Dr. Omprakash Gadgeppa Bhusnure

Channabasweshwar Pharmacy College (Degree), Latur · Quality Assurance

This study demonstrates the successful synthesis of silver nanoparticles (AgNPs) using Achyranthes japonica root extract Phytogenic AgNPs have been characterized by various physiochemical methods , such as UV-Vis, FT-IR, XRD, FE-SEM, and HR-TEM analyses. The UV-vis plasmon resonance spectra of AgNPs showed a maximum at 447 nm; XRD powder analysis w...

The 3D printing technology has been newly employed in the design and formulation of different dosage forms with the aim formulation and evaluation of 3D printed Pregabalin tablets for the treatment of neuropathic pain by QbD approach. Drug (Pregabalin) together with other excipients, were mixed and extruded into filaments by hot melt extrusion. The...

In this study we describe the development of an effective nanofiber (NF) formulation that uses two low-cost and easily available polymers, PVA and PVP, to embed and release a well-known anticancer drug, 5-flurouracil (5FU), which is intended to treat colon cancer. PVA:PVP polymers in a variety of ratios (10:2, 8:4, 6:6, 4:8, 2:10) were used for NF...

Phytosomes are a newly introduced novel drug delivery system and novel botanical formulation to induce lipophilic molecular complexes to enhance absorption and bioavailability of phytoconstituents. Terminali aarjuna phospholipid complex and it’s tablet formulations targeted for cardiovascular systems was prepared. Our study aims is for improving th...

Cochlospermum religiosum (Linn.) Alston. (Bixaceae) otherwise known as Yellow silk cotton tree.Traditionally, the plant is used in the treatment of cough, asthma, jaundice, tuberculosis, inflammation, gonorrhea, fever and dysentery. In the present studymicromorphological investigations and the physicochemical analysis of Cochlospermum religiosumlea...

Carbon nanotubes (CNT) are the allotropes of carbon in nanosize rendering them popular in the field of medicines. These nano-based technologies are gaining interest in the treatment of disease which was previously seemed to be impossible for treating. CNT gained significance in the treatment of the majority of disorders such as Malaria, Alzheimer’s...

The scrutiny of medical devices industry as well as pharmaceutical industry for its application in health care industry on different platform is captured the 3D printing technique. 3D printing technology withstand for a very long duration only because of the approval of medical devices, 3D printed tablets and also with the advent of USFDA guideline...

All equipment’s used in the production of products shall be properly Validated, Qualified and Calibrated to demonstrate that it is suitable for its intended purpose. Qualification is an important aspect of the pharmaceutical quality system. When the equipment is properly qualified, verified and maintained, there is the possibility of Consistent per...

For a long time scientists have tried to describe disorders are due to genetic as well as environmental factors. In the past few years, revolution in technology that has made it possible to decipher the human genome. Epigenetics explains the capability gene expression regulation without modifying the genetic sequence. Epigenetic mechanisms are root...

Melatonin is N-acetyl-5-methoxytryptamine and is an indoleamine. It is synthesized in the pineal gland by the conversion of tryptophan to serotonin, which is acetylated by N-acetyltransferase (NAT) to N-acetyserotonin. N-acetylserotonin is subsequently converted to melatonin by the enzyme hydroxyindole-omethyltransferase. Melatonin receptors are G-...

The aim of the present study is to develop a complex of standardized Tamarindus indica (STI) and phospolipid with a goal to improve the bioavailability of its phytoconstituents. Tamarind is a flavonoid, glycoside that possesses different therapeutic activity.The poor solubility and dissolution rate limit its oral absorption and bioavailability. The...

The methods having requisite precision, accuracy, specificity and robustness were developed and validated for quantitative determination of Apixaban in pharmaceutical dosage forms. The chromatographic column used was a reverse phase 250 μ 4.6 mm, 5 μm (particles) packing Inertsil ® ODS-3V C18 HPLC column. The column and the HPLC system were kept at...

Oxygen uptake while breathing cause’s free radical production and in addition to that environmental factors such as pollutants, smoke and certain chemicals also contribute to their formation. Reactive oxygen species is a collective term that includes all reactive forms of oxygen, including both oxygen radicals and several non-radical oxidizing agen...

Bioanalysis is an essential part in drug discovery and development. Bioanalysis is related to the analysis of analytes (drugs, metabolites, biomarkers) in biological samples and it involves several steps from sample collection to sample analysis and data reporting. The first step is sample collection from clinical or preclinical studies; then sendi...

To develop a simple, cheap, accurate, and rapid Reverse Phase High Performance Liquid Chromatographic (RP-HPLC) method and validate as per ICH guidelines for estimation of Didanosine in pharmaceutical dosage forms. The separation was conducted by using mobile phase consisting of methanol: water in the ratio (30:70). The wavelength was found at 246n...

ABSTRACT Quality by Thought is a unique innovative approach for the management of human Health. The thoughts that run through the mind can be positive or negative, progressive or retrogressive – this depends on the kind of information previously stored, and the new ones being added to it. While we may not have total control over every thought that...

Quality by Thought is a unique innovative approach for the management of human Health. The thoughts that run though the mind can be positive or negative, progressive or retrogressive this depends on the kind of information previously stored, and the new ones being added to it. While we may not have total control over every thought that flashes thro...

A quest for more potent new antitubercular agents has prompted to design and synthesize aryloxy‐linked dimeric 1,2,3‐triazoles (4a–j), from azides (2a‐e) and bis(prop‐2‐yn‐1‐yloxy)benzene (3a–b) on 1,3‐dipolar cycloaddition reaction via copper (I)‐catalyzed click chemistry approach with good to better yields. The titled compounds (4a–j) were design...

A simple, sensitive and accurate RP-UPLC method has been developed for the determination of Linezolid in Tablet formulation. The mix of the Linezolid was found to be 251nm in Acetonitrile: Buffer [40:60(v/v)]. The method shows high sensitivity with linearity 5 to 3 0μg/ml (regression r 2 = 0.999). This method was tested and validated for various pa...

Novel Drug Delivery System is need of time, as it makes bioavailability, securityand overall therapeutics of a drug easy-going and in the bat of an eye. In the recent days, most of the regnant maladies and nutritional disorders are treated with herbal medicines because of their less after math, economical and easily accessible. The potency of any h...

Effective targeted drug delivery system has been a dream for a long time, but it has been largely frustrated by the complex chemistry that is involved in the development of new systems. Topical drug delivery system has many problems like poor permeability, skin irritation, allergic reactions etc. major problems of newly developed chemical entities...

National conference on DST-FIST funded Global opportunity in Chemical, Biological and Material Sciences organized by KKHA Arts, SMGL commerce, Shriman PH Jain Science college, Neemnagar, Chandwad. Dist Nashik.

Herbs are now a days widely used because plant herbs provide many benefits of human health another reason is no side effect herbs, synthetic drug have more side effects on the human body. India is popularly known for traditional medicines. Traditional plants have been used from ancient time for the treatment of many diseases like antiemetic, antipy...

Background: Diosmin is a flavonoids glycoside that possesses different therapeutic activity include vascular-protecting agent used to help improving chronic venous insufficiency (CVI), haemorrhoids, etc. Diosmin is bioactive flavones constituent with wide range of biological activity. The poor solubility and dissolution rate limit its oral absorpti...

Abstract A simple, specific and economic UV spectrophotometric method has been developed using as a solvent methanol:water (80:20) to determine the Nabumetone content in bulk and pharmaceutical dosage formulations. The quantitative determination of the drug has been carried out at a predetermined λmax of 270nm, it was proved linier in the range 2-1...

Chemical hazards are a major occupational health and safety (OHS) issue in Pharma industry. Management of chemical hazards requires the combined efforts of OHS specialists, including generalist OHS professionals, occupational hygienists, and occupational health practitioners. This paper is about industrial chemicals, the manner in which their toxic...

