Doug Carithers

Doug Carithers
Boehringer Ingelheim, Duluth, GA · Veterinary Services

Doctor of Veterinary Medicine

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37
Publications
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434
Citations

Publications

Publications (37)
Article
Full-text available
Leptospirosis vaccine for dogs in the United States is considered a lifestyle or non-core vaccine, making individual veterinary practitioners responsible for determining if vaccination is necessary for their patients. Veterinary professionals often base their vaccination decisions on local rates of clinical cases. However, even subclinical leptospi...
Article
Full-text available
A study was performed to compare the 12-hour efficacy of FRONTLINE® Gold (fipronil/(S)-methoprene/pyriproxyfen) with that of SIMPARICA® (sarolaner) against Ixodes scapularis tick infestations on dogs. Based on pre-treatment tick count, 24 dogs were allocated to one of three groups, eight dogs in each group. On Day 0, each dog in Group B was treated...
Article
Full-text available
A study was performed to compare the 6-hour efficacy of FRONTLINE® Gold (fipronil/(S)-methoprene/pyriproxyfen) with that of SIMPARICA® (sarolaner) against Ctenocephalides felis flea infestations on dogs. Twenty-four dogs were allocated to one of three groups, eight dogs in each group. On Day 0, each dog in Group B was treated with a dose of commerc...
Article
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Two separate studies were performed to evaluate the 24-hour efficacy of FRONT-LINE® Plus for Dogs (fipronil/(S)-metho-prene, Boehringer Ingelheim, Duluth, GA, USA) and FRONTLINE Gold for Dogs (fipronil/(S)-methoprene/pyriproxyfen, Boehringer Ingelheim, Duluth, GA, USA) against Ixodes scapularis ticks on Days 2, 9, 16, 23, and 30. From a pool of 28...
Article
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A single topical application of a combination of fipronil, (S)-methoprene, pyriproxyfen (Frontline® Gold, Merial, now part of Boehringer Ingelheim) on cats significantly prevented flea egg development (Ctenocephali-des felis) in a simulated home environment for 15 weeks. Six healthy male cats were treated and then split in two groups of 3, and each...
Article
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Two studies were performed to determine the 24-hour efficacy of FRONTLINE ® Plus (fipronil/(S)-methoprene) against the Tampa 2014 isolate of Ctenocephalides felis fleas. This isolate of fleas was collected during a field study where there was a perceived lack of efficacy of FRONTLINE Plus for Dogs against Ctenocephalides felis fleas. Two well-contr...
Article
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Abstract The efficacy of oral treatment with chewable tablets containing afoxolaner 2.27% w/w (NexGard®, Merial, now part of Boehringer-Ingelheim) or 1.875% w/w of afoxolaner and 0.375% w/w milbemycin oxime (NexGard Spectra®, Merial, now part of Boehringer-Ingelheim) was each assessed in eight dogs diagnosed with generalized demodicosis in this pa...
Article
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Macrocyclic lactones (MLs), specifically the avermectins and milbemycins, are known for their effectiveness against a broad spectrum of disease-causing nematodes and arthropods in humans and animals. In most nematodes, drugs in this class induce paralysis, resulting in starvation, impaired ability to remain associated with their anatomical environm...
Article
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Three studies were performed to assess the efficacy, speed of kill, and residual effects of FRONTLINE® Gold for Dogs (fipronil/ (S)-methoprene/pyriproxyfen, Boehringer Ingelheim, Merial, Inc., Duluth, GA) against Ctenocephalides felis fleas. Although temporally separate, all three studies were performed at the same facility, each using eight dogs p...
Article
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Background The efficacy of a single 2.5 mg/kg dose of afoxolaner (NexGard®, Merial) against induced Otodectes cynotis infestations was assessed in eight afoxolaner-treated dogs, compared to eight untreated dogs. Methods After O. cynotis infestations were established and confirmed by otoscopic assessments in 16 dogs, all of the dogs were included in...
Article
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Background A study was conducted to evaluate the efficacy of FRONTLINE® TRITAK® For Dogs (fipronil/(S)-methoprene/cyphenothrin, Merial, Inc., Duluth, GA) against a known strain of fleas with a history of reduced susceptibility to fipronil and pyrethroids, KS1 (Kansas State 1), of Ctenocephalides felis felis fleas. Methods One day after topical trea...
Article
Full-text available
Background Acceptability and palatability of oral formulations are critical issues in establishing and maintaining optimal owner compliance, especially for essential, regularly administered treatments such as monthly flea/tick control products. Such dosage forms are generally developed to be highly palatable if possible, to best ensure they are vol...
Article
Full-text available
Background Efficacy of FRONTLINE® TRITAK® For Dogs (fipronil/(S)-methoprene/cyphenothrin, Merial, Inc., Duluth, GA) against Ixodes scapularis was evaluated in two separate, but concurrent laboratory studies. Methods One day after topical treatment with placebo or active, dogs (n = 24) were infested with 50 unfed adult Ixodes scapularis ticks, with...
Article
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A study was conducted to evaluate the effectiveness of afoxolaner chewables to control flea populations in naturally infested dogs in private residences in Tampa FL, USA. Evaluations of on-animal and premises flea burdens, flea sex structure and fed-unfed premises flea populations were conducted to more accurately assess flea population dynamics in...
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Cats may be infected by heartworm, Dirofilaria immitis, through mosquito bites. They can develop severe heartworm disease when infective D. immitis larvae migrate and develop into adults in the pulmonary vasculature or other tissues. As there is no curative treatment for feline heartworm infection, the monthly administration of preventative treatme...
Article
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This study was performed to assess the field efficacy of a professional and home-care barrier gel against the development of plaque, calculus, gingival bleeding, and gingivitis in client-owned cats over a 56-day period compared with negative controls. In a randomized, negative-controlled, outcome evaluator-blinded, client-owned animal clinical fiel...
