Dr Pranav Kumar Prabhakar

Dr Pranav Kumar Prabhakar
Lovely Professional University | LPU · Lovely Faculty of Applied Medical Sciences

PhD (Biotechnology)

About

85
Publications
75,198
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
1,400
Citations
Additional affiliations
January 2006 - May 2011
IIT Madras, Chennai
Position
  • PhD
Description
  • Interaction of Pure phytochemicals with commercial oral Anti-diabetic Drugs
Education
April 2001 - August 2004
Patna University
Field of study
  • Biochemistry
April 1996 - July 1999

Publications

Publications (85)
Article
Full-text available
Low-density lipoprotein (LDL) has a major role in the origination and development of atherosclerosis and Cardio Vascular Diseases (CVD). Over the past few years, many studies have been concerned with different subclasses of LDLs and their atherogenicity. Low-density lipoproteins (LDLs) include many subclasses. The most common are large buoyant (LB)...
Article
COVID-19 is caused by the SARS-CoV-2 virus, which has afflicted more than 245.37 million individuals worldwide and resulted in more than 4.9 million deaths as of today, with a mortality rate of 2.1%. Diabetes mellitus (DM) and its secondary complications are the major serious global health concerns today due to its growth rate, the fastest growing...
Article
Full-text available
Phytotherapy, based on medicinal plants, have excellent potential in managing several diseases. A vital part of the healthcare system is herbal medicines, consisting of therapeutic agents with high safety profile and no or least adverse effects. Herbs or medicinal plants show anticancer, antioxidant, and gene-protective activity, which is useful fo...
Preprint
Background: Increasing evidence revealed the role of adipokines in glucose and fat metabolism. The present study was designed to evaluate the adiponectin, leptin and resistin levels in prediabetes subjects and assess the relationship between these adipokines and insulin resistance. Material and Methods: A case-control study was conducted for a peri...
Article
COVID-19 is a multisystem sickness caused by the complex interaction of inflammatory, immunological, and coagulative cascade. Risk assessment, choice of appropriate treatments, monitoring, and timely discharge are important aspects of COVID patient management. Along with proper clinical evaluation, laboratory markers can offer extra information tha...
Article
One of the common clinical complications of diabetes is diabetic neuropathy affecting the nervous system. Painful diabetic neuropathy is widespread and highly prevalent. At least 50% of diabetes patients develop diabetic neuropathy eventually. The four main types of diabetic neuropathy are peripheral neuropathy, autonomic neuropathy, proximal neuro...
Article
Full-text available
Diabetes-related delayed wound healing is a multifactorial, nuanced, and intertwined complication that causes substantial clinical morbidity. The etiology of diabetes and its related microvascular complications is affected by genes, diet, and lifestyle factors. Epigenetic modifications such as DNA methylation, histone modifications, and post-transc...
Chapter
Full-text available
Polycystic ovarian syndrome (PCOS) is the most common endocrinopathy that affects 8–20% of the reproductive age females and adolescent girls every year worldwide and approximately 5 million cases reported in the USA annually. It is more prevalent in urban areas as compared to the rural areas because of the difference in the lifestyles of rural and...
Article
Full-text available
Diabetes Mellitus is the most prevalent metabolic disorder that is increasing at an alarming rate worldwide. The unregulated glucose level leads to various types of health disorders, and one of the major diabetic complications is delayed wound healing. Due to the more side effects of synthetic drugs, there is a need to explore plants and their phyt...
Chapter
More than 50% of the respiratory system infection is caused by rhinovirus, one of the most important members of Picornaviridae family. Since the discovery of rhinovirus by Dr. Price in 1956, it has been found to be the commonest cause of common cold. It is ubiquitous in prevalence, even though we have very limited knowledge and understanding of its...
Chapter
Colorectal cancer is placed at the second place in terms of mortality by cancer. Even after the improvement and development in the colorectal cancer management, the prognosis of metastatic colorectal cancer is very poorly explored. And hence there is a requirement of very efficient, novel, and effective management strategies for the colorectal canc...
Chapter
A few years ago, extracellular vesicles (EVs) came into light for their role in intercommunication between the tumor cells, transferring oncogenic molecules, and the development of cancer. The EVs are released by almost all types of body cells and can be isolated easily from most of the body fluids. They contain molecular cargos like various types...
