Dr Vijay Sharma

IFTM University | IFTM · Pharmacy Academy

The work presented below aimed to successful development of optimized fast dissolving tablet of vilazodone hydrochloride with natural superdisintegrants prepared by Lepidum sativum Seed using “Quality by Design”. Central composite design was used to optimize the tablet formulation which was compressed by direct compression followed by sublimation t...

Evaporation of the solvent was utilized in this study to produce and characterize nanoparticles that were loaded with ciprofloxacin. Nine different batches of nanoparticles were manufactured, each of which included a different proportion of ethyl cellulose and polyvinyl alcohol. An investigation of the effects of E.C. and P.V.A. on one to nine form...

The work presented aimed to implement of “Quality by Design” (QbD) approach to develop optimized fast dissolving tablet (FDT) of Fluoxentine. A face centered Central composite design was employed to develop optimized dosage form. FDTs were prepared by direct compression followed using sublimation technique with additive effect of super disintegrant...

The goal of nanotechnology is to develop new nanoscale components by designing, fabricating, and using materials that are atomically, molecularly, and macromolecular organized. For several decades, there has been an abundance of scientific curiosity in the administration of medicines using particle delivery systems as carriers for small and big mol...

This research work aimed to study process variable studies for the tasteless drug resin complex of Propranolol hydrochloride and Kyron-T 314. The effect of different parameters such as swelling time, stirring time, pH, Temperature, drug resin ratio, as well as resin activation, was optimized by taste and percentage of drug loading. The formulation...

Background Poor solubility of curcumin results in poor rate of absorption, rapid biotransformation as well as rapid rate of elimination. Due to this curcumin does not show better therapeutic effect through oral administration, to avoid poor rate of absorption, rapid biotransformation and topical drug delivery system plays a vital role. Objective T...

Abstract The current investigation entail systematic Quality by Design (QbD)-enabled approach for the development of Sustained released embedded drug delivery systems of L-Arginine employing ionic gelation technique to attain improved patient compliance. Hence, in this QbD enabled systematic approach; quality target product profile (QTTP) was defin...

Alginate and chitosan polymers are widely used in the preparation of drug release. These two polymers can be used together or separately to form modified drug-loaded release beads. A method of ionotropic gelation and subtle modification in various ways is used to fix these beads of different characteristics. Bead characteristics such as morphology,...

The gold standard in the pharmaceutical industry is oral delivery because it is a simple, safe, cost-effective and convenient method of drug delivery. Oral contraceptives have become a very popular application over the past few decades and in the pharmaceutical industry the industry has become a fast-growing area. Melting pills when put into the mo...

Aim of this research work was to develop oral dispersible tablet that disintegrates rapidly in mouth by using tasteless complex of Propranolol hydrochloride and Kyron-T 314. Effect of different parameter such as Swelling time, resin activation, drug resin ratio as well as Stirring time was optimized by taste and percentage drug loading. Formulated...

The fast-dissolving drug delivery system is rapidly gaining interest in the pharmaceutical industry among the various novel drug delivery systems. The most convenient route for drug administration for pharmaceutical dosage forms is the oral route. More than 50% of pharmaceutical products are orally administered for several Reasons, and undesirable...

Objectives: The objective of the present study was to preparation of microbeads of L-arginine by ionotropic gelation technique, dissolution and determines the effect of chelating agent on release of drug from microbeads, optimization of microbeads was done by 3 2 factorial designs using response surface methodologies. Materials and Methods: Microbe...

Objectives: The objective of the present study was to preparation of microbeads of L-arginine by ionotropic gelation technique, dissolution and determines the effect of chelating agent on release of drug from microbeads, optimization of microbeads was done by 3 2 factorial designs using response surface methodologies. Materials and Methods: Microbe...

Aim Aim of the present work is implementation of Quality by Design principles for the evolution of optimized sustained release drug delivery system Background Quality by Design (QbD) approach refers to an advance approach to develop a optimized dosage form.QbD has become a vital modern scientific approach to develop a quality dosage form.In modern...

A rapid, specific and accurate proton nuclear magnetic resonance spectroscopy (1H-NMR) method was developed to determine Clarithromycin macrolide antibiotic drug drug in pharmaceutical tablet formulation. The method was based on quantitative NMR spectroscopy (QNMR) using Tetra methyl benzene (TMB) as an internal standard and deuterated dimethy...

Background Floating tablets extend drug residence time, enhance bioavailability and promote the delivery of local drugs to the stomach. With this objective, floating tablets were prepared for the treatment of gastric ulcers containing aqueous extract of liquorice and Isabgol. Methods Tablets containing HPMC K100M (hydrophilic polymer), liquorice e...

The aim of the work was to check the therapeutic effect of L-arginine for liver cell regeneration. L-arginine is a semi-essential amino acid works as a nitric oxide precursor. Sustained released matrix beads of L- arginine were developed and tested for its hepatoprotective effect in rats (paracetamol was used to induce liver toxicity). Various bioc...

Background Conventional approach of formulating a new dosage form is a comprehensive task and uses various sources like man, money, time and experimental efforts. While, using the Artificial intelligence (AI), it can help to get the optimized pharmaceutical formulation with desired (best) attributes. AI minimizes use of resources and increases the...

Aim of present work is to develop optimized sustained release dosage form of Bupropion hydrochloride using Formulation by Design (FbD) approach. Development and optimization of formulation batches was done by design experiment using Central Composite Design (CCD). Tablets were formulated by direct compression technique and evaluated. The impact of...

Aim of present work is to develop optimized sustained release dosage form of Bupropion hydrochloride using Formulation by Design (FbD) approach. Development and optimization of formulation batches was done by design experiment using Central Composite Design (CCD). Tablets were formulated by direct compression technique and evaluated. The impact of...

Z Amaç: Yeni bir doğum sisteminin geliştirilmesine yönelik geleneksel yaklaşım, kapsamlı bir görevdir ve insan, para, malzeme ve zaman gibi birtakım kaynakları gerektirir. Bu sorunun üstesinden gelmek için Tasarım Üzerinde Kalite (QbD), istenen (en iyi) kalitenin farmasötik ürününün, yukarıda belirtilen kaynakların asgari kullanımı ile istenilen il...

The primary and foremost modes of transmission of bacterium are our hands. Hand hygiene is the single most important, simplest, and least expensive means of preventing nosocomial infections Proper Hand Washing is the most important means of preventing the spread of infection. Hence it brings us to the use of antiseptic for hand washing purposes. Th...

Objectives: The traditional approach of developing a new delivery system is an exhaustive task and requires a number of resources like manpower, money, material, and time. To overcome this problem Quality by Design (QbD) can be utilized to obtain pharmaceutical products of desired (best) quality with minimum use of the above resources as well as d...

INTRODUCTION Pectin comes under the important plant cell wall components. Pectin is obtained by the aqueous extraction of the appropriate plant materials and basically from citrus fruit peel and apple pomace etc, followed by a decided precipitation using alcohol or salt. The raw materials used have a large amount of pectin with good quality and are...

Depression is the most common psychiatric disorder reported in every next person in today‟s lifestyle. Depression has become the third leading cause of global disease burden, and is accounting for 4.3% of total disability-adjusted life years. If this continues for long it will become the leading cause of disease burden by the year 2030. According t...

Aims: The aim of the present work is to formulate a fast dissolving nutraceutical tablet containing clove powder as drug, by direct compression method. Tablets contain super-disintegrant which disintegrate and dissolve fast and give its rapid onset of action in pain. Place and Duration of Study: Clove (Eugenia caryophyllus) was procured from local...

Purpose of the research work was aimed to develop a optimised controlled release dosage form of L-arginine with minimum efforts by using a combination of statistical and analytical approach by applying Quality by Design (QbD). Controlled release formulation of L- Arginine was developed by using ionotropic gelation technique and effect of various in...

Aim of this research work was to develop repressed release dosage form of L-arginine with understanding of various process variables that may affect desired characteristics of an ideal dosage form. Controlled release formulation of L- Arginine was prepared by using ionotropic gelation. All possible formulations were prepared using different concent...

Objectives: The design of effective and safe novel drug delivery systems has become an integral part for the development and formulating of new medicines. So, research continuously keeps on searching for new ways to deliver drugs over a long period of time or for a well-controlled release profile, to minimizing the loss of drug, to reduce the side...

