Drzislav Kalafatic

Drzislav Kalafatic
University of Zagreb · Department of Gynecology and Obstetrics

About

43
Publications
1,834
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517
Citations
Citations since 2017
10 Research Items
161 Citations
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2017201820192020202120222023051015202530
2017201820192020202120222023051015202530

Publications

Publications (43)
Article
Full-text available
Background and Objectives: To estimate the effectiveness of Kegel exercises versus extracorporeal magnetic innervation (EMI) in the treatment of stress urinary incontinence (SUI). Materials and Methods: A parallel group, randomized clinical trial was conducted in the Department of Obstetrics and Gynecology, Clinical Hospital Centre Zagreb, Croatia....
Article
Full-text available
Objective. This study aims to compare the readability and reliability of Wiki-pedia articles with corresponding Society for Maternal-Fetal Medicine (SMFM) patient education leaflets. Materials and Methods. We selected Wikipedia articles on high-risk pregnancy and birth control options based on the series of online patient educational leaflets publi...
Article
Objective: Although available diagnostic criteria are intelligible, combination of OAB and anxiety in the same patient presents a perfect example of medical causality dilemma, commonly stated as the question: "which came first: the chicken or the egg?". The aim of this review article is to address available insights in bidirectional association be...
Article
Full-text available
Stress urinary incontinence (SUI) is defined as a complaint of inadvertent loss of urine occurring as a result of an increase in intraabdominal pressure. Strong evidence supports the use of pelvic floor muscle training (PFMT) as the first-line conservative treatment for SUI. Extracorporeal magnetic stimulation (EMS) is a noninvasive, effective, acc...
Article
Objectives The present study was conducted with the aim to translate, adapt, and validate the 8-item Overactive Bladder Questionnaire (OAB-V8) in Croatia. Methods This study included a total of 58 female patients with OAB and 66 healthy women. The translation to Croatian followed standardized procedure. All eligible participants completed OAB-...
Article
Full-text available
Introduction: Bladder exstrophy (BE) is a rare congenital malformation estimated to occur in up to 1 / 250,000 female live births. The evidence supporting incidence, uterine preservation and its overall fertility rate in patients with pelvic organ prolapse (POP) and BE is not precisely determined. Methods: We report the case of BE and POP in 27-yea...
Article
Full-text available
Ovarian cancer (OC) is the most lethal female gynecological malignancy, mostly due to diagnosis in late stages when treatment options are limited. Hedgehog-GLI (HH-GLI) signaling is a major developmental pathway involved in organogenesis and stem cell maintenance, and is activated in OC. One of its targets is survivin (BIRC5), an inhibitor of apopt...
Conference Paper
Full-text available
Introduction Signalling pathway Hedgehog-Gli (Hh-Gli) is involved in embryonal ovarian development, but its atypical activation can lead to different types of ovarian tumours. Our previous studies showed aberrant Hh-Gli activity in some ovarian tumour types and hypermethylation in a promoter of tumour suppressor gene PTCH1 in the CpG islands near t...
Article
Full-text available
Hedgehog signaling pathway has been implicated in the pathology of ovarian cancer, and Survivin (BIRC5) has been suggested as a novel target of this pathway. Herein we investigated the role of Hedgehog signaling pathway and Survivin in ovarian carcinoma and borderline tumor samples. We aimed to determine possible ways of pathway modulation on prima...
Article
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We report a case of a 53-year-old woman with Grade 1 serous cystadenocarcinoma on her left ovary and metastatic serous adenocarcinoma on her right ovary. Serous carcinoma is the most common type of ovarian cancer, representing approximately half of all cases. Because of positive family history, the patient was referred for BRCA1/2 screening. Germli...
Article
To report the efficacy and complications of anterior pelvic organ prolapse (POP) repair with mesh placed through the transobturator route (Perigee system; AMS, Minnetonka, MN, USA). In total, 198 women with anterior POP grade II or higher according to the POP Quantification (POP-Q) system were treated with the Perigee procedure. The primary outcome...
Article
The aim of this study was to determine the extension of cervical intraepithelial neoplasia grade III (CIN III) into endocervical canal and depth of endocervical crypts involvement by CIN with the regard to patients' age and parity. Correlation between the area of CIN involvement and the extension into endocervical canal was estimated. A total of 21...
Article
Full-text available
The aim of this study was to determine the efficacy and operative complications of the suprapubic arc (SPARC) procedure in stress incontinent women with and without previous anti-incontinence surgery. One-hundred and twenty-one patients with stress urinary incontinence (SUI) were treated with SPARC for correction of urethral hypermobility (N = 65)...
Article
Full-text available
Objectives. Our first short-term results of transobturator mesh interposition (Perigee System) for the correction of cystoceles are presented. Methods. This is our initial study on 22 women with cystocele > Grade 2 who underwent the Perigee procedure in our Center between January 2006 and March 2007. In 15 cases lateral cystocele defect was ¬diagno...
Article
Objectives. Our first short-term results of transobturator mesh interposition (Perigee System) for the correction of cystoceles are presented. Methods. This is our initial study on 22 women with cystocele > Grade 2 who underwent the Perigee procedure in our Center between January 2006 and March 2007. In 15 cases lateral cystocele defect was diagnos...
Article
To compare reproductive outcome in women with uterine anomalies and women with a normal uterus, and evaluate the effect of resectoscope metroplasty. The pregnancy outcomes, past and present, of 105 women with congenital uterine anomalies were compared with those of 182 women with a normally shaped uterus. The outcomes of 25 women with septate and b...
Article
To analyze the incidence of neurodevelopmental disabilities in triplets and to find out possible connection between the outcome and perinatal events. Retrospective cohort study of 94 triplets and their outcome at 24-144 months of age correlated with gestational age, birth weight, pregnancy complications, early neonatal period, neonatal cranial ultr...
Article
To investigate whether maternal serum interleukin-6 (IL-6), interleukin-1beta (IL-1beta) and high sensitive C-reactive protein (CRP) could be used as markers of tocolysis failure and adverse neonatal outcome in pregnancies with preterm labor (PL). Forty-seven maternal blood samples taken because of PL at admission and delivery were analyzed. Contro...
Article
The perinatal mortality at Department of Gynaecology and Obstetrics of Clinical Hospital Centre in Zagreb has remained less than 10‰ during the last three years. In the year 2004 for all newborns ≥1000 g the fetal mortality was 5.9‰, the early neonatal 3.6‰, and the perinatal mortality 9.5‰. For all newborns ≥500 g perinatal mortality was 15.6‰, fe...
Article
Antenatal use of corticosteroids is not useful before 24 and after 34 weeks of pregnancy. In the period 24-28 weeks the corticosteroids do not decrease the rate but they mitigate the heaviness of RDS and decrease the rate of intraventricular hemorrhage and consecutive mortality of very preterm newborns. Following 34 weeks the rate of RDS, of intrav...
Article
In the year 2003 are »in utero« to the Department transferred 195 infants, predominantly of low, very low and extremely low birth-weight. Fetal, early neonatal and perinatal mortality are the highest in newborns 500-999 grams, lower and alike in newborns of 1000-1499 and 1500-1999 grams, the lowest in newborns over 2000 grams. The mortality exceedi...
Article
Cardiotocography, fetal biophysical profile assesment and fetal Doppler are already traditional methods of antenatal assessment of fetal oxygenation that are widely implemented in obstetrical practice and that have well-documented favourable effect on perinatal outcome and on the reduction of perinatal mortality. In this paper the review of the lit...
Article
The aim of the study was to preoperatively predict the biologic behavior of the endometrial carcinoma using immunohistochemical analysis of the p53 protein and Ki-67 expression, and estrogen receptor (ER) and progesterone receptor (PR) status, in the material obtained by fractional curettage. One hundred and thirty-six patients with primary endomet...
Article
In the year 2003 are »in utero« to the Department transferred 195 infants, predominantly of low, very low and extremely low birth-weight. Fetal, early neonatal and perinatal mortality are the highest in newborns 500–999 grams, lower and alike in newborns of 1000–1499 and 1500–1999 grams, the lowest in newborns over 2000 grams. The mortality exceedi...
Article
To assess the value of alpha-fetoprotein (AFP), total human chorionic gonadotropin (ThCG) and unconjugated estriol in predicting certain complications of pregnancy other than fetal aneuploidy. Among 2384 women that underwent biochemical screening between 15 and 22 weeks of gestation, pregnancy outcome was evaluated in 677 women under 35 years of ag...
