost of commonly used noble metal electrodes, nickel (Ni) and nickel-rare earth (RE = Ce, Sm, Dy) alloys are synthesised and evaluated as electrode materials...
Article
Full-text available
Dregamine (1), a major monoterpene indole alkaloid isolated from Tabernaemontana elegans, was submitted to chemical transformation of the ketone function, yielding 19 azines (3–21) and 11 semicarbazones (22–32) bearing aliphatic or aromatic substituents. Their structures were assigned mainly by 1D and 2D NMR (COSY, HMQC, and HMBC) experiments. Comp...
Article
Background and purpose: Advances in the treatment of triple-negative breast cancer (TNBC) and ovarian cancer (OC) remain challenging. In particular, resistance to the available therapy, by restoring or overexpressing the DNA repair machinery, has often been reported. New strategies to improve the therapeutic outcomes of these cancers are needed. H...
Article
Commercially available materials for fabricating cell bodies, electrodes, pipes, and pumps for alkaline water electrolyzers, include conventional steels and stainless steels, nickel, valve metals, polymers, and other materials. In this review paper, most of these construction materials are briefly described and discussed. Special attention is given...
Article
Typical direct liquid fuel cells (DLFCs) use a liquid fuel and O2 as the oxidant. However, for applications where O2 is not available (e.g., space and underwater), the gas has been replaced by H2O2 as a liquid oxidant. This work presents a study of various ceramic disc electrodes with K2NiO4 structure and nominal compositions La2NiO4, La2CuO4, La1....
Article
Use of ionic liquids (ILs) as electrolyte additives for highly efficient alkaline water electrolysis at low temperatures is evaluated. The hydrogen evolution reaction (HER) was studied with platinum cathode in 8 M KOH solution with and without addition of 2 vol.% of [Emim][MeSO3] in the 25-85 °C temperature range using voltammetry, chronoamperometr...
Article
Full-text available
Towards commercialization of fuel cell products in the coming years, the fuel cell systems are being redefined by means of lowering costs of basic elements, such as electrolytes and membranes, electrode and catalyst materials, as well as of increasing power density and long-term stability. Among different kinds of fuel cells, low-temperature polyme...
Article
Full-text available
Sodium borohydride (BH, NaBH4) has wide application as a reducing agent in organic and inorganic synthesis. Herein, sodium benzylborohydride (BBH, NaC7H7BH3), sodium phenylborohydride (PBH, NaC6H5BH5) and sodium 4-chlorophenylborohydride (CPBH, NaC6H4BH3Cl) are synthesized with high purity, as confirmed by NMR and FTIR. A direct relationship betwee...
Article
Full-text available
Three 1-ethyl-3-methylimidazolium ([Emim])-based room temperature ionic liquids (RTILs), namely [Emim][Ac] (acetate), [Emim][EtSO4] (ethylsulfate) and [Emim][MeSO3] (methanesulfonate), are tested as additives to alkaline solutions for hydrogen evolution reaction (HER). Electrochemical measurements are performed with a platinum foil working electrod...
Article
Developing novel and efficient electrocatalysts is vital to overcome most of the technical and economic issues associated with the hydrogen production via water electrolysis. Herein, Pd-based alloy nanoparticles, namely AuPd and FePd, assembled on reduced graphene oxide (rGO) are investigated as cathode electrocatalysts for hydrogen evolution react...
Article
Full-text available
The use of hydrogen peroxide (H2O2) as an oxidant is considered a good alternative to oxygen for the cathodic process in liquid fuel cells. Herein, we studied the reduction of H2O2 at nickel and at nickel-rare earth (RE = Ce, Sm, Dy) alloys containing 5 and 10 at.% of RE metal. The alloys were prepared by arc melting, starting from the stoichiometr...
Article
Sodium borohydride (NaBH4) has wide application as a reducing agent in organic and inorganic synthesis. In this work, sodium benzylborohydride (C7H7BH3Na) and sodium phenylborohydride (C6H5BH3Na) are synthesized and a direct relationship between the organic substituents and the reducing power of the borohydride center is investigated. Platinum and...
Article
Three 1-ethyl-3-methylimidazolium [Emim]-based room temperature ionic liquids (RTILs), namely [Emim][Ac] (acetate), [Emim][EtSO4] (ethylsulfate) and [Emim][MeSO3] (methanesulfonate), were tested as additives in alkaline solutions for hydrogen evolution reaction (HER). Electrochemical measurements were performed with a platinum foil working electrod...
Article
Direct borohydride fuel cells, which use sodium borohydride as the fuel, are recently focussing on the use of hydrogen peroxide as oxidant instead of the traditional oxygen gas. Herein we study the electrocatalytic activity of nanostructured 3D Cu-M (M = Fe, Co, Ni) and single metal Ni and Co foams for hydrogen peroxide reduction reaction (HPRR) in...
Article
Full-text available
Bipolar Electrochemistry is a conventional method based on the polarization of an isolated substrate under an applied electric field. This technique has been applied to electrolysis, corrosion and other areas of chemical engineering since the 20th century. However, it has been recognized as a powerful tool in many modern domains after water splitti...
Article
The corrosion behavior of nickel (Ni)-based alloys used for low-temperature aqueous or condensed systems is reviewed in detail in this paper. Commercially available pure Ni, nickel-copper (Ni-Cu), nickel-molybdenum (Ni-Mo), nickel-chromium-molybdenum (Ni-Cr-Mo), and nickel-chromium-iron (Ni-Cr-Fe) alloys as well as cast Ni-based alloys are addresse...
Article
Three-dimensional (3D) nanostructured nickel-copper (Ni-Cu) foams have been prepared by electrodeposition using a dynamic hydrogen template. These 3D materials were tested as electrodes for the borohydride oxidation reaction (BOR) in alkaline media for possible application as anodes of direct borohydride fuel cells. Their activity in BOR was studie...
Article
Sodium vanadate and sulphate form deposits, liquid at high temperature, which cause corrosion of boiler pipes. The analysis of properties and of electrochemical corrosion in melted sodium vanadate allows to understand, in a simple case, a complex process, and to compare corrosion resistance of different metals by a quick and simple method.
Article
Full-text available
Three-dimensional (3D) nickel-copper (Ni-Cu) nanostructured foams were prepared by galvanostatic electrodeposition, on stainless steel substrates, using the dynamic hydrogen bubble template. These foams were tested as electrodes for the hydrogen evolution reaction (HER) in 8 M KOH solutions. Polarisation curves were obtained for the Ni-Cu foams and...
Article
Cancer is a quite serious scientific and health problem, for which conventional or alternative therapies are used to solve these subjects. Among several methods, electrotherapy has been recently used by applying low and continuous electric current. In 1983, Nordenström reported in a systematic way for the first time, the main experiences and result...

Questions

Question (1)
Question
I was starting a new work by using organic electrolytes instead of aqueous solutions. However, after using an Ag/AgCl reference electrode in a DMSO electrolyte solution it got destroyed. Is there any suggestion for electrode references in organic media? Is there any problem of using SCE as reference electrode in DMSO?
Thank you for your time.

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Projects

Project (1)
Project
Sodium borohydride (NaBH4) is a solid white powder that finds wide applications as a reducing agent not only for fuel cells but also in organic and inorganic synthesis. Organic chemists have successfully tuned the reducing power of NaBH4 by attaching organic electron donating or withdrawing groups to the boron center, which can also drive regio- and stereoselectivity. Organoborohydrides have received much recent attention for their role in frustrated Lewis pair systems, as well as in hydrogen fuel carriers. The electrochemical characterization of the organoborohydride compounds is being carried out by cyclic voltammetry (CV) in static conditions and by linear scan voltammetry (LSV) using a rotating ring-disc electrode (RRDE) system. This allows the determination of several parameters, including number of exchanged electrons, charge transfer coefficient, diffusion coefficient and activation energies by testing the compounds at temperatures ranging from 25 to 65 ºC.