Dr. Chellasamy Panneerselvam

• Ph.D.,
• Professor (Associate) at University of Tabuk

Breast cancer (BC) is the most prevalent form of malignancy among women on a global scale, ranking alongside lung cancer. Presently, conventional approaches to cancer treatment include surgical procedures followed by chemotherapy or radiotherapy. Nonetheless, the efficacy of these treatments in battling BC is often compromised due to the adverse ef...

The current research aspires to explore the novel utilization of Annona squamosa bark extract consisting of various phytochemical components as a capping agent with zinc acetate as a precursor to form zinc oxide particles. The origination of ZnO NPs is implied by the UV-Visible absorption band at 357 nm and the distinctive XRD peaks at the appropri...

Lung cancer, particularly non-small cell lung cancer (NSCLC), is a leading cause of cancer-related deaths worldwide. This study investigates the molecular mechanisms behind the anti-cancer effects of the tropical desert plant Retama raetam (R. raetam) on the A549 NSCLC cell line. The research examined R. raetam's anti-proliferative effects, cytotox...

Iron oxide nanoparticles (Fe3O4 NPs) have gained considerable attention due to their diverse applications in various fields. However, concerns about their potential toxic effects on the environment and living organisms have also emerged. In this study, we synthesized and characterized Fe3O4 NPs and assessed their immunotoxicity on the coelomocytes...

Worldwide, dengue, Zika, and Chikungunya have the greatest potential for epidemics since they are primarily spread by the bites of infected Aedes mosquitoes. There is an urgent need for eco-friendly control tools on dengue vectors. The present research suggested a novel method of mangrove-mediated synthesis of silver nanoparticles (AgNPs) employing...

The exponential growth of obesity rates is a pressing issue, as it is now firmly established as a primary driver behind the development of metabolic disorders. Natural products are crucial in drug discovery, prompting an increasing need for further research on bioactive compounds to understand molecular and pharmacological mechanisms and expand ava...

Storage grain infestation is a critical problem, with insect pests and rodents causing economic losses and reductions in the quality of food grains and food products. It has been assessed as affecting 9% of goods in developed countries and more than 20% of goods in developing countries. The chemical insecticides used for storing products protect ag...

In this research, cell-free extracts from magnesite mine-isolated actinobacterial strain (M10A62) were used to produce silver sulfide nanoparticles (Ag2SNPs). Streptomyces minutiscleroticus JX905302, actinobacteria capable of producing Ag2SNPs, was used to synthesize Ag2NPs. The UV–vis range was used to confirm the biosynthesized Ag2NPs; Fourier tr...

Surgery, chemotherapy, and radiation therapy are all forms of cancer treatment, as well as more recent methods including interventional radiology and immunotherapy. In this study, we synthesize a novel chitosan (CH) nanocomplex (NC)-based polysaccharide Krestin (PSK) for drug delivery. This technique was used to develop PSK@CH@NC. According to the...

Storage grain infestation is a critical problem, with insect pests and rodents causing economic losses and reductions in the quality of food grains and food products. It has been assessed as affecting 9% of goods in developed countries and more than 20% of goods in developing countries. The chemical insecticides used for storing products protect ag...

In this investigation, using the biogenic approach, Plectranthus vettiveroides root extract was used to synthesize chitosan nanoparticles ( P. vettiveroides CNPs). The produced nanoparticles (NPs) were characterized using UV-visible (UV/vis) absorption spectroscopy, Fourier transform infrared (FTIR) spectroscopy, and scanning electron microscopy (S...

The biogenic manufacture of nanoparticles utilising endophytic fungus is an eco-friendly, cost-effective, and secure alternative to constructing chemical methods. The prime focus of the study was to fabricate ZnONPs using the biomass filtrate of endophytic Xylaria arbuscula isolated from Blumea axillaris Linn. and to evaluate their biological prope...

The present study was designed to green synthesize titanium dioxide nanoparticles (G-TiO2 NPs) using Salacia reticulata leaf extract as a reducing and capping agent to assess antidiabetic, anti-inflammatory, and antibacterial effects as well as toxicity evaluation in zebrafish. Besides, zebrafish embryos were employed to study the effect of G-TiO2...

This study focused on testing manufactured silver nanoparticles (AgNPs) against the malaria pathogen Plasmodium falciparum and the malaria vector Anopheles stephensi using the plant filtrate from Madhuca longifolia. The M. longifolia leaf extracts were used to synthesize the AgNPs, which were then subjected to several physicochemical methods to det...