Aim of review is to treat the arthritis. Rheumatoid arthritis is an auto-immune joint disorder involving pain and inflammation. Various drugs are used for pain management and relief from arthritis with single and multiple dose therapy. Different drugs are especially suitable for achieving controlled and delayed release profile with low risk of dose...

Polymers are formed of repeating structural units which are joined together by covalent chemical bonds. These are having a broad classification on different basis.Use in manufacturing of solid monolithic matrix systems, implants , films , beads , micro-particles , nanoparticle, inhalable and injectable system as well as viscous liquid formulations...

Aim of present work is to prepare and optimized mouth dissolving tablets (MDTs) by using tasteless complex of levocetirizine. Materials and Methods: Formulation and optimization of tablets was done by using computer optimization technique. Formulated taste masked complex of drug was characterized by taste evaluation, percentage drug loading, therma...

Formulation and characterization of taste masked oral suspension of Mefenamic acid and Paracetamol by ion exchange resin method. The pediatric Population are most sensitive for the bad taste of medicaments. And pediatric are also unable to take tablets and capsule easily. So, taste mask suspension play an important role in the pediatric health. Bec...

Objectives: The objective of the present study was to preparation of microbeads of L-arginine by ionotropic gelation technique, dissolution and determines the effect of chelating agent on release of drug from microbeads, optimization of microbeads was done by 3 2 factorial designs using response surface methodologies. Materials and Methods: Microbe...

Traditional approach of formulating a new drug product is an exhaustive task and involves a number of resources like man, money, time and experimental efforts, using this Quality by Design (QbD) approach one can get the pharmaceutical product of desired (best) quality with minimizing above resources as well as knowing the influence of one factor ov...

SUMMARY. The present study examined the formulation variables and resulted in successful optimization of buoyant beads of glipizide using combination of sodium alginate, light liquid paraffin and chitosan with a computer optimization technique and response surface methodology utilizing polynomial equations. Different concentration of light liquid p...

The present study examined the formulation variables and resulted in successful optimization of buoyant beads of glipizide using combination of sodium alginate, light liquid paraffin and chitosan with a computer optimization technique and response surface methodology utilizing polynomial equations. Different concentration of light liquid paraffin a...

In this study, a combination of statistical and analytical approach have been used in the formulation development and optimisation guided by " formulation by design " (FbD) for air entrapped microcarriers of alginate of glipizide. Microcarriers of glipizide were prepared by ionotropic-gelation technique, taking concentrations of sodium alginate (SA...

In this study, a combination of statistical and analytical approach have been used in the formulation development and optimisation guided by " formulation by design " (FbD) for air entrapped microcarriers of alginate of glipizide. Microcarriers of glipizide were prepared by ionotropic-gelation technique, taking concentrations of sodium alginate (SA...

Purpose: To formulate an optimized gastric floating drug delivery system (GFDDS) containing glipizide with carbomers and cellulosic polymers. Method: Central composite design (CCD) was employed in formulating the GFDDS using hydroxypropyl methylcellulose K4M (HPMC K4M) (A) and Carbopol 934P (CP934P) (B), as independent variables. Floating lag time...

Microbeads as being a novel approach for drug delivery is used for various kinds of drugs because of its advantages like sustained release of drug, it avoids local gastric irritation, targeting to specific site and many more. Microbeads have been used successfully to deliver drugs which are acid-labile and due to this reason they provide a path to...

Aim of this research work was to develop and formulate tasteless complex of extremely bitter drug Ondansetron Hydrochloride and ion exchange resin Tulsion 335(weak cation exchange resin). Effect of different parameters such as swelling time, resin activation, drug resin ratio as well as stirring time was optimized by taste and percentage drug loadi...

Floating drug delivery system is the form of gastro-retentive drug delivery system. That controls kinetic release rate of drug to a specific site for its pharmacological action. These are achieved by use of various polymeric substances including natural polymer such as xanthan gum. This delivery system prolongs the retention time of the drug in the...

Orally disintegrating tablets (ODTs) are an emerging trend in novel drug delivery system and have received ever-increasing demand during the last few decades. ODTs are solid unit dosage forms, which disintegrates or dissolves rapidly in the mouth without chewing and water. This type of property in dosage form can be attained by addition of differen...

