
Dr. Karuppaiya VimalaPeriyar University · Division of Cancer Nanomedine, Department of Zoology
Dr. Karuppaiya Vimala
M.Sc., M.Phil., Ph.D.,
About
44
Publications
15,973
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1,003
Citations
Introduction
Additional affiliations
September 2012 - June 2015
September 2010 - December 2011
Position
- IN VITRO STUDIES ON IDENTIFICATION OF PHYTOCHEMICALS FROM Prosopis juliflora TO INDUCE APOPTOSIS AND DEVELOPMENT OF SiRNA (E2F3) BASED GENE SILENCING THERAPY FOR BREAST CANCER
Description
- The aim of this study was to emphasize that the levels of E2F3 are increased in breast cancer and highlights the efficacy of siRNA targeted to E2F3.
Education
January 2012 - May 2014
July 2008 - December 2011
Publications
Publications (44)
This present study deals with the synthesis of gelatin-loaded zinc oxide nanocomposites (GN/ZnONCs) using Coccinia indica seed extract using the green preparative method. Synthesized GN/ZnONCs were confirmed by using various characterization techniques for chemical and physical properties. The results of the UV–Vis spectral absorption peak showed 2...
This present study deals with the synthesis of gelatin-loaded zinc oxide nanocomposites (GN/ZnONCs) using Coccinia indica seed extract using the green preparative method. Synthesized GN/ZnONCs were confirmed by using various characterization techniques for chemical and physical properties. The results of the UV-Vis spectral absorption peak showed 1...
Alzheimer's disease (AD) is a neurodegenerative disease characterized by amyloid-beta (Aβ) aggregation, neuroinflammation, oxidative stress, and dysfunction in the mitochondria and cholinergic system. In this study, the synthesis of chitosan-polylactic acid-loaded magnesium oxide nanocomposite (CH/PLA/MgONCs) was examined using the green precipitat...
Non-healing wounds are a serious complication of bacterial infections, and finding effective treatments is crucial. The novelty of the current study is the synthesis and characterization of gelatin-loaded magnesium hydroxide nanocomposite using an extract from Coleus amboinicus leaves. Investigations presented that the Ge/Mg(OH)2NCs exhibited highe...
The goal of this research was to determine the effect of dietary supplementation of vitamin C-loaded chitosan nanoparticles (VC-CSNPs) on the antioxidant activity, disease resistance, non-specific immunity, and gene expression of the whiteleg shrimp Litopenaeus vannamei which was fed for eight weeks and challenged with Vibrio harveyi. Antioxidants...
This study delved at how the natural substance dieckol (DCL) prevents prostate cancerous cells from proliferating and migrating by blocking the JAK/STAT3 signaling pathway in PC‐3 cells. For numerous tests, the cells were treated to DCL at a range of concentrations (0–20 μM) for 24 h. DCL mediated cytotoxicity was analyzed by MTT assay. To evaluate...
Alzheimer's disease (AD) is a neurodegenerative disease characterized by amyloid-beta (Aβ) aggregation, neuroinflammation, oxidative stress, and dysfunction in the mitochondria and cholinergic system. In this study, the synthesis of chitosan-polylactic acid-loaded magnesium oxide nanocomposite (CH/PLA/MgONCs) was examined using the green precipitat...
In every century of history, there are many new diseases emerged, which are not even cured by many developed countries. Today, despite of scientific development, new deadly pandemic diseases are caused by microorganisms. Hygiene is considered to be one of the best methods of avoiding such communicable diseases, especially viral diseases. Illness ca...
Retraction of ‘Smart rose flower like bioceramic/metal oxide dual layer coating with enhanced anti-bacterial, anti-cancer, anti-corrosive and biocompatible properties for improved orthopedic applications’ by N. Murugan et al. , RSC Adv. , 2015, 5 , 85831–85844, https://doi.org/10.1039/C5RA17747B.