Mosquitoes serve as reservoirs for viruses and other microorganisms, posing a significant health-related issue for both humans as well as livestock. Control of these deadly disease-producing mosquito vectors is of paramount importance. The chemical analysis of Parmotrema reticulatum was examined by GC–MS. Further, lichen-mediated AgNPs were confirm...

The birch tree-derived pentacyclic lupine type-triterpenoid Betulinic acid has demonstrated a variety of biological activities BetA is known for its harmlessness on normal healthy cells. However, recent investigations have indicated that BetA can cause cellular changes in mouse normal embryonic fibroblasts even with a minimal concentration. This re...

Graphitic-carbon nitride (g-C3N4) (GCN) has emerged as the most promising material for the fabrication of next generation cutting–edge electronic and optoelectronic devices, due to its excellent and promising electrical and physicochemical properties. In this work we report on strategies to enhance the electrical conductivity of GCN thin films thro...

Conventional Zinc oxide nanoparticle (ZnO NPs) synthesis techniques employ toxic elements that are hazardous to both human being and the environment. When compared to previous approaches, the green chemistry technique for nanoparticle synthesis is faster, cost-effective, more environmentally friendly, and less hazardous. In this work, we used a gre...

This work investigates the sustainable route for the preparation of copper oxide nanoparticles (CuO NPs) from Piper betle leaf extract via the green synthesis route. The unique physico-chemical properties of synthesized P–CuO NPs was characterized by XRD, FTIR, UV–visible spectroscopy, TEM and EDAX and DLS. The synthesized P–CuO NPs mostly were in...

The corn silk (CS) is composed of the thread-like stigmas of female inflorescences of Zea mays L. and represents an important waste material from maize crop production that can be recycled in further applications. In this research, the CS was used for the bio-fabrication of Ag nanoparticles (AgNPs) that were evaluated against (I–V) larval instars a...

Mosquitoes are important vectors, which transmit many communicable diseases throughout the world. Synthetic insecticides, such as organophosphate and pyrethroids, are commonly used for their control in the vector control program. Insecticidal compounds from natural sources, notably from plants and synthesized nanoparticles (NPs) are promising tools...

The main aim of the study, green route to the synthesis of silver nanoparticles (AgNPs) is a new technique that has recently gained popularity due to several advantages over conventional chemical methods. The objective of the study was focused on the green synthesis of AgNPs using Barleria buxifolia leaf extract via a rapid and eco-friendly ultraso...

The main aim of the study, green route to the synthesis of silver nanoparticles (AgNPs) is a new technique that has recently gained popularity due to several advantages over conventional chemical methods. The objective of the study was focused on the green synthesis of AgNPs using Barleria buxifolia leaf extract via a rapid and eco-friendly ultraso...

Cellular breakdown in the lungs is the most well-known human disease, and it is also the leading cause of death. The majority of anticancer therapies have substantial toxicity and serious health issues because of the multidrug resistance upon treatment with various drugs. Thus development of successful therapeutic solutions remains as a key factor...

Design and development of new generation smart sensors for medical applications have gained considerable interest of research community in the recent past. In this work, we propose the fabrication of highly sensitive paracetamol sensors-based iron oxide nanoparticles intercalated with graphitic carbon nitride (g-C 3 N 4) (GCN) via insitu chemical s...

Mosquito borne diseases are on the rise because of their fast spread worldwide and the lack of effective treatments. Here we are focusing on the development of a novel anti-malarial and virucidal agent with biocidal effects also on its vectors. We have synthesized a new quinoline (4,7-dichloroquinoline) derivative which showed significant larvicida...

Herein, we report a strategy to synthesize zinc oxide nanoparticles (ZnO NPs) from Clitoria ternatea flower extract through green synthesis platform. The bioactive components in the C. ternatea flower extract acts as a stabilizing and capping agent, which enables the synthesis of ZnO NPs without the use of chemical reagents. Synthesis of of ZnO NPs...

Organic electronic devices with low cost, wearable and flexible electrodes have become forefront of scientific and technological development of optoelectronic research. Electrode fabrication techniques with superior multi-functionalities such as conductivity, optical transparency, and mechanical flexibility remains a biggest challenge for research...

In the present work, an improved class of protein functionalized fluorescent 2D Ti3C2 MXene quantum dots (MXene QDs) was prepared by hydrothermal method. Exfoliated 2D Ti3C2 sheets is used as the starting precursor and transport protein bovine serum albumin (BSA) is used to functionalize the MXene QDs. BSA functionalized MXene QDs exhibited excelle...

