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Dr Sumanta Mondal

Dr Sumanta Mondal
GITAM (Deemed to be University) · Pharmaceutical Chemistry

Diploma in Pharmacy, B. Pharm, M. Pharm, PhD
Associate Professor and NSS Programme Officer (Unit-IX); INSTITUTE OF PHARMACY; GITAM (Deemed to be University)

About

279
Publications
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Introduction
Dr Sumanta Mondal currently works as Associate Professor at GITAM Institute of Pharmacy, GITAM (Deemed to be University). Current project:“PHYTOCHEMICAL AND BIOLOGICAL STUDIES ON FEW INDIAN MEDICINAL PLANTS’’ & "ANALYTICAL METHODS DEVELOPMENT".
Additional affiliations
July 2010 - July 2016
GITAM University
Position
  • Professor
June 2010 - present
GITAM University
Position
  • Lecturer
June 2010 - June 2019
GITAM University
Position
  • Professor (Associate)
Education
August 2006 - May 2011
Berhampur University
Field of study
  • Pharmacy (Phytochemistry)
July 2004 - June 2006
Institute of Pharmacy & Technology, Salipur
Field of study
  • Pharmaceutical Chemistry
September 1999 - June 2004

Publications

Publications (279)
Article
Background: The necessity for newer anti-HIV and anti-tubercular medications has arisen as a result of the prevalence of opportunistic infections caused by HIV (human immunodeficiency virus). Objective: A series of ten new hydrazono 1,3-thiazolidin-4-one derivatives were synthesized in one-pot and evaluated for anti-HIV and anti-tubercular activiti...
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Homology modeling in computer aided drug design. How it designed and the various steps involved during homology modeling .
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Exocyclic and endocyclic double bonds are parts of chemical compounds which are cyclic or ring structures. These two double bonds differ from each other according to the location of the two carbon atoms that are involved in the formation of the double bond.
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Fake Charge is another name for a Formal Charge. It's a theoretical charge over a single atom of an ion, because the actual charge over a polyatomic molecule or ion is spread throughout the entire ion, not just one atom.
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To identify the presence of alcoholic functional group in a given organic compound.
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UNIT –I: Structural isomerisms in organic compounds
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INRODUCTION Breast cancer (BC) is the most common cancer in women and the second most common cancer overall. Despite being treatable, metastatic breast cancer (MBC) is still a nearly incurable condition, with a median overall survival of just three years 1 and a 5-year OS of just 25%. Palbociclib, ribociclib, and abemaciclib 2 have recently been ap...
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Proteins: Chemistry and classification of amino acids and proteins, Physico-Chemical properties of protein and their structure, general methods of analysis of proteins and amino acids, Digestion, absorption and metabolism of proteins.
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Vitamins: classification of vitamins, methods of analysis of vitamins, Principles of microbial assay of vitamins of B-series.
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The entire research work which involved an array of innovative active ingredients (APIs) and their measurement in bulk and tablet dose by UV spectroscopy, HPLC, UPLC and human plasma measurement by LC-MS / MS. All those established methodologies have been introduced and the drawbacks of few published methods were very well discussed and have bee...
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Lipids: Classification, general methods of analysis, refining of fats and oils; hydrogenation of vegetable oils, Determination of adulteration in fats and oils, Various methods used for measurement of spoilage of fats and fatty foods. ▪ Lipids are a heterogeneous group of water-insoluble (hydrophobic) organic molecules that can be extracted from ti...
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Carbohydrates: classification and properties of food carbohydrates, General methods of analysis of food carbohydrates, Changes in food carbohydrates during processing, Digestion, absorption and metabolism of carbohydrates, Dietary fibre, Crude fibre and application of food carbohydrates.
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Principle-Anthrone test is also another general test for all carbohydrates. In this test also, carbohydrate gets dehydrated when react with conc. H2SO4 to form furfural. This furfural reacts with anthrone to give bluish green colored complex. Reagents-Anthrone reagent: 2 g of Anthrone is dissolved in 1 liter of concentrated H2SO4. The freshly prepa...
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In this study, a new simple, rapid and accurate, sensitive isocratic method was developed for the simultaneous determination of the Anti-retroviral drugs in pharmaceutical dosage forms. The chromatography was run through Denali C18 column (150 x 4.6 mm and 5 µm particle size). Mobile phase containing mixer of buffer 0.1% OPA (PH.4.6) acetonitrile i...