The design of effective and safe new drug delivery systems has become an integral part for the development and formulating of new medicines. So, research continuously keeps on searching for new ways to deliver drugs over a long period of time or for a well-controlled release profile, to minimizing the loss of drug, to reduce the side effect. Synthe...

Starch is a naturally occurring, biodegradable, inexpensive and abundantly available polysaccharide molecule. In acetylation, hydrophilic hydroxyl groups are substituted with hydrophobic acetyl groups. Acetylation makes starch more hydrophobic and prevents the formation of hydrogen bonding between hydroxyl groups and water molecules. The comparativ...

Starch is a major carbohydrate easily extractable from various native sources, like potato, maize, corn, wheat, etc, which finds wide application in various food and non food industries. Since time immemorable various attempts are being made in order to modify this highly flexible polymer with an aim to enhance the positive attributes and eliminate...

Oral route is most common route of drug administration and it is the first way investigated in the development of new dosage forms. In oral drug formulations major problem arises is the low bioavailability due to poor aqueous solubility. Mostly new drug candidates have poor water solubility resulting into low bioavailability, high intra and inter-s...

Native rajgira starch and carboxymethyl rajgira starch (CMS) were evaluated as tablet disintegrants in comparison with rice starch. Tablets were prepared with wet granulation method and dibasic calcium phosphate was used as filler, each starch at various concentrations between 3-12% w/w as a disintegrant and magnesium stearate as a lubricant. Parac...

Success of oral drug delivery system depends on its degree of absorption through GIT. Thus, the idea of enhancing drug absorption in the GIT pioneered the idea of development of Gastroretentive drug delivery system. To design and evaluate the performance of GRDDS, it is important to understand the relevant anatomy and physiology of the GI tract. To...

Aim of this research work was to develop mouth dissolve tablet that disintegrates rapidly in mouth and formulate tasteless complex of drug Cefixime. Cefixime is an oral third generation cephalosporin antibiotic. It is used to treat gonorrhea, tonsillitis, and pharyngitis. The tablets were prepared using different concentration of disintegrant by di...

Fast disintegrating tablets (FDTs) aim for designing dosage forms, convenient to be manufactured and administered, free of side effects, offering immediate release and enhanced bioavailability, to achieve better patient compliance. Usually, elderly people experience difficulty in swallowing the conventional dosage forms such as tablets, capsules, s...

Ion exchange resins are said to be revolutionary agents, is widely being used in pharmaceutical industry with several advantages, because of their unique properties discussed in the review. IER are being used as taste masking agent, disintegrant, stabilizer, in novel drug delivery system, enhance dissolution and also in various formulations.

A study has been carried out to investigate the binding and disintegrating properties of modified starch, isolated form Amaranthus paniculatus Linn (Amaranthaceae). (Amaranth starch) .After modifications of Amaranth starch (MAS) dissolution profiles were studied. Paracetamol (500 mg) was used as a marker drug and dissolution data of MAS compared wi...

Native rajgira starch and carboxymethyl rajgira starch (CMS) were evaluated as tablet disintegrants in comparison with rice starch. Tablets were prepared with wet granulation method and dibasic calcium phosphate was used as filler, each starch at various concentrations between 3-12% w/w as a disintegrant and magnesium stearate as a lubricant. Parac...

Acceptability of any drug dosage form mainly depends over its taste i.e. mouth feel. drug molecule interacts with taste receptor on the tongue to give bitter, sweet or other taste sensation, when they dissolve in saliva. This sensation of taste is the result of signal transduction from the receptor organs for taste, commonly known as taste buds. No...

S Acceptability of any drug dosage form mainly depends over its taste i.e. mouth feel .drug molecule interacts with taste receptor on the tongue to give bitter, sweet or other taste sensation, when they dissolve in saliva. This sensation of taste is the result of signal transduction from the receptor organs for taste, commonly known as taste buds....

Nyctanthes arbortristis Linn. (Fam: Nyctanthaceae) is commonly known as 'Harsinghar' and its leaves are traditionally used to treat fevers, rheumatism, liver disorders and as expectorant. The present work is aimed to evaluate the effect of leaves of N. arbortristis on antioxidant enzymes status in streptozotocin induced diabetic rats. STZ diabetic...