Dorcas James

Dorcas James
Ahmadu Bello University | ABU · Department of Biochemistry

About

38
Publications
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Introduction
Dorcas James currently works at the Department of Biochemistry, Ahmadu Bello University. Dorcas does research in Nutraceuticals, toxicology and medicinal plantsThe current project is evaluation of anticancer, anti diabetes of medicinal plant, dietary inclusion of some functional foods

Publications

Publications (38)
Preprint
Background Maternal nutrition plays a major role in the outcome of pregnancy. Nutrition and metabolism in pregnancy determine the intrauterine environment, which influences the development of the fetus and a child's health from birth to death. Although dyslipidemia during pregnancy has long-term effects on mother and child, routine antenatal clinic...
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Objective: The study assessed the knowledge, attitude and management practices of diabetes patients attending medical outpatient department in Federal Capital Territory Abuja. Materials and Methods: A total of 120 randomly selected respondents between 18 - 65 years were assessed using standard methods in a cross-sectional survey involving the use o...
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Vitex doniana leaves are used in traditional medicine systems for the treatment of inflammatory-related disorders and breast cancer in West Africa. However, there is a dearth of scientific evidence on the effectiveness of the plant leaves on cancer cells or on the safety of the plant if used continuously. This study examined the effects of V. donia...
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Background Changes in blood lipid level (dyslipidemia) play a central role in the onset and pathogenesis of macrovascular complications of diabetes mellitus. Traditional herbal healers commonly use anti-diabetic polyherbal formulations to provide a multi-therapeutic approach for the treatment of diabetes mellitus and its associated complications. T...
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Postmenopausal osteoporosis is a global health problem characterized by decreased in bone mineral density (BMD) and progressive deterioration of microarchitecture and subsequent increase in bone fragility and susceptibility to fracture. More than 200 million people suffer from osteoporosis worldwide with about 8.9 million fractures and the prevalen...
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Vitex doniana leaves are used traditionally in West Africa for the treatment of swellings and cancer. We investigated if Vitex doniana leaves extract could ameliorate 7, 12-dimethylbenz[a]anthracene (DMBA)-induced mammary damage. Female Wistar rats aged 52 ± 2 day were administered 80 mg/kg DMBA. After monitoring for 150 day, rats were administered...
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Background: Inflammation has been implicated in many disorders, including cancer and available therapies elicit adverse effects. Plants of the family Rubiaceae have shown potency against inflammation. The anti-inflammatory and anti-oxidant potential of Feretia apodanthera was investigated in this study to evaluate its effectiveness. Methods: The...
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Background: Vernonia amygdalina (VA) is used in the traditional management of diabetes in Nigeria. Previous scientific verification of VA is on Type‑1 diabetes model, in spite of the continuous increase in Type‑2 diabetes (T2D) among adults. This study aimed to validate the antidiabetic effects of VA leaf fraction (VALF) in a unique T2D rat model...
Article
Breast cancer remains a burden in both developed and developing countries, with higher mortality in developing countries. Attempts to eradicate cancer have not been successful despite the progress made in the development of more novel chemotherapeutic drugs. Reactive-oxygen-species-mediated oxidative stress is known to play a role in breast cancer...
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Background Garcinia kola is used in traditional medicine in various parts of Africa including Nigeria for the amelioration of hypertension, cough, diabetes, sickle cell anemia, bacterial and fungal infections amongst others. The prophylactic and therapeutic efficacy of Garcinia kola biflavonoid fractions (GKBF); root bark (RBBF), stem bark (SBBF) a...
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Background and Purpose. Traditional management of sickle cell disease (SCD) is ubiquitous in Africa. In south-eastern Nigeria, Telfairia occidentalis (T. occidentalis) is strongly recommended for consumption by SCD patients, owing to its presumed therapeutic effect. This study investigates the antisickling and membrane regenerative potentials of T....
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The effect of 10% supplementation of fermented and unfermented Telfaira occidentalis and Gnetum africanum leaves for 21 days on haemoglobin-iron, haematological parameters and serum ferritin was investigated to determined if the leaves could replenish haemoglobin in iron deficient rats. Iron deficiency significantly (p<0.05) decreased the relative...
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Objective: The effect of aqueous extracts of the ripped fruit peel of three cultivars of Musa sapientum (Saro, Ominni and Oranta) on the lipid profile of normolipidemic and hyperlipidemic rats were examined. Methods: Aqueous peel extracts of the 3-cultivars of Musa sapientum (100mg/Kg bw) were administered to normolipidemic and poloxamer-407 induce...
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The ethanol extracts of leaves, stem bark, and root bark of Vitex doniana were evaluated for antioxidant activity in poloxamer-407-induced hyperlipidemic rats. Fifty four (54) mixed sex Wistar rats weighing between 100 and 200 g were used. The animals were divided into nine different groups of six rats per group; normal control, hyperlipidemic cont...
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Objective: To perform phytochemical and mineral analyses on leaves, stem and seeds of Telferia occidentalis (T. occidentalis), and examine the inhibition of methemoglobin build-up in sickled erythrocytes. Methods: The phytochemical evaluation was carried out by qualitative and quantitative analyses, whereas mineral elements were quantitatively a...