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Ayurvedic formulations have been utilised in healthcare for thousands of years and have made significant contributions to human health protection and improvement. Although its treatments have been used for millennia and are known to be non-toxic or considered non-toxic, there is a lack of verifiable data to support the numerous claims. The current...
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For thousands of years, Ayurvedic medicines have been utilised in healthcare profession and have made significant contributions to preserving and improving human health. Despite the fact that its medicines have been used for millennia and are known to be non-toxic and assumed to be non-toxic, there is no objective verifiable data to back up the num...
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The gluten-free pseudocereal Fagopyrum esculentum Moench (Silver hull buckwheat) belongs to the Polygonaceae family, which has a long history of both edible and medicinal use. It's a highly nutritious food ingredient that's been shown to have a variety of health benefits. Plasma cholesterol levels are lowered, neuroprotection is given, anticancer,...
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DRUG TODAY-1
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Herbal remedies- Toxicity and Regulations: Herbals vs Conventional drugs, Efficacy of herbal medicine products, Validation of Herbal Therapies, Pharmacodynamic and Pharmacokinetic issues. Herbal drug standardization: WHO and AYUSH guidelines.
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Pericyclic reactions Mechanism, Types of pericyclic reactions such as cyclo addition, electrocyclic reaction and sigmatropic rearrangement reactions with examples.
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Lecture Notes: Unit: III Testing of natural products and drugs: Effect of herbal medicine on clinical laboratory testing, Adulterant Screening using modern analytical instruments, Regulation and dispensing of herbal drugs, Stability testing of natural products, protocol. Monographs of Herbal drugs: Study of monographs of herbal drugs and comparativ...
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Objectives: The present article involved the development of sensitive and validated Ultraviolet (UV) Spectrophotometric and reverse phase liquid chromatographic and method for the determination of lapatinib in bulk and pharmaceutical dosage form. Materials and Methods: The present UV method is based on measurement of absorption at maximum at 268 nm...
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Anti-tubercular Agents: Synthetic anti tubercular agents: Isoniozid*, Ethionamide, Ethambutol, Pyrazinamide, Para amino salicylic acid* Anti-tubercular antibiotics: Rifampicin, Rifabutin, Cycloserine, Streptomycin, Capreomycin sulphate
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1 | P a g e-Clindamycin is a lincosamide antibiotic used to treat serious infections caused by susceptible anaerobic, streptococcal, staphylococcal, and pneumococcal bacteria.-Clindamycin is an antibiotic used for the treatment of a number of bacterial infections, including bone or joint infections, pelvic inflammatory disease, strep throat, pneumo...
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Antimalarials: Etiology of malaria. Quinolines: SAR, Quinine sulphate, Chloroquine*, Amodiaquine, Primaquine phosphate, Pamaquine*, Quinacrine hydrochloride, Mefloquine. Biguanides and dihydro triazines: Cycloguanil pamoate, Proguanil. Miscellaneous: Pyrimethamine, Artesunete, Artemether, Atovoquone.
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A prodrug is a drug product that is inert in its expected pharmacological activities and must be transformed into a pharmacologically active agent by metabolic or physicochemical transformation. Prodrugs can be found in nature, such as several phytochemicals/botanical constituents and endogenous compounds, or they can be created by synthetic or sem...
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Melanin is a natural skin pigment. Hair, skin, and eye color in people and animals mostly depends on the type and amount of melanin they have. Special skin cells called melanocytes make melanin. Everyone has the same number of melanocytes, but some people make more melanin than others.
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To develop a new, validated ultra-performance liquid chromatographic method for the bulk and tablet dosage form of etodolac estimation. The chromatographic separation was achieved using DIKMA Waters BEH C18 (50 x 2.6 mm, 1.7 µm) column. A mixture phosphate buffer:ethanol 10:90 v/v. was utilized as a mobile phase with the isocratic elution mode and...
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Background Alogliptin is the inhibitor of dipeptidyl peptidase-4. It acts to regulate blood sugar by increasing the amount of insulin in the body. Aim A liquid chromatography-mass spectroscopy/mass spectroscopy method was developed for the estimation of alogliptin in spiked human plasma. Liquid-liquid extraction technique was adopted for the extrac...