Over the past three decades, orodispersible tablets (ODTs) have gained considerable attention as a preferred alternative to conventional tablets and capsules due to better patient compliance, improved solubility and stability. ODTs are solid dosage forms containing medicinal substances which disintegrate rapidly, usually in a matter of seconds, whe...

In the treatment of hypertension fast onset of action is the major concern. The problem of slow onset of action of drugs can be overcome by development of appropriate dosage forms. Fast disintegrating tablets in mouth are best suited and have gained popularity in the oral antihypertensive drug therapy. These are advantageous over other conventional...

A simple, specific, precise and accurate Reverse Phase High Performance Liquid Chromatography (RP-HPLC) method was developed and validated for the estimation of Diltiazem Hydrochloride in bulk and pharmaceutical dosage form. The chromatographic determination was performed on isocratic high performance liquid chromatography system of Agilent model n...

Objective: The objective of the present investigation was to formulation & evaluation of oral fast dissolving sublingual film of Propranolol HCl. Methods: In the present investigation an attempt was made to develop fast dissolving sublingual film of propranolol HCl by using two polymers. Fast dissolving films of propranolol hcl were formulate using...

Innovations in transdermal delivery systems (TDS) have made important contributions to medical practice by providing advances in the delivery of treatment with existing and novel drugs. Today about 74% of drugs are taken orally and are found not to be as effective as desired. To improve such characters transdermal drug delivery system was emerged....

Nanotechnology plays an important role in the development of biosensors. The application of nanotechnology in life sciences, nanobiotechnology, is already having an impact on diagnostics and drug delivery. Now, researchers are starting to use nanotechnology in the field of drug discovery. A sensitive monitoring of biological analytes, such as biomo...

The scientific way to develop a simple and robust analytical HPLC method for the critical separation is QbD approach. Quality-by-design (QbD) is a systematic approach to product or process development, which begins with predefined objectives, and uses science and risk management approaches to gain product and process understanding and ultimately pr...

Quality is a heart of the pharmaceutical industry. The ICH Q8-Q11 is described the concepts of Analytical Quality by design (QbD) for drug and related substance. The ICH Q8 is Pharmaceutical Development, ICH Q9 is Quality Risk Management, and ICH Q10 is Pharmaceutical Quality Systems is the ICH guidelines gives the complete procedure for applying a...

According to International Conference on Harmonization (ICH Q8 [R2]) guidelines, an experimental work was planned for both spectroscopic method development and its validation. QbD (Quality-by-Design) approach was implemented for spectroscopic method development and its validation. The research work demonstrated that the UV is valid for the determin...

Quality is a heart of the pharmaceutical industry. The ICH Q8-Q11 is described the concepts of Analytical Quality by design (QbD) for drug and related substance. The ICH Q8 is Pharmaceutical Development, ICH Q9 is Quality Risk Management, and ICH Q10 is Pharmaceutical Quality Systems is the ICH guidelines gives the complete procedure for applying a...

A simple, specific and economic UV spectrophotometric method has been developed using as diluents 0.1N NaOH to determine the tenoxicam content in bulk and pharmaceutical dosage formulations. The quantitative determination of the drug has been carried out at a predetermined λ max of 370nm, it was proved linier in the range 2-12 μg/mL and exhibited g...

A simple, specific and economic UV spectrophotometric method has been developed using as a solvent methanol:water (8:2) to determine the daclatasvir content in bulk and pharmaceutical dosage formulations. The quantitative determination of the drug has been carried out at a predetermined λ max of 317nm, it was proved linier in the range 2-12 μg/mL a...

The aim of this study was to develop a new, rapid and highly sensitive UV spectrophometer method for the Sofosbuvir bulk drug. The mobile phase consisted of Water & Ethanol in the ration of 60:40v/v and the wavelength to maximum absorbance at 260 nm. Analytical calibration curves were linear within a concentration range from 2 to 12μg/ml and coeffi...

Abstract : A simple, specific and economic UV spectrophotometric method has been developed using as a solvent methanol:water (8:2) to determine the daclatasvir content in bulk and pharmaceutical dosage formulations. The quantitative determination of the drug has been carried out at a predetermined λmaxof 317nm, it was proved linier in the range...

Plants are attracting more attention among contemporary pharmacy scientists because some human diseases resulting from antibiotic resistance have gained worldwide concern. A number of methods are available and are being developed for the isolation of nucleic acids from plants. Catharanthus is in the Apocynaceae family, well known for being rich in...

Smart polymers are materials that respond to small external stimuli. These are also referred as stimuli responsive materials or intelligent materials. Smart polymers that can exhibit stimuli-sensitive properties are becoming important in many commercial applications. These polymers can change shape, strength and pore size based on external factors...

Spectroscopic method was developed according to Quality by Design(QbD) approach as per ICH Q8 (R2) guidelines for Melatonin. QbD approach was carried out by varying various parameters and these variable parameters were designed into Ishikwa diagram. The critical parameters were determined by using principle component analysis as well as by observat...

The aim of the present investigation was to develop fast disintegrating tablet of Nortriptyline. Fast disintegrating tablet FDT were prepared by direct compression method. Fast disintegrating tablets containing 10 mg of Nortriptyline were manufactured using direct compression method. Experiments were evaluated for effects of formulation parameters...

Abstract The herbal drugs comprising major amount of active constituents with excellent bioactivity in vitro but less in vivo because of their poor lipid solubility and improper size of the molecules. This results in poor absorption and bioavailability of active constituents from herbal extract. A phyto-phospholipid complex vesicle (Phytosome) is t...

Various regulatory authorities like ICH, USFDA, Canadian Drug and Health Agency areemphasizing on the purity requirements and the identification of impurities in ActivePharmaceutical Ingredient’s (API’s). Qualification of the impurities is the process of acquiringand evaluating data that establishes biological safety of an individual impurity; thus...

Many researchers have attempted to use computer-aided design (C.A.D) and computer-aided manufacturing (CAM) to realize a scaffold that provides a three-dimensional (3D) environment for regeneration of tissues and organs. As a result, several 3D printing technologies, including stereolithography, deposition modeling, inkjet-based printing and select...

A facile and highly efficient one-pot synthesis of multisubstituted pyrrole derivatives is reported via a four-component reaction of amines, aldehydes, acetylacetone and nitromethane using Pr³⁺ doped CoFe2O4 as a catalyst in solvent free conditions at 90°C. The catalyst is easily recoverable using magnet and could be reused without a significant lo...

There is an opportunity for dramatically increased synergy between electronics and biology, fostered by the march of electronics technologies to the atomic scale and rapid advances in system, cell, and molecular biology. In the next decade, it may become possible to restore vision or reverse the effects of spinal cord injury or disease; for a lab-o...

Painful diabetic neuropathy (PDN) is a debilitating consequence of diabetes that may be present in as many as one in five patients with diabetes. The objective assessment of PDN is difficult, making it challenging to diagnose and assess in both clinical practice and clinical trials. No single treatment exists to prevent or reverse neuropathic chang...

The objective of this investigation was to prepare extended release tablet containing interpolyelectrolyte complex (IPEC) formation technique using Eudragit E100 and Eudragit L100 polymers andEE was selected as the cationic polymer. The other cationic types of Eudragit cannot be used because they are insoluble in aqueous solutions. And, EL, which i...

From the desk of Organizing Secretary & Program Co-ordinator We feel great pleasure in welcoming all of you on the occasion of One Day National Level Seminar on “Current Regulatory Scenario and Challenges for Food and Pharmaceutical Industry” which is Sponsored & Supported by Indian Pharmaceutical Association (IPA), Association of Pharmaceutical Te...

Objective: To optimize microwave assisted solvent free synthesis of Schiff bases of substituted benzaldehydes and aromatic amines (3-amino-6-bromo/Iodo-2-phenylquinazoline-4(3H) one) by using wetting reagent 000-ethoxyethanol. The goal of this study was to investigate the % yields and time required for the completion of reaction for Schiff bases by...