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Objective: To evaluate the hepatocurative effects of aqueous root bark, stem bark and leaves of Vitex doniana in carbon tetrachloride (CCl4) induced liver damage and non induced liver damage albino rats. Methods: A total of 60 albino rats (36 induced liver damage and 24 non induced liver damage) were assigned into liver damage and non liver dama...
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The preventive and therapeutic effects of Garcinia kola biflavonoid fractions on some haematological parameters in Poloxamer 407 (P407) induced hyperlipidemic rats was studied for a period of 21 days. Sixty mixed sex Wistar rats weighing 150-200 g were divided into two major groups; Preventive group comprising the following sub-groups: normal contr...
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This study was designed to investigate the effect of Eugenia jambolana on haematological parameters and lipid profile being a commonly used plant in Nigerian folklore medicine. Aqueous extracts of the leaves, stem bark and root bark of Eugenia jambolana were screened for phytochemicals and its effect on haematological parameters and lipid profile i...
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Objective: The antioxidant effects of aqueous root bark, stem bark and leaves of Vitex doniana (V. doniana) were evaluated in carbon tetrachloride (CCl4) induced liver damage and non induced liver damage albino rats. Methods: A total of 60 albino rats (36 induced liver damage and 24 non induced liver damage) were assigned into liver damage and non...
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The phytopreventive and phytotherapeutic effects of Garcinia kola biflavonoid fractions on some biochemical parameters in Poloxamer 407 (P407)-induced hyperlipidemic rats were studied for a period of 21 days. Sixty mixed sex Wistar rats weighing 150–200 g were divided into two major groups: (1) phytopreventive group comprising the following subgrou...
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The effects of aqueous extract of Phyllathus amarus and Vitex doniana stem bark on blood glucose of Streptozotocin (STZ) induced diabetes rats and some liver biochemical parameters were investigated. Study was conducted with 36 albino rats (wistar strain). Thirty- six rats (30 diabetic and 6 non-diabetic) were assigned into six groups of 6 rats eac...
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Effects of aqueous extracts of leaves and stem of Vitex doniana on carbon tetrachloride induced liver injury in rats was assessed. Thirty- six (36) albino rats were divided into six groups of 6 animals each by the randomized random design method, each were allowed food and water ad libidium. Group I (control) was given olive oil, while the rest gro...
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The aqueous extracts of the leaf, stem bark and root of Ximenia americana was evaluated for its phytochemical constituents. A study was also conducted with 20 albino rats (Wistar strain) weighing between 100-130 g to access for hepatic effect and haematological effect. The extracts were administered every day for a period of 21 days. Group 1 was th...
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Aqueous extract of the whole plant of Phyllanthus amarus was assessed for some biochemical effect in albino rats. Oral administration of aqueous extract at doses of 50, 100 and 200 mg/kg body weight shows that the extract promote glucose uptake. Daily administration of the extracts (50, 100 and 200 mg/kg bodyweight) for 14 days showed that the extr...
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The effect of aqueous extract of the w hole plant of Phyllanthus amarus was assessed for somebiochemical effect in albino rats. Different doses (50, 100 and 200mg/kg bodyweight) of crude extract wasadministered Intraperitoneal for 14 consecutive days. Glucose tolerance test shows that there was significant(p < 0.05) reduction in the serum blood glu...
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2 National Research Institute for Chemical Technology Bassawa, Zaria Nigeria. Accepted 26 May, 2009 A study was conducted with 24 albino rats (wistar strain) ages 3 weeks to determine the effect of substitution of diets with processed neem seed cake on growth, performance and nitrogen metabolism of rats. Group 1 and those of groups II and III were...
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The root, stem bark and leaf of Ximenia americana from the Olacaceae family which is used as herbal remedies for the cure of many ailments by natives in the Northern part of Nigeria was studied. The aqueous and methanolic extracts of the afore mentioned parts of the plant were subjected to phytochemical screening and antibacterial evaluation. From...
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In vitro and in vivo trypanocidal activity of the leaf extract of Guira senegalensis against Trypanosoma brucei brucei have been investigated. Extract obtained from fresh leaves heated with methanol had highest in vitro activity against the parasite at concentration of 8.3 mg mL <sup>1</sup> of blood. Dried leaf methanolic extract also had in vitro...
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Production of raw starch degrading amylase by a mixed culture of Aspergillus niger and Saccharomyces cerevisae grown on sorghum pomace as nutrient source was investigated. Effect of mineral nutrient supplementation of sorghum pomace on raw starch degrading amylase activity was also determined. Sorghum pomace medium significantly (P<0.05) induced hi...
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A survey was carried out in Kaduna State of Nigeria to establish the indigenous knowledge system for treating trypanosomiasis in domestic animals. Questionnaire and interviews were, respectively, administered to, or conducted with about 200 livestock farmers and traders spread around the state. Data obtained revealed the use of several plants eithe...

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Project (1)
Project
The aim of the study is to evaluate the effectiveness of supplementary feeding programme in Rafin-Magaji Primary Health Care Centre (PHC) Kufena ward, Zaria LGA.