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The present research work was carried out the High Performance Thin Layer Chromatography (HPTLC) and Gas Chromatography-Mass Spectrometry (GC-MS) analysis and assessment of pharmacological activities of Phoenix loureiroi Kunth (Arecaceae) ethanolic leaves extract at doses of 200, 400 and 600 mg/kg, body weight, per os. Preliminary phytochemical scr...
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UNIT – I: Antibiotics - Tetracyclines: Tetracycline, Oxytetracycline, Chlortetracycline, Minocycline, Doxycycline
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Spondias pinnata (L.f.) Kurz., belongs to the Anacardiaceae family, generally referred to as Indian Hog plum, a deciduous, glabrous tree with a healthy fruit to eat. Hog plum is a mild deciduous tree plant of high nutritional value, stubby calories and abundant in vegetable proteins, zinc, chitin, starch, vitamins and minerals. Traditional use of v...
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Objectives: The present article involved the development of sensitive and validated Ultraviolet (UV) Spectrophotometric and reverse phase liquid chromatographic and method for the determination of lapatinib in bulk and pharmaceutical dosage form. Materials and Methods: The present UV method is based on measurement of absorption at maximum at 268 nm...
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Aims and objective: The aim of this study was to develop and validate a novel ultra-performance liquid chromatographic method for estimation of darunavir in a bulk and tablet dosage form. Materials and methods: The chromatographic separation was achieved using DIKMA Endoversil (2.1mm x 50mm, 1.7 µm) column. A mixture of 40% buffer (0.1% octa sul...
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Hybridization:-Hybridization and general principles explain how covalent bonding in organic chemistry is possible.-Hybridization happens when atomic orbitals mix to form a new atomic orbital. The new orbital can hold the same total number of electrons as the old ones. The properties and energy of the new, hybridized orbital are an 'average' of the...
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An elimination reaction is a type of organic reaction in which two substituents are removed from a molecule in either a one or two-step mechanism. The one-step mechanism is known as the E2 reaction, and the two-step mechanism is known as the E1 reaction. • The Zaitsev (Saytseff) Rule-When alkyl halides have two or more different β carbons, more tha...
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Begonia grandis Dryand (Family: Begoniaceae) was screened for its phytoconstituents and evaluated for its ethnomedicinal potential as an antioxidant and hepatoprotective agent. The preliminary phytochemical studies of the B. grandis revealed the presence of alkaloids, flavonoids, glycosides, triterpenoids, and steroids. Antioxidant effect of the me...
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A new, simple and efficient method for the synthesis of novel 1, 3-dithiane derivatives under ultrasonic conditions via a one-pot three-component reaction of activated methylene group malononitrile with carbon disulfide in the presence of arylidene malononitriles was reported. The effects of LiOH.H2O as a base under ultrasonic conditions at differe...
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Background: The present research work described about the systemic de-velopment of High-Performance Liquid Chromatography (HPLC) method for the quantitative determination of ruxolitinib in bulk and tablet dosage form. The subsequent validation and degradation study was also per-formed. Methods: The chromatographic Separation was achieved with a HPL...
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Its a meglitinide analog is an oral symptom designed to common hour aldohexose excursions. Through not an antidiabetic, it acts in AN analogous manner by binding to antidiabetic receptor likewise on alternative one distinct receptor-» closure of adenosine triphosphate dependent K+ channel-» of depolarization-» internal secretion unharnesses. Repagl...
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A simple and efficient method for the synthesis of fifteen novel ketene dithioacetals (2-(6-amino5-cyano-4-aryl-4H-1,3-dithiin-2-ylidene) malononitrile) via a one-pot three-component reaction of activated methylene group malononitrile with carbon disulfide in the presence of arylidene malononitriles were reported. The effects of LiOH.H2O as a base...
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Its a meglitinide analog is an oral symptom designed to common hour aldohexose excursions. Through not an antidiabetic, it acts in AN analogous manner by binding to antidiabetic receptor likewise on alternative one distinct receptor-» closure of adenosine triphosphate dependent K+ channel-» of depolarization-» internal secretion unharnesses. Repagl...
