Dr Mohammad Haneef

Dr Mohammad Haneef
Integral University · Department of Bioengineering

Ph.D in Bioinformatics

About

16
Publications
16,404
Reads
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363
Citations
Citations since 2016
4 Research Items
348 Citations
2016201720182019202020212022020406080
2016201720182019202020212022020406080
2016201720182019202020212022020406080
2016201720182019202020212022020406080
Introduction
My research work is intensive on “Interactions of Cigarette Smoke Carcinogens and their derivatives with Cell Cycle Regulatory Proteins: An assessment of Cancer Risk” particularly CDKs (Cyclins dependent Kinases) and cyclins and other cell cycle regulatory proteins for assessment of cancer risk.My current research effort is basically focused on the analysis and characterization of the protein-conformations and their functional changes during protein-protein and protein–ligand interaction.
Additional affiliations
January 2012 - present
Integral University
Position
  • Professor (Assistant)
Description
  • My current research thrust is analysis of the protein- conformations, p-p interaction, protein–ligand interaction by insilico . As academic credentials are concerned, I ARS-NET, and GATE qualified individual with papers in peer-reviewed journals.
August 2008 - present
Integral University
Position
  • Senior Instructor in Microbiology LAB
Description
  • I have three years 4 Months microbiology research lab experience in the following: experimental works: growth kinetics of microorganisms, antibacterial and antifungal assays,
Education
July 2009 - December 2014
Aligarh Muslim University
Field of study
  • Bioinformatics and Microbiology

Publications

Publications (16)
Article
Full-text available
Cell cycle is maintained almost all the times and is controlled by various regulatory proteins and their complexes (Cdk+Cyclin) in different phases of interphase (G1, S and G2) and mitosis of cell cycle. A number of mechanisms have been proposed for the initiation and progression of carcinogenesis by abruption in cell cycle process. One of the impo...
Article
Full-text available
In osteosarcoma tissue, both MMP-2 and MMP-9 are over expressed compared to their expression in non-affected stromal tissue. Hence, gelatinases are attractive targets for anti-osteosarcoma drugs. To study the inhibitory activity of compounds isolated from Ageratum houstonianum against MMP-2 and MMP-9 by in-silico approach. We performed docking stud...
Article
Full-text available
Recently, bioinformatics has advanced to the level that it allows almost accurate prediction of molecular interactions that hold together a protein and a ligand in the bound state. For instance, the program AutoDock has been developed to provide a procedure for predicting the interaction of small molecules with macromolecular targets which can easi...
Article
Full-text available
DNA damage occurs almost all the times in cells, but is repaired also continuously. Occurrence of all these mutations and their accumulation in one cell which finally becomes tumorigenic/carcinogenic appears possible if the DNA repair mechanism is hampered. We hypothesize that alterations in DNA repair pathways, either all or at least at one i.e. g...
Article
Full-text available
An increasing number of research evidences indicate linkage between type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD); the two most common diseases of aging. In addition, T2DM and AD also share some common pathophysiological features. Therefore, dual therapy that targets both the diseases can be regarded as a beneficial approach. Acetylc...
Article
Full-text available
Across the world, a heavenly use of chemical fertilizer is major environmental issue in agricultural fields for sustainable growth of plants. Hence, the chemical fertilizers show adverse environmental effects in human life along with degrade the quality of soil fertility and polluting the water. So there is a need to develop an alternative approach...
Article
Full-text available
The aroma and fragrance industry is billion dollar world market which grows at the rate of 18 billion per year and the essential oil in International trade increases 10% annually.In both developing and developed countries the requirement of aromatic plants containing essential oil has risen exponentially and it is expected that in future the demand...
Article
Full-text available
At the present time, treatment of two most common degenerative disorders of elderly population i.e., Type 2 Diabetes Mellitus (T2DM) and Alzheimer’s disease (AD) is a major concern worldwide. As there are several evidences that proved strong linkages between these two disorders, the idea of using dual therapeutic agent for both the diseases might b...
Article
Full-text available
Fullerenes have attracted considerable attention due to their unique chemical structure and potential applications. In this study fullerenes (C20 to C180) were interacted with different forms of DNA i.e. A, B and Z-forms. And no such change in the binding score was observed with the change in the sequence of DNA. In fact, binding score increases wi...
Article
Full-text available
Arsenic is the most toxic metalloid present in the natural environment in both organic and inorganic arsenic forms. Inorganic arsenic is often more hazardous than the organic form. Arsenite and arsenate compounds are the major inorganic forms which are toxic causing severe human health dysfunction including cancer. Excretion of arsenic from the sys...
Article
Full-text available
Arsenic is the most toxic metalloid present in the natural environment in both organic and inorganic arsenic forms. Inorganic arsenic is often more hazardous than the organic form. Arsenite and arsenate compounds are the major inorganic forms which are toxic causing severe human health dysfunction including cancer. Excretion of arsenic from the sy...
Article
The present study emphasizes the molecular interactions between human brain acetylcholinesterase (AChE) and the natural ligand Huperzine-B and its comparison to ‘AChE-Tolserine interactions’. Docking between Huperzine-B and AChE was performed using ‘Autodock4.2’. Hydrophobic interactions and hydrogen bonds both play an equally important role in the...
Article
Full-text available
Recently, bioinformatics has advanced to the level that it allows almost accurate prediction of molecular interactions that hold together a protein and a ligand in the bound state. For instance, the program AutoDock has been developed to provide a procedure for predicting the interaction of small molecules with macromolecular targets which can easi...

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