
Dong LiuNanjing Institute of Geography and Limnology; Chinese Academy of Sciences · Department of geographic information science
Dong Liu
Doctor of Philosophy
About
120
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Introduction
Publications
Publications (120)
The sea surface skin temperature (SSTskin) is of critical importance with regard to air–sea interactions and marine carbon circulation. At present, no single remote sensor is capable of providing a gap-free SSTskin. The use of data fusion techniques is therefore essential for the purpose of filling these gaps. The extant fusion methodologies freque...
Qiyan Lin Xiyu Ge Xia Li- [...]
Cunwu Chen
Wuzi Yanzong decoction (WZYZD) belongs to the traditional formula for treating male infertility caused by oligoasthenozoospermia (OLI). This research aims to elucidate the therapeutic substance basis and potential pharmacological mechanisms of WZYZD in treating OLI. A total of 52 chemical ingredients were identified from WZYZD. HE and TUNEL stainin...
Yellow River is famous for its exceptionally higher suspended sediment concentrations (SSC), displaying significant spatiotemporal heterogeneity across diverse sections. Although SSC monitoring of the Yellow River and some of its tributaries has been achieved using Landsat data, it remains unclear whether the inclusion of higher spatial resolution...
Previous studies typically assumed a constant total organic carbon (OC) storage in the lake water column, neglecting its significant variability within a changing world. Based on extensive field data and satellite monitoring techniques, we demonstrate considerable spatiotemporal variability in OC concentration and storage for 24,366 Chinese lakes d...
Against the background of climate warming, marine heatwaves (MHWs) and terrestrial drought events have become increasingly frequent in recent decades. However, the combined effects of MHWs and terrestrial drought on CO2 uptake in marginal seas are still unclear. The East China Sea (ECS) experienced an intense and long-lasting MHW accompanied by an...
Accurate and consistent observations of diurnal variability of sea surface temperature (SST DV) and its impact on air–sea heat fluxes over large areas for extended periods are challenging due to their short time scale and wide coverage. The hourly gap-free SSTs generated from Japan Aerospace Exploration Agency-Japan Agency for Marine–Earth Science...
The study of river sediment is a broad and complex field. One of the very important parameters is suspended particle size (SPS), which is indispensable for understanding water–sediment dynamics. As one of the most serious soil erosion areas in the world, the Loess Plateau delivers a large amount of sediment to the Yellow River and its numerous trib...
The spatiotemporal variations in suspended sediment concentration (SSC) in the lower reaches of the Yellow River exhibit significant variability and are influenced by reservoir operations. Understanding the spatiotemporal distribution characteristics of SSC in water holds crucial implications for environmental protection and reservoir operation man...
Variations in the concentrations and distribution of suspended particulate matter (SPM) of lakes can be used to show the responses of lake environment to climate and landscape change. However, the shifts and trends of SPM and potential drivers have not been well investigated across large spatial and temporal dimensions. This study developed a robus...
Riverine organic carbon (OC) transport plays a role in regulating terrestrial and marine carbon pools and deteriorating coastal water quality. However, long-term OC transport in Asian rivers and its diffusion in marginal seas have remained unreported. This study reported the spatiotemporal variations in OC resources for Hong Kong waters, China, bas...
Dissolved organic matter (DOM) plays an essential role in the global lake carbon cycle. Understanding DOM composition and monitoring its spatiotemporal dynamics are of great significance for understanding the lake carbon cycle, controlling water pollution, and protecting water resources. However, previous studies have focused mainly on eutrophic fr...
Introduction:
Youthful blood environment was shown to decelerate the aging process of kidney and to attenuate senile renal fibrosis in a young-old parabiotic animal model; in addition, we identified a stem cell factor (SCF) that is closely linked with the process. This research was to investigate the effect of youthful blood environment on senile...
Satellite observation can significantly reduce the uncertainties in CO 2 emission estimations compared to insufficient field data. However, big challenges remain in developing remote sensing-based models for mapping concentrations of dissolved carbon dioxide (cCO 2) in lakes at regional or global scales. We developed a cCO 2 estimation model using...
Water clarity, indexed by Secchi disk depth (Zsd), comprehensively reflects water quality and can be monitored by satellite. Zsd may vary across lakes globally, driven by natural and human activities (climate, land use/land cover, lake morphological characteristics, etc.). Based on Sentinel-3 Ocean and Land Color Instrument (OLCI) imagery, we explo...
A robust and reliable chlorophyll-a (Chla) concentration algorithm is still lacking for optically complex waters due to the lack of understanding of the bio-optical process. Machine learning approaches, which excel at detecting potential complex nonlinear relationships, provide opportunities to estimate Chla accurately for optically complex waters....
