Donald Hedeker

Donald Hedeker
University of Chicago | UC · Department of Public Health Sciences

PhD

About

312
Publications
61,567
Reads
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19,757
Citations
Additional affiliations
September 2014 - present
University of Chicago
Position
  • Professor
August 1993 - August 2014
University of Illinois at Chicago
Position
  • Professor
Education
September 1981 - March 1989
University of Chicago
Field of study
  • Quantitative Psychology
September 1976 - June 1980
University of Chicago
Field of study
  • Economics

Publications

Publications (312)
Article
Background: Compared to the effects of stress on hunger, the temporal effect of hunger on stress levels is less understood, especially in the context of everyday lives of vulnerable populations with unstable access to food. Objective: Our objective was to examine the effects of food insecurity and momentary hunger on momentary stress and stress...
Article
Background Tobacco use is the leading cause of preventable morbidity and mortality. Adults with low income and members of certain racial and ethnic minority groups are less likely to quit, and therefore, they experience profound tobacco-related health disparities. Mindfulness training can increase the rates of smoking cessation and lapse recovery,...
Article
Ecological momentary assessment and other modern data collection technologies facilitate research on both within‐subject and between‐subject variability of health outcomes and behaviors. For such intensively measured longitudinal data, Hedeker et al extended the usual two‐level mixed‐effects model to a two‐level mixed‐effects location scale (MELS)...
Article
Objective: PA habits reflect stable, consistent patterns in behaviours that are performed automatically in response to temporal or contextual cues. Mothers face multiple demands and complex schedules related to parenting. This study examined how subject-level mean, variability, and slopes in device-measured moderate-to-vigorous physical activity (M...
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Research examined how acute affect dynamics, including stability and context-dependency, contribute to changes in children’s physical activity levels as they transition from late-childhood to early-adolescence. Children (N = 151) (ages 8–12 years at baseline) participated in an ecological momentary assessment and accelerometry study with six semi-a...
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We estimated sibling resemblance in health-related physical fitness (PF) and examined how individual characteristics and shared natural environment accounted for sibling similarities. The sample comprised 656 sibling pairs and 102 triplets (6–15 years of age), from three geographical areas of Peru. PF components included morphological (waist circum...
Article
Background: Cardiovascular disease (CVD) persists as the leading preventable cause of death in the US and worldwide. The American Heart Association (AHA) defines ideal cardiovascular health as the presence of: non-smoking, normal weight, adequate physical activity, healthy diet, normal blood pressure, normal fasting plasma glucose, and normal chole...
Article
We address the issue of (non‐) responsivity of self‐initiated assessments in Ecological Momentary Assessment (EMA) or other mobile health (mHealth) studies, where subjects are instructed to self‐initiate reports when experiencing defined events, for example, smoking. Since such reports are self‐initiated, the frequency and determinants of nonrespon...
Article
Introduction A large body of literature indicates that nicotine results in an acute mood “boost,” including increased positive affect and decreased negative affect. Young adults frequently engage in polysubstance use of cigarettes with cannabis and alcohol—a trend that is likely to accelerate with the expanding legalization of cannabis. However, li...
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Background Longitudinal assessments of usage are often conducted for multiple substances (e.g., cigarettes, alcohol and marijuana) and research interests are often focused on the inter-substance association. We propose a multivariate longitudinal modeling approach for jointly analyzing the ordinal multivariate substance use data. Methods We descri...
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This study investigated the associations between biological and environmental factors and gross-motor coordination (GMC) in Peruvian children and adolescents. The sample comprised 7401 boys and girls, aged 6–14 years, recruited from three geographical regions: sea-level, Amazon and high-altitude. Biological variables included age, sex, height, BMI,...
Article
Objective: While the U.S. adult smoking rate has declined, Black smokers disproportionately face more barriers to accessing brief effective tobacco cessation treatments compared with other racial groups. This study developed and tested the effects of a novel, evidence-based, brief smoking intervention culturally targeted for disadvantaged Black smo...
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Objective: We applied the ORBIT model to digitally define dynamic treatment pathways whereby intervention improves multiple risk behaviors. We hypothesized that effective intervention improves the frequency and consistency of targeted health behaviors and that both correlate with automaticity (habit) and self-efficacy (self-regulation). Method:...
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Purpose To evaluate weight change patterns over time following the diagnosis of breast cancer and to examine the association of post-diagnosis weight change and survival outcomes in Black and White patients. Methods The study included 2888 women diagnosed with non-metastatic breast cancer in 2000–2017 in Chicago. Longitudinal repeated measures of...
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Hidden Markov models (HMM) presents an attractive analytical framework for capturing the state-switching process for auto-correlated data. These models have been extended to longitudinal data setting where simultaneous multiple processes are observed by including subject specific random effects. However, application of HMMs for intensive longitudin...
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We use a multivariate multilevel model to study the links between physical fitness (PF) and gross motor coordination (GMC) and investigate the influence of predictors affecting their levels across age. We sampled 7918 Peruvians, aged 6‐15 yrs, from sea‐level, Amazon region and high‐altitude. Composite markers of GMC and PF were derived (GMCz and PF...
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Ecological Momentary Assessment (EMA) studies aim to explore the interaction between subjects’ psychological states and real environmental factors. During the EMA studies, participants can receive prompted assessments intensively across days and within each day, which results in three-level longitudinal data, e.g., subject-level (level-3), day-leve...
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People differ from each other to the extent to which momentary factors, such as context, mood, and cognitions, influence momentary health behaviors. However, statistical models to date are limited in their ability to test whether the association between two momentary variables (i.e., subject-level slopes) predicts a subject-level outcome. This stud...
Article
Introduction In a sample of dual users of cigarettes and electronic nicotine delivery systems (ENDS; e-cigarettes), we evaluated psychometric properties of ENDS versions of the Nicotine Dependence Syndrome Scale (NDSS), the brief Wisconsin Inventory of Smoking Dependence Motives (WISDM), and the Fagerstrom Test of Nicotine Dependence (FTND). Using...
Article
Background: Cardiovascular disease (CVD) remains the leading cause of death globally. Seven health factors are associated with ideal cardiovascular health: being a non-smoker; not overweight; physically active; having a healthy diet; and normal blood pressure; fasting plasma glucose and cholesterol. Whereas approximately half of U.S. youth have id...
Preprint
Full-text available
Purpose: To evaluate weight change patterns over time following the diagnosis of breast cancer, and to examine the association of post-diagnosis weight change and survival outcomes in Black and White patients. Methods: The study included 2,888 women diagnosed with non-metastatic breast cancer in 2000-2017 in Chicago. Longitudinal repeated measures...
Preprint
Full-text available
Purpose: To evaluate weight change patterns over time following the diagnosis of breast cancer, and to examine the association of post-diagnosis weight change and survival outcomes in Black and White patients. Methods: The study included 2,888 women diagnosed with non-metastatic breast cancer in 2000-2017 in Chicago. Longitudinal repeated measures...
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Full-text available
RationaleLittle is known about relapse among non-daily, intermittent smokers (ITS), who have difficulty quitting, despite a lack of dependence.Objectives To analyze situations associated with temptations to smoke and smoking lapses among ITS trying to maintain abstinence.Methods Participants were 130 initially abstinent ITS in the placebo arm of a...
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Objective Intensive behavioral obesity treatments face scalability challenges, but evidence is lacking about which treatment components could be cut back without reducing weight loss. The Optimization of Remotely Delivered Intensive Lifestyle Treatment for Obesity (Opt‐IN) study applied the Multiphase Optimization Strategy to develop an entirely re...
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Background: Gross motor coordination (GMC) is a potential correlate of lifestyle behaviours and health outcomes in childhood and adolescence. Aims: The aim of this study was to examine how sex, age, biological maturation, overweight, stunting, and physical fitness are associated with GMC in children and adolescents from Peru, and to examine asso...
Article
Introduction Light avoidance is a common coping behavior of individuals with migraine headaches. It is not known whether timing of light exposure is different in individuals with chronic migraine (CM) compared to those without migraine and how this may relate to headache frequency and severity. We tested this by examining timing of the brightest an...
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Stunting, defined as linear growth retardation, is a serious public health problem in developing countries. We aimed to (1) describe the prevalence of stunting in Peruvian youth living in three geographical regions, and to (2) determine height and physical fitness (PF) differences between stunted and normal-growth children across age and sex. We sa...
Article
Despite the need for sensitivity analysis to nonignorable missingness in intensive longitudinal data (ILD), such analysis is greatly hindered by novel ILD features, such as large data volume and complex nonmonotonic missing‐data patterns. Likelihood of alternative models permitting nonignorable missingness often involves very high‐dimensional integ...
Article
OBJECTIVE: Cancer diagnosis in adolescents and young adults (AYA) coincides with the developmental initiation of substance use and emergence of affective disturbance. We examined substance use behaviors and risk-stratified associations with mental and physical health, as well as objective indicators of tobacco and cannabis use and concordance with...
Article
Purpose: This study aims to: (1) describe mean changes in muscular and motor fitness components in sib-ships over 2 years; (2) analyze individual tracking of fitness within sib-ships; (3) investigate sibling resemblance in fitness over time, and (4) examine the joint influence of biological, behavioral and familial characteristics on fitness. Met...
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The use of intensive sampling methods, such as ecological momentary assessment (EMA), is increasingly prominent in medical research. However, inferences from such data are often limited to the subject-specific mean of the outcome and between-subject variance (i.e., random intercept), despite the capability to examine within-subject variance (i.e.,...
Article
Ecological Momentary Assessment data present some new modeling opportunities. Typically, there are sufficient data to explicitly model the within‐subject (WS) variance, and in many applications, it is of interest to allow the WS variance to depend on covariates as well as random subject effects. We describe a model that allows multiple random effec...
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Background/objectives: Obesity markers evolve over time and these changes are shared within the family orbit and governed by individual and environmental characteristics. Available reports often lack an integrated approach, in contrast to a multilevel framework that considers their concurrent influence. Hence, this study aims to (1) describe mean...
Article
This study modelled children's gross motor coordination, investigated sex-differences and identified the effects of fixed and dynamic correlates on motor coordination development. A total of 344 Portuguese children (170 girls), from 6 age cohorts (5 to 9 years of age), were followed consecutively for three years (age range 5 to 11 years) using a mi...
Article
The present study investigated the consequences of ignoring a nested data structure on the Rasch/one parameter item response theory model. Although most large-scale educational assessment data do exhibit a nested data structure, current practice often ignores such data structure and applies the standard Rasch/IRT models to conduct measurement analy...
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Background and aim: Overweight prevalence in children and adolescents shows great variability which is related to individual-level and environmental-level factors. The present study aimed to determine the prevalence of and factors associated with overweight in Peruvian children and adolescents living at different altitudes. Methods: 8568 subject...
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Introduction The National Academies of Sciences (NAS) emphasize the need for interdisciplinary team science (TS) training, but few training resources are available. COALESCE, an open-access tool developed with National Institutes of Health support and located at teamscience.net , is considered a gold standard resource but has not previously been ev...
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This study aims to estimate sibling resemblance in metabolic syndrome (MS) markers, and to investigate the associations of biological and behavioral characteristics with MS. The sample comprises 679 biological siblings (363 females; 316 males) aged 9–20 years. MS markers included waist circumference (WC), high-density lipoprotein cholesterol (HDL-C...
Article
Background: Stepped care is a rational resource allocation approach to reduce population obesity. Evidence is lacking to guide decisions on use of low cost treatment components such as mobile health (mHealth) tools without compromising weight loss of those needing more expensive traditional treatment components (e.g., coaching, meal replacement)....
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Introduction Compensatory sleep behaviors (e.g., naps, going to bed earlier) are often used to cope with headaches. However, it is not known if these coping behaviors lead to subsequent disturbances in nocturnal sleep. We tested this hypothesis by examining the temporal relationships between headaches, daytime naps, and nocturnal sleep in women wit...
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Background: The development of gross motor coordination (GMC) is governed by biological and environmental factors whose effect sizes are still unclear. Aim: To investigate sibling resemblance in GMC as well as biological and environmental correlates of GMC among Peruvian children. Material and Methods: The sample comprised 1256 biological siblings...
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The co-occurrence of health-related markers and their associations with individual, family, and environmental characteristics have not yet been widely explored in siblings. We aimed to identify multivariate profiles of health-related markers, analyze their associations with biological, sociodemographic, and built environment characteristics, and es...
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In this paper, we address the problem of accounting for informative missing in the context of ecological momentary assessment studies (sometimes referred to as intensive longitudinal studies), where each study unit gets measured intensively over time and intermittent missing is usually present. We present a shared parameter modeling approach that l...
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Latent trait shared‐parameter mixed models for ecological momentary assessment (EMA) data containing missing values are developed in which data are collected in an intermittent manner. In such studies, data are often missing due to unanswered prompts. Using item response theory models, a latent trait is used to represent the missing prompts and mod...
Article
Affective volatility (i.e., variability) is typically conceptualized as a marker of poor mental and behavioral health. The current research challenges this notion. Among individuals who typically experience low positive affect (PA), vacillation between bouts of joy and marked anhedonia may be associated with better behavioral health relative to a r...
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Background and objective: The popular assumption of ignorability simplifies analyses with incomplete data, but if it is not satisfied, results may be incorrect. Therefore it is necessary to assess the sensitivity of empirical findings to this assumption. We have created a user-friendly and freely available software program to conduct such analyses...
Article
Background: Prenatal tobacco exposure (PTE) is associated with more frequent smoking among young, light smokers. Little is known about how nicotinic acetylcholine receptor (CHRN) genes may contribute to this relationship. Methods: Data were drawn from a longitudinal cohort of young light smokers of European ancestry (N = 511). Three single nucle...
Article
This study describes cigarette smoking trajectories, the influence of social smoker self-identification (SSID), and correlates of these trajectories in two cohorts of U.S. young adults: a sample from the Chicago metropolitan area (Social Emotional Contexts of Adolescent and Young Adult Smoking Patterns [SECAP], n = 893) and a national sample (Truth...
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Background: Prevalent co-occurring poor diet and physical inactivity convey chronic disease risk to the population. Large magnitude behavior change can improve behaviors to recommended levels, but multiple behavior change interventions produce small, poorly maintained effects. Objective: The Make Better Choices 2 trial tested whether a multicomp...
Article
The first aim of this study was to investigate the relationship between motor performance and body fatness among 3- to 5-year-old children. The second aim was to assess whether this relationship works similarly for boys and girls. We also investigated whether socioeconomic status (SES) and geographical area when children are aged 3 years old predic...
Article
Research is inconclusive about whether physical activity (PA) should be performed every day or performed less frequently but in longer bouts to obtain mental health benefits. The current study examined the extent to which day-to-day variability in PA is associated with adults' mental health, and if this association differed by Body Mass Index (BMI)...
Article
Objectives Higher levels of positive affect and feelings of energy are associated with greater physical activity (PA) and lower sedentary time (ST). However, whether fluctuations in these feelings contribute to the regulation of these behaviors is unclear. This study examined the extent to which subject-level variability (i.e., degree of intraindiv...
Article
Ecological momentary assessment studies usually produce intensively measured longitudinal data with large numbers of observations per unit, and research interest is often centered around understanding the changes in variation of people's thoughts, emotions and behaviors. Hedeker et al developed a 2-level mixed effects location scale model that allo...
Article
Full-text available
The purpose of this study was to describe children’s daily compliance with moderate-to-vigorous physical activity (MVPA) recommendations across a week in different parts of the world, and to identify individual- and school-level correlates that may explain differences in daily MVPA compliance. The sample included 6553 children aged 9–11 years from...
Article
Objectives: To investigate the relationships of biological, behavioral, familial, and environmental characteristics with siblings´ physical activity (PA) levels as well as the intrapair resemblance in PA. Methods: The sample comprises 834 (390 females) biological siblings [brother-brother (BB), sister-sister (SS), brother-sister (BS)] aged 9 to...
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Background: The 12-minute run is a commonly used indicator of cardiorespiratory fitness in youth. Variation in growth and maturity status as potential correlates of test performance has not been systematically addressed. Aim: To evaluate biological and environmental determinants of 12-minute run performance in Portuguese youth aged 7-17 years....
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Background and aims: The implications of the rapid rise in electronic cigarette (e-cigarette) use remain unknown. We examined mutual associations between e-cigarette use, conventional cigarette use, and nicotine dependence over time to 1) test the association between e-cigarette use and later conventional smoking (both direct and via nicotine depe...
Article
Introduction: E-cigarettes (Electronic Nicotine Delivery Systems, or ENDS) are an increasingly popular tobacco product among youth. Some evidence suggests that e-cigarettes may be effective for harm reduction and smoking cessation, although these claims remain controversial. Little is known about how nicotine dependence may contribute to e-cigaret...
Article
Background: Inpatient service handoffs are a vulnerable transition during a patients' hospitalization. We hypothesized that performing the service handoff at the patients' bedside may be one mechanism to more efficiently transfer patient information between physicians, while further integrating the patient into their hospital care. Methods: We p...
Article
e18095 Background: A cancer diagnosis in adolescents and young adults (AYA) comes at a complex developmental interval that often coincides with risky behaviors, such as substance use. Modifiable risk behaviors are an important area of research to minimize morbidity for AYA. Our goal was to examine substance use, affect, and other health indicators...
Article
Objective: To determine the effects on weight loss of three abbreviated behavioral weight loss interventions with and without coaching and mobile technology. Methods: A randomized controlled efficacy study of three 6-month weight loss treatments was conducted in 96 adults with obesity: 1) self-guided (SELF), 2) standard (STND), or 3) technology-...
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This article discusses marginalization of the regression parameters in mixed models for correlated binary outcomes. As is well known, the regression parameters in such models have the "subject-specific" (SS) or conditional interpretation, in contrast to the "population-averaged" (PA) or marginal estimates that represent the unconditional covariate...
Article
This study investigates biological, behavioural and sociodemographic correlates of intra-pair similarities, and estimates sibling resemblance in health-related physical fitness (PF). The sample comprises 1101 biological siblings (525 females) aged 9–20 years. PF components and markers were: morphological [waist circumference (WC) and %body fat (%BF...
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Full-text available
This study aimed to jointly analyse moderate-to-vigorous physical activity (MVPA) and sedentariness, and their correlates, in children within their school contexts, using a multivariate multilevel approach. The sample comprises 499 Portuguese children (284 girls) from 23 schools. MVPA and sedentary time were estimated by accelerometer. A set of pre...