Article
Background: Urolithiasis (Mutrakricchra) is an age-old disorder which has multi-factorial etiological as well as associated with re-occurrence. It is standout among the most troubling disorders related to urinary tract. Acharya Sushruta, a pioneer in the art of surgery, described the root causes and management of urolithiasis (Mutrakricchra). In pr...
Article
Full-text available
Background: Abrin is a type of ribosome-inactivating protein that inhibits eukaryotic protein synthesis which leads to apoptosis and cell death. Abrin is isolated from the plant Abrus precatorius L. (A. precatorius) it is a valuable plant from the family Fabaceae. It is commonly known as Gunja or Jequirity, it is found easily throughout India mainl...
Article
The cardiovascular complications of type 2 diabetes mellitus (T2DM) include myocardial infarction, heart failure, peripheral vascular disease and, stroke and retinopathy, nephropathy and neuropathy are microvascular complications. While the newer therapies like glitazones or even dipeptidyl-peptidase-IV (DPP-IV) inhibitors increase the risk of ther...
Article
Diabetes mellitus is one of the fastest growing noncommunicable disease. Diabetes mellitus is causes due to destruction of pancreatic beta cell or due to insulin resistance and characterised by hyperglycaemia. Diabetes imposes a very serious economic crisis as the diabetic drug market is growing very rapidly. Even after very path breaking scientifi...
Experiment Findings
Full-text available
Lectins are the glycoprotein that has the ability to agglutinate all types of human blood. The glycoprotein from the 0.9% of normal saline extracts of Bryophyllum pinnatum leaves was purified by dialysis with 50% of ammonium sulfate. At 4C with the gradual addition of 50% ammonium sulfate in dialyzed extracts, the lectin gets precipitated. After 10...
Article
Full-text available
Diabetes mellitus and thyroid gland abnormalities are interlinked and coexist with influencing each other. Current study was planned and conducted to evaluate thyroid status in patients with type-2 diabetics. The main aim of the study was to understand the relationship between diabetes mellitus and thyroid abnormalities. Total 100 known diabetic pa...
Article
Full-text available
Diabetic complications, such as, retinopathy, nephropathy lead to blindness and end stage renal failure respectively, various neuropathies, and ultimately increased mortality. While the exact mechanisms that lie behind the pathological changes associated with diabetes remain obscure, however, it is widely believed that chronic or intermittent hyper...
Chapter
Almost 20 years after the publication of the first microbial sequences, today's world is growing in the direction of the post-genomic era with the understanding of transcriptomics and proteomics, which offer insight into cellular physiology. As the function of protein is associated with the phenotypic characters of an organism, the power to exceed...
Article
Background Polycystic ovarian syndrome (PCOS) is the most common endocrinopathy that affects 8% to 20% of the reproductive age females and adolescent girls every year worldwide and approximately 5 million cases reported in the USA annually. It is more prevalent in urban areas as compared to the rural areas because of the difference in the lifestyle...
Article
Full-text available
In this article, we are focusing on the beneficial effect of cinnamon (Cinnamomum zeylanicum) and ginger (Zingiber officinale Rosc.) on the performance of broiler nutrition. Cinnamon and ginger are commonly used as medicine as well as spices in human food. These two spices are commonly available in the market and used as a feed supplement in broile...
Article
Conventional delivery of antidiabetic drugs faces many problems like poor absorption, low bioavailability, and drug degradation. Nanoemulsion is a unique drug technology, which is very suitable for the delivery of antidiabetic drugs. In recent years, the flaws of delivering anti-hypoglycaemic drugs have been overcome by choosing nanoemulsion drug t...
Chapter
Probiotics, the living microorganisms such as bacteria and yeast, are used for the treatment of various disorders like allergies, diarrhoea, vaginosis, inflammatory and irritable bowel disease, lactose intolerance, diabetes and cancer. In recent time, anticancer properties of probiotics have been extensively studied. Some probiotics reduce the prol...
Article
Full-text available
Recently in China, a novel coronavirus outbreak took place which caused pneumonia-like symptoms. This coronavirus belongs to the family of SARS and MERS and causes respiratory system disease known as COVID-19. At present we use polymerase chain reaction (PCR) based molecular biology methods for the detection of coronavirus. Other than these PCR bas...
Chapter
Gastrointestinal or gastric cancer is a prominent cause of mortality in several parts of the world and it ranks at fourth in the death caused due to cancer-related disease. The preliminary detection may give a better medical result, but the major issue is the asymptomatic nature of the disease in early stages, patients get medical attention only in...