Docetaxel (DTX) is an important broad-spectrum antitumor drug, but poor water solubility and multidrug resistance often limit clinical application. A nitric oxide (NO) donor docetaxel prodrug (DISMN-DTX) was designed and synthesized, through a two-step procedure starting from isosorbide mononitrate. The novel amphiphilic small molecule prodrug is r...
Paederia foetida L. belonging to Rubiaceae family is a perennial medicinal herb widely distributed in India and China. The first complete chloroplast genome sequence of P. foetida was assembled and characterized in this study. The total chloroplast genome was 153,591 bp in length with 37.74% GC content, composed of a large single-copy (LSC) region...
Rivers serve as regulators of global climate by releasing greenhouse gases, burying particulate carbon, and connecting different ecosystem carbon pools. However, long-term organic carbon (OC) transport features across different Asian rivers are not well known due to unavailable data. Based on routinely monitored environmental and hydrological data...
Osteoarthritis (OA) treatment is a highly unmet medical need. Development of a disease-modifying OA drug (DMOAD) is challenging with no approved drugs on the market. Inhibition of ADATMS-4/5 is a promising OA therapeutics to target cartilage degradation and potentially can reduce joint pain and restore its normal function. Starting from the reporte...
Rubia yunnanensis Diels, an important medicinal herb, is mainly distributed in Yunnan province, Southwest China. In this study, the complete chloroplast genome of R. yunnanensis was successfully sequenced. The assembled chloroplast genome was 155,108 bp in length with an overall GC content of 36.98%, including a pair of inverted repeat (IR) regions...
The attention to chiral drugs has been raised to an unprecedented level as drug discovery and development strategies grow rapidly. However, separation of enantiomers is still a huge task, which leads to an increasing significance to equip a wider range of expertise in chiral separation science to meet the current and future challenges. In the last...
Saposhnikovia divaricata, a well-known Chinese medicinal herb, is the sole species under the genus Saposhnikovia of the Apiaceae subfamily Apioideae Drude. However, information regarding its genetic diversity and evolution is still limited. In this study, the first complete chloroplast genome (cpDNA) of wild S. divaricata was generated using de nov...
Stimulator of interferon genes (STING) activation induces type I interferons and pro-inflammatory cytokines which stimulate tumor antigen cross presentation and the adaptive immune responses against tumor. The first-generation of STING agonists, cyclic di-nucleotide (CDN), mimicked the endogenous STING ligand cyclic guanosine monophosphate adenosin...
Temperature gradient‐induced Marangoni convection has attracted much attention for basic research and applications since it provides an effective means for mass and heat transfer through a liquid surface flow. Here the authors first propose a general principle to enhance such surface flow by hindering its transition to recirculation flow using an e...
RNA can be modified by over 170 types of distinct chemical modifications, and the most abundant internal modification of mRNA in eukaryotes is N6-methyladenosine (m6A). The m6A modification accelerates mRNA process, including mRNA splicing, translation, transcript stability, export and decay. m6A RNA modification is installed by methyltransferase-l...
Unhealthy diet, in particular high-fat diet (HFD) intake, can cause the development of several metabolic disorders, including obesity, hyperlipidemia, type 2 diabetes mellitus (T2DM), non-alcoholic fatty liver disease (NAFLD), and metabolic syndrome (MetS). These popular metabolic diseases reduce the quality of life, and induce premature death worl...
The respiratory system holds crucial importance in the biology of vertebrate animals. Injuries of the respiratory system caused by viral infections (e.g., by COVID‐19, MERS, and SARS) can lead to severe or lethal conditions. So far there are no effective treatments for respiratory injuries. This represents a highly unmet clinical need, e.g., during...
Water clarity serves as a sensitive tool for understanding the spatial pattern and historical trend in lakes' trophic status. Despite the wide availability of remotely sensed data, this metric has not been fully explored for long-term environmental monitoring. To this end, we utilized Landsat top-of-atmosphere reflectance products within Google Ear...
With the rapid development of nanotechnology, new types of fluorescent nanomaterials (FNMs) have been springing up in the past two decades. The nanometer scale endows FNMs with unique optical properties which play a critical role in their applications in bioimaging and fluorescence-dependent detections. However, since low selectivity as well as low...
The complex and changeable robotic operating environment will often cause the low success rate or failure of the robot grasping. This paper proposes a grasp pose detection method based on the cascaded convolutional neural network, which can be applied to grasp unknown irregular objects under unstructured environment. The grasping feature and the gr...