Article
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To generate data on the effects of firocoxib administration to horses with osteoarthritis. Client-owned horses with signs of lameness and joint pain associated with osteoarthritis. Firocoxib was administered as an oral paste (0.1 mg/kg, q 24 h) for 14 days. Assessments were performed on day 0 (baseline) and days 7 and 14. 390 of 429 horses from 80...
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Case #1: Fleas in a Flash! This is the first of a five-part series of cases that formed part of a field-study research project conducted by the Kansas State University Flea Team in 2009 in Tampa, Florida. In this case, you will learn where in their own yard pets are most likely to acquire new fleas, what other animals might share the yard, and how...
Article
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This is the third of a five-part series of cases that formed part of a field-study research project conducted by the Kansas State University Flea Team in 2009 in Tampa, Florida. BOX 1 describes the criteria for inclusion and the methods used in this study. Veterinarians often hear pet owners say that they don't need a flea control product for their...
Article
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Flea efficacy of FRONTLINE (R) Plus (fipronil + (S)-methoprene) was evaluated at 12, 18, and, 24 hours following product application and subsequent infestations on clays -1, 7, 14, 21, 28, and 35 after a single treatment. Twenty-four dogs were randomly allocated to groups based on 24 hour flea counts, following day -5 pretreatment flea infestations...
Article
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The objective of the study was to confirm the acaricidal effcacy of a single topical treatment of the combination of fpronil/ amitraz/(S)-methoprene (CERTIFECT®) against induced infestations of Dermacen-tor variabilis. Sixteen healthy mixed breed mongrels (8 males and 8 females), approximately 9.6 to 13.7 months of age on Day 0, and weighing 16.2 t...
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A multi-clinic, investigator blinded, randomized, prospective field trial enrolling 379 dogs compared deracoxib and firocoxib administered orally over 30 days to treat musculoskeletal disorders considered by the veterinary investigator as caused by osteoarthritis (OA). Over 60% of dogs improved within 7 days of treatment initiation (Day 0), and imp...
Article
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The efficacy of frail/(S)-methoprene (FRONTLINE® Plus, Menial Limited, Duluth, GA, USA) for household feat control was assessed against existing natural feat populations in homes in Tampa, Florida. Twenty-seven households fulfilled requirements for inclusion into and completed this non-randomized, multiple site (household), prospective field study....
Article
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This study evaluated overall efficacy, percentage of dogs free of live ticks, retention of ticks, and efficacy against retained ticks of fipronil (9.8% w/w) + (S)-methoprene (8.8% w/w) and imidacloprid (8.8% w/w) + permethrin (44% w/w) spot-on topical solutions against Dermacentor variabilis infesting dogs. Fipronil + (S)-methoprene provided signif...
Article
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Veterinarians currently have a choice of six registered NSAIDs for use in the management of canine osteoarthritis. There is a need for data to clarify whether there is an increased risk of side effects occurring in the event of a switch between different members of the NSAID class. In this retrospective analysis of extensive data collected in the 1...
Conference Paper
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In 2005, a heartworm survey was sent out to over 25,000 veterinary practices by the American Heartworm Society, in cooperation with Merial. Responses were received from more than 12,000 veterinary clinics, and based upon these responses, more than 250,000 dogs in the US tested positive for heartworms in 2004. These numbers were up slightly from 244...
Article
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For the Previcox (firocoxib, Merial) Experience Trial, practicing veterinarians across the United States were asked to enroll dogs diagnosed with osteoarthritis (OA). At an initial visit, owners of dogs deemed suitable for NSAID therapy were given Previcox and instructed to maintain a daily diary and to return 10 and 40 days after treatment began....
Article
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This study compared the efficacy of two of the most widely veterinary-dispensed topical products for control of ticks on dogs: fipronil-(S)-methoprene and imidacloprid-permethrin. Eighteen healthy beagle dogs of both sexes were divided into three groups of six dogs. Group 1 served as the untreated control. Dogs in group 2 were treated with fipronil...
Article
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To determine whether conditions representing activities that are typical in the recreational use of horses, including transport to and from show grounds, stall confinement in unfamiliar surroundings, and light exercise, are associated with increased incidence of gastric ulcers in horses. Randomized controlled study. 20 client-owned horses. Horses h...
Conference Paper
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Rhipicephalus sanguineus (brown dog ticks) were applied directly on Days 1, 7, 14, 21, and 28 to dogs tl1at had been treated on Day 0 witl1 K9 ADVANTIX"' (imidacloprid + permethrin) or had been left untreated as controls. Dogs were examined one hour after direct application of 50 unfed R. sanguineus ticks to determine the number of ticks repelled (...
Conference Paper
Full-text available
The efficacy of three commercially available topical (spot-on) ectoparasiticides - fipronil /(S)-methoprene, imidacloprid/permethrin, and imidacloprid - was evaluated against fleas and ticks on dogs. Each product was administered topically once on Day 0 at the recommended label dose and according to the instructions for use. Challenges occurred wee...
Conference Paper
Full-text available
Hookworms are a zoonotic threat as well as a health concern for pets. The objective of this study was to compare the efficacy of commercially available formulations of ivermectin/pyrantel (Heartgard Plus, Merial Limited) and milbemycin oxime (Interceptor, Novartis Animal Health US, Inc.) against repeated hookworm infections in dogs when administere...

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