Doris Klingelhoefer

Doris Klingelhoefer
  • Master of Science
  • Goethe University Frankfurt

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193
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2,959
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Current institution
Goethe University Frankfurt

Publications

Publications (193)
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Background Artificial intelligence (AI) will have a lasting and drastic impact on medical research and healthcare. In addition to the benefits, the associated risks are also the subject of controversial debate and there are fears of serious consequences. There is an urgent need for action, which must be underpinned by scientific information. Metho...
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As Nipah virus (NiV) infection is characterised by a possible pandemic risk, being currently limited to a small but deadly belt, the attention of other countries is essential. It has often been pointed out that NiV is an under‐researched virus with a high‐risk potential. This study aimed to show the global research history and status quo based on a...
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Introduction Tobacco companies conduct and fund research. They are not always interested in open-ended research. They promote their interests through public relations campaigns. It’s a proven fact that they influence the scientific community by impairing scientific reputation, especially in the case of health-related research. Methods To obtain a...
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Zusammenfassung Seuchenausbrüche wie die Coronavirus-Disease-2019-Pandemie (COVID-19-Pandemie) sind wiederkehrende Ereignisse, welche starke universitäre Forschungsstrukturen in Form von eigenständigen Lehrstühlen erfordern. In Deutschland wurde in den letzten 30 Jahren jedoch aus verschiedenen pandemierelevanten Fachbereichen von ungenügenden Fors...
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Zusammenfassung Hintergrund Aerosole sind eine Mischung fester oder flüssiger Partikel mit einer Größe zwischen 1 nm und mehreren 100 µm in einem Gas oder Gasgemisch. Nicht nur Berufsgruppen im Gesundheitswesen können von infektiösen Aerosolen betroffen sein. Zudem können auch nichtinfektiöse Aerosole, z. B. Pilzsporen, Nanopartikel, Stäube, Chemi...
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Introduction Diabetic neuropathy (DN) is a prevalent and debilitating complication of diabetes, imposing a significant burden on individuals and healthcare systems worldwide. This study presents a comprehensive analysis of the global research landscape in DN, aiming to provide scientists, funders, and decision-makers with valuable insights into the...
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The question of whether nuclear energy—as a source with relatively low carbon dioxide emissions—can be classified as a sustainable energy source has come into focus in connection with climate change. There is a controversy over securing independence from fossil fuels and gas supplies from other countries through a revival of nuclear energy. On the...
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Currently, West-Nile virus (WNV) is spreading worldwide to colder regions due to climate change. Human mortality and morbidity are prevalent and steadily increasing, associated with costs to public health systems. Therefore, the question of the impact of scientific engagement arises. What trends, barriers, and incentives for research related to glo...
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Background With the increasing impacts of climate change, heatwaves are placing an enormous burden on health and social systems and threatening ecological diversity around the world. Heatwaves are increasing not only in frequency but also in severity and magnitude. They are causing the deaths of thousands of people. Research is needed on a multidis...
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Following the current outbreak, the mpox virus (formerly: monkeypox virus) is a highly threatening pathogen with public health significance, although mpox is still considered a neglected disease. Previously confined mainly to Africa, the virus spread globally in 2022. However, knowledge about mpox is limited, causing a distorted perception of the d...
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Background Unlike most other commodities, rare earth elements (REEs) are part of a wide range of applications needed for daily life all over the world. These applications range from cell phones to electric vehicles to wind turbines. They are often declared as part of “green technology” and, therefore, often called “green elements”. However, their p...
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Background The spread of ticks has also led to the emergence of regional, previously unknown tick-borne diseases (TBDs) that pose an immediate threat to public health systems worldwide. People who spend time or work outdoors are at risk without closer awareness of regional exposures. That is especially true for tourists, who very easily come into c...
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The broad-spectrum insecticides in the neonicotinoid group are the most widely used worldwide because of their widely recognized advantages in the mode of action. Therefore, their use is growing on a large scale and, moreover, is often used preventively without considering the ecological impact. Studies demonstrated harmful effects on non-target or...
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Particulate matter emitted during autopsies can serve as a vector for numerous viruses or bacteria and can lead to infections. Reducing the exposure of those particles in indoor working environments is, therefore, an important issue. To assess the health risk for employees in forensic medicine, we measure particulate matter in the ambient air durin...