The red palm weevil, Rhynchophorusferrugineus (Olivier 1790) caused a high lose in date palm in gulf region especially in Saudi Arabia. Previous estimations of palm weevil haplotype diversity in Saudi Arabia was not satisfactory because of choice of marker and small sampling area. Assessing haplotype diversity using COI gene was found ineffective....

The thread of resistance development among insects and bacterial pathogens has created the need for developing highly effective and safe drugs. In this research, we studied the toxicity of AC-Ag nanocomposite prepared from cigarette butts (CBs) on key mosquito vectors, Anopheles stephensi, Aedes aegypti and Culex quinquefasciatus, and gram-negative...

Herein, we report a strategy to synthesize zinc oxide nanoparticles (ZnO NPs) from Clitorea ternatea flower extract through green synthesis platform. The bioactive components in the C. ternatea flower extract acts as a stabilizing and capping agent, which enables the synthesis of ZnO NPs without the use of chemical reagents. Synthesis of of ZnO NPs...

Mosquitoes are a great menace for humankind since they transmit pathogenic organisms causing Malaria, Dengue, Chikungunya, Elephantiasis and Japanese encephalitis. There is an urgent need to discover new and novel biological tools to mitigate mosquito-borne diseases. To develop bioinsecticides through newly developed nanotechnology is another optio...

Marine algae contain many bioactive constituents. In the current research, the brown seaweed Sargassum muticum was collected from Red Sea and its extract used as a capping agent for the formulation of biocompatible stable silver nanoparticles (AgNPs). The seaweed-fabricated AgNPs were studied through UV–vis, TEM, XRD, EDX, FTIR and Zeta potential a...

Herein, we present fabrication of a novel methane sensor based on poly (3,4-ethylenedioxythiophene:poly (styrene sulfonic acid)) (p-PEDOT-PSS) and gold nanoparticles (AuNPs) treated with dimethyl sulfoxide (DMSO) and Zonyl using a spin coating technique. The nanocomposite films were further post treated with H2SO4 to improve the charge transport me...

Arthropods are highly effective vectors for a number of life threatening pathogens, parasites, viruses etc., across the world. Hyalomma dromedarii Koch is the prominent tick species infesting camels. Therefore, in this research we studied the insecticidal efficacy of commercially available deltamethrin (DM), Cypermethrin (Cym) and α-Cypermethrin (α...

Crithmum maritimum L. (Apiaceae), also known as sea fennel, is a halophythe plant colonizing cliffs and coastal dunes and pebble of the Mediterranean sea and Atlantic ocean. Based on previous reports, this herb produces an essential oil endowed with insecticidal effects against various pests and insect vectors. In the present work, we investigated...

: Mosquito-borne diseases are causing serious damage to public health worldwide, and control of these deadly mosquito vectors is a major thrust area for epidemiologists and public health workers. Therefore, the present research reports an eco-friendly solution with multipotency of silver nanoparticle fabricated from shrimp shell biowaste in control...

This chapter is a brief discription of all the chapters included in this book. It includes different topics related to DNA barcoding and molecular phylogeny along with some unique case studies. They include topics related to implications of DNA barcoding, invasive align species identification through DNA barcoding, microbial DNA barcoding, applicat...

The effective management of mosquito vectors is a timely challenge for medical and veterinary entomology. In this study, we evaluated the acoustic Larvasonic device to control young instars of the mosquito Aedes aegypti in diverse freshwater environments. Under laboratory conditions, we investigated the effect of exposure time and distance from the...

Mosquitoes act as vectors for several deadly diseases that have devastating effect on millions of people throughout the world. Controlling the spread of these mosquito vectors is a challenging task. Here, we propose a mangrove-mediated production of AgNPs from cheap aqueous extracts of Heritiera fomes from the Sundarbans UNESCO World Heritage Site...

Worldwide, billions of people are at risk from viruses, parasites and bacteria transmitted by mosquitoes, ticks, fleas and other vectors. Over exploitation of chemical pesticides to overcome the mosquito borne diseases led to detrimental effects on environment and human health. The present research aims to explore bio-fabrication of metal silver na...

This book presents a comprehensive overview of DNA barcoding and molecular phylogeny, along with a number of case studies. It discusses a number of areas where DNA barcoding can be applied, such as clinical microbiology, especially in relation to infection management; DNA database management; and plant -animal interactions, and also presents valuab...