Amyloid-β (Aβ) plaque formation, neuronal cell death, mitochondrial and cholinergic dysfunction are key indicators of Alzheimer's disease (AD). In this study, gelatin and polyvinyl alcohol (PVA) were tethered with magnesium hydroxide (Mg(OH)2) to synthesize nanocomposite (Ge/PVA/Mg(OH)2) through alkali co-precipitation. The characterization studies...
Recent treatments for malignant colon cancer in clinics are not efficacious and often result in deprived patient compliance due to short therapeutic efficacy and sturdy systemic side effects. To overcome this issue in the present study, we designed and formulated nanomaterial (PEGylated AuNPs-DOX@Kaempferol) for drug delivery system against colon c...
The development of multifunctional nanocomposite can greatly improve therapeutic effects to impair tumor proliferation.
In the present study, we developed a new class of dual-drug delivering system, the Selenium Mesoporous Silica (SMS)
nanocomposites to achieve molecular based tumor-targeting. A series of experiments have been performed to tether
M...
Cancer continues to be one of the leading causes of death worldwide and is a major obstacle to increased life expectancy. However, survival has not improved significantly with average cancer standard treatment strategies over the past few decades; survival rates have remained low, with tumor metastasis, adverse drug reactions, and drug resistance....
Current epidemiological data on global cancer incidence and mortality reveal the second leading cause of cancer death with a ~ 1 rate in 6. In 2018, it is estimated that 9.6 million people die of cancer worldwide. Timely diagnosis and management of cancer can knock down the burden of cancer worldwide patients. Conventional treatments are dispersed...
Chitosan (CS) is one of the most abundant biopolymers present on the wings of arthropod members like insects, prawns, etc. It has potential biomedical value in developing drugs and drug delivery systems. Such a biomedically valuable polymer was combined with mesoporous silica nanoparticles (MSNs) to form chitosan-poly (acrylic acid) coated mesoporo...
Correction for ‘Mitochondrial dysfunction-induced apoptosis in breast carcinoma cells through a pH-dependent intracellular quercetin NDDS of PVPylated-TiO 2 NPs’ by Thondhi Ponraj et al. , J. Mater. Chem. B , 2018, 6 , 3555–3570.
In this article, we report the validation of cancer nanotherapy for treatment of cancers using Quercetin (Qtn). There is healthy attention using nanoparticles (NPs) to deliver the drug of interest in vitro/in vivo. Highly developed NPs-based nano drug delivery systems (NDDS) is an attractive approach to target cancer cell apoptosis responsible for...
Development of nano-drug cum nano-carrier in a single platform seems to be conquered by almost are missionary fanaticism towards unraveling more and more about their bioavailability and anticancer activity at the molecular level. The present work is mainly focusing on bioformulation of silver nanoparticles (AgNPs) as a carrier for Berberine (BBR) a...
Lectins are proteins that show a variety of biological activities. Nevertheless, information on lectin from Gluttonous beauts and their anticancer activities are very limited. In this study, we purified a lectin from hemolymph of G. beauts and identified its molecular weight to be 66 kDa. The effect of lectin at different concentrations (μg/mL) on...
Modern therapies for malignant breast cancer in clinics are not efficacious and often result in deprived patient compliance owing to squat therapeutic effectiveness and strong systemic side effects. In order to overcome this, we combined chemo-photothermal targeted therapy of breast cancer within one novel multifunctional drug delivery system. Foli...
A 12- week feeding trial was conducted to determine the effects of dietary vitamin C levels on the growth performance, antioxidant ability, muscle composition and enzyme activity in freshwater prawn, Macrobrachium rosenbergii. The experimental basal diets were supplemented with M. rosenbergii at the rates of 0 (control), 25, 50, 75, 150 and 300 mg/...
A 12- week feeding trial was conducted to determine the effects of dietary supplementation with folic acid on growth performance, digestive enzyme activity, muscle composition, immune response, antioxidant ability and enzyme activity of freshwater prawn Macrobrachium rosenbergii. The experimental basal diets were supplemented with folic acid at the...
In the present study was conducted to examine the effects and interactions of dietary vitamin C levels on the growth performance, antioxidant ability, muscle composition and enzyme activity in freshwater prawn Macrobrachium malcolmsonii (M. malcolmsonii). Additional, the vitamins C was dietary supplemented for freshwater prawn M. malcolmsonii. The...
Selenium nanoparticles (SeNPs) have garnered a great deal of attention as potential cancer therapeutic payloads. However, the in vivo targeting drug delivery has been challenging. Herein, we describe the synthesis of PEG functionalized SeNPs (PEG-SeNPs) and its use as a cancer-targeted delivery vehicle to achieve enhanced anticancer efficacy. Croci...
The green synthesized Mn3O4 nanoparticles (manganese-oxide nanoparticles) using Ananas comosus (L.) peel extract was characterized by various techniques. HR-SEM photograph showed that manganese-oxide nanoparticles (Mn-oxide NPs) were spherical in shape, with an average size of 40–50 nm. The Zeta potential revealed the surface charge of Mn-oxide NPs...
Among the various nanoparticles explored for diverse biological applications, palladium nanoparticles still remain far too behind in the field of cancer therapeutics. Nanoparticles synthesized by chemical methods aggregate in physiological conditions hindering their biomedical applications. Therefore, in the present study, a plant mediated green sy...
The fact that many health problems arise due to the use of synthetic ingredients has directed research to investigate the importance of natural products. Many fruits and vegetables are of nutritional value and considered as health promoters, due to the presence of various phytochemicals. It is known that Dahlia x hybrida contain secondary metabolit...
Efficient delivery of therapeutics into tumor cells to increase the intracellular drug concentration is one of the key issues in cancer therapy. In this work, we designed pH responsive PEGylated palladium nanoparticles (PdNPs) as an anticancer drug nanocarrier system for effective drug delivery. The synthesis of the nanocarrier involved conjugation...
Metallic implants suffer from numerous problems such as stress shielding, poor prolonged osseointegration and corrosion under in vivo environments. Such problems are often faced by bone cancer patients as they receive orthopedic implants after cancerous bone resection. Unfortunately, there are no orthopedic materials developed so far that simultane...
New drug development
73P CODELIVERY OF E2F3 SIRNA AND DOXORUBICIN BY ZINC
OXIDE NANORODS (ZNONRS) PROMOTED BREAST TUMOR
SUPPRESSION
K. Vimala1, S. Kannan2
1Zoology, Bharathiar University, Coimbatore, INDIA
2Zoology, Periyar University, Salem, INDIA
RNAi on their own are not significantly taken up by most of the mammalian cells in a
way that blocks...
Epidermal growth factor receptor antibody (EGFRAb) conjugated silica nanorattles (SNs) were synthesized and used to develop receptor mediated endocytosis for targeted drug delivery strategies for cancer therapy. The present study determined that the rate of internalization of silica nanorattles was found to be high in lung cancer cells when compare...
The E2F3 transcription factor claims its role in controlling cell cycle progression. As reported earlier, nuclear E2F3 overexpression leads to development of bladder and prostate cancer in humans. Accordingly, the present investigation has been designed to assess to what extent E2F3 would be overexpressed in breast cancer. The aim of this study was...
ARCMED-D-11-00656). Background and Aims. The E2F3 transcription factor claims its role in controlling cell cycle progression. As reported earlier, nuclear E2F3 overexpression leads to development of bladder and prostate cancer in humans. Accordingly, the present investigation has been designed to assess to what extent E2F3 would be overexpressed in...
Backgrou nd and Aims. The E2F3 transcrip tion factor claims its role in controlling cell
cycle progr ession. As repor ted earli er, nuclear E2F3 overexpres sion lea ds to development
of blad der and prostat e cancer in huma ns. Acc ordingl y, the present investigation has been
designed to asse ss to wha t extent E2F3 would be overex pressed in brea...
Questions
Questions (3)
Can be used Swiss albino mice used for induced breast cancer xenograft animal model?
How much basepairs to detect the electrophoretic migration of siRNA formulations (naked siRNA for E2F3).
Surface modified nanoparticle used to carry for drug