Dr Umar Farooq Gohar

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• Ph D
• Assistant Professor at Government College University, Lahore

Caralluma edulis (Apocynaceae) is well known for its medicinal properties, including antioxidant, anti-inflammatory, antimicrobial, and hypoglycemic activities, and has been used as a valuable remedy in various cultures. This scientific study aimed to validate the efficacy of C. edulis in lowering lipid profiles using two hyperlipidemic animal mode...

This study builds upon prior research where the principal components, phenethylamine and α-tocopherol, of Lavandula stoechas (L. stoechas) were identified as responsible for its nootropic potential. The current investigation aimed to determine the acute and xchronic toxicity profiles of the active fraction of L. stoechas (AfL.s) in albino mice. Acu...

Nonsterile pharmaceutical finished products are not manufactured through aseptic processes so are not completely free from microbial contaminations, which can impact their efficacy due to the degradation of active ingredients. The aim of present study was to enumerate, isolate and identify the microbial contaminations in non-sterile liquid finished...

Lavender being a member of the mint family, is cultivated worldwide because of its charming flowers and beautiful scent. It is cultivated throughout the world but its chief producers are Bulgaria (52%), France (26%) and China (12%). Lavender has countless applications in the field of medicine and can be used as an antibiotic, inhaled anesthetic and...

Hyoscyamus niger is known as black henbane found in most regions of Asia and Europe. This plant is hallucinogenic that includes anticholinergic compounds. Direct ingestion of this plant can cause psychophysical deterioration and even it causes death. The intoxication is similar to the one caused by atropine. This plant causes hypertension, irregula...

Dioscorea, wild yam or yam plants are member of the family Dioscoreaceae and genus Dioscorea. This genus has a variety of over 600 species of flowering plants. Its nutritive material is stored in tubers (single or more) of variable shapes and colours. This genus is from the division Monocotyledon with more than 350 species. An herb that may be annu...

Plantago ovata Forsck., is a herbaceous annual medicinal plant, usually known as commonly psyllium or Isabgol. It has been used traditionally used for various purposes in folk medicines. It is mostly grown for mucilaginous seeds husk, which is most effect laxative. It is native to Asia and Europe and has rooted throughout the world in tropical and...

The genus Mentha belongs to the family Lamiaceae has many species and cultivars depending on the geographical origin and distribution. Mentha is directly used as a flavoring agent in foods and culinary items. The extract of mint has strong medicinal properties due to the presence of various terpenoids and essential oils which is the indirect use in...

Aniseed is a medicinal flowering plant, scientifically known as Pimpinella anisum L, belonging to a wide spectrum genus of herbaceous plants, which has its origin from Eastern Mediterranean area. The plant requires care while growing and needs fertile, light and loam sandy soil with a pH of 6.3–7.3. The optimum temperature requirements are 8–25 °C,...

The increasing demand for pharmaceutically important metabolites from plants has shifted the focus of research toward plant tissue culture. Micropropagation has become vital for the rapid multiplication of medicinal plants for the production of essential metabolites and pharmaceutically important compounds. Callus and cell suspension cultures, shoo...

The expanding global cancer burden necessitates a comprehensive strategy to promote possible therapeutic interventions. Nanomedicine is a cutting-edge approach for treating cancer with minimal adverse effects. In the present study, chitosan-silver nanoparticles (ChAgNPs) containing Eugenol (EGN) were synthesized and evaluated for their anticancer a...

Dengue fever is a viral infection caused by the dengue virus and is a growing concern for public health worldwide, particularly in tropical and subtropical regions. This study aimed to assess the diagnostic accuracy of a commercially available NS1 ELISA kit for dengue fever in Pakistan using multiplex qRT-PCR as the gold standard. The study recruit...

Significant efforts and initiatives were already made in the health care systems, however in the last few years; our world is facing emergences of viral infections which potentially leading to considerable challenges in terms of higher morbidity, mortality, increased and considerable financial loads on the affected populations. Over ten major epide...

Hundreds of the plants have been explored and evaluated for antioxidant and anti-amnesic activities, so far. This study was designed to report the biomolecules of Pimpinella anisum L. for the said activities. The aqueous extract of dried P. anisum seeds was fractionated via column chromatography and the fractions so obtained were assessed for the i...

Irrational and injudicious use of antibiotics, easy availability of them as over-the-counter drugs in economically developing countries, and unavailability of regulatory policies governing antimicrobial use in agriculture, animals, and humans, has led to the development of multi-drug resistance (MDR) bacteria. The use of medicinal plants can be con...

