Dr Arun Kumar

• PhD
• Senior Scientist at Mahavir Cancer Sansthan

Epithelial ovarian cancer (EOC) is the leading cause of death among all gynecologic cancers around the world. This is so because women diagnosed with early-stage disease have a better prognosis and hence better chances of survival. Cancer antigen (CA)-125 is a high-molecular-mass glycoprotein produced both by ovarian cancer cells and also by the no...

Arsenic (As), a well-known environmental toxicant naturally found in rocks in the earth’s crust contaminates groundwater. Patna, a highly populated district of Bihar, India, is situated on the banks of the river Ganges in the area commonly referred to as the Gangetic-Zone. The entire district of Patna is divided into 23 blocks. The purpose of this...

Export Date: 18 October 2014

Mercury is a persistent, bio-accumulative, and hazardous contaminant. When released into the environment, it accumulates in water sediments, converting it to poisonous methylmercury that enters the food chain. The present study was carried out in habitations from the 11 districts of Bihar (India). In the study, n = 224 lactating women and their inf...

Prostate cancer frequently goes undetected at its early stage and it’s a major concern in male population. To address this challenge, we provide a new approach based on electrochemical biosensing for efficient detection of prostate cancer using PCA3 DNA biomarkers. Initially, screen-printed paper electrodes were fabricated and further modified by g...

Triple-negative breast cancer (TNBC) is characterized by a diverse range of molecular features that have been extensively studied. MYC plays a critical role in regulating metabolism, differentiation, proliferation, cell growth, and apoptosis. Dysregulation of MYC is associated with poor prognosis and contributes to the development and progression o...

Groundwater poisoning by heavy metals has caused serious health hazards in the exposed population globally. Manganese (Mn) poisoning causing human health hazards is very meagerly reported worldwide. The present research elucidates for the first time the catastrophic effect of manganese causing cancer in the Gangetic plains of Bihar (India). The blo...

Article Breast cancer remains a leading cause of cancer-related morbidity and mortality among women globally. Breast cancer is the most diagnosed cancer in women. Metastasis is the primary cause of mortality for breast cancer patients. In Bihar, there are so many cases of Breast Cancer patients found but most of them collected near the Gangetic pla...

Prostate cancer is one of the most prevalent cancers afflicting men worldwide, often detected at advanced stages, leading to increased mortality rates. Addressing this challenge, we present an innovative approach employing electrochemical biosensing for early-stage prostate cancer detection. This study used Indium–Tin Oxide (ITO) as a substrate and...

Background The pattern of head-and-neck cancer (HNC) differs across India due to considerable differences in regional customs, tobacco consumption behaviors, socio-economic status, and other regional risk-factors. Objectives The primary objective of this study was to assess the epidemiological and demographic profile of patients with HNC from Biha...

Groundwater arsenic poisoning has posed serious health hazards in the exposed population. The objective of the study is to evaluate the arsenic ingestion from breastmilk among pediatric population in Bihar. In the present study, the total women selected were n = 513. Out of which n = 378 women after consent provided their breastmilk for the study,...

The first-line medications used in clinics for colorectal cancer (CRC) are 5-FU based chemotherapy and its prodrug, capecitabine. Nevertheless, there are still relatively few patients responding to 5-FU/capecitabine-based therapy. Up to 30% of patients treated with 5-FU experience early-onset severe toxicity, including diarrhea, nausea, mucositis,...

The present research experimentally investigated the physicochemical parameters and mineral content in honey and chicken eggs from different regions of Haryana. The egg samples were evaluated for pH, protein content, length, width, shape index and weight, whereas honey samples were evaluated for pH, moisture content, acidity, optical density, prote...

The present study was aimed at showing the importance of HPV DNA status and the clinical history of the patients required by the cytologist for accurate reporting. A total of 1250 symptomatic women who attended the gynaecology outpatient department of the Mahavir Cancer Sansthan and Nalanda Medical College, Patna, for pap smear examinations were sc...

Purpose: Infection of high-risk HPV types 16/18 have been known to be the principal causative agents for the development of cervical cancer. The objective of the present study was to examine whether positive oncogenic HPV types 16/18 in a negative inflammatory Pap smear could be an indicator of cervical cancer risk in a symptomatic woman. Methods:...

