Donald Harvey Marks

• MD PhD
• Graduate at University of California, Los Angeles

Specific individual face recognition in the brain has been demonstrated with analysis of three dimensional neural activation patterns-cognitive engrams-revealed by functional magnetic resonance imaging (fMRI). Individual faces can also be differentiated by biometric pattern recognition from camera images using biometric analysis. A correlation betw...

Methodology to determine causal relatedness between medicine and vaccines and an adverse event

s disease (PD) is a neurodegenerative disease caused by deficiency of dopamine production in the substantia nigra region of the brain. Characteristic features of PD include resting tremor, rigidity, bradykinesia and postural instability. Interestingly, a very similar syndrome in its clinical presentation can be produced by exposure to the metal man...

The impetus for this review was recent increased warnings of cardiovascular toxicity, fractures and bladder cancer associated with glitazone use. A drug utilization review was performed regarding the use of Actos (pioglitazone) and Avandia (rosiglitazone) at Cooper Green Mercy Hospital (CGMH), an inner city safety net hospital in Birmingham, Alabam...

A wide range of neurological complications have been reported via the medical literature and the VAERS system after vaccination with recombinant outer surface protein A (OspA) of Borrelia. To explore this issue, 24 patients reporting neurological adverse events (AE) after vaccination with Lymerix, out of a group of 94 patients reporting adverse eve...

Neuroimaging was applied to provide visual documentation of the presence of pain in a patient complaining of long-term neck pain. Activation in the pain-related brain matrix was increased after induced pain, compared with a resting baseline condition, and decreased after the pain had subsided somewhat - See more at: http://archive.ispub.com/journal...

Interferon (IFN), a biological medication used to treat viral hepatitis and certain cancers, has clinically significant potential to cause a wide range of adverse neuropsychiatic effects. The spectrum ranges from agitation, aggression, insomnia and irritability, to suicidal thought and drug-seeking behavior (DSB). Out of a total population of 353 p...

Five patients with hepatitis C (HCV), three of whom were treated with interferon alpha2 (IFN) and two who were not treated with IFN, developed homicidal ideation (HI) during a 4-year period. Following accepted rules for determining causation, there appeared to be a causal relatedness between IFN use and the development of homicidal ideation for tho...

Two patients with a history of suicidal ideation (SI) underwent functional MR imaging while undergoing treatment with interferon alpha 2 (IFN) for Hepatitis C virus infection (HCV). Patient #77 had a remote history of SI, but no current SI when treated with IFN. Patient #288 experienced an IFN-heightened SI, although she denied intent, a plan or a...

Mild cognitive impairment (MCI), a perceivable decrease in thought processes, primarily memory, occurs in individuals who are otherwise able to function in everyday activities. These patients have difficulty remembering the names of people, performing calculations, navigating in a mall parking lot, and keeping track of common objects. Various level...

Most studies comparing the response of African American (AA) patients to other groups for treatment of hepatitis C virus (HCV) have been performed in academic centers in the setting of clinical trials. In general, AA patients have lower response rates that are only partially explained by unfavorable prognostic factors, such as infection with genoty...

A patient is described who developed cardiomyopathy after receiving a therapeutic course of dextroamphetamine/amphetamine. The patient's cardiac function deteriorated to the point of heart failure, necessitating a heart transplantation. Cardiomyopathy associated with amphetamine use is a serious and potentially lethal condition. With early diagnosi...

Interferon alfa2 (IFN-alpha2) is a parenterally administered cytokine used to treat patients with Hepatitis C and B, and malignancy. Interferon (INF) has a relatively high rate of central nervous system (CNS) adverse effects, including agitation, depression, fatigue, cognitive dysfunction, suicidal thought and drug craving. Using functional magneti...

The increasing number and density of the human population, the emergence of lethal influenza strains, and the potential use of designer influenza virus as a bioweapon, collectively highlight a critical need for more rapid production of influenza vaccines and less invasive means of delivery. We have developed a nonreplicative adenovirus-vectored inf...

A controlled, randomized, double-blind clinical trial evaluated whether two attenuated recombinant poxviruses with identical Japanese encephalitis virus (JEV) gene insertions, NYVAC-JEV and ALVAC-JEV, were safe and immunogenic in volunteers. Groups of 10 volunteers distinguished by vaccinia immune status received two doses of each vaccine. The vacc...

Lyme disease is a multisystem inflammatory disease caused by infection with the tick-borne spirochete Borrelia burgdorferi and is the most common vector-borne infection in the United States. We assessed the efficacy of a recombinant vaccine consisting of outer-surface protein A (OspA) without adjuvant in subjects at risk for Lyme disease. For this...

Lyme disease is a multi-system inflammatory disease caused by Borrelia burgdorferi, an organism that expresses OspA. Sera-protection studies in animals showed that anti-OspA protected against challenge with Bb. The OspA vacdne is an E. coli expressed lipoprotein that induces an immune response in both animals and humans; and is well tolerated. This...

To evaluate the safety and immunogenicity of a recombinant outer surface lipoprotein A (OspA) Lyme vaccine in healthy adults. Randomized, double-blind, placebo-controlled trial. Clinical research unit of a medical center. Thirty-six healthy adult volunteers aged 18 through 65 years. Volunteers were randomly assigned to receive two 10-micrograms dos...

Objective. —To evaluate the safety and immunogenicity of a recombinant outer surface lipoprotein A (OspA) Lyme vaccine in healthy adults. Design. —Randomized, double-blind, placebo-controlled trial. Setting. —Clinical research unit of a medical center. Participants. —Thirty-six healthy adult volunteers aged 18 through 65 years. Interventions....

In previous studies, enhanced toxicity of hemoglobin when combined with endotoxin has suggested a specific binding site. This binding may take place even when endotoxin-free hemoglobin is administered, due to some low levels of endotoxin usually present in the portal vein. To test this hypothesis, we administered endotoxin-free, stroma-free human h...

An antibacterial membrane (ABM) proved to be more effective than a cell washer in removing fecal contamination from blood. The ABM was prepared by coating a charged cellulose support matrix with an analog of the anti-endotoxin antibiotic polymyxin B, and placed inside an autotransfusion bag. In addition to aerobic and anaerobic bacteria, some of th...

This study examined the effect of modified stroma-free Hgb solution (SFHS) as a resuscitative fluid for rats in an ischemic intestinal shock model. The experiments compared the effect of SFHS with two other resuscitative fluids: lactated Ringer's solution (RL) and 3% albumin in RL. The control group received no fluids. After the induction of shock,...

A red cell additive solution (AS-005) containing ascorbate-2-phosphate (AsP) to maintain 2,3-diphosphoglycerate, plus adenine, phosphate, and mannitol to retain viability and reduce hemolysis, was evaluated by human clinical trials. A crossover design was used with another additive solution (Nutricel AS-3, Cutter Laboratories) serving as the contro...

Studies were conducted to determine the conditions necessary to optimize the reaction for each step in the synthesis of pyridoxalated polymerized stroma-free hemoglobin solution (SFHS-PP) synthesis. Fractional factorial designs and regression modeling were used to examine the effects of different pHs, temperatures, and reagent concentrations. The r...

E. coli bacteria were successfully removed from contaminated RBC/plasma by using a special matrix of micro-encapsulated albumin activated charcoal (ACAC). Efficacy of removing the bacteria was directly related to the amount of time the contaminated blood was in contact with the charcoal. The data indicated that the bacteria adhered to the ACAC, but...

We evaluated the antigenicity of pyridoxalated polymerized stroma-free human hemoglobin (SFHS-PP) under condition of anticipated emergency use (hemorrhagic shock). SFHS-PP was administered intravenously to two groups of dogs. One group was subjected to hemorrhagic shock (mean arterial pressure 40 torr for 30 min) prior to resuscitation with a volum...

This study examines the effects of modified stroma-free hemoglobin solution as an oxygen-carrying volume support fluid. Dogs were subjected to hemorrhagic shock to a mean arterial pressure (MAP) of 40 torr for 30 minutes, and then resuscitated with pyridoxalated polymerized stroma-free hemoglobin solution (SFHS-PP), lactated Ringer's (LR) solution,...

Although considerable work is being carried out with pyridoxalated glutaraldehyde-stabilized stroma-free hemoglobin solution (SFHS-pp) as a possible blood substitute, it is not known whether the SFHS-pp has any adverse effect on some aspects of reticuloendothelial (RE) function. To determine this, 131I-gelatinized trioleate (GT) was injected 30 min...

A 41-year-old anticoagulated woman presented with increasing pelvic pain that had begun two days prior during intercourse. An ultrasound and computerized tomographic (CT) scan confirmed the diagnosis of pelvic hematoma. The hematoma resolved spontaneously with normalization of clotting studies. The emergency physician should consider this rare caus...

Effective treatment of cyanide poisoning requires rapid diagnosis, good supportive treatment and the use of a specific antidote. The currently available antidotes offer demonstrated efficacy along with significant potential adverse side effects. We have investigated an alternate approach to antidote therapy for cyanide poisoning by using Stroma-Fre...