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Globally, air pollution and, by association, particulate matter (PM) is responsible for more than seven million premature deaths per year.¹ In a recent study, very high PM emissions were ascertained by Indonesian Kretek cigarettes.² Apart from that, little research exists on PM levels in secondhand smoke from country-specific cigarettes from the So...
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Background After nearly a quarter-century of declining poverty, the numbers are rising again significantly. This is due not only to effects of climate change but also to the COVID-19 pandemics and armed conflict. Combined with the enormous health impacts, that will cause misery and health care costs worldwide. Therefore, this study provides backgro...
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Zusammenfassung Radon ist ein ubiquitär im Erdmantel sowie in der Luft und im Wasser vorkommendes radioaktives Edelgas. Obwohl die mit der Exposition assoziierten Erkrankungen seit dem Mittelalter bekannt waren, ist eine kausale Zuordnung von Agens und Krankheit erst in der Mitte des letzten Jahrhunderts gelungen. Durch die physikalischen Eigenscha...
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Background The proportion of women in medicine, especially in pediatrics, is noticeably increasing. Yet, leadership positions are predominantly occupied by men. Methods Academic authorships of 156,642 pediatric original research articles were analyzed with regard to gender disparities. The evaluation included the proportion of female authorships (...
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Cervical cancer has caused substantial morbidity and mortality for millions of women over the past decades. While enormous progress has been made in diagnosis, prevention and therapy, the disease is still fatal for many women—especially in low-income countries. Since no detailed studies are available on the worldwide research landscape, we here inv...
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Introduction: In Indonesia, smoking is widespread. The same applies to second-hand smoke (SHS) exposure. More than 90% of Indonesian smokers smoke clove cigarettes, so-called Kreteks. They often contain more tar and nicotine than conventional cigarettes, but little is known about particulate matter (PM) emissions. In smokers' homes, SHS is the mai...
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Although the global tobacco market of cigarillos is substantial, little is known about their particulate matter (PM) emissions. For exposure risk assessment of cigarillos, the PM fractions PM10, PM2.5, and PM1 of eight cigarillo brands (four with filters) and a reference cigarette were measured. For this purpose, second-hand smoke was generated by...
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Introduction: Obesity is classified as a global epidemic and judged to be the greatest public health threat in Western countries. The tremendously increasing prevalence rates in children lead to morbidity and mortality in adults. In many countries, prevalence has doubled since the 1980s. Other countries show a continuous increase or stagnate at a...
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Nitrogen oxides (NO x ), especially nitrogen dioxide (NO 2 ), are among the most hazardous forms of air pollution. Tobacco smoke is a main indoor source of NO x , but little information is available about their concentrations in second-hand smoke (SHS), particularly in small indoors. This study presents data of NO x and its main components nitric o...
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Observed weather and projected climate change suggest increases in the transmission of vector-borne diseases (VBDs) in the Hindu Kush Himalayan (HKH) region. In this study, we systematically explore the literature for empiric associations between the climate variables and specific mosquito-borne diseases and their vectors in the Himalaya Hindukush...
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Objectives: Inadequate oral hygiene still leads to many serious diseases all over the world. Therefore, this study aimed to analyze scientific research in the field of oral health in order to be able to comprehend their relevant subject areas, research connections, or developments. Methods: This study aimed to assess the global publication output o...
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Background: SARS-CoV-2 is one of the most threatening pandemics in human history. As of the date of this analysis, it claimed about two million lives worldwide and the number is rising sharply. Governments, societies, and scientists are equally challenged under this burden. Objective: This study aimed to map global coronavirus research in 2020 a...
Preprint
BACKGROUND SARS-CoV-2 is one of the most threatening pandemics in human history. As of the date of this analysis, it had claimed about 2 million lives worldwide, and the number is rising sharply. Governments, societies, and scientists are equally challenged under this burden. OBJECTIVE This study aimed to map global coronavirus research in 2020 ac...
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In the middle of the twentieth century, the from North America sooty bark disease (SBD) of maples was first discovered in England and has spread in the last decades in Central Europe, in particular. The trigger of SBD is the mould fungus Cryptostroma (C.) corticale. The most common infested maple is the sycamore, Acer pseudoplatanus , a common tree...