Article
The aim of this study was to check the validity of the biochemical screening of pregnancies with Down's syndrome during the second trimester of pregnancy, in order to reduce the incidence of invasive diagnostic procedures. We used the optimal balance between sensitivity and specificity to determine the "cut off" values to estimate the results of th...
Article
Objective. To examine and compare the course and outcome of pregnancies with microbiologically positive versus microbiologically negative cervical smears in the first trimester of pregnancy and particularly to determine the impact of chlamydial and ureaplasma colonization on perinatal outcome. Methods. In a group of 155 pregnancies at high risk for...
Article
To compare pregnancy complications and neonatal outcome of 85 triplet gestations cared for during the 15 years in a single perinatal unit. Pregnancies were divided in two groups according to the differences in the management plan and their outcomes were compared. Group I (N = 44) consisted of pregnancies cared from 1986 to 1995, using standard mode...
Article
To compare the course and outcome of triplet gestations under a preventive care strategy that includes hospitalization, surveillance, bed rest, and daily specialized care from the beginning of the second trimester, with pregnancies managed according to the Croatian standard outpatient care protocol for multiplets. A retrospective study of 79 triple...
Poster
Objective The aim of the study is to determine the neuro-developmental outcome of children with IUGR due to placental insufficiency diagnosed by Color Doppler during pregnancy.Patients and methods25 children who were diagnosed with IUGR were included. The intrauterine growth was evaluated by repeated US and Doppler examinations and the resistance i...
Article
The problem of labor and delivery, either at term or occurring prematurely, are among the greatest problems facing physicians nowadays. The understanding of the process of preparation and initiation of active labor is of utmost importance. Currently, the clinical methods to assess the changes of the uterus and cervix are still subjective, inaccurat...
Article
Full-text available
To determine the activity of glutathione (GSH) and concentrations of glutathione S-transferases (GST), urokinase type plasminogen activator (uPA), and plasminogen activator inhibitor type 1 (PAI-1), and to evaluate their diagnostic and prognostic value and possible correlation with clinical and histopathological prognostic factors for ovarian carci...
Article
To study the association between fetal blood flow abnormalities and the occurrence of long-term neurologic sequelae. Umbilical, aortic and middle cerebral artery blood flow parameters were obtained by Doppler examination and retrospectively analyzed in 128 high-risk singleton pregnancies, followed by neurologic examination of the surviving children...
Article
To evaluate the therapeutic efficacy of intravesically administered ketoprofen in patients with urodynamically verified detrusor instability. This double-blind randomized placebo-controlled cross-over study included 30 patients with urodynamically verified detrusor instability. Their mean age was 44+/-3.6 years (range 37-49) and the median of the p...
Article
To correlate pregnancy outcome with complications in pregnancy and transplantation-to-pregnancy interval in renal transplant recipients in Croatia. Data on 23 pregnancies after prepregnancy stabilization of blood pressure and normalization of graft function were retrospectively analyzed. The mean interval between transplantation and conception was...
Article
We present a rare case of adrenal pheochromocytoma in pregnancy, with serial 24-h urine specimen collections showing normal concentrations of catecholamine metabolites. The diagnosis was based on clinical presentation, abdominal ultrasound, and magnetic resonance imaging, and was confirmed on post-operative pathohistological examination. Clinical s...
Article
Full-text available
Examination and comparison of the natural histories of triplet versus quadruplet and quintuplet gestations. A retrospective study of sixty-four multifetal pregnancies (fifty-two sets of triplets, nine sets of quadruplets and three sets of quintuplets) cared for during past 12 years in our department. Quintuplets and quadruplets were compared with t...
Article
The aim was to find out whether platelet activation might be a link between LAC positivity and adverse pregnancy outcome and what is the benefit of anticoagulant therapy. Methods: Prospective, nonrandomized analysis of LAC, platelet count and platelet aggregation in 121 selected high risk pregnancies cared for during a 5-year period. Forty five (45...

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