Donald Cohen

Donald Cohen
University of Florida | UF · Academic Health Center

About

273
Publications
23,473
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
3,157
Citations

Publications

Publications (273)
Article
Blue nevus is a benign melanocytic tumor that commonly occurs on the skin. It appears as a solitary, well-demarcated, dark blue nodule or smooth-surfaced macule. Blue nevus has been reported in the lymph nodes, parotid, and prostate glands. In the oral cavity, blue nevus accounts for one-third of all oral mucosal melanocytic nevi, with the palate b...
Article
Introduction Secretory carcinomas (SC) of minor and major salivary gland (SG) are rare neoplasms that demonstrate microscopic overlap with acinic cell carcinomas (ACC), adenocarcinoma NOS (AdNOS), and mucoepidermoid carcinomas (MEC) respectively. Recently alternative translocations of ETV6-RET gene locus have been recognized in a small group of SC....
Article
Introduction HPV-related benign papillary epithelial neoplasms are common lesions affecting any region of the oral cavity. This study evaluated the trends in frequency, location, and demographics of these lesions over 20 years. Materials and Methods Following IRB approval, the archives of UF Oral Pathology Biopsy Service between 19952015 were quer...
Article
Objective Neurofibromatosis type 1 is an autosomal dominant disorder caused by mutations in the NF1 gene at chromosomal location 17q11.2. We present a patient with bone abnormalities and a myriad of lesions secondary to his redeveloping renal failure and NF1. Clinical Presentation A 21-year-old male renal transplant recipient with NF1 presented wi...
Article
Background Verrucous gingival lesions are common within the spectrum of proliferative verrucous leukoplakia (PVL), and the gingiva is not an unusual location for oral carcinoma. However, non-PVL associated dysplastic gingival lesions appear to be less common and may not progress directly to malignancy. In addition, it appears HPV likely plays a lim...
Article
Introduction Vesiculobullous disorders encompass several rare conditions with varying pathology and morbidity, but similar signs and symptoms. Materials and Methods With IRB approval, the record systems of the UF Oral Medicine and UF Dermatology Clinics were searched for cases diagnosed between 2011 and 2020 of the following disorders: pemphigus v...
Article
Introduction Carcinomatous transformation in odontogenic cysts is rare, with few cases described in the literature. Squamous cell carcinoma (SCC) is the most common form of malignant transformation in odontogenic cysts. Radicular and dentigerous cysts are the most common odontogenic cysts to undergo malignant transformation. We present three cases...
Article
Introduction Oral cavity sarcomas are rare and account for 1% of all malignancies in this site. This study aims to evaluate the prevalence, variety and distribution of soft tissue and gnathic sarcoma in the oral cavity. Methods An IRB approved retrospective review encompassing years 2010-2020 of the University of Florida Oral Pathology Biopsy Serv...
Article
Background Extragnathic xanthomas are rare benign tumors associated with excess lipid production. Its gnathic counterpart was first reported in 1964. Only 45 cases of central xanthoma of jaw (CXJ) have been reported in the English literature. The etiopathogenesis of CXJ is highly suggestive of a reactive process or a metabolic condition. Materials...
Article
Introduction Sjogren syndrome (SS) is a chronic autoimmune rheumatic disease characterized by lymphocytic infiltration of exocrine glands and other organs. The spectrum of clinical manifestations suggests that SS clinical phenotype in children is more heterogeneous than that in adults. The objective of this study was to perform histopathological an...
Article
Introduction Odontogenic keratocyst (OKC) represents approximately 11% of all odontogenic cysts and may be an early sign of Nevoid Basal Cell Carcinoma syndrome (NBCCS). We aim to identify histologic variations in syndromic OKC in patients under 30 years of age that correlate with the protein patched homolog-1 (PTCH-1) immunohistochemical (IHC) sta...
Article
Background Oral Melanoacanthoma (OM) is an unusual, likely reactive heavily pigmented, benign epithelial proliferation. OM often grows rapidly mimicking melanoma and leading to anxiety for both the patient and the clinician. We present a large series of OM including demographics, description of clinical appearance and characteristics, histology, an...
Article
Full-text available
Human papillomavirus (HPV)-related benign papillary epithelial neoplasms are common lesions affecting any region of the oral cavity. This study evaluated the trends in frequency, location, and demographics of these lesions over 20 years in a large biopsy service. Following IRB approval, the archives of UF Oral Pathology Biopsy Service between 1995...
Article
Oral lesions may be the initial or only manifestation of leukemia and can be the key to early diagnosis. The varied nature of presenting signs and dentists' general lack of familiarity with oral presentations makes diagnosis challenging. This retrospective review reports a series of cases of leukemia to familiarize dentists with the oral manifestat...
Article
Introduction: Buccal bifurcation cyst is an inflammatory odontogenic cyst and constitutes up to 5% of all odontogenic cysts. The aim of this study was to report a series of cases, review the recent literature, and facilitate recognition and proper treatment of this entity. Methods: With institutional review board approval, the authors retrieved...
Article
Objective: Adenomatoid odontogenic tumor (AOT) is a benign odontogenic tumor with an excellent prognosis, often seen in children and young adults. The aim was to examine the spectrum of clinical, radiographic, and histologic attributes of AOT and assess clinician recognition of this entity. In addition, diagnostic considerations and treatment moda...
Article
Full-text available
Oral hairy leukoplakia (OHL) is an Epstein-Barr virus (EBV) related lesion seen in severely immunocompromised patients especially, those with concomitant human immunodeficiency virus (HIV) infection. It has been rarely reported in immunocompetent patients. OHL most often presents on the lateral border of the tongue as an asymptomatic, white, and co...
Article
Full-text available
Secretory carcinoma (SC) is an uncommon salivary gland neoplasm of the oral cavity that microscopically may mimic acinic cell carcinoma (ACC) and mucoepidermoid carcinoma (MEC). This study describes a series of SC in minor glands with a literature review. We performed a retrospective search for oral SC, within the archives of the University of Flor...
Article
Full-text available
Gingival growths, barring a few are mostly reactive and seldom exhibit significant true neoplastic potential. The common etiology is local irritation from dental plaque/calculus, trauma as well as medication-related overgrowth. Such lesions are easily distinguishable and categorized into diagnoses such as pyogenic granuloma, peripheral ossifying fi...
Article
Ameloblastic fibro-odontoma (AFO) is a rare benign mixed odontogenic tumor that affects children and young adults. AFO occurs mainly intraosseous. Extraosseous AFO is extremely rare. We report two cases of rare peripheral ameloblastic fibro-odontoma in 2 and 12-year-old females. Microscopic examination revealed a benign proliferation of odontogenic...
Article
Steatocystoma is a benign adnexal tumor that originates from sebaceous glands or ducts. Steatocystoma simplex presents as a solitary, noninherited tumor that affects adults with equal sex predilection. It can af- fect any part of the body and is seen most commonly on the skin of the face and neck. Involvement of the oral mucosa is extremely rare. T...
Article
We present a patient with bone abnormalities and a myriad of lesions secondary to his redeveloping renal failure and neurofibromatosis type 1. A 21-year-old male renal transplant recipient with NF1 presented with painless masses and large, irregular radiolucent lesions in the maxilla and mandible. Following histological examination, the lesion was...
Article
Full-text available
The many diverse terms used to describe the wide spectrum of changes seen in proliferative verrucous leukoplakia (PVL) have resulted in disparate clinical management. The objective of this study was to produce an expert consensus guideline for standardized assessment and reporting by pathologists diagnosing PVL related lesions. 299 biopsies from 84...
Article
Objective Idiopathic pulmonary fibrosis (IPF) patients commonly present with sicca symptoms. This study aims to assess labial minor salivary glands (LMSG) in those patients to rule out Sjögren's syndrome (SS), in which sicca symptoms are the clinical hallmark. Study Design Cases of IPF patients with sicca symptoms referred to the Oral Medicine Cli...
Article
Objective The calcifying epithelial odontogenic tumor (CEOT) is a rare benign neoplasm that makes up less than 1% of all odontogenic tumors. This study aims to describe a case series of CEOT spanning 25 years and to review, and compare our results with, the existing literature. Study design With IRB approval, all CEOT archival cases from the UF Or...
Article
Oral squamous cell carcinoma (OSCC) is an extremely rare occurrence during pregnancy. OSCC accounts for less than 2% of all malignancies in pregnant women, with an average mortality rate of 36%. Understanding the features of this tumor during pregnancy is important; however, the paucity of reports in the literature makes this challenging. Case pres...
Article
Full-text available
Odontogenic myxoma (OM) is an uncommon benign odontogenic tumor arising in the jaw. Though it has slight histologic overlap with other entities, definitive diagnosis is imperative considering the tumor’s aggressive nature, high recurrence rate, and necessity of radical surgical intervention in large-sized lesions. With IRB approval, a retrospective...
Article
Full-text available
Salivary gland neoplasms of the buccal mucosa are relatively rare and often present with an unusual histopathologic profile when compared with other intraoral locations. We present a series of minor salivary gland neoplasms of the buccal mucosa and discuss demographics, clinical presentation, and histologic findings. An IRB approved retrospective s...
Article
Full-text available
We present a report of bilateral mandibular radiolucent lesions that were diagnosed as synchronous ameloblastoma and odontogenic keratocyst (OKC) in a 75‐year‐old female patient. To the best of our knowledge, the simultaneous occurrence of ameloblastoma and OKC of the jaws, as contralateral lesions, has not been previously reported.
Article
Full-text available
Verruciform xanthoma (VX) of the oral cavity is an uncommon, reactive lesion of unknown etiology. In this study, we present a large series of VX with analysis of demographics, clinical appearance, histologic presentation and extensive review of literature. To the best of our knowledge, this is the largest series of oral VX reported to date. Followi...
Article
Full-text available
Background: Potentially malignant lesions of the gingiva may frequently present as well-demarcated white lesions confined to the marginal gingiva. These lesions often become thick and verrucoid and spread along the marginal gingiva to encircle the tooth. Some cases of marginal gingival leukoplakia, over time, progress to extensively involve the gi...
Article
Full-text available
Purpose Squamous odontogenic tumor (SOT) is a rare benign, locally infiltrative odontogenic tumor of gnathic bones. It is comprised of islands of bland, well-differentiated squamous epithelium of varying shape and size. Due to histologic overlap, SOT has often been overdiagnosed as ameloblastoma and squamous cell carcinoma. It, thus, becomes import...
Article
Full-text available
Fibrous dysplasia (FD) is a rare condition commonly involving the jaws. While FD has a typical clinical and histological presentation, considerable variation exists. Moreover, overlap of features with other disorders is possible. This study serves to characterize the features of a large case series of FD of the jaws. With IRB approval, the Universi...
Presentation
Introduction: p53 overexpression is well documented in premalignant lesions of the oral cavity. However, recent studies have shown increased expression of podoplanin (D2-40) in oral dysplasia. This study aims to evaluate the efficacy of both markers in predicting malignant transformation in cases of proliferative verrucous leukoplakia (PVL), a reca...
Article
Full-text available
The use of diverse terminology may lead to inconsistent diagnosis and subsequent mistreatment of lesions within the proliferative verrucous leukoplakia (PVL) spectrum. The objectives of this study were: (a) to measure inter-observer variability between a variety of pathologists diagnosing PVL lesions; and (b) to evaluate the impact of diverse termi...
Article
Full-text available
BACKGROUND Carcinosarcoma of the sinonasal tract is an extremely rare malignant neoplasm; it is often designated as carcinoma with spindle cell or sarcomatoid features. We report a case of carcinosarcoma arising in a pre-existing inverted Schneiderian papilloma in the left maxillary antrum and nasal cavity of a 72-year old male patient. CASE REPORT...
Article
Full-text available
Verrucous hyperkeratosis (VH), verrucous carcinoma (VC) and the relentless, truly pre-malignant variant proliferative verrucous leukoplakia often exhibit lichenoid histologic features that may create a diagnostic dilemma for pathologists. This study aims to evaluate and categorize the frequency and the histopathologic patterns of lichenoid features...
Article
Introduction: p16INK4a is a tumor suppressor protein that retards cell cycle progression from G1 to S phase. Prior studies have evaluated p16INK4a expression in odontogenic keratocyst and ameloblastoma, but data regarding other odontogenic cysts and tumors have been sparse. Methods: With IRB approval, cases from the following entities were ident...
Article
Full-text available
Chronic ulcerative stomatitis (CUS) is a poorly understood disease with clinical and histologic overlap with lichen planus (LP). Unlike classic LP, direct immunofluorescence (DIF) studies in cases of CUS exhibit a granular pattern of IgG in nuclei of basal and parabasal cells. This study assesses the demographic, clinical, histologic, and DIF featu...
Article
Background Enhancer of zeste homolog-2 (EZH2) is a member of the polycomb group PcG of proteins; the genes that are involved in transcriptional repression. Cell cycle regulation and cell proliferation is associated with EZH2 expression and EZH2 overexpression stimulates cell proliferation and invasiveness. Conversely, inhibition of EZH2 precludes c...
Article
Full-text available
Objective The use of diverse terminology may lead to inconsistency in the diagnosis and subsequent treatment of lesions within the proliferative verrucous leukoplakia (PVL) spectrum. The objective of this study was to determine inter-observer variability between pathologists in the diagnosis of PVL spectrum lesions. Methods Digitally scanned slide...
Article
Objectives Chronic ulcerative stomatitis (CUS) is a rare disease of unknown etiology. The histopathologic features are similar to lichen planus, but direct immunofluorescence (DIF) studies show characteristic presence of IgG in basal and parabasal epithelial nuclei.This study will review a case series of CUS and assess if the entity is more similar...
Article
Objectives MAML2 expression has been demonstrated in the majority of mucoepidermoid carcinomas (MEC) arising in the salivary glands. MEC may also arise intraosseously in the jawbone (IMEC). Glandular odontogenic cyst (GOC) is an odontogenic cyst with some histologic overlap with IMEC. MAML2 expression has not been extensively studied in IMEC or in...
Article
Introduction Chairside clinical oral pathology consultations are frequently provided in most dental schools; however, the outcome and efficacy of those consults remains largely unanalyzed. We designed a retrospective study to assess the utilization of consults by Oral and Maxillofacial Pathology (OMP) providers at the UF College of Dentistry (UFCOD...
Article
Introduction Studies on inflammatory response to oral squamous cell carcinoma (OSCC) generally do not include verrucous carcinoma (VC), which typically carries a far better prognosis. While high CD8 expression is associated with favorable outcome in head and neck cancers, the role of CD4+ lymphocytes remains controversial. B cell involvement has be...
Article
Carcinosarcoma or carcinoma with spindle cell/sarcomatoid features of the nasal cavity and paranasal sinuses is an exceedingly rare malignancy. We report a case of carcinosarcoma with synchronous inverted papilloma developing in the left nasal cavity and maxillary sinus, in a 72-year-old male with a history of radiation therapy for sinonasal squamo...
Article
Background The jaws are an uncommon location for primary aneurysmal bone cysts (ABCs), and few gnathic cases have been tested for USP6 rearrangement. Rearrangements of CDH11 and/or USP6 are identified in approximately 70% of primary extragnathic ABCs. MATERIALS/METHODS Herein, this multi-institutional, IRB-approved study investigates the USP6 stat...
Poster
Full-text available
Premalignant and malignant lesions of the gingiva frequently present as a white ring or cuff initially involving the crevicular gingival margin of the tooth. This phenomenon is not well-recognized or documented in the literature. The objective of this study is to report a case series of premalignant and malignant peri-gingival leukoplakic cuffing -...
Presentation
INTRODUCTION: Idiopathic pulmonary fibrosis (IPF) is a chronic lung condition characterized by a progressive diminution in lung function. Certain forms of interstitial lung disease have been reported secondary to Sjögren syndrome (SS). However, IPF-related oral symptoms mimicking SS have not been reported. This study is the first retrospective case...
Presentation
Introduction: Epithelioid hemangioendothelioma (EHE) is an unusual vascular neoplasm of indeterminate biologic behavior, classified as intermediate between benign and malignant. It may microscopically mimic other vascular and spindle cell lesions, and definitive diagnosis is paramount owing to its potential for local recurrence and infiltrative nat...
Article
Full-text available
Intraoral neural neoplasms though unusual may be clinically significant. The aim of this study was to categorize and evaluate oral neural tumors in a large oral pathology biopsy service. With IRB approval, a retrospective search of all neural neoplasms of the oral cavity in the archives of the University of Florida Oral Pathology Biopsy Service spa...
Article
Lichenoid granulomatous reaction can be subcategorized into lichenoid granulomatous dermatitis or lichenoid granulomatous stomatitis. It is described in the literature as demonstrating a band-like lichenoid infiltration with clusters of histiocytic or granuloma formation. In this study we presented a large case series of lichenoid granulomatous sto...