Groundwater under urban areas faces numerous sources of potential contamination, including the presence of antimicrobial-laden wastes (Zainab et al., 2020). Worryingly, the use of antimicrobials has resulted in the emergence and transfer of antibiotic resistance genes (ARGs) in pathogenic bacteria found in groundwater which may be used as drinking...

In Bihar, an estimated 10 million are exposed to arsenic poisoning through drinking of water. The entire Gangetic plain region people are exposed to arsenic poisoning which is causing lot of health hazards including the problem of infertility. Usually, the infertility problem is associated with the hormonal imbalances and arsenic is a xenoestrogen...

Arsenic contamination is a serious issue throughout the world and is substantial risk factor in most of the countries including India. Chronic arsenic exposure from drinking water to humans is causing major public health related issues. The present study aims to investigate the ameliorative effect of Citrullus lanatus (Watermelon) seeds against ars...

Arsenic catastrophe has caused serious health hazards to the exposed population. An estimated 10 million people are exposed to arsenic poisoning through groundwater. The arsenic contamination through ground water has caused health diseases such as skin manifestations, loss of appetite, nausea, bowel disorders, neurological disorders etc. Therefore,...

Groundwater contamination in India exposes an estimated 70 million people to arsenic. Over 10 million people in the state of Bihar (India) are at risk of arsenic poisoning. As reported 27 districts of the state's thirty-eight districts are under a state of catastrophe. Symptoms noticed by those who have been exposed to the arsenic caused disease ar...

Purpose: The present study was aimed at showing the importance of HPV DNA status and clinical history of the patients required to cytologist for accurate reporting. Methods: A total of 1250 symptomatic women who attended the gynaecology outpatient department of the Mahavir Cancer Sansthan and Nalanda Medical College, Patna, for pap smear examinatio...

Cell No. +91-9334740800. Orcid I.D. https://orcid.org/0000-0002-8946-5909 CC License CC-BY-NC-SA 4.0 Abstract Globally, 300 million people worldwide are exposed to groundwater arsenic poisoning in the recent time, while an estimated 10 million population are exposed to arsenic poisoning in Bihar (India). The arsenic contamination in ground water ha...

The present study is focused to combat the deleterious effect of arsenic toxicity in animal models utilizing medicinal plant extract. The animals (Charles Foster rats) were treated with Sodium arsenite at the dose of 8 mg per kg body weight for 90 days to make arsenic model and upon these arsenic pre-treated rats leaf extract of Calendula officinal...

Arsenic poisoning in groundwater is the most common environmental pollutant, which is leading to serious pollution worldwide. Chronic arsenic exposure from drinking water to humans causes major public health-related issues. The present study was conducted to investigate the antidote effects of Foeniculum vulgare (Fennel) against arsenic-induced hep...

The present study aims to develop the antidote against arsenic induced male reproductive toxicity in animal models. The study was carried out on Charles Foster rats after the approval from Institutional Animal Ethics Committee. A total of n=18, rats (12 weeks old) of an average weight of 160 ± 20 g were used for the study. The study group included...

The presence of arsenic (As) metalloid in groundwater poses serious threat to human and animal’s health. Approx. 300 million people of about 105 countries in the world are affected due to arsenite poisoning. Except mitigation there is no such mode by which the population can be prevented from being exposed to arsenic. Elaeocarpus sphaericus (E. sph...

This research aimed to evaluate the effects of exercise, dance, and games on human physiological parameters, salivary metabolic parameters, and physicochemical parameters in human saliva. Sixty-eight clinically healthy participants participated in this study (29 for exercise, 26 for cricket games, and 13 for dance). Anthropometric parameters such a...

Head and Neck Cancer (HNC) has emerged as a major public health concern in India. The Indian state Bihar, which ranks fourth in the total number of new cancer cases, head and neck cancer is the second most common cancer and has an increasing trend. The application of machine learning (ML) in disease diagnosis is increasing gradually. With this back...

Cell No. +91-9334740800. ORCID I.D. https://orcid.org/0000-0002-8946-5909 CC License CC-BY-NC-SA 4.0 Abstract: The presence of arsenic (As) metalloid in groundwater poses serious threat to human and animal's health. Approx. 300 million people of about 105 countries in the world are affected due to arsenite poisoning. Except mitigation there is no s...

The present investigation was aimed to examine the antifertility effects of estradiol and phytochemical influences of Selaginella bryopteris (Sanjivani) in Swiss albino mice. Male twenty- four (n=24) mice were selected which was divided into four different group (n=6; each). Group-1 (G1): control, Group-2 (G2): estradiol treated, Group-3 (G3): Pre-...

Arsenic, a highly hazardous metalloid present ubiquitously in the Earth's crust, poses a significant threat to global groundwater contamination. This study aimed to evaluate the hepato-nephro alterations, enzymatic inhibition , and neurobehavioral flux in Charles Foster rats exposed to arsenic. The rats were divided into control and arsenic-exposed...

Background: Arsenic is present in above permissible safe limits in groundwater, soil, and food, in various areas of the world. This is increasing exposure to humankind and affecting health in various ways. Alternation in cognition is one among them. Epidemiological research has reflected the impact of arsenic exposure on children in the form of dim...

Biochar, a promising carbon-rich and carbon-negative material, can control water pollution, harness the synergy of sustainable development goals, and achieve circular economy. This study examined the performance feasibility of treating fluoride-contaminated surface and groundwater using raw and modified biochar synthesized from agricultural waste r...

Global groundwater is frequently discovered to have high arsenic (As) concentrations, which is critically endangered and potentially toxic to aquatic organisms and humans. This work investigates As(V) adsorption using raw nanobiochar (RnBC) and activated magnetic nanobiochar (AMnBC), which are synthesized via pre-treating rice straw biomass with Zn...

Groundwater arsenic contamination causes health hazards in more than 30 countries worldwide. It causes serious health hazards in arsenic arsenic-exposed populations. Existing arsenic removal technologies are not very effective in the removal of arsenic due to high costs, the requirement of continuous power supply, and honor ship conflict in rural a...

The present study was carried out in the village Kaliprasad of Bhagalpur district of Bihar to know the arsenic exposure effect in the exposed population. A total of n = 102 households were studied, and their water and biological samples such as urine and hair were collected and analyzed in a graphite furnace atomic absorption spectrophotometer (GF-...

The distribution and composition of dissolved organic matter (DOM) affects numerous (bio)geochemical processes in environmental matrices including groundwater. This study reports the spatial and seasonal controls on the distribution of groundwater DOM under the rapidly developing city of Patna, Bihar (India). Major DOM constituents were determined...

Routine monitoring of inorganic arsenic in groundwater using sensitive, reliable, easy-to-use and affordable analytical methods is integral to identifying sources, and delivering appropriate remediation solutions, to the widespread global issue of arsenic pollution. Voltammetry has many advantages over other analytical techniques, but the low elect...

Arsenic (As) is an environmental toxin distributed in groundwater which is presently a global concern. The present study aimed to investigate the efficacy of SCEE in the mitigation of arsenic-induced hepato-renal dysfunction and oxidative stress in rats. Thirty male Charles foster rats (140-160 g) were randomly assigned into three groups. Group I (...

The presence and distribution of emerging organic contaminants (EOCs) in freshwater environments is a key issue in India and globally, particularly due to ecotoxicological and potential antimicrobial resistance concerns. Here we have investigated the composition and spatial distribution of EOCs in surface water along a ∼500 km segment of the iconic...

Citation:Sethi J, Kumar C, Kumar A (2023) Anticancerous Effect of Fruit pulp of Aegle marmelos against Benzo[A] pyrene Induced Lung Tumours in Rats. Int J Drug Dev Res J, Vol. 15 No. 3: 1001. Abstract In the recent times, the lung cancer disease burden in the population has increased manyfolds globally. Among those carcinogen-Benzo[A]pyrene is one...

The extremely hazardous trace metal arsenic is ubiquitous in the Earth’s crust contaminating groundwater globally. The present study was conducted to evaluate the arsenic-induced hepato-nephro alterations, enzymatic inhibition and neurobehavioral instability and in Charles foster rats. Rats were divided into four groups (n = 6; each) weighing with...

In recent times Gallbladder cancer (GBC) incidences increased many folds in India and are being reported from arsenic hotspots identified in Bihar. The study aims to establish association between arsenic exposure and gallbladder carcinogenesis. In the present study, n = 200 were control volunteers and n = 152 confirmed gallbladder cancer cases. The...

An estimated 70 million population are exposed to arsenic poisoning in India in the 2020. The present study is aimed to develop the antidote for arsenic-induced toxicity in Charles Foster rats. A total of n=18 rats (12 weeks old) of an average weight of 160 ± 20 g were used for the study. The study group included three groups, n=6 control (Group I:...

Arsenic a genotoxic metalloid has become a major threat to the living world in the present scenario. Its distribution in the environment and the many sources of exposure make it more hazardous to humanity. Various sources of arsenic exposure from contaminated groundwater have become a global public health concern, with over 300 million people affec...

Cancer cell metabolism changes are considered a crucial hallmark in the development of cancer. Cancer cells undergoing uncontrolled proliferation need to rewire their metabolism to meet increased nutritional requirements compared to their normal counterparts. During tumor progression cancer cells counter various metabolic challenges by trying to gr...

Corona virus is pandemic and responsible for more than 5.6 million deaths. It was observed that its severity was reported in varied ways in different countries and even in different states of India. This variation was critically evaluated in the area with high contamination of Arsenic (As) to understand the arsenic toxicity and Covid epidemiology a...

Arsenic poisoning has recently resulted in significant health problems in the exposed population. In India, the Indo-Gangetic plains are the region where the arsenic threat has increased. In Bihar, it is estimated that 10 million people are exposed to arsenic poisoning. The present study aims to develop a novel drug as an antidote against arsenic-i...

Nowadays, about 14% of couples have difficulty in conceiving, and half of the cases are attributed to men. Asthenozoospermia or poor sperm motility is considered as the cause of infertility in males which is most common. Even though energy metabolism is considered the main reason for the etiology of asthenospermia, few attempts are made to determin...

Fast growing arsenic menace is causing serious health hazards in Bihar, India, with an estimated 10 million people at risk. The exposed population is often unaware of the problem, which only amplifies the burden of arsenic health effects. In the present study, we have assessed the current situation of arsenic exposure in Chapar village of Samastipu...

Arsenic poisoning in ground water is one of the most sensitive environmental pollutant causing serious pollution all over the world. Chronic arsenic exposure through drinking water to humans leads to major public health related issues. There have been very meagre studies which reported that, the plant constituents proved to exhibit protective effec...

The presence of arsenic (As) and other inorganic contaminants in groundwater is a key public health issue in India and many other parts of the world. Whilst a broad range of remediation technologies exist, performance can be highly variable, and appropriate selection and management of remediation approaches remains challenging. Here, we have identi...

Objective: Human papillomavirus (HPV) is a sexually transmitted virus which play a vital role to developing Cervical cancer. It is presumed and accepted that sexually exposed women will have occurred HPV infection at least once in their whole life. Hence, determined the actual cause of transmission of HPV infection in sexually active women with si...

Glycolysis has been one of the major hallmarks of cancer, as cancer cells exhibit a high rate of glucose consumption beyond that required for energy production. Glucose acts as a substrate to generate biomass and regulates cell signaling that is required for the cancer progression. Glucose transporters (GLUTs) have been majorly playing their role i...

Head and neck cancer is the sixth most common cancer across the globe. This is generally associated with tobacco and alcohol consumption. Cancer in the pharynx majorly arises through human papillomavirus (HPV) infection, thus classifying head and neck squamous cell carcinoma (HNSCC) into HPV-positive and HPV-negative HNSCCs. Aberrant, mesenchymal-e...

Large river systems, such as the River Ganges (Ganga), provide crucial water resources for the environment and society, yet often face significant challenges associated with cumulative impacts arising from upstream environmental and anthropogenic influences. Understanding the complex dynamics of such systems remains a major challenge, especially gi...

Background In recent times Gallbladder cancer (GBC) incidences increased many folds in India. Majority of GBC cases are being reported from arsenic hotspots identified in Bihar. Methods In this prospective study volunteers were selected who underwent surgery in our cancer institute. There were 11 control benign gallbladder cases and 28 confirmed ga...

Diabetes is a metabolic disorder and global health issue. It arises because of an absolute or relative insulin deficiency that causes hyperglycemia. The study aimed to assess the antihyperglycemic, hepatoprotective, and renal protective effects of ethanolic fruit extract of Moringa oleifera, on alloxan-induced diabetic mice. Four mice were assigned...

The prime objective of the present study was to establish fenugreek (Trigonella foenum-graecum L.) seeds extract as an antidote against arsenic induced hepato-renal toxicity in rats. The male Charles Foster rats (weighing 160-180 g) were selected to make arsenic intoxicated model. The arsenic treated group of rats were orally treated with sodium ar...

