
Doris KumadohCentre for Plant Medicine Research · Pharmaceutics
Doris Kumadoh
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Publications (43)
Background: Visceral Leishmaniasis is a systemic disease caused by the invasion of reticuloendothelial cells in the liver, spleen, and bone marrow by Leishmania spp. parasites. Current medications have numerous adverse effects and some resistance has been reported. Most treatments are administered parenterally, leading to non-compliance and treatme...
Abstract
Introduction
There are no strict pH standards for herbal formulations; however, pH can affect the characteristics of drugs and herbal formulations. In this study, the pHs of different herbal formulations produced in the past two batch years at the Centre for Plant Medicine Research (Mampong-Akuapem, Ghana) were analyzed. We aimed to evalu...
Introduction
Malaria is a parasitic disease that is endemic in tropical areas and can be life-threatening. There has been a decrease in the prevalence of malaria in Ghana but the burden of the disease is still high in the country. Many Ghanaians depend on herbal products for malaria treatment. This study aimed to survey and evaluate commercial herb...
The focus of most pharmaceutical research in recent times has been the use of natural products like gums as pharmaceutical excipients because they are safer, economical and readily available. This study aimed to investigate the applicability of gum extracted from the exudates from the stem bark of Pentadesma butyracea as a binder in conventional re...
A combination of inorganic and organic hybrid systems is of high research interest as they provide novel hybrid systems for the improvement of existing properties, overcoming limitations of the parent materials, and for the optimization of their controlled release potential. This study sorted to develop and pharmaceutically assess the release profi...
Conventionally, the microorganisms in liquid herbal mixtures are curtailed due to the fresh preparation before the administration to patients. Prolonged storage of liquid herbal preparations (due to commercialization) coupled with primeval routine production processes may increase the potential of microbial contamination in liquid herbal preparatio...
Background:
Medicinal plants represent a valuable source for new effective and safe antimicrobial drugs making them an alternative therapy. Existing antimicrobial agents are costly and mostly associated with possible side effects. The aim of the present study therefore, was to assess the antimicrobial property and phytochemical composition of hydr...
The development of herbal medicines as a remedy for several illnesses has been recognized and accepted worldwide by health experts. Parquetina nigrescens is a perennial evergreen woody climber from the Apocynaceae family, widely used in Africa for the treatment of many diseases. The current study is intended to review and put together information a...
Utilization of plant extracts for the synthesis of nanomaterials is a green technology that is safe to the environment. The current study, zinc oxide nanoparticles (ZnO NPs) was synthesised using the methanolic root bark extract of Cassia sieberiana as capping and stabilizing agents for the first time. The ZnO NPs were then characterized using Four...
Ethnopharmacological relevance
Bridelia ferruginea belonging to the family Euphorbiaceae identified as an important commonly growing shrub, is used in traditional medicine for managing arthritis, dysentery, constipation, chronic diabetes, skin diseases, bladder and intestinal disorders, oral infections, thrush, bites and as an arrow poison antidote...
Background
Leishmaniasis, a neglected tropical disease, is caused by parasites from the genus Leishmania and transmitted by the female phlebotamine sandfly. Visceral Leishmaniasis is the systemic and most severe form of the disease, which is brought on by Leishmania donovani and Leishmania infantum complexes. Current treatment options have been pla...
Antiaris is a monoherbal decoction produced by the Centre for Plant Medicine Research (CPMR), Mampong-Akuapem, Ghana. It is prepared from the stem bark of Antiaris africana Engl. (Moraceae), prescribed, and dispensed to patients for the management of nervous disorders. This current formulation presents notable challenges in patients’ adherence to t...
Elimination of microorganisms from herbal products has been a major concern due to its implicated health risk to consumers.
Drying of herbal materials has been employed for centuries to reduce the risk of contamination and spoilage. )e present study
adopted three drying approaches in an attempt to eliminate microorganisms from Lippia multiflora tea...
Capparis erythrocarpos is a shrub plant with a large natural distribution used in traditional medicines to cure various illnesses. The study sought to review and compile all data available on this medicinally important plant, which will help inform scientists and researchers the gap needed to be filled in studying the plant. The present review summ...