The development of novel mosquito control tools is a key prerequisite to build effective and reliable Integrated Vector Management strategies. Here, we proposed a novel method using cigarette butts for the synthesis of Ag nanostructures toxic to young instars of the malaria vector Anopheles stephensi, chloroquine (CQ)-resistant malaria parasites Pl...

Anopheles stephensi is a mosquito vector of malaria, which is still considered a relevant public health problem due to increasing outdoor transmission, growing resistance to insecticides used to target vectors, and antiplasmodial drugs as well. Thus, there is a vital need to explore novel sources of effective compounds. In this study, the hydrother...

The development of eco-friendly and effective insecticides is crucial for public health worldwide. Herein, we focused on the desert wormwood (Artemisia herba-alba), a plant widely used in Arabian traditional medicine, as a source of green nanoinsecticides against mosquito vectors, as well as growth inhibitors to be employed against microbial pathog...

Mosquitoes represent a key threat for millions of humans worldwide, since they act as vectors for malaria, dengue fever, yellow fever, Zika virus, filariasis, and encephalitis. In this study, we tested chitosan-synthesized silver nanoparticles (Ch–AgNP) using male crab shells as a source of chitosan, which acted as a reducing and capping agent. Ch–...

The employ of nano-formulated biopesticides for mosquito control represents a promising strategy. Recently, it has been outlined that differences in the green reducing extracts used in nanosynthesis led to the production of nanoparticles with distinct bio-physical properities. In the present investigation, Hedychium coronarium-synthesized silver na...

The effective prevention and treatment of malaria still represent a major public health challenge. Here, the solution combustion method was used for the synthesis of hierarchically structured V2O5 nanoflakes. The toxicity of V2O5 nanoflakes was evaluated on the malaria vector Anopheles stephensi and on the malaria parasites Plasmodium falciparum an...

Helicoverpa armigera Hubner is an important polyphagous agricultural insect pest, highly mobile, with a worldwide distribution. In India, it causes substantial losses to cotton, legume, pulses, cereal oil seed and vegetable crops. Malaria is caused by parasites from the genus Plasmodium that are transmitted by female anopheline mosquitoes. Anophele...

Mosquitoes (Diptera: Culicidae) represent a deadly threat for millions of humans and animals worldwide. Seaweeds are an important resource for marine biotechnology and are currently investigated as sources of reducing and capping agents for the nanosynthesis of mosquitocides. Culex quinquefasciatus is a major vector of lymphatic filariasis, while c...

A main challenge in parasitology is the development of reliable tools to prevent or treat mosquito-borne diseases. We investigated the toxicity of magnetic nanoparticles (MNP) produced by Magnetospirillum gryphiswaldense (strain MSR-1) on chloroquine-resistant (CQ-r) and sensitive (CQ-s) Plasmodium falciparum, dengue virus (DEN-2), and two of their...

Culex quinquefasciatus (Diptera: Culicidae) is a vector of many pathogens and parasites of humans, as well as domestic and wild animals. In urban and semi-urban Asian countries, Cx. quinquefasciatus is a main vector of nematodes causing lymphatic filariasis. In the African region, it vectors the Rift Valley fever virus, while in the USA it transmit...

Cadmium is among the toxic and hazardous metal widely dispersed in the environment in high levels. Current studies have provided new insights on antioxidant properties of bioflavonoid which have emerged as probable therapeutic and nutraceutical agents. The present study is geared to investigate the possible role of Cymbopogon schoenanthus (L.) Spre...

The overuse of synthetic pesticides to control insect pests leads to physiological resistance and adverse environmental effects, in addition to high operational cost. Insecticides of botanical origin have been reported as useful for control of agricultural and public health insect pests. This research proposed a novel method of mangrove-mediated sy...

Vector control is a critical requirement in epidemic disease management, and improved mosquito control methods that are economic and effective are necessary. Cyclopoid copepods are common predators in numerous aquatic ecosystems and have been used as biological agents in programs to control mosquito larvae. In this study, we proposed a green synthe...

Recently, it has been highlighted an overlooked connection between the biting activity of Anopheles mosquitoes and the spread of cancer. The excellent physico-chemical properties of graphene quantum dots (GQDs) make them a suitable candidate for biomedical applications. We focused on the toxicity of GQDs against Plasmodium falciparum and its vector...

The control of dengue vectors with effective tools is crucial. Here, we fabricated silver nanoparticles (AgNP) using a cheap method relying to a mangrove extract (Sonneratia alba) as a reducing and stabilizing agent. AgNP were characterized by UV–vis spectroscopy, Fourier transform infrared spectroscopy, scanning electron microscopy and X-ray diffr...