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Heat is a universal solvent, melting out of things their power of resistance, and sucking away and removing their natural strength with its fiery exhalations so that they grow soft, and hence weak, under its glow.
Article
Background: A series of novel aryl (4-aryl-1H-pyrrol-3-yl) (thiophen-2-yl) methanone derivatives was synthe-sized from sequential addition reaction with chalcones and toluenesulfonylmethyl isocyanide (TosMIC). Methods: The de-rivatives were screened against anti-inflammatory, anti-ulcer activities with an inhibition of 80.65% for PY-5 compound at 2...
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The objective of the current study was to develop Ibuprofen (IBP) gel using different polymers individually and in combination and then to select best gel formulation based on various in-vitro evaluation parameters such as bioadhesive strength, gel strength, spreadability, viscosity and drug release study. The selected gel formulation was found to...
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Objectives: To Developed a novel, rapid, validated ultra-performance liquid chromatographic (UPLC) method for estimation of Ketoconazole in a bulk and tablet dosage form according to ICH Guidelines. Methods: The chro-matographic separation was achieved using Endoversil (50 x 2.1mm, 1.7µm) UPLC column. The mobile phase used was a mixture of Phosphat...
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On 31 December 2019, the World Health Organization was informed about a cluster of cases of pneumonia with unknown origin detected in Wuhan City, Hubei Province, China. The infection spread first in China and then in the rest of the world, and on the 11th of March, the World Health Organization declared COVID-19 as a pandemic. The world is in the g...
Thesis
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CERTIFICATE This is to certify that the thesis entitled-Pharmacognostical standardization, phytochemical isolation and ascertainment of pharmacological activities of a rare mangrove Aegialitis rotundifolia Roxb., leaves in the management of wound injuries‖, submitted by Mr. Debjit Ghosh in the Department of Chemistry, GITAM Institute of Science, GI...
Cover Page
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Clinical Research Essentials of Drug Development and Clinical Trials This book is designed to provide the fundamentals of clinical research to students of pharmacy and other health sciences. An important goal of this book is to enhance students’ perceptions of the relevance of clinical research to pharmacy practice. The book includes important conc...
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Carica papaya Linn., (Family: Cariaceae) is a very well known plant which is found in various parts of India. The main aim of this study is to assay the wound healing activity of ethanolic extract of C. papaya leaf by using healthy rats of both sex and almost same age. Three types of models namely excision wound, incision wound and burn wounds whic...
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Objective: An accurate reverse phase High Performance liquid chromatography (RP-HPLC) method has been developed, validated and applied to stability indicating studies to determine Lercanidipine HCl in dosage form. Methods: Optimized chromatographic conditions were achieved by using Symmetry C18 Column, 250 mmx4.6 mm and 5μm particle size as station...
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There are many biological resources in nature that are essential in relation to health care. Due to their flexible health benefits documented in various epidemiological studies, there has been increasing interest in research on flavonoids from plant sources. Since flavonoids are directly related to human dietary ingredients and health, structure an...
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Objectives: The present research work involve the development of a novel UV-Spectrophotometric and stability-indicating RP-HPLC methods for the irbesartan in bulk as well as tablet dosage form. Methods: The RP-HPLC method is performed on the Phenomenex C 18 column (150 x 4.6 mm, 5 μm) particle size, using 0.1% Formic acid buffer (pH 3.2): Acetonitr...
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1  Thyroid-stimulating hormone, also known as thyrotropin, is secreted from cells in the anterior pituitary called thyrotrophs, finds its receptors on epithelial cells in the thyroid gland, and stimulates that gland to synthesize and release thyroid hormones.  TSH is a glycoprotein hormone composed of alpha subunit bound to the TSH beta subunit,...
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- Polycystic ovary syndrome (PCOS) is a hormonal disorder common among women of reproductive age. - Women with PCOS may have infrequent or prolonged menstrual periods or excess male hormone (androgen) levels. - The ovaries may develop numerous small collections of fluid (follicles) and fail to regularly release eggs. - Common to all women with PC...
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In the present practice, the use of metallic sodium for fusion with organic compound is terribly hazardous and is a cause of great worry and concern in a student laboratory. The idea of fusion with sodium metal is to convert the water insoluble organically bound extra elements to water-soluble sodium salts which can be easily detected by various te...
