Dorsemans Anne-Claire

Background and Objectives No effective cure is available for neurogenetic diseases such as Huntington disease, spinocerebellar ataxias, and Friedreich ataxia, all of which cause progressive motor, cognitive, and psychiatric symptoms leading, in the long term, to severe communication (among other) impairments. In end-of-life situations, advanced dir...

Arboviruses have been shown to circulate in Madagascar, including West Nile, dengue, and chikungunya viruses, though the extent of their circulation remains poorly documented. We estimated the seroprevalence of these three arboviruses in Madagascar and determined risk factors associated with seropositivity. Serum samples obtained from 1680 individu...

The authentic teaching and learning approach introduce real-world scenarios into the classroom to better engage Generation Z students. Considering this, we introduced an authentic learning practical exercise (breakfast meal and glycemic variation) to undergraduate biology students at the University of La Reunion (France). Here, students were initia...

Background Neurogenetic diseases are associated with progressive loss of cognitive and/or motor abilities, sometimes making communication impossible. In end-of-life situations with complex ethical tensions, written advanced directives (AD), or end-of-life wishes, are an important decision making resource for relatives, caregiver and healthcare prac...

Background: West Nile virus (WNV) is a vector-borne virus maintained through an arthropod-borne transmission cycle involving bird hosts and Culex mosquito species. The disease affects humans in North America, Europe, Africa and Indian Ocean islands including Madagascar. In Madagascar, despite the surveillance of WNV, unreported WNV encephalitis (WN...

As physiology teachers within the higher education sector, a major priority is to strongly develop students to exhibit a strong internal motivation for learning and critical thinking. Although various factors may impact this process, the role of stress (acute and chronic) is a crucial factor that may impact a student’s performance. For example, emo...

Le diabète de type 2 est une pathologie complexe et multifactorielle caractérisée par une hyperglycémie chronique et une résistance à l’insuline. Actuellement, le diabète de type 2 est une préoccupation majeure et mondiale de santé publique. Les objectifs de cette thèse étaient d’étudier l’impact de l’hyperglycémie (aiguë, récurrente et chronique)...

Clinical benefit for mechanical thrombectomy (MT) in stroke was recently demonstrated in multiple large prospective studies. Acute hyperglycemia (HG) is an important risk factor of poor outcome in stroke patients, including those that underwent MT. The aim of this therapy is to achieve a complete reperfusion in a short time, given that reperfusion...

The circadian timing system is a complex biological network of interacting circadian clocks that regulates 24hour rhythms of behavioral and physiological processes. One intriguing observation is that stem cell homeostasis is subject to circadian clock regulation. Rhythmic oscillations have been observed in a variety of embryonic and adult stem cell...

Hyperglycemia is a major health issue that leads to cardiovascular and cerebral dysfunction. For instance, it is associated with increased neurological problems after stroke and is shown to impair neurogenic processes. Interestingly, the adult zebrafish has recently emerged as a relevant and useful model to mimic hyperglycemia/diabetes and to inves...

Le sucre fait partie de notre alimentation mais, comme toute chose, consommé en excès, il peut avoir des effets néfastes sur la santé.

The prevalence of diabetes rapidly increased during the last decades in association with important changes in lifestyle. Diabetes and hyperglycemia are well-known for inducing deleterious effects on physiological processes, increasing for instance cardiovascular diseases, nephropathy, retinopathy and foot ulceration. Interestingly, diabetes also im...

A growing body of evidence supports hyperglycemia as a putative contributor to several brain dysfunctions observed in diabetes patients, such as impaired memory capacity, neural plasticity, and neurogenic processes. Thanks to the persistence of radial glial cells acting as neural stem cells, the brain of the adult zebrafish constitutes a relevant m...

First seen as a storage organ, the white adipose tissue (WAT) is now considered as an endocrine organ. WAT can produce an array of bioactive factors known as adipokines acting at physiological level and playing a vital role in energy metabolism as well as in immune response. The global effect of adipokines in metabolic activities is well establishe...