Dr. Yarlagadda Ankamma Chowdary

Dr. Yarlagadda Ankamma Chowdary
NRI Group of Colleges · NRI college of pharmacy

M.Pharm,Ph.D

About

29
Publications
42,607
Reads
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133
Citations
Citations since 2016
2 Research Items
105 Citations
201620172018201920202021202205101520
201620172018201920202021202205101520
201620172018201920202021202205101520
201620172018201920202021202205101520

Publications

Publications (29)
Article
Full-text available
In present study a spectrophotometric method was developed for the estimation of piperine in ayurvedic formulation Kankasava. Piperine obeys Beer Lambert's law in concentration range 20-100 μg/ml at the λ max 343 nm. The correlation coefficient (r2) was indicates the good linearity between the concentration and absorbance. The content of piperine i...
Article
The objective of present study was to improve solubility and dissolution rate of rosuvastatin by formulating it as a self micro emulsifying drug delivery system (SMEDDS). The SMEDDS were prepared by using capmul McM and capryol 90 as oils Polaxomer 407 as surfactant and Transcutol hP and Soluphor P as co-surfactants. The liquid SMEDDS were then con...
Article
Full-text available
Purpose: To prepare and characterize tablets loaded with self-nanoemulsifying drug delivery system (SNEDDS) containing docetaxel (DTL). Method: SNEDDS of docetaxel were prepared using various oils, surfactants, co-surfactant and solvents to improve the dissolution rate and bioavailability of the poorly water-soluble chemotherapeutic agent. The SNED...
Article
Full-text available
Ornamental flowers have been traditionally used for the treatment of different ailments such as pain, inflammation, dandruff, dermatitis, hair growth and scabies. The present study was aimed to investigate the phytochemical and cytotoxic activity of aqueous and chloroform extracts of various ornamental flowers (Ixora coccinia, Allamanda cathartica,...
Article
Full-text available
A rapid, simple, selective and precise UV-Visible Spectrophotometric method has been developed for the determination of Curcumin in bulk and in Nano-Formulation. The spectrophotometric detection was carried out at an absorption maximum of 421nm using methanol as solvent. The method was validated for various validation parameters. The linearity rang...
Article
Full-text available
The objective of the present study was to investigate the influence of polymer level and type of some hydrophobic polymers, Dammar gum and Copal gum with meltable carriers such as Poly ethylene glycol 6000 (PEG 6000) and carnauba wax, on the release rate and mechanism of lamivudine (LM) from matrix tablets prepared by hot- melt granulation techniqu...
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Full-text available
In the treatment of type 2 diabetes mellitus a continuous therapy is required which is a more complex one. As in these patients there may be a defect in both insulin secretion and insulin action exists. Hence, the treatment depends on the pathophysiology and the disease state. In the present study, multilayered tablets of pioglitazone hydrochloride...
Article
Full-text available
A substituted napthofuran derivative was prepared. The structure of compound was confirmed by spectral data of IR study. Compound with optimum antimicrobial activity was selected for formulation of antimicrobial gel. The gel was formulated by varying the polymer ratio. Gel formulations were characterized for appearance, odor, pH, viscosity measurem...
Article
Full-text available
Aim: The present study was focused on the screening of the phytochemical, in vitro cytotoxic and antimicrobial activities of various flower extracts [ethanolic (ECG), Ethyl acetate (EACG) and aqueous (ACG)] of Couroupita guianensis Aubl. (Family: Lecythiadaceae). Method: Preliminary phytochemical analysis of extract revealed the presence of alkaloi...
Article
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The main objective of this research was to elevate the better combination of known herbal drugs (Curcuma longa, Coriander sativum and Occimum sativum) for better anti-ulcer activity. Herbal extracts prepared from shade dried rhizomes, leaves using alcohol and water as solvents by soxhlet extraction, further all the extracts were subjected to p...
Article
Full-text available
The objective of the present study is to isolate natural polysaccharide from the endosperm of seeds of Delonix regia (Bojer ex.Hook.) (Family: Caesalpiniaceae) and evaluate its sustained release property using metoprolol succinate as model drug. Delonix regia endosperm gum and cotyledon gum was isolated and analysed for the chemical properties. Fur...
Article
In the present study, an effort was made to formulate and evaluate matrix tablets of tarogum utilizing metaprolol succinate as the model drug. 3 2 full optimization procedure was adopted where two factors are studied at three levels. The amount of taro gum (X1) and polyvinylpyrrolidone (PVP) K30 (X2) were selected as independent variables. The time...
Article