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Background: Since mammography belongs to the most important preventive techniques in modern medicine, this study maps the related worldwide research output, which encompasses quantitative and qualitative aspects of the scientific activity and socio-economic features. Methods: The New Quality and Quantity Indices in Science (NewQIS) computing pla...
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Glyphosate is a systemic broad-spectrum herbicide that is by now the most extensively used herbicide in the world and has been the source for a still heated controversy about its harmful effects on human health and the environment. The different weighting of scientific studies has led to different attitudes in most countries towards appropriate han...
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Improving spatial accessibility to hospitals is a major task for health care systems which can be facilitated using recent methodological improvements of spatial accessibility measures. We used the integrated floating catchment area (iFCA) method to analyze spatial accessibility of general inpatient care (internal medicine, surgery and neurology) o...
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Zusammenfassung Das Endometriumkarzinom (EC) ist weltweit die sechsthäufigste Krebserkrankung der Frau. Im Jahr 2018 wurden mehr als 380.000 Neuerkrankungen und mehr als 89.000 Todesfälle registriert. Bekannte Risikofaktoren sind das steigende Lebensalter, ein erhöhter Body-Mass-Index (BMI) und eine alleinige Hormontherapie mit Östrogenen ohne Gest...
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Background Needlestick injuries have caused a deleterious effect on the physical and mental health of millions of health-care workers over the past decades, being responsible for occupational infections with viruses such as HIV or hepatis C. Despite this heavy burden of disease, no concise studies have been published on the global research landscap...
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Background Climate change is safe to be one of the biggest challenges of mankind. Human activities, especially the combustion of fossil fuels, contribute to the increase of greenhouse gases in the atmosphere and thus to the pace of climate change. The effects of climate change are already being felt, and the resulting damage will most likely be eno...
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Background From a global viewpoint, endometrial cancer belongs to the most common female cancers. Despite the heavy burden of diseases and numerous unanswered questions, no detailed pictures of the global structure of endometrial cancer research are available so far. Therefore, this malignancy was reviewed using the New Quality and Quantity Indices...
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Background: The currently prevailing global threat of COVID-19 caused the publication numbers on coronaviruses to explode. The awareness of the scientific and public community is enormous. But what about the sense of all these undertakings and what can be learned about the future for a better understanding? These questions were answered with estab...
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Obstructive Sleep Apnea is emerging as a global health epidemic, particularly due to the obesity pandemic. However, comprehensive prevalence data are still lacking and global OSA research has not yet been structurally evaluated. Using the latest comprehensive age/gender-specific BMI and obesity data, a global landscape estimating the risk/burden of...
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The risk of increasing dengue (DEN) and chikungunya (CHIK) epidemics impacts 240 million people, health systems, and the economy in the Hindu Kush Himalayan (HKH) region. The aim of this systematic review is to monitor trends in the distribution and spread of DEN/CHIK over time and geographically for future reliable vector and disease control in th...
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Purpose: The coronavirus disease 2019 (COVID-19) poses major challenges to health-care systems worldwide. This pandemic demonstrates the importance of timely access to intensive care and, therefore, this study aims to explore the accessibility of intensive care beds in 14 European countries and its impact on the COVID-19 case fatality ratio (CFR)....
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Background The adequate allocation of inpatient care resources requires assumptions about the need for health care and how this need will be met. However, in current practice, these assumptions are often based on outdated methods (e.g. Hill-Burton Formula). This study evaluated floating catchment area (FCA) methods, which have been applied as measu...
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Zusammenfassung Das Endometriumkarzinom (EC) zählt weltweit zur sechsthäufigsten Krebserkrankung der Frau. Im Jahr 2018 wurden weltweit mehr als 380.000 Neuerkrankungen und mehr als 89.000 Todesfälle registriert. Es ist vorrangig eine Erkrankung der Industrienationen, wo die höchsten Inzidenzzahlen in den USA und Europa erreicht werden. In diesen R...
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Children are commonly exposed to second-hand smoke (SHS) in the domestic environment or inside vehicles of smokers. Unfortunately, prenatal tobacco smoke (PTS) exposure is still common, too. SHS is hazardous to the health of smokers and non-smokers, but especially to that of children. SHS and PTS increase the risk for children to develop cancers an...
Article
Objective Although breech presentations occur in 3-4% of term deliveries, the mode of delivery still remains a topic of debate. Hence, this study aimed to analyze the worldwide research output on breech presentation. All relevant publications issued in the Web of Science from 1900 to 2014 were assessed by an objective, standardized bibliometric pro...
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Background: Aedes aegypti is a potential vector for several arboviruses including dengue and Zika viruses. The species seems to be restricted to subtropical/tropical habitats and has difficulties in establishing permanent populations in southern Europe, probably due to constraints during the winter season. The aim of this study was to systematical...
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Although the big tobacco companies offer the same cigarette brands across countries, little is known about the potential regional differences of the particulate matter (PM) emissions of apparently equal brands. PM emissions of three cigarette brands (Marlboro Gold, Winston Red resp. Classic, Parliament Platinum resp. Night Blue) from the United Ara...
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Background and aims: Despite decades of effort, numerous aspects on ulcerative colitis (UC) remain unknown and require further investigation. Scientists experience numerous challenges to survey >40,000 items that have been published on UC since 1900, to evaluate their scientific impact or to identify collaborative networks publishing the most rele...
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Zusammenfassung John B. Calhouns Experiment „Universum 25“ war die Fortsetzung einer Reihe verhaltensbiologischer Experimente an Mäusen und Ratten zur Überbevölkerung. Der Versuchsaufbau war konzeptioniert, um vermeintlich perfekte Überlebensbedingungen auf begrenztem Raum zu schaffen. Zunächst wurde ein starkes Wachstum der Kolonie beobachtet, wel...
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Ochratoxin, especially Ochratoxin A, is assumed to be one of the five most important mycotoxins contaminating food and feed. Primarily developing countries are affected due to the climate conditions and poorer modes of production. The overall adverse health effects on humans are still unclear, although threatening associations have been proven. Kno...
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Background: Although the incidence and mortality of gastric cancer (GC) decreased in the last years, some countries remain highly affected. Especially in high-income economies the cases of cardia types are steadily increasing. Currently, GC is ranked third as cause for cancer death worldwide, whereby two-thirds of deaths still occur in lowincome c...
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Background: Fabry disease (FD), the second most prevalent lysosomal storage disorder, is classified as a rare disease. It often leads to significant quality of life impairments and premature death. Many cases remain undiagnosed due to the rarity and heterogeneity. Further, costs related to treatment often constitute a substantial financial burden...
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Slim tobacco products shall appear by their look less harmful. In 2013, the European Union ministers discussed to ban them. However, only a ban on small package sizes was realized. To add more data for exposure risk assessment of slim tobacco products, the particulate matter (PM) amount in second-hand smoke (SHS) of super-slim size cigarettes compa...
Preprint
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Background Although the big tobacco companies offer the same cigarette brands across countries, little is known about regional differences of particulate matter (PM) emissions of apparently equal brands. PM emissions of three cigarette brands (Marlboro, Winston, Parliament) from the United Arab Emirates (UAE) and Germany were analysed. Second-hand...
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Systematic reviews represent the core and backbone of evidence-based medicine (EBM) strategies in all fields of medicine. In order to depict a first global sketch of the international efforts in the Cochrane database systematic reviews (CDSR), we analyzed the systematic reviews of the Cochrane database. Our global maps of systematic reviewing offer...
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Purpose: Today, the majority of medical graduates in countries such as the UK, the US or Germany are female. This poses a major problem for workforce planning especially in urology. We here use first the first time the previously established Brüggmann Groneberg (BG) index to assess if female academic career options advance in urology. Methods: D...
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Microplastics can be found all over the world, in the remotest regions and even in the Arctic snow. Primary microplastic is either produced as microparticles or enters the natural environment already as microparticles. Whereas secondary microplastic is generated by fragmentation or abrasion of other products in the natural environment. Both pollute...
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Objective The death of Dan Mishell Jr. – a true pioneer in reproductive health, reproductive endocrinology, infertility and family planning - was a great loss for the academic and clinical research community. Dan Mishell was the founder and editor of the Journal Contraception for over 43 years and his work has influenced the lives of women all over...
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Strategies employing information science and scientometric approaches were introduced to science policy and management over the past decades. As a rapidly evolving field, new bibliometric parameters are proposed and discussed continuously and the fields also benefits from the introduction of novel visualization techniques. The present article summa...
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From a global viewpoint, a lot of time is spent within the indoor air compartment of vehicles. A German study on mobility has revealed that, on average, people spend 45 minutes per day inside vehicles. In recent years the number of cars has increased to around 43 million vehicles in private households. This means that more than one car can be used...
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Background Esophageal cancer (EC) is one of the deadliest cancers worldwide. The contemporary strong increase of the adenocarcinomas in Western countries and the high mortality rates require the intensification of prospective multinational studies. Methods Therefore, this global health issue has been chosen for the bibliometric review of the globa...
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Zusammenfassung Die Infektion mit dem Bakterium Bartonella quintana (B. q.) kann zum sog. Schützengrabenfieber führen, welches auch Wolhynisches Fieber oder Fünftagefieber genannt wird. B. q. wird dabei über den Kot von infizierten Menschenläusen, den diese während des Blutsaugens abgeben, auf den Menschen übertragen. Für die Infektion des Menschen...
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Zusammenfassung Die humane Ehrlichiose und Anaplasmose sind Infektionskrankheiten. Sie können als Folge einer vor allem durch verschiedene Arten von Zecken übertragenen Infektion mit obligat intrazellulär lebenden Bakterientypen des Genus Ehrlichia (E.) und Anaplasma (A.) ausgelöst werden. Das klinische Bild reicht von milden, subklinischen Symptom...
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Abstract Beginning in the first decade of the 21st centruy, there was a growing disregard for the benefits of the German medical system concerning the junior obstetricians/gynecologists (OB/GYN) job situation. As in other fields of medicine, numerous colleagues left Germany to work in other countries such as the United Kingdom, Noway, Sweden, or Sw...
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Zusammenfassung Auch heutzutage sind Pilzintoxikationen mit schwerwiegenden Krankheitsfolgen ein bedeutendes Thema, sogar mit steigender Tendenz in den letzten Jahren. In diesem Beitrag werden die Häufigkeit, die Symptome und gesundheitliche Komplikationen sowie mögliche Therapie- und auch Präventionsmaßnahmen im Falle einer Exposition mit dem Pant...
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The inhalation of particulate matter (PM) in second-hand smoke (SHS) is hazardous to health of smokers and non-smokers. Tobacco strength (amount of tar, nicotine, and carbon monoxide) and different additives might have an effect on the amount of PM. This study aimed to investigate the influence of tobacco strength or additives on PM. Four cigarette...
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Objective Inhaled particulate matter (PM) in secondhand smoke (SHS) is deleterious for smokers and non-smokers. Different additives in cigarettes might effect the amount of PM. This study aimed to assess the influence of additives on the PM emissions from different cigarette types in SHS. Design An experimental study of PM measuring in SHS of ciga...
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Being the most proliferative journal of oncology a cancer research of the past decade, the Open Access journal Oncotarget had reached more than 20,000 publications and a relatively high impact factor score in the past years. In 2018, the journal citation report decided to withdraw the status of an impact factor journal. Since there was a large disc...
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The attacks of 9-11 have been not only the cause of the deaths of thousands of people but have also had an enormous impact on the health of the survivors, the rescue workers, the fire fighters and many more people worldwide. This study aims to depict a representative global picture of the research output of 15 years after the attacks of 9-11 by ana...
Article
Die fokale Dystonie bei Instrumentalmusikern ist in Deutschland seit August 2017 als Berufskrankheit anerkannt. Sie ist eine Erkrankung des zentralen Nervensystems, die sich als Verlust der feinmotorischen Kontrolle beim Musizieren manifestiert. Ausgelöst wird die Erkrankung durch die Ausführung feinmotorischer repetitiver Übungen, die über Jahre i...
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Zusammenfassung Die Katzenkratzkrankheit ist eine bakterielle Zoonose, die hauptsächlich durch Bartonella henselae ausgelöst wird. In der Großzahl der Fälle entsteht sie nach einem Katzenbiss oder einer Kratzverletzung v. a. durch junge Katzen. Die Erkrankung kennzeichnet sich typischerweise durch Fieber, eine Pustel/Papel am Ort der Inokulation so...
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Die Schizophrenie stellt ein schwerwiegendes psychiatrisches Krankheitsbild dar. Weltweit sind ca. 21 Mio. Menschen von Schizophrenie betroffen. Im Jahr 2001 wurde die Erkrankung im Weltgesundheitsbericht als einer der 10 Hauptgründe für „durch Behinderung beeinträchtigte Lebensjahre“ genannt. Seit der Einführung des Schizophreniebegriffs im Jahr 1...
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Zusammenfassung Eine Infektion mit Listerien kann in Abhängigkeit von Subspezies, Übertragungsweg, Erregermenge und individueller Immunität zu einer akut lebensbedrohlichen Erkrankung führen. Der häufigste humanpathogene Erreger ist Listeria monocytogenes. Es ergeben sich verschiedene wichtige Aspekte im beruflichen Kontext vor allem für Tierärzte,...
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Background Immigration has a strong impact on the development of health systems, medicine and science worldwide. Therefore, this article provides a descriptive study on the overall research output. Methods Utilizing the scientific database Web of Science, data research was performed. The gathered bibliometric data was analyzed using the establishe...
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Human papilloma virus (HPV) infection is linked to cervical cancer, which represents the world's fourth most common cancer in women. So far, no detailed map of the worldwide HPV research architecture has been constructed. Hence, this study focuses on the chronological development and geographical distribution of the global HPV-specific publications...
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Zusammenfassung Gebärmutterhalskrebs ist weltweit die vierthäufigste Krebsart bei Frauen und die siebthäufigste Krebserkrankung insgesamt. Nach Schätzungen der Weltgesundheitsorganisation (WHO) erkrankten im Jahr 2012 insgesamt 528.000 Frauen an einem invasiven Zervixkarzinom und 266.000 Frauen verstarben daran. Während es in Deutschland nur noch d...
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Zusammenfassung Die Hand-Fuß-Mund-Krankheit ist eine weitverbreitete Infektionserkrankung, die durch verschiedene Enteroviren der Gruppe A ausgelöst wird. Der typische Verlauf kennzeichnet sich durch allgemeine Symptome eines grippalen Infektes, in dessen Verlauf sich ein typischer Hautausschlag an Händen, Füßen und Mund anschließt. Die Transmissio...
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After publication of the original article [1], the authors reported two errors which needed to be corrected.
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Die vorliegende Übersicht zum Tumormarker Her2-/neu („human epidermal growth factor 2“) wird im Rahmen der Serie „Tumormarker“ des Zentralblatts für Arbeitsmedizin, Arbeitsschutz und Ergonomie publiziert, die sich mit dem immer häufigeren Gebrauch der Bestimmung von spezifischen Markern bei sog. Manager-Vorsorgen und Check-up-Untersuchungen beschäf...
Article
Background As a metabolite of Aspergillus flavus and Aspergillus parasiticus, Aflatoxin is a carcinogenic and mutagenic mycotoxin that is confirmed as a class-1 agent. It contaminates the most of our staple foods, affecting 25% of global crops. It is a global threat to human health by causing liver cancer in conjunction with Hepatitis B. Developing...
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Fleckfieber beschreibt ein Krankheitsbild, das durch die humane Infektion mit Rickettsia prowazekii (R. p.) ausgelöst wird. R. p. wird dabei hauptsächlich über die Ausscheidungen von Körperläusen auf den Menschen übertragen. Während Infektionen mit R. p. durch die konsequente Bekämpfung von Kleiderläusen in Nordeuropa und Nordamerika heute Seltenhe...
Article
Implications: Particulate matter (PM) in ETS endangers the health of nonsmokers and smokers. This study considers the effect of menthol, an additive in cigarettes, on PM emissions. Does menthol increase the amount of PM? Due to the exposure to secondhand smoke nearly 900,000 people die each year worldwide. The aim of the study is to measure the pa...
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Background: Despite the numerous associations of vitamin D with health and disease, vitamin D deficiency is still common from a global perspective. While basic research, clinical and preventive activities grow constantly in vitamin D research, there is no in-depth analysis of the related global scientific productivity available so far. Methods:...
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Zusammenfassung Nokardiose bezeichnet die akute oder chronische Infektion durch verschiedene aerobe Bodensaprophyten des Genus Nocardia (N.). Zu einer humanen Infektion kann es zumeist nach Inhalation oder durch direkte Inokulation der Haut kommen. Der häufigste humane Erreger ist N. asteroides. Eine Infektion betrifft in erster Linie Immunsupprimi...
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Zusammenfassung Die Shigellose stellt ein weltweites Gesundheitsproblem dar. Es sind 4 Spezies von humanpathogenen Shigellen (S.) als Auslöser der Erkrankung (d. h. Shigellose) beim Menschen derzeit bekannt: S. dysenteriae, S. flexneri, S. boydii und S. sonnei. Diese werden in weitere Subspezies unterteilt. Die typischen Symptome einer akuten Shige...
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Die humane Infektion mit Burkholderia pseudomallei, einem gramnegativen Bakterium, welches sich v. a. im Boden und Wasser findet, kann zu einer potenziell lebensbedrohlichen Erkrankung führen: der Melioidose. Der Verlauf der Erkrankung hängt maßgeblich von Subspezies, Übertragungsweg, Erregermenge, individueller Suszeptibilität und/oder Immunität a...
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Zusammenfassung Dieser Artikel stellt einige Ergebnisse der DAK-Studie aus dem Jahr 2017 zum Thema Schlafverhalten vor und gibt eine grundlegende Übersicht zum Thema Schlafstörung. Die Schlafstörungen haben laut DAK im Vergleich zum Jahr 2010 zugenommen. Sie führen nur im geringen Maße dazu, dass sich Arbeitnehmer krankmelden. Arbeitnehmer mit Schl...
Article
Uterine fibroids can severely impact a woman's quality of life, result in significant morbidity and are a leading indication for hysterectomy. Many aspects of the disease remain largely obscure. Despite these knowledge gaps, no detailed maps of the global fibroid research architecture have yet been generated. This study used the NewQIS approach to...
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Objective About 2% of all pregnancies are complicated by the implantation of the zygote outside the uterine cavity and termed ectopic pregnancy. Whereas a multitude of guidelines exists and related research is constantly growing, no thorough assessment of the global research architecture has been performed yet. Hence, we aim to assess the associate...
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Zusammenfassung Das Klimakterium der Frau umfasst alle mit dem Nachlassen der vollen Geschlechtsreife verbundenen psychischen und physischen Veränderungen. Es fällt in eine Lebensphase, in der Frauen häufig sowohl im privaten als auch beruflichen Bereich stark gefordert werden. Die durch die hormonellen Veränderungen im Klimakterium verursachten Be...
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Die Bestimmung von Tumormarkern im Serum stellt einen wesentlichen Bestandteil der Diagnostik, Verlaufskontrolle und Therapieüberwachung maligner Tumoren dar. CA 15-3 ist ein Marker, der in der Diagnostik des Mammakarzinoms wertvolle Aussagen ermöglicht. Aufgrund eines geringen positiven prädiktiven Werts ist dieser Tumormarker zum Screening asympt...
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Die Bestimmung von Tumormarkern im Serum stellt einen wesentlichen Bestandteil der Diagnostik, Verlaufskontrolle und Therapieüberwachung maligner Tumoren dar. Das karzinoembryonale Antigen (CEA) ist ein Marker, der in der Diagnostik des kolorektalen Karzinoms wertvolle Aussagen ermöglicht. Er zeichnet sich mit hoher Sensitivität und Spezifität aus....
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Die Bestimmung von Tumormarkern stellt einen wesentlichen Bestandteil der Diagnostik, Verlaufskontrolle und Therapieüberwachung maligner Tumoren dar. Das SCC ist ein Marker für Plattenepithelkarzinome, der wertvolle Aussagen über das Tumorstadium ermöglicht. Er zeichnet sich durch hohe Sensitivität und Spezifität aus. Die Ursache von Plattenepithel...

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