Antibiotic resistance development and spread in clinical pathogens is an immense threat that has already outpaced the discovery and development of novel and more effective antibiotic drugs. Recently the focus has been shifted to medicinal plants as novel therapeutic options for reversing antibiotic resistance by targeting different resistance mecha...

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Background: Thalassemia is a genetic defect characterized by abnormal hemoglobin in red blood cells and resultant anemia. Currently, regular blood transfusion or fetal hemoglobin inducers or a combination of these is clinically used to manage these patients. Aim: To observe effectiveness of Hydroxyurea in β-Thalassemia patients, particularly focusi...

Chromium is one of the highly toxic heavy metals and a chief pollutant in soil and water. Present study describes an efficient biosorption system for the chromium removal from water using mycelia of Aspergillus oryzae. The effect of different variables like pH, initial chromium conc., size of biomass and time of contact on the chromium uptake by A....

Achyranthes aspera seeds and leaves are believed to reverse antibiotic resistance and increase the efficacy of current drugs. Achyranthes aspera seeds and leaves contain many secondary metabolites needed for the redressal of antibiotic resistance. In the present study, seven different antibiotics were used against five different strains of bacteria...

Response surface methodology Water quality analysis In the present investigation, dyes effluent samples were randomly selected and subjected to biological treatment. The physicochemical characterization such as pH, turbidity, chemical oxygen demand (COD) biological oxygen demand (BOD), conductivity, color and total dissolved solids (TDS) were studi...

The past 30-35 years have witnessed rapid development in the field of biotechnology; the applications which were once only anticipated ideas of technological expertise have finally come to fruition. With the increase in population, changing diet patterns, changing purchase priorities and urbanization conventional methods of improving food productiv...

The rapidly growing global burden of cancer poses a major challenge to public health and demands a robust approach to access promising anticancer therapeutics. In parallel, nanotechnology approaches with various pharmacological properties offer efficacious clinical outcomes. The use of new artificial variants of nanosponges (NS) as a transporter of...

The rapidly growing global burden of cancer poses a major challenge to public health and demands a robust approach to access promising anticancer therapeutics. In parallel, nanotechnology approaches with various pharmacological properties offer efficacious clinical outcomes. The use of new artificial variants of nanosponges (NS) as a transporter of...

Introduction: The conventional interferon therapy of hepatitis C virus has been substituted substantially with sofosbuvir and daclatasvir due to constraints in efficacy and tolerability. This study aimed diagnostically to monitor the effectiveness and side effects of direct-acting antivirals in the management of HCV infections. Methodology: This...

Rapid and unchecked industrialization and the combustion of fossil fuels have engendered a state of fear in urban settlements. Smog is a visible form of air pollution that arises due to the over-emissions of some primary pollutants like volatile organic compounds (VOCs), hydrocarbons, SO2, NO, and NO2 which further react in the atmosphere and give...

Throughout history, nature has been acknowledged for being a primordial source of various bioactive molecules in which human macular carotenoids are gaining significant attention. Among 750 natural carotenoids, lutein, zeaxanthin and their oxidative metabolites are selectively accumulated in the macular region of living beings. Due to their vast ap...

Lavandula Stoechas L. is widely known for its pharmacological properties. This study was performed to identify its biomolecules, which are responsible for enhancement of memory. L. stoechas aqueous extract was first purified by liquid column chromatography. The purified fractions were analyzed for in vitro anti-cholinesterase activity. The fraction...

Podophyllotoxin, along with its various derivatives and congeners are widely recognized as broad-spectrum pharmacologically active compounds. Etoposide, for instance, is the frontline chemotherapeutic drug used against various cancers due to its superior anticancer activity. It has recently been redeveloped for the purpose of treating cytokine stor...

COVID-19 is a respiratory disorder caused by a previously unidentified Betacoronavirus, SARS-CoV-2. This infection emerged in December 2019, from a local sea market in Wuhan (China), and soon was declared a global pandemic. The novelty of the virus posed diagnostic and therapeutic challenges at first; however, serological tests, radiography analysi...

Advance bacteria have acquired several mechanisms to deal with antibiotics and are becoming more powerful with the passage of time. Klebsiella pneumoniae belonging to the class of Enterobacteriaceae is also a part of this race and is becoming resistant to almost all types of antibiotics. Colistin which was the last option for treatment is now becom...

Development of antibiotic resistance in bacteria is one of the major issues in the present world and one of the greatest threats faced by mankind. Resistance is spread through both vertical gene transfer (parent to offspring) as well as by horizontal gene transfer like transformation, transduction and conjugation. The main mechanisms of resistance...