Article
Aim Evaluation of antidiabetic potential of polyherbal formulation containing copper nanoparticles. Background Copper, popularly known as “Tamra”, is well known for its use as Bhasma (incinerated powder) in Ayurveda herbal preparations in Indian traditional system of medicine. Further, Trigonella foenum- graecum, Allium sativum, Aloe vera and Phyl...
Book
Full-text available
This book contains comprehensive and up-to-date reviews of multidrug resistance mechanisms. The book intends to provide a state-of-the-art collection of reviews and methods for both basic and clinician investigators who are interested in multidrug resistance mechanisms and reversal strategies. We believe that this information will be of value to cl...
Article
The bacterial infection is one of the major health issues throughout the world. To protect humans from the infection and infectious agents, it is important to understand the mechanism of interaction of pathogens along with their susceptible hosts. This will help us to develop a novel strategy for designing effective new drugs or vaccines. As iron i...
Article
Background : The occurrence of chronic wounds, account for significant suffering of diabetic people, together with increasing healthcare burden. The chronic wounds associated with diabetes do not undergo the normal healing process rather stagnate into chronic proinflammatory phase as well as declined fibroblast function and impaired cell migration....
Article
Full-text available
Abstract Aim: Sepsis, a systemic inflammation, mainly originated due to infectious viral, fungal, or parasitic infections. No long-term data are available which compare the procalcitonin (PCT) levels and C-reactive protein (CRP) levels in different emergency conditions as well as differentiating the PCT levels in males and females in sepsis or o...
Article
Full-text available
Hashimoto's thyroiditis (HT) is an autoimmune thyroid disorder, an organ-specific disease, which is characterized by diffused goiter with lymphocytic infiltration, which leads to destruction of thyroid gland causing hypothyroidism. This is a condition where the thyroid gland does not release enough of thyroid hormone called thyroxin due to the insu...
Article
Lactococcus lactis is a lactic acid bacterium widely used in various food and fermentation processes. L. lactis is one of the organism which is treated as generally regarded as safe (GRAS) organisms, whichch is used for as genetic machinery for the genetic and chromosomal engineering and vectors to facilitate cloning and gene expression and produce...
Article
Diabetes mellitus and thyroid dysfunction are the two well-known endocrine disorders which are experienced in clinical practice. Different studies have evidenced that diabetes and thyroid disorders mutually influence each other and both disorders tend to co-exist. The unidentified thyroid disorders may adversely affect the metabolic control and inc...
Article
Full-text available
Coronavirus has become one of the major concern worldwide after its sudden outbreak in Wuhan (China); which mainly targets human respiratory system. It's been identified as zoonotic pathogen based on its similarities with SARS, hence termed severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2);
Chapter
Diabetes mellitus (DM) the fastest-growing noncommunicable metabolic endocrine disorder, and it is characterized by the hyperglycemia. The main reason for hyperglycemia is the insufficiency of insulin, the inefficiency of insulin, or both. According to the International Diabetes Federation Atlas, there are 425 million diabetic people, which is expe...
Article
Full-text available
Objective: Autoimmune thyroid disease is one of the organs specific autoimmune disorders. The onset is much more common in women than in men. Worldwide, 2-4% of women and only 1% of men have affected and the rate increases with age. Thyroperoxidase (TPO) antibodies (Abs) level helps to diagnose autoimmune thyroid disease along with levels of thyroi...
Article
Repurposing of drugs/natural or synthetic chemicals is a promising approach to identify the new therapeutic indication/use and mode of action. In pharmaceuticals, this process is used to save the time and cost for the drug discovery process with reduced risk of failure. In the present studies, repurposing of a natural molecule: sabinene (major phyt...
Article
Full-text available
Acne is one of the most common problem faced by today's youth and is listed in eighth position in the prevalence. It is affecting almost 9.4% of the global population in the world. This skin ailment is mostly occurring in the teenagers. There is no medicine is available in the market which can cure acne. And also, there are some limitations to thes...
Book
Full-text available
Multiple Choice Questions (MCQs) are the backbone for all entrance examinations throughout the world. MCQs are used to evaluate student’s cognitive acumen in all the fields and discipline. This book contains 28 chapters covering almost all of the biochemistry syllabus through 3500+ MCQs. Each MCQ is validated from the reference biochemistry books....
Article
Background Diabetes is a multifactorial disease and a major cause for many microvascular and macrovascular complications. The disease will ultimately lead to high rate mortality if it is not managed properly. Treatment of diabetes without any side effects has always remained a major challenge for the health care practitioners. Introduction The cur...