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The Kadam tree is highly regarded as religiously and culturally in India being sacred to Lord Krishna, and hence, the tree is also known as Haripriya, God’s favorite. This article provides a detailed review of Anthocephalus cadamba (Roxb) Miq. (family – Rubiaceae) that covers taxonomical classification, vernacular names, geographical distribution,...
Thesis
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Aim & Objective: The Present research work was conducted to study the toxicity profile, preparation and evaluation of various nanoparticle formulations and the in vivo cytotoxicity study of all the prepared Meloxicam and Ketorolac nanoparticle formulations. Materials & Methods: The toxicity study was conducted for acute and sub-acute toxicities for...
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The present study aimed to develop and validate stability indicating methods for the determination of drugs belonging to antiviral and anticancer categories using analytical techniques such as RP-HPLC and UPLC. The antiviral drugs in combination pharmaceutical dosage form were determined using RP – HPLC whereas the anticancer drugs in single form...
Article
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The Kadam tree is highly regarded as religiously and culturally in India being sacred to Lord Krishna, and hence, the tree is also known as Haripriya, God’s favorite. This article provides a detailed review of Anthocephalus cadamba (Roxb) Miq. (family – Rubiaceae) that covers taxonomical classification, vernacular names, geographical distribution,...
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A large number of populations are suffering due to various reasons from hepatic disorders of unknown origin. The development of anti-hepatotoxic drugs has drawn the attention of scientists in the field of natural product research because synthetic drugs may cause serious side effects. The present work was aimed to study the in-vivo hepatoprotective...
Article
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Begonia grandis Dryand (Family: Begoniaceae) was screened for its phytoconstituents and evaluated for its ethnomedicinal potential as an antioxidant and hepatoprotective agent. The preliminary phytochemical studies of the B. grandis revealed the presence of alkaloids, flavonoids, glycosides, triterpenoids, and steroids. Antioxidant effect of the...
Article
Full-text available
Objectives: The present article involved the development of sensitive and validated reverse phase liquid chromatographic and UV-spectrophotometric method for the determination of etodolac in bulk and pharmaceutical dosage form. Methods: The presents UV method is based on measurement of absorption at maximum at 226 nm using methanol and water (70:30...
Presentation
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A vitamin is an organic compound required as a nutrient in tiny amounts by an organism A compound is called a vitamin when it cannot be synthesized in sufficient quantities by an organism, and must be obtained from the diet. Thus, the term is conditional both on the circumstances and the particular organism. For example, ascorbic acid functions as...
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Introduction: The flavonoids are polyphenolic compounds possessing 15 carbon atoms; two benzene rings joined by a linear three carbon chain.  The skeleton above can be represented as the C 6-C 3-C 6 system.  The chemical structure of flavonoids are based on a C 15 skeleton with a CHROMANE ring bearing a second aromatic ring B in position 2, 3 or...
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Alkaloids are basic nitrogen containing compounds obtained from plants, animals & microorganisms having a marked physiological action usually derived from an amino acid. Proto-alkaloid do not have heterocyclic ring with nitrogen, but are also derived from amino acid.
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Background: The present research work described about the systemic development of High-Performance Liquid Chromatography (HPLC) method for the quantitative determination of ruxolitinib in bulk and tablet dosage form. The subsequent validation and degradation study was also performed. Methods: The chromatographic Separation was achieved with a HPLC...
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Montelukast: leukotriene receptor antagonist.
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Structure & Properties of organic molecules: a. Structure of atom, Periodic table & Periodic properties b.Structure of Molecules-Atomic and molecular orbitals, molecular orbital theory, Covalent bond formation in organic compounds, hybridization, Calculations for determining empirical & molecular formula c. Properties of Organic Molecules- polarit...
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"DIURETIC" is an agent that increases urine volume, while a "NATRIURETIC" causes an increase in renal sodium excretion. Because natriuretics almost always also increase water excretion, they are usually called diuretics.
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Types of Reaction Mechanisms and Methods of Determining Them: Organic reactions are chemical reactions involving organic compounds. The basic organic chemistry reaction types are addition reactions, elimination reactions, substitution reactions, pericyclic reactions, rearrangement reactions, photochemical reactions and redox reactions. In organic s...
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UNIT- I: Basic Aspects of Organic Chemistry