Peptic ulcer disease affects many people globally. With the increasing resistance to some orthodox antibiotics such as Clarithromycin and Metronidazole, it is important that new acceptable, safer and effective therapies are developed to manage this disease. Various herbal medicines have been used traditionally for the remedy of peptic ulcer disease...
Advances in the field of nanotechnology, especially with regards to polymeric formulations has paved the way for promising and successful therapeutics for lung disease through pulmonary delivery. Polymeric nano-particulate drug delivery systems are appealing as they have unique properties and tailored to suit pulmonary therapeutic needs usually adm...
The lung is a unique anatomical structure with very minimal interactions between it and other organs of the body. However, it is most vulnerable to infection and injury from the external environment because of its constant exposure to particles, chemicals, and infectious organisms in ambient air. Lung diseases can affect respiratory function, or th...
Herbal medicines are currently being adopted as alternatives to orthodox medicines for the management of drug-resistant and emerging multidrug-resistant microbial strains of various diseases, including typhoid fever. A herbal decoction, MA 001, manufactured by the Centre for Plant Medicine Research (CPMR), has been used for the treatment of typhoid...
Management of diarrhea has evolved over the years from relatively inadequate interventions in the early years to more successful physiological approaches. The use of herbal medicinal products and supplements has grown significantly over the past three decades, with more than half of the global population depending on it for some aspect of their pri...
Background:
The growth or multiplication of harmful microorganisms in addition to harmful human activities has led to many disorders in humans. Consequently, there is a search for medications to treat these disorders. Interestingly, medicines of plant origin are known to be among the most attractive sources of new drugs and have shown promising re...
In Ghana, the encapsulated blend of the powdered stem and root bark of Cassia sieberiana is prescribed and dispensed to patients at the Centre for Plant Medicine Research (CPMR), for the management of dysmenorrhea and gastric ulcer pain. This current formulation has significant challenges in manufacturing and optimization of therapeutic outcomes du...
Research indicates an increased use of hand sanitizers globally, and in particular developing countries where
bacterial epidemics such as cholera are common. While there is evidence of availability, high demand and use of
hand sanitizers, the incidence of cholera in developing countries remains unabated. Several reasons have been put
forward, and c...
Ethnomedicinal importance: Cassia sieberiana, mostly found in Africa has been used in traditional medicine as purgative, diuretic, analgesic, antibiotic, anti-inflammatory agent and many others for decades. This review focuses on discussions about its traditional therapeutic benefits, Ethnopharmacological studies, pharmacological, toxicological and...
Ethnopharmacological relevance:
Capparis erythrocarpos is a medicinal plant used widely in many parts of Africa for the management of pain and inflammatory conditions such as rheumatoid arthritis. Its wide range of use, popularity and high value, make C. erythrocarpos containing products a target for economically driven adulteration. This is made...
Context: Excipients play a key role in the quality of medicines and contribute to viable delivery systems. This has intensified the search for new natural polymer pharmaceutical excipients. Cocoa pod husks (CPHs) are a rich source of pectin. A study of CPH pectin showed that it possesses the requisite physicochemical properties to be employed as a...
Natural polymer research has recently become the focus of intensive research in the quest for new enabling excipients for novel
drugs in pharmaceutical formulation for optimal treatment outcomes. Evaluations of some excipients have shown deleterious
haematological efects of varying extents on the safety profle of these excipients. A 90-day subchron...
There has been an upsurge in the use of herbal medicinal products across both developing and advanced countries. Finished herbal products are presented in various dosage forms such as decoctions, herbal powders, alcoholic beverages, capsules, tablets, ointments and creams. The growing demand for herbal medicinal products across the world has result...
The study aimed to develop oral capsules from Enterica herbal decoction used in Ghana for the treatment of
typhoid fever and produced by the Centre for Scientific Research into Plant Medicine (CSRPM). The amount of
dry extract per dose (30ml) of Enterica and the wavelength of maximum absorption (λmax) of aqueous solutions
of Enterica extract were d...
The study sought to transform Asena herbal decoction produced by the
Centre for Scientific Research into Plant Medicine (CSRPM),
Mampong-Akwapim, Ghana, into oral capsules. Asena decoction is a
popular herbal remedy used in Ghana for the treatment of arthritis and
generalized body pains. The amount of dry extract per dose (30ml) of
Asena decoction...