Article
Full-text available
Thyroid hormones (T3 and T4) synthesized by thyroid gland and play an essential role in normal body development and tissue metabolism. Iodine is an essential factor that is required for the synthesis of thyroid hormones. The secretion of thyroid hormones is regulated by Negative feedback mechanism. After reached in blood circulation the majority of...
Article
Diabetes is one of the most common endocrine non-communicable metabolic disorder which is mainly caused either due to insufficient insulin or inefficient insulin or both together and is characterised by hyperglycemia. Diabetes emerged as a serious health issue in industrialized and developing country specially in Asian pacific region. Out of two ma...
Article
DNA is one of the most important biomolecules of living cells which carries genetic information from generation to generation. Many endogenous and exogenous agents may disrupt the structure of DNA. Change in the cellular genome can lead to errors in replication, transcription and in protein synthesis. DNA damage occurs naturally or result from a me...
Article
Cancer is the second leading cause of death worldwide. There are various classes of medications available for the management of cancer. Nanoparticles based drugs are the most preferred category among them due to their specificity towards target and reduction in the dose of drugs. Nanotechnology includes multiple subdisciplines like nanostructures,...
Article
Aim: Sepsis, a systemic inflammation, mainly originated due to infectious viral, fungal, or parasitic infections. No long-term data are available which compare the procalcitonin (PCT) levels and C-reactive protein (CRP) levels in different emergency conditions as well as differentiating the PCT levels in males and females in sepsis or other related...
Article
Full-text available
Objective: The present study was investigated to determine the correlation of body mass index (BMI) with thyroid-stimulating hormones (TSH) in thyroid patient.Methods: The data which are used in this study were taken in Tagore Hospital and Heart Care Centre (Jalandhar). A total of 90 volunteers both males and females in the age group between 17 and...
Article
In recent years, the curiosity to investigate the relationship between gut microbiota and diabetes development has increased. Evidence from previous studies suggests that gut microbiota manipulation may assure to prevent diabetes development in future, primarily in susceptible individuals. Here, we reviewed special gut microbiota types proposing de...
Article
Full-text available
In recent years, the curiosity to investigate the relationship between gut microbiota and diabetes development has increased. Evidence from previous studies suggests that gut microbiota manipulation may assure to prevent diabetes development in future, primarily in susceptible individuals. Here, we reviewed special gut microbiota types proposing de...
Article
Background and purpose: Ferulic acid, an anti-oxidant phytochemical present in several dietary components, is known to produce wide range of pharmacological effects. It is approved for use in food industry as a preservative and in sports food. Previous reports from our lab have shown synergistic interaction of ferulic acid with metformin in cell l...
Article
Hashimoto's thyroiditis (HT) is an autoimmune thyroid disorder, an organ-specific disease, which is characterized by diffused goiter with lymphocytic infiltration, which leads to destruction of thyroid gland causing hypothyroidism. This is a condition where the thyroid gland does not release enough of thyroid hormone called thyroxin due to the insu...
Article
Full-text available
Diabetes mellitus is commonly known worldwide by the name of diabetes which occurs in all age groups. About >90% of diagnosed patient specially are Type-2 diabetes. The hallmark of Type 2 diabetes developments is increased insulin resistance, whereas Type 1 is related to less production of insulin which leads to uncontrolled hyperglycemia. Hypergly...
Article
Full-text available
Objective: Injudicious use of antibiotics in the management of pyogenic infections leads to emergence and spread of antibiotic resistance among pyogenic bacteria. This study aimed toward the determination of the bacterial isolates from pus samples and their antibiotic resistance pattern. Methods: A retrospective analysis of 359 consecutive pus spec...
Article
Full-text available
The aim of this work was to do phytochemical extraction and screening and also evaluation of their antibacterial and antioxidant properties for Tinospora cordifolia. The crude drug (Stem part) was successively extracted by Soxhlet assembly using various solvents. Preliminary phytochemical screening of different extracts was carried out using severa...
Article
Full-text available
Objective: The aim of this work was preliminary phytochemical screening and determination of in vitro antimicrobial activity of C. sappan leaves (Leguminosae) collected from forest area of Tamilnadu, India. Methods: The crude drug was successively extracted by Soxhlet assembly using Petroleum ether, dichloromethane, ethyl acetate and methanol as so...