Development of solid dispersions of poorly water soluble drugs is one of the most widely used approaches to enhance the solubility as well as dissolution rate. In the current investigation, Ezetimibe is selected as model drug to improve the solubility and dissolution rate by solid dispersion method. Solid dispersions were prepared using solvent eva...

The environment in which businesses today compete is rapidly changing and the rate of change is increasing. They are locked in a battle to meet demanding customer expectations while competing successfully to gain market share and to grow revenues and profit. Individuals who know and work to master the concepts, techniques, and tools of quality know...

The herbal drugs comprising major amount of active constituents with excellent bioactivity in vitro but less in vivo because of their poor lipid solubility and improper size of the molecules. This results in poor absorption and bioavailability of active constituents from herbal extract. A phyto-phospholipid complex vesicle (Phytosome) is the promis...

According to ICH Q8 (R2) guidelines, an experimental work was planned for both spectroscopic and chromatographic method development and its validation. QbD approach was implemented for spectroscopic method development and its validation but chromatographic method development and validation was performed by conventional method. The research work dem...

ABSTRACT The scientific way to develop a simple and robust analytical HPLC method for the critical separationsis QbD approach. Quality-by-design (QbD) is a systematic approach to product or process development, which begins with predefined objectives, and uses science and risk management approaches to gainproduct and process understanding and ultim...

Fast dissolving tablet format is designed to allow administration of an oral solid dose form in the absence of water or fluid intake. Such tablets readily dissolve or disintegrate in the saliva. Nifedipine is a calcium channel blocker which is used as an antianginal and antihypertensive drug. The aim of this study was to improve the solubility of N...

Presently, the research using Zebrafish is expanding into areas such as pharmacology, clinical research as a disease model and interestingly in drug discovery. Mammalian models of absorption, distribution, metabolism and excretion (ADME)/pharmacokinetics and efficacy are expensive, laborious and consume large quantities of precious compounds. There...

ABSTRACT Oral disintegrating tablets are an emerging trend in novel drug delivery system and have received ever-increasing demand during the last few decades. Superdisintegrants are used to improve the efficacy of solid dosage forms. This is achieved by decreasing the disintegration time which in turn enhances drug dissolution rate. Disintegrants a...

ABSTRACT Green revolution, going green, environmental protection, sustainable life style, sustainable development, protecting our earth and many more has become a natural phenomenon in our everyday life. Green Purchasing, Green Productivity and Green Quality Management Systems are as tools used by many companies in various industries to follow this...

ABSTRACT Day by day dependency of people is rising on herbal or ayurvedic formulation not only for chronic ailments but also for number of acute problems. The assurance of therapy with minimal side effects has been proven that ayurvedic formulation is to be promising for cosmetic use too. In the scenario of changing food habits, stress level and de...

Quality by Design is the modern approach for quality of pharmaceuticals. The aim of the pharmaceutical development is to design a quality product and its manufacturing process to consistently deliver the intended performance of the product. Quality cannot be tested into products but quality should be built in by design. It is an essential part of t...

The objective of present investigation was to formulate floating matrix tablet of pregabalin using experimental design (Box-Behnken) to study the effects of swelling index and buoyancy properties. Formulation were prepared using three independent variables Sodium alginate (X1), Sodium bicarbonate (X2), Citric acid (X3) where floating lag time and s...

Now-a-days, graying of hair has become one of the most common problems for both men and women; this is due to the adoption of unhealthy lifestyle, pollution, stress, poor diet, hormonal changes and usage of detergents. The number of pigment granules naturally begin to decrease as a person ages. The person usually begins to gray between twenty-eight...

In the recent years, scientific and technological advancements have been made in the research and development of novel drug delivery systems by overcoming physiological troubles such as short gastric residence times and unpredictable gastric emptying times. Several approaches are currently utilized in the prolongation of the gastric residence times...