Mosquitoes (Diptera: Culicidae) act as vectors for devastating pathogens and parasites. Zika virus, an Aedes mosquito-borne flavivirus, is becoming a worldwide public health concern following its suspected association with over 4000 recent cases of microcephaly in the infants of some women who were pregnant when they contracted the disease. There a...

Nanotechnology is a promising fi eld of interdisciplinary research. It opens up a wide array of opportunities in various fi elds like insecticides, pharmaceuticals , electronics, and agriculture. Biosynthesis of insecticides from plant extracts is currently under exploration. Plant extracts are very cost-effective and eco-friendly and thus can be a...

A number of Diptera species have medical and veterinary importance as they cause myiasis and act as vectors for protozoans, helminth eggs, as well as bacterial pathogens. In this research here, eleven Diptera species were monitored in five locations in Northwestern part of Saudi Arabia, using three types of traps (lure-baited traps, window fly trap...

Mosquitoes act as vectors of devastating pathogens and parasites, representing a key threat for millions of humans and animals worldwide. Eco-friendly control tools are urgently required. We proposed a novel method of fern-mediated biosynthesis of silver nanoparticles (AgNP) using Dicranopteris linearis, acting as a reducing and capping agent. AgNP...

The impact of green-synthesised mosquitocidal nanoparticles on non-target aquatic predators is poorly studied. In this research, we proposed a single-step method to synthesise silver nanoparticles (Ag NP) using the seed extract of Melia azedarach. Ag NP were characterised using a variety of biophysical methods, including UV-vis spectrophotometry, s...

Major part of our planet includes the marine habitat which faces severe threat due to overexploitation of its bio resources. Assessment of biodiversity in the massive and diverse marine ecosystem is a challenging task. In this introductory chapter, we give a brief description of the marine habitat and types of marine organisms, followed by the conc...

Mosquitoes are insects of huge public health importance, since they act as vectors for important pathogens and parasites. Here, we focused on the possibility of using the neem cake in the fight against mosquito vectors. The neem cake chemical composition significantly changes among producers, as evidenced by our HPTLC (High performance thin layer c...

Shewanella oneidensis MR-1 (MR-1)-impregnated alginate capsules with 3D porous structure were prepared through cation crossing-linking and was used for the Cr(VI) reduction and removal. After being encapsulated by alginate, the endurance of the MR-1 was largely enhanced under conditions of high Cr(VI) concentrations (up to 4 mM) and low pH (pH 5)....

Objective: To investigate the effectiveness of slow release formulations of Bacillus thuringiensis israelensis (AM 65-52) (B. thuringiensis israelensis) and spinosyns against the West Nile vector Culex pipiens (Cx. pipiens) in Saudi Arabia. Methods: We tested slow release insecticide formulations of Natular DT, Tap 60 and VectoBac granule against I...

Objective: To explore the effects of different chemical larvicides, bioinsecticides and insect growth regulators against the West Nile vector Culex pipiens (Diptera: Culicidae) (Cx. pipiens) in Saudi Arabia. Methods: We tested seven commercial mosquito larvicides, including classic cyfluthrin, diazinon and propoxur, bioinsecticides Bactilarvae and...

Mosquitoes (Diptera: Culicidae) as as vectors for important diseases and parasites causing millions of deaths every year. The use of synthetic pesticides against Culicidae leads to resistance and environmental concerns. Therefore, eco-friendly control tools are a priority. In this research, Nicandra physalodes-mediated synthesis of silver nanoparti...

It aimed to investigate and evaluate the soil amelioration process of bauxite residues with the amendments of organic materials from different sources. Wheat straw, poultry manure compost, and biosolids were chosen as the added organic materials. A series of essential soil properties were analyzed to evaluate the effects of organic materials on the...

Objective To evaluate the ovicidal, larvicidal and adulticidal potential of neem cake fractions of different polarity against the rural malaria vector Anopheles culicifacies (An. culicifacies). Methods Neem cake fractions' total methanol extract (NTMeOH), total ethyl acetate extract (NTAcOEt), ethyl acetate fraction after repartition with NTMeOH (...

Malaria transmission is a serious emergence in urban and semiurban areas worldwide, becoming a major international public health concern. Malaria is transmitted through the bites of Anopheles mosquitoes. The extensive employ of synthetic pesticides leads to negative effects on human health and the environment. Plant-synthesized nanoparticles have b...