The objective of this study was to develop a solid dispersion method for enhancing the aqueous solubility of aprepitant (BCS class II drug). In the present study a simplified definitive equivalent formulation is targeted by preparing a solid dispersion using hot melt extrusion. Model formulation isolated from a range of carrier-plastizer mixtures b...
Article
Objective: Atomoxetine HCl is extremely bitter in taste and is available as capsule dosage forms in various markets. In order to improve the pediatric compliance, the present study was aimed to mask the bitter taste of Atomoxetine HCl. Methods: Bitter taste of Atomoxetine HCl was masked by multi-unit particulate pellet coating (MUPS) technology usi...
Article
A New, simple, sensitive spectrophotometric method in U.V region has been developed for the determination of Esomeprazole in bulk and in its dosage form. Esomeprazole shows maximum absorbance at 275 nm in Dimethyl formamide (DMF) solvent for first dilutio n and further dilution with 50:50 v/v of DMF:Water. Beers laws obeyed in the concentration ran...
Article
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Abrus precatorius linn (Fabaceae) is a climbing shrub widely distributed in India, tropical and subtropical regions of the world. The objective of this research work is to evaluate the in vitro cytotoxic effects of the ethanolic extract (AHE) and ethyl acetate (AEE) against MCF-7 cell lines by using MTT assay. Tamoxifen was used as a standard to co...
Article
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Omeprazole is a proton pump inhibitor used in the treatment of dyspepsia, peptic ulcer disease (PUD), Gastroesophageal reflux disease (GERD), laryngopharyngeal reflux disease (LPR) and Zollinger-Ellison syndrome. The present study deals with the formulation of omeprazole fast dissolving tablets utilising cross linked alginic acid and calcium silica...
Article
Full-text available
A series of piperazine nucleus contained novel chalcones (RC-7 to RC-8) are synthesized by using Clasien-Schimdt reaction, in which piperazine acetophenone was condensed with various aromatic aldehydes. The yields of synthesized chalcones were obtained between 66.6 and 80.7%. Their chemical structure was elucidated by means of FT-IR and 1 H-NMR (CD...
Article
Flecainide acetate is a class Ic anti arrhythmic agent used to prevent and treat tachyarrhythmias, a wide variety of cardiac arrhythmias including paroxysmal atrial fibrillation, paroxysmal supraventricular tachycardia and ventricular tachycardia. In the current study an effort was made to prepare the fast dissolving tablets of flecainide acetate b...
Article
Full-text available
Angiogenesis, the process of new blood vessel formation, plays a central role in both local tumor growth and distant metastasis. Healthy adults require angiogenesis only for wound healing, endometrial proliferation and pregnancy. Thus the inhibition of angiogenesis offers an attractive therapeutic target with little expected toxicity. However, mu...
Article
Angiogenesis, the process of new blood vessel formation, plays a central role in both local tumor growth and distant metastasis. Healthy adults require angiogenesis only for wound healing, endometrial proliferation and pregnancy. Thus the inhibition of angiogenesis offers an attractive therapeutic target with little expected toxicity. However, muta...
Article
he approach of solid dispersion for improving the dissolution of poorly soluble drugs. Aceclofenac , was selected as a model for the study, by using Mannitol as carrier and give more ra pid onset of action compared to oral conventional dosage form to improve bioavailability and patient compliance . Solid dispersion of Aceclofenac and Mannito...
Article
Full-text available
The Fast Dissolving Drug Delivery Systems was an advancement that came into existence in the early 1970's and combat over the use of the tablets, syrups, capsules which are the other oral drug delivery systems. Fast Dissolving Drug Delivery Systems serves as a major benefit over the conventional dosage forms since the drug gets rapidly disintegrate...
Article
Full-text available
Ethanolic extract of flowers of Calotropis procera R. Br. (Asclepiadaceae) shows antibacterial action against four Gram positive micro-organisms, (Staphylococcus aureus, Bacillus subtilis, Bacillus pumilis, and Micrococcus lutes and Gram Negative micro-organism (Escherichia coli Pseudomonas aeruginosa, and Proteus vulgaris). The antibacterial actio...
Article
The problem of bitter taste of drug in pediatric formulations is a challenge to the formulators in the present scenario. In order to ensure patient compliance, masking of bitterness becomes essential. Atomoxetine HCl is a selective norepinephrine reuptake inhibitor drug used in the treatment of Attention deficit hyperactivity disorder (ADHD) in chi...
Article
Full-text available
latex (DL) and flowers of C.procera and its ethanolic extracts against MCF-7 and HeLa cell line cultures. The MTT assay developed by Mosmann, it was modified and used to determine the inhibitory effects of test compounds on cell growth in vitro. Different concentrations of test compounds were used (Sample: 1 DL extract, Sample: 2 Flower extract) (4...

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