Article
Full-text available
Diabetes mellitus (DM) is the most common endocrine metabolic disorder, characterized by hyperglycemia. The cause of this hyperglycemia is either insufficient or inefficient insulin that leads to the imbalance in the metabolism of not only carbohydrates but also protein and lipids. DM is associated with various kinds of abnormalities which affects...
Article
Full-text available
Globally, cervical cancer is the second most common cancer, and in India, it is the most common cancer in women. Human papilloma virus (HPV) is the main cause of it. Although there are several methods for preventing cervical cancer, primary prevention by vaccination is the most effective option. HPV vaccine is safe and effective. It is expensive an...
Chapter
Full-text available
Diabetes mellitus is characterised by hyperglycemia which is caused by inefficient or insufficient insulin. There are two main types of diabetes mellitus i.e., type 1 diabetes mellitus and type 2 diabetes mellitus. Type-1 diabetes is caused mainly because of destruction of pancreatic b-cells whereas type-2 diabetes is caused by insulin resistance c...
Chapter
Full-text available
Nutraceuticals are food or part of food which provides medical or health benefits also includes the prevention and/or treatment of diseases. Nutraceuticals are better option to chemical or synthetic medicines as these avoid side effects, have natural origin and are part of dietary supplements. Nutraceuticals are treated as the bioactive substances...
Article
Liver transplantation is the surgical treatment of choice for several irreversible liver diseases where a partially or completely diseased liver is replaced with a healthy liver. The continued use of immunosuppressant causes certain serious consequences such as hepatotoxicity, nephrotoxicity and post-transplant hyperglycemia. Inter individual varia...
Article
Full-text available
Plants are known to be the source of many bioactive chemical compounds. Medicinal plants were used by people of ancient cultures without knowledge of their active ingredients. The common practice of taking crude extract orally is laden with hazards as the extracts may contain some toxic constituents. For current study we have selected four traditio...
Article
Full-text available
Magnetite nanoparticles were prepared with starch as surfactant by ball milling for 30 h a toluene medium. The nanoparticles were synthesized with different amounts of surfactant addition (8-12 wt%) and the variation in their effective anisotropy and magnetic properties with surfactant content is investigated. The samples were characterized by X-ra...
Article
Full-text available
Introduction:Hypovitaminosis D (25[OH] D) with high prevalence in both developed and developing world, has been implicated in the development of diabetes and the metabolic syndrome' and it has also been shown to play a role in glycaemic control in diabetic patients. The main objective of the present study is to examine the incidence of 25[OH] D ins...
Article
The iron nanoparticles coated with oleic acid and drugs such as folic acid/Amoxicillin were synthesized by high energy ball milling and characterized by X-ray diffraction, Transmission electron microscope, zeta potential, dynamic light scattering, Fourier Transform Infra red (FT-IR) measurements, and thermo gravimetric analysis (TGA). FT-IR and TGA...
Article
Hydroxycinnamic acid derivatives are naturally occurring substances found in fruits, vegetables, and flowers and are consumed as dietary phenolic compounds. The effect of cinnamic acid, ferulic acid, p-coumaric acid, eugenol, chlorogenic acid, and caffeic acid, alone and in combination with two commercial oral hypoglycemic drugs (OHD), namely, thia...
Article
Biocompatibility of medical grade polyurethane coated with polyaniline (PANi) and polyaniline-silver nanoparticle composite (PANi-AgNp) is reported here. These modified films showed 23 and 18% of 3T3 L1 cell death when compared to 41% with virgin polyurethane (PU) after 48h of incubation, respectively. All the surfaces elucidated inflammatory respo...
Article
Full-text available
Diabetes mellitus (DM) is a metabolic disorder caused by insufficient or inefficient insulin secretary response and it is characterized by increased blood glucose levels (hyperglycemia). DM is a heterogonous group of syndromes. Glucose is the main energy source for the body, and in the case of DM, management of glucose becomes irregular. There are...
Article
Full-text available
The management of diabetes with insulin and synthetic oral hypoglycemic drugs (OHDs) can produce serious side effects and in addition fails to prevent diabetes-related complications in many patients. A new diabetes management strategy is needed that is more effective and has fewer side effects. This paper analyzes the dose- and time-dependent effec...
Article
CoFe2O4 nanoparticles of different sizes were synthesised by controlling the digestion time using precipitation method and were characterised by X-ray diffraction, transmission electron microscopy, dynamic light scattering, and vibrating sample magnetometer. The average crystalline size increases from 13.9 to 19 nm as the digestion time is increase...