Globally, ~ 300 million people are exposed to arsenic poisoning while in India an estimated 70 million people are affected by consumption of arsenic contaminated water. The state of Bihar is an endemic belt for arsenic contamination in groundwater affecting over 10 million people with moderate to serious health manifestations. Life threatening dise...

Head and Neck tumors are metabolically highly altered solid tumors. Head and Neck cancer cells may utilise different metabolic pathways for energy production. Whereas, glycolysis is the major source coupled with oxidative phosphorylation in a metabolic symbiosis manner that results in the proliferation and metastasis in Head and Neck Cancer. The mo...

Arsenic poisoning through groundwater is the world’s greatest normal groundwater catastrophe which got an immense effect on worldwide general wellbeing. India is confronting the outcomes of arsenic poisoning in the zone of Ganga Brahmaputra alluvial plains. In Bihar, out of 38 districts, 18 districts are exceptionally influenced with groundwater ar...

Objective The present study aims to carry out the assessment of arsenic contamination in groundwater samples along with the health status of the exposed population of Buxar district of Bihar.Methods In the present study, randomly 80 groundwater samples were collected from the handpumps across the village households. For the health assessment, blood...

Arsenic poisoning has become a global problem in the recent times. It is estimated that >300 million population are exposed to arsenic worldwide. In India, Bihar is the state which lies in the lower middle Ganga plains and there are seven major tributaries originating from Great Himalayas. This entire Gangetic plain area is highly fertile land and...

Arsenic poisoning has become a global problem in the recent times. It is estimated that >300 million population are exposed to arsenic worldwide. Bihar is the state in India, which is in the vicinity of river Ganges where seven major tributaries from Great Himalayas through Nepal meet river Ganges. This entire Gangetic plain area is highly fertile...

Details concerning a person's wellbeing, such as prescription history, immunizations, allergies, and medical test records, should be held in a uniform format. A systematic database of a person's health-care records will aid in assessing the appropriate treatment plan for someone who requires treatment at some point in their life. The majority of co...

Reportedly, 300 million people worldwide are affected by the consumption of arsenic contaminated groundwater. India prominently figures amongst them and the state of Bihar has shown an upsurge in cases affected by arsenic poisoning. Escalated arsenic content in blood, leaves 1 in every 100 human being highly vulnerable to being affected by the dise...

Arsenic poisoning through groundwater is the world's greatest normal groundwater catastrophe which got an immense effect on worldwide general wellbeing. India is confronting the outcomes of arsenic poisoning in the zone of Ganga Brahmaputra alluvial plains. In Bihar out of 38 districts, 18 districts are exceptionally influenced with groundwater ars...

Arsenic is one of the most abundant metals in the Earth’s crust. It exists in both organic and inorganic forms. Contamination of drinking water globally by significant environmental exposure of Arsenic is one of the major public health problems. It is found that more than 100 million people are exposed to Arsenic worldwide. Drinking water Arsenic c...

Arsenic poisoning is one of the most serious health hazards of recent times. It has been estimated that more than 200 million people of about 105 countries in the world are affected due to arsenic poisoning. Except mitigation, there is no such mode by which the population can be prevented from being exposed to arsenic. Tinospora cordifolia (T. cord...

Breast cancer is among most common form of cancer worldwide. It is also the major cause of death in female cancer patient around the world. Despite various therapeutic measures, it remains associated with high mortality rate. Aegle marmelos (L.) Correa has been extensively used in Indian medicine system Ayurveda, due to its various medicinal proper...

Aquatic pollution from emerging organic contaminants (EOCs) is of key environmental importance in India and globally, particularly due to concerns of antimicrobial resistance, ecotoxicity and drinking water supply vulnerability. Here, using a broad screening approach, we characterize the composition and distribution of EOCs in groundwater in the Ga...

Breast cancer has been one of the most common form of malignancy globally among women, for more than a decade. Despite various preventive and treatment measures, it remains associated with high incidence and mortality rate. Pterocarpus santalinus Linn. f. has been extensively used in Indian medicine system Ayurveda , due to its various medicinal pr...

Autophagy is an essential mechanism of cellular degradation, a way to protect the cells under stress conditions, such as deprivation of nutrients, growth factors and cellular damage. However, in normal physiology autophagy plays a significant role in cancer cells. Current research is in progress to understand how autophagy and cancer cells go hand...

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