When a laser beam induces surface tension gradient at the free surface of a liquid, a weak surface depression is expected and has been observed. Here we report giant depression and rupture in “optothermocapillary fluids” under the illumination of laser and sunlight. Computational fluid dynamics models were developed to understand the surface deform...
Nonlinear optical property of atomically thin materials suspended in liquid has attracted a lot of attention recently due to the rapid development of liquid exfoliation methods. Here we report laser-induced dynamic orientational alignment and nonlinear-like optical response of the suspensions as a result of their intrinsic anisotropic properties an...
In order to execute complex tasks in complex environment successfully, robot need to make detailed planning for high-level task and low-level motion according to the requirements of task scenes. In this paper, a method based on the combination of classical planning and motion planning is discussed. In terms of high-level tasks, the robot decomposes...
The inflection point temperature of rheology (IPTR) of heavy oil transforming from a non-Newtonian fluid into a Newtonian fluid is a key parameter in the steam huff- and-puff process. It is particularly relevant in terms of optimizing injection parameters, calculating the heating radius, and determining well spaces. However, the current approach ex...
Dissolved organic carbon (DOC) in lakes serves as a substrate for heterotrophic bacterial growth, a regulator of the global carbon cycle, and a light absorption agent. DOC in eutrophic lakes is greatly influenced by phytoplankton phenology and terrigenous input by rivers. Therefore, it is necessary and significant to dynamically monitor the concent...
It is well known that an outward Marangoni convection from a low surface tension region will make the free surface of a liquid depressed. Here, we report that this established perception is only valid for thin liquid films. Using surface laser heating, we show that in deep liquids a laser beam pulls up the fluid above the free surface generating fo...
The population structure of Phytophthora capsici among asexual and sexual progenies was analyzed using ISSR. Thirty asexual progenies of one parent and three sexual populations were assayed for genetic diversity using 5 ISSR primers and DNA from 120 offspring of P. capsici was amplified. In total, 71 reproducible ISSR fragments were obtained, of wh...
Thrombosis, which seriously endangers human health and life, is the leading cause of morbidity and mortality globally. Antithrombotic drugs can interfere with the occurrence and development of thrombotic diseases and play an important role in the treatment of thrombotic diseases. However, unsatisfactory efficacy and serious adverse effects of exist...
The impacts of COVID-19 lockdowns on air quality around the world have received wide attention. In comparison, assessments of the implications for water quality are relatively rare. As the first country impacted by COVID-19, China implemented local and national lockdowns that shut down industries and businesses between January and May 2020. Based o...
Water clarity provides a sensitive tool to examine spatial pattern and historical trend in lakes trophic status. Yet, this metric has insufficiently been explored despite the availability of remotely-sensed data. We used three Secchi disk depth (SDD) datasets for model calibration and validation from different field campaigns mainly conducted durin...
The oncological role of the density of nerve fibers (NFs) in the tumor microenvironment (TME) in intrahepatic cholangiocarcinoma (iCCA) remains to be determined. Therefore, data of 95 iCCA patients who underwent hepatectomy between 2010 and 2019 was analyzed regarding NFs and long-term outcome. Extensive group comparisons were carried out and the a...
Algal blooms happen widely in eutrophic lakes. The satellite-derived surface algal bloom area and chlorophyll-a (Chl-a) concentration are commonly used as indicators to judge the water quality. However, vertical migration of phytoplankton may seriously affect the assessment accuracy of water quality with the surface status as an indicator. In fact,...
Selecting an appropriate object transfer point can effectively improve human comfort in the process of human -robot object transfer. In this paper, a human-robot handover system based on human behavior patterns is proposed. Firstly, the arm joint torque model and the medium joint angle model were combined to establish the human comfort model, and a...
Water color is an important parameter in water quality assessment. However, the existing water color investigations have mostly focused on the lakes with areas greater 1 km2. In order to improve the understanding of the color of water bodies in China, a cloud-free composite image of China for the summer of 2015 was generated using time-series of La...
Background: Rhabdomyolysis (RM) is a clinical syndrome characterized by breakdown of skeletal muscle fibers and release of their contents into the circulation. Myoglobin-induced acute kidney injury (AKI) is one of the most severe complications of RM. Based on our previous research, exogenous biological renal support alleviates renal ischemia–reperf...
The formation of a thermally insulating vapor layer at the Leidenfrost state poses a major concern for heat transfer performance and safety operation of many phase change thermal systems. It is desirable to develop effective means to suppress the Leidenfrost state and to elevate the Leidenfrost point (LFP). In this work, the electrostatic suppressi...
Clinical success of IL-17/IL-23 pathway biologics for the treatment of moderate to severe psoriasis suggests that targeting RORγt, a master regulator for the proliferation and function of Th17 cells, could be an effective alternative. However, oral RORγ antagonists (VTP43742, TAK828) with high systemic exposure showed toxicity in phase I/II clinica...
Low-frequency high-magnitude storms can flush disproportionate amounts of terrigenous dissolved organic carbon (DOC) and particulate organic carbon (POC) into rivers during a short period. However, previous studies focused on the impacts of storms on organic carbon transport in headwater streams that are minimally influenced by human activities and...
Dendrobium huoshanense is a precious medicinal plant belonging to Dendrobium of Orchidaceae. It is a special medicinal material and extremely scarce in Huoshan county, Anhui province. At present, D. huoshanense has been greatly protected, which also makes it possible to industrialize relying on tissue culture and artificial cultivation technology....
It is well accepted that an outward Marangoni convection from a low surface tension region will make the surface depressed. Here, we report that this established perception is only valid for thin liquid films. Using surface laser heating, we show that in deep liquids a laser beam actually pulls up the fluid above the free surface generating fountai...
Fusarium oxysporum f. sp. cucumerinum (FOC) is one of the most destructive pathogens in many cucumber-growing countries around the globe. There is still lack of high-resistant cucumber cultivars against this pathogen, and the use of fungicides is threatening the environmental conditions. However, biocontrol is an environment-friendly technique in p...
Magnolia officinalis Rehd. et Wils. is an important traditional Chinese herbal medicine and widely distributed in the south of Yangtze River in China. In this study, the complete chloroplast genome sequence of wild M. officinalis was assembled and characterized from high-throughput sequencing data. The chloroplast genome was 160,009 bp in length, c...
Phytophthora sojae can cause soybean phytophthora blight, and greatly reduce soybean production. It is helpful to understand the pathogenic mechanism of P. sojae to prevent soybean phytophthora blight and ensures food security. Glycosyl hydrolases (GHs) disintegrate plant cell walls for nutrition and invasion, and they may act as an important virul...
Background
Rhabdomyolysis (RM) is a clinical syndrome characterised by the breakdown of skeletal muscle fibres and release of their contents into the circulation. Myoglobin-induced acute kidney injury (AKI) is one of the most severe complications of RM. Based on our previous study, exogenous biological renal support alleviates renal ischaemia-reper...
The purpose of this paper is to provide details on the implementation of an accurate and intelligent automation solution to achieve the abdomen cutting operation of the porcine carcass. The system consists of an industrial robot, a binocular camera, an end effector, and an industrial computer. Threshold segmentation is used to detect the contour of...
Background: youthful blood environment was shown to decelerate the aging process of kidney and to attenuate senile renal fibrosis in a young-old parabiotic animal model; in addition, we identified a stem cell factor (SCF) that is closely linked with the process. To further investigate the effect of youthful blood environment on renal interstitial f...
Purpose
Pulmonary surfactants (eg, sinapultide) are widely used for the treatment of lung injury diseases; however, they generally induce poor therapeutic efficacy in clinics. In this study, sinapultide-loaded microbubbles (MBs) were prepared and combined with ultrasound (US) treatment as a new strategy for improved treatment of lung injury disease...
Lakes play an important role in the global carbon cycle; however, there are still large uncertainties in the estimation of global lake carbon emission due to the limitations in conducting field surveys at large geographic scales. Using long-term Moderate-Resolution Imaging Spectroradiometer (MODIS) imagery and field observation data in eutrophic La...
Water transparency, usually denoted by Secchi disk depth (SSD), represents the first-order description of water quality and has important implications for the diversity and productivity of aquatic life. In China, lakes supply freshwater and ecosystem services to nearly a billion people. Therefore, real time monitoring of lake transparency is of gre...
The Sustainable Development Goal (SDG) 6.3.2 of the United Nations (UN) focuses on ambient water quality, while water clarity simplistically and visually reflect water quality and can potentially support SDG 6.3.2 reporting. In this study, based on extensive field data and Sentinel-3 Ocean and Land Color Instrument (OLCI) imagery, a random forest r...
Fruit curving lowers the commercial value of cucumber and leads to significant economic losses. The mechanism driving the abnormal curving of cucumber is largely unknown. Through our previous work, we discovered that 2 days post-anthesis (DPA) was the key time point at which various phenotypic and genotypic characteristics of cucumber fruits are de...