Dr. Inayat Bashir Pathan

Government College of Pharmacy, Aurangabad · Department of Pharmaceutics

Aceclofenac is a nonsteroidal anti-inflammatory drug (NSAID) belonging to BCS Class II, has a constraint over its therapeutic benefits owing to its poor aqueous solubility. In this study, co-amorphous mixtures of Aceclofenac (ACE) with Aspartame (ASPA) of various molar ratios at specific milling times were produced through ball milling (BM) techniq...

PurposeCilnidipine (BCS class II drug) is a calcium channel blocker used in the treatment of hypertension. Poor water solubility, unreliable oral absorption, and poor bioavailability make it a probable candidate for designing novel drug delivery. The objective of the present investigation was to formulate, optimize, and study in vitro and in vivo p...

The present investigation involves preparation, optimization, and evaluation of the Cilnidipine (CLN) nanosuspension to enhance the dissolution rate and bioavailability. CLN nanosuspension was formulated by precipitation-ultrasonication method. The factors affecting the formulation of CLN nanosuspension were screened by Plackett–Burman design. The...

Mupirocin is a broad-spectrum antibiotic effective in treatment of skin infection (Impetigo), but the poor bioavailability limits its use as a conventional dosage form such as tablets, ointment and cream. The present investigation was aimed to design, optimize and evaluate Mupirocin (MC) loaded nanostructured lipid carriers (NLCs) based gel for top...

Quercetin (QCT) shows many therapeutic applications but is constrained to its oral use due to its low bioavailability. In this study, co-amorphous mixture QCT with different amino acids (Arginine, Glutamic acid, Aspartic acid, Tryptophan, and Glycin) of different molar ratios was prepared using ball milling method. The solubility and physicochemica...

Curcumin is known for its various therapeutic properties like anti-inflammatory, antioxidant, anticancer, however, its oral use is restricted due to its low solubility and dissolution rate in alkaline pH. In this study co-amorphous mixture of curcumin–ascorbic acid (CU:AA) of different molar ratios was prepared using the ball milling method. The so...

Migraine is the chronic neurological disorder identified by recurrent moderate to severe headache. Research was highlighted to formulate target drug delivery to treat migraine via the olfactory lobe through the intranasal route using ethosomal thermoreversible gel. Ethosomes were prepared by thin film hydration method using 32 factorial design. The...

Background Transdermal delivery of meloxicam is advantageous than the oral route in the treatment of pain management. Objective The goal of the present study is to formulate and evaluate meloxicam (MX) loaded nanosuspensions based gel for transdermal application. Methods The formulation parameters were optimized using Box Behnken design (BBD) tak...

Purpose: The purpose of this study was to develop and evaluate nanoemulsion-based gel (nanogel) for transdermal delivery of ketoprofen. Among the various excipients tested, oleic acid, tween 80 and ethanol were selected as oil, surfactant, and co-surfactant respectively. Methods: The nanoemulsions region was identified by constructing pseudo-terna...

The objective of the present investigation was to formulate curcumin loaded fish scale collagen (FSC)-hydroxypropyl methyl cellulose (HPMC K100) nanogel (CNG) for wound healing application. The curcumin nanoemulsion was prepared, characterized and loaded in FSC-HPMC nanogel. The nanogel was evaluated for ex-vivo permeation, in-vivo, skin irritation...

Curcumin has an excellent safety profile with varied pleiotropic actions, including anti-inflammatory, antioxidant, antitumoural, anticancer, and antimicrobial activities, with the potential for neuroprotective activity but the poor oral bioavailability limits its use as an oral dosage form. Hence the present investigation was aimed to fabricate, d...

The purpose of present study was to investigate the analgesic and anti-inflammatory activity of Lantana camara (Verbenaceae) leaf and bark extract. The methanol extract of Lantana camara (MELC) was screened for possible analgesic activity by acetic acid, hot plate and anti-inflammatory activity by carrageenan and histamine induced paw edema. The re...

Objective: The purpose of the present study is to develop an ion sensitive in situ nasal gel of Fluoxetine hydrochloride for brain delivery. A 32 factorial design was used to investigate effect of independent variable on dependent variables. Methods: Formulations were evaluated for gelation study, viscosity, gel strength, mucoadhesion strength, dru...

Objectives: Argemone mexicana have been widely studied for its several pharmacological benefits and has been used in traditional medicine to treat constipation like symptoms. The present study carried out to evaluate the extract for its diuretic and laxative potential. Methods: The aqueous extract of Argemone mexicana prepared using percolation me...

The purpose of the present study is to develop a thermoreversible intra nasal gel of Nortriptyline hydrochloride (NTH). The prepared formulations were evaluated for gelation temperature, viscosity, gel strength, mucoadhesion strength, and drug content, ex vivo drug permeation, and stability study. The results found that as the concentration of polo...

Objective: The purpose of the present study is to develop an ion sensitive in situ nasal gel of Fluoxetine hydrochloride for brain delivery. A 3² factorial design was used to investigate effect of independent variable on dependent variables. Methods: Formulations were evaluated for gelation study, viscosity, gel strength, mucoadhesion strength, dru...

Meloxicam is used to treat pain or inflammation in treatment of rheumatoid arthritis, osteoarthritis, and other joint diseases. The main objective of this study is to develop a potential of nanoemulsion for transdermal delivery of meloxicam for the treatment of rheumatoid arthritis. Solubility of the meloxicam was determined in different oils, surf...

The aim of the present work was to develop and characterisation of stable ethosomal formulation as a carrier for transdermal delivery of paroxetine hydrochloride. To prepare this ethosome, different concentrations of soya lecithin and ethanol was taken. Vesicular size, polydispersity index, zeta potential, entrapment effiency was determined by phot...

The aim of the present work was to develop and characterisation of stable ethosomal formulation as a carrier for transdermal delivery of paroxetine hydrochloride. to prepare this ethosome, different concentrations of soya lecithin and ethanol were taken. Vesicular size, polydispersity index, zeta potential, entrapment effiency were determined by ph...

Venlafaxine hydrochloride in situ nasal gel to brain delivery to provide sustained release by improving the residence time of the drug in the nose providing rapid antidepressant effect should improve patient compliance and treatment. The aim of the present study was to develop a venlafaxine hydrochloride (VLF) nasal in situ gel based upon the conce...

The aim of present study was to investigate the anti-diarrheal activity of Ficus microcarpa against experimentally induced diarrhea in rats. Albino rats were used for the experiment. Anti-diarrheal activity was determined by castor oil induced diarrhea. The extract of the bark administered orally at a dose 300 mg/kg and 600 mg/kg. The extract of Fi...

Hypertension is the most common cardiovascular disease; its prevalence increases with advancing age. Oral route has the drawbacks namely poor bioavailability due to hepatic metabolism (first pass) and the tendency to produce rapid blood level spikes (both high and low), leading to a need for high and/or frequent dosing, which can be both cost prohi...

Aim: Venlafaxine hydrochloride, commonly used as antidepressant, has poor bioavailability due to extensive first pass metabolism. The objective of present study is to develop novel method of preparing compressed tablets for venlafaxine hydrochloride with high porosity which dissolves rapidly in mouth, using camphor as sublimating agent. Methods: A...

For locally acting intranasal drugs, an extended residence time in the nasal cavity is desirable and related to a prolonged effect. The aim of the present work was to design a nasal delivery system with improved mucoadhesive properties that could provide prolonged retention time for the treatment of allergic rhinitis. A 32 factorial design was used...

Ficus Microcarpa L. is a medicinal plant used for the treatment of various body pains in India traditionally. It is also used in various conditions like diabetes, ulcers, burning sensations, haemorrhages, leprosy, itching, liver disease. The methanol extract of its leaves was investigated for its analgesic and anti-inflammatory activities in animal...

The aim of the present study was to develop and characterize nanoemulsion formulation of tamoxifen citrate (TAM) for transdermal drug delivery system. Various oil-in-water nanoemulsions were prepared by the aqueous titration method. The prepared nanoemulsions were subjected to thermodynamic stability study and characterized for droplet size, transm...

The purpose of this research was to obtain directly compressible agglomerates of aceclofenac-paracetamol containing desired ratio of drugs using a crystallo-co-agglomeration technique. Crystallo-co-agglomeration is an extension of the spherical crystallization technique, which enables simultaneous crystallization and agglomeration of 2 or more drug...

The main objective of this study was to develop a potential of nanoemulsion formulation for transdermal delivery of tamoxifene citrate for breast cancer. Of the oils tested, arachis oil was chosen as the oil phase of the nanoemulsion, as it showed a good solubilizing capacity and excellent skin penetration rate of drug. The nanoemulsion area was id...

The aim of the present study was to evaluate the stability of tamoxifen citrate using novel nanoemulsion formulation. Optimized nanoemulsion formulation of tamoxifen citrate was prepared by spontaneous emulsification method (aqueous titration method). Stability studies were performed for the period of 3 months. Droplet size, viscosity and refractiv...

Topical gels of valdecoxib were prepared using two different gelling agents (viz, carbopol and hydroxypropylmethylcellulose). Formulations were evaluated for pH, rheological behavior, drug content and in vitro drug diffusion. Formulations of both the gelling agents appeared to be non-Newtonian and pseudo plastic. Drug content was found to be high (...

In this study, matrix-type transdermal patches containing furosemide were prepaid using ethylcellulose and polyvinylpyrrolidone by solvent evaporation technique. Effect of polyvinylpyrrolidone and penetration enhancers on the in vitro permeation of drug through human cadaver skin was investigated. Incorporation of essential oils and propylene glyco...

Skin as an important site of drug application for both local and systemic effects. However in skin, the stratum corneum is the main barrier for drug penetration. Penetration enhancement technology is a challenging development that would increase the number of drugs available for transdermal administration. The permeation of drug through skin can be...

Ethylcellulose transdermal patches for diclofenac diethylamine (DDA) using chemical penetration enhancers developed. Effect of drug loading and penetration enhancers on the in vitro permeation of drug through cellophane membrane and rat skin was investigated. Incorporation of penetration enhancers enhanced the moisture content, moisture uptake capa...

Ethylcellulose transdermal patches for diclofenac diethylamine (DDA) using essential oils as penetration enhancers developed. Effect of drug loading and penetration enhancers on the in vitro permeation of drug through cellophane membrane, rat skin and human cadaver skin was investigated. Incorporation of essential oils enhanced the moisture content...