The effects of three hydrophilic polymers, namely, carboxymethyl cellulose sodium (CMC-Na), polyvinyl alcohol (PVA) and poloxamer-188 (PXM-188) on the solubility and dissolution of diflunisal (DIF) in complexation with β-cyclodextrin (βCD) or hydroxypropyl β-cyclodextrin (HPβCD), were investigated. The kneading method was used at different drug to...

In present study, different leaves, roots and floral extracts i.e. methanol, chloroform, and n-hexane of Ranunculus laetus (R. laetus) were tested to find out their bioactivities. The yield obtained from the methanolic extracts was 15.12%, 20.5% and 31.3%, while that of chloroform extracts 4.15%, 16.15% and 29.6% and that of n-hexane extract 4.52%,...

Piper betle leaf is deep green heart shaped belongs to family Piperaceae. This plant is used for the treatment of different diseases like diabetes, cancer, inflammatory responses, oxidant injuries etc. in the present study ethanolic extract of Piper betle leaf was used (300 mg/kg). Diabetes was induced in male albino rats by using Alloxan (150 mg/k...

Background Dual antiplatelet therapy causes gastric bleeding and requires incorporation of gastro protective agent. Objectives: Formulation and invitro evaluation of multistage release bilayer tablets containing three active ingredients (clopidogrel, aspirin & ranitidine) for site specific release i.e. stomach & duodenum. Method: Here, immediate re...

Flurbiprofen, an NSAID, is a water insoluble drug that is also notorious for gastric irritation and inflammation. This study was aimed at using a natural gastrprotective oil as the internal phase to develop flurbiprofen micro emulsion (ME) to improve it solubility and ameliorate its gastric side effects. Upon screening of ME components for drug sol...

Background and Objectives: Dyslipidemia is gaining much attention among healthcare professionals because of its high association with the malfunctioning of a number of normal physiological and metabolic processes in the body. Obesity is directly interconnected with dyslipidemia and is said to be a denouement of hyperlipidemia and, if left untreated...

Resealed erythrocytes have been explored in various dimensions of drug delivery, owing to their high biocompatibility and inability to initiate immune response. The present research was designed to evaluate the drug delivery potential of erythrocytes by loading a hydrophobic anti-malarial drug, Artemether. Three different loading techniques were ap...

Renal Tubular Acidosis is characterized by the failure of kidney to excrete acid in urine by affecting the reabsorption of bicarbonate ion or excretion of ammonia. Different treatments are used to treat underlying cause but the first goal of treatment is to neutralize the acid in blood. Shohl's solution (bicitra, polycitra & polycitra K) is used to...

The aim of present study was to determine the self-medication trends in children by their parents, knowledge of selfmedication and their attitude towards this practice. Factors that enforced them to do this practice were also determined along with their source of information about drug use. Total 400 parents were randomly selected and interviewed....

One of the greatest challenges in the field of medicine is the effective and efficient drug delivery to the defected cells or tumor cells with minimal toxic side effects. Due to lacking properties like specification and solubility of drug molecule, patient requires high doses of the drug to attain the desired therapeutic effect for the disease trea...

Voriconazole is a broad-spectrum antifungal drug. It belongs to triazole group, and is available in market as oral as well as intravenous (IV) forms. It is highly effective against a number of clinically important fungi causing invasive infections. Its pharmacokinetic profile is non-linear with extensive inter-individual and intra-individual variab...

Taxol is naturally obtained from the inner bark of several species Taxus. But its accumulation in the Taxus is very low. Alternative way to produce taxol is through fermentation processes by using taxol producing fungi. In the present study, about 150 endophytic fungal strains were isolated from ten different indigenous plants. These strains were s...

The lab scale optimization of lovastatin production through submerged fermentation by Aspergillus terreus has been described. Fermentation experiments for the screening of fermentation media showed that A. terreus NRRL 265 utilized fermentation medium (M2) for maximum production of lovastatin i.e., 212.54 mg/L & 120.98 mg/L in the fermentation brot...

The objective of this study was to determine the lipase production, from locally isolated Bacillus spp., of soil, under different cultural conditions and optimize them. Mustard oil cake was found as an ultimate source of carbon for the production of lipase (1.8 U/ml). Among different nitrogen sources yeast extract was found to be the ideal one for...

In the present study, cephalosporin was produced through submerged fermentation in 250 ml Erlenmeyer flask. About one hundred fungal strains were isolated and screened for maximum productivity of the antibiotic cephalosporin. Among these, the strain IIB-10 identified as Acremonium chrysogenum was found to have maximum production of cephalosporin wh...