Dominique Huvent-Grelle

Centre Hospitalier Régional Universitaire de Lille · geriatric clinique

Background Patients with Alzheimer’s disease and related dementias and their caregivers can be defined as people with higher risk of developing medication-related problems due to aging and polypharmacy.AimTo assess the medication exposure of patient with Alzheimer’s disease and related dementias and their caregivers.Method Ancillary cross-sectional...

Background: Psychosocial interventions for caregivers of patients with Alzheimer disease and relative dementias (ADRD) reported a caregiver burden improvement. Multicomponent intervention integrating pharmaceutical care has not yet been evaluated while ADRD patients and their caregivers are exposed to high risk of drug-related problems. The PHARMA...

The successful design of musical interventions for dementia patients requires knowledge of how rhythmic abilities change with disease severity. In this study, we tested the impact of the severity of the neurocognitive disorders (NCD) on the socioemotional and motor responses to music in three groups of patients with Major NCD, Mild NCD, or No NCD....

Objectives: We investigated serum neutralizing activity against BA.1 and BA.2 Omicron sublineages, and T cell response before and 3 months after booster vaccine in healthcare workers (HCWs). Methods: HCWs aged 18-65 years, vaccinated and boosted with the BNT162b2 vaccine were included. Anti-SARS-CoV-2 IgG levels and cellular response (through IF...

Background: Dementia has a negative impact on the quality of life of the person with dementia and their spouse caregivers, as well as on the couple's relationship, which can lead to high levels of distress for both partners. Hypnosis has been shown to be effective in managing distress and increasing the quality of the relationship. Objective: Th...

Background: The present study aimed to evaluate the persistent immunogenicity offered by a third dose of BNT162b2 against Delta and Omicron variants, in nursing home (NH) residents. Methods: In this monocenter prospective observational study, anti-spike IgG levels, S1 domain reactive T cell counts, serum neutralizing antibody titers against Delta a...

Sensorimotor synchronization (SMS), the coordination of physical actions in time with a rhythmic sequence, is a skill that is necessary not only for keeping the beat when making music, but in a wide variety of interpersonal contexts. Being able to attend to temporal regularities in the environment is a prerequisite for event prediction, which lies...

Long-term care facility (LTCF) older residents display physiological alterations of cellular and humoral immunity that affect vaccine responses. Preliminary reports suggested a low early postvaccination antibody response against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The aim of this study was to focus on the specific T-cell r...

Although music therapy may engender clinical benefits in patients with neurodegenerative disease, the impacts of social and musical factors of such activities on socio-emotional and motor engagements are poorly understood. To address this issue, non-verbal behaviors of 97 patients with or without major cognitive impairment (CI) were assessed when l...

We quantified S1-specific IgG, neutralizing antibody titers, specific IFNγ secreting T cells and functionality of specific CD4+ and CD8+ T cells in 130 young adults (median age 44.0 years) and 106 older residents living in a long-term care facility (86.5 years) after 2 doses of BNT162b2. Three months after the first injection, humoral and cellular...

Background: The institutionalization of a patient with Alzheimer's disease or other dementia (ADOD) is the last resort for the latter's family and/or caregivers. We hypothesized that the degree of kinship between the patient and his/her caregiver would influence the likelihood of institutionalization. Objective: To assess the association between...

Since January 2020, with the spread of the SARS-Cov-2 virus, France has had to deal with a new pandemic which mainly affects the elderly. No preventive or curative treatments have yet been developed. Consequently, hopes are focused on vaccination. Various studies have shown that old patients suffering from cognitive disorders are frail and therefor...

Background: Music-based interventions appear to be efficient approaches to improve emotional, social, and cognitive functioning of patients with neurodegenerative diseases. Objective: Because benefits seem to increase with patient's motor involvement, we studied sensorimotor synchronization (SMS) abilities of patients with cognitive impairments...

Introduction: Memory clinics (MCs) are the main model for dementia diagnosis and care. Following the development of a MC network in Northern France, our objectives were to assess its impact on patient characteristics over 20 years. Methods: The characteristics of new consultants were studied from 1997 to 2016. Results: New consultants increase...

The COVID-19 epidemic that started in November in China became a national epidemic from March 16, 2020 with the declaration of population containment in order to reduce the spread of the virus in France. From March 17 to March 27, 2020, the monitoring unit of the French society of geriatrics and gerontology decided to conduct a survey to analyze th...

clown thérapie with AD patients

Background To evaluate the prevalence and management of heart failure (HF) in very old patients in geriatric settings. Methods Members of the French Society of Geriatrics and Gerontology throughout France were invited to participate in a point prevalence survey and to include all patients ≥80 years old, hospitalized in geriatric settings, with HF...

Contexte : En Établissement d’hébergement pour personnes âgées dépendantes (EHPAD), le résident a le libre choix de son médecin traitant. Objectif : Ce travail s’est intéressé à analyser les pratiques et le ressenti de tous les médecins généralistes libéraux (MGL) de Boulogne-sur-Mer (62) intervenant en EHPAD auprès des résidents âgés. Méthodologie...

RÉSUMÉ La consommation quotidienne de jus de cranberry a été proposée pour prévenir les infections urinaires récidivantes chez la femme âgée, mais les résultats des nombreux travaux publiés sur son efficacité sont contradictoires. Même s’il existe donc une controverse quant à l’efficacité supposée de cette baie, son utilisation est courante en étab...

Abstract Introduction: Alzheimer's Disease and Related Diseases (ADRD) are associated with a caregiver burden that increases with the progression of the disease. Psychosocial interventions reported a moderate improvement on caregivers' burden. Patients with ADRD and their older caregivers are also exposed to a higher risk of developing drug-relate...

Alzheimer's disease and other vascular cognitive disorders are common disturbances in the elderly. Dementia often has a serious impact on family life. Most demented patients are cared for at home by family members, usually elderly spouses. Adult grandchildren (AGCs) are also a significant contingent of care providers for the elderly. The number of...

Abstract Introduction: Quality of life (QOL) is an important dimension to consider in Alzheimer's disease (AD), but few large-scale studies have analyzed self and caregiver reports of patient QOL. Methods: Patient QOL was evaluated in a cohort of 574 AD patients with the QOL-AD scale over 2 years. Results: Caregiver reports of patient QOL were l...

Background: Executive dysfunctions in Alzheimer's disease (AD) have been assessed using variable batteries and/or in selected populations. Objective: The primary objective of this observational study was to determine the prevalence and severity of executive dysfunction in AD patients using a previously validated battery. The secondary objective wa...

Background It is well known that informal care giving for Alzheimer patients can be a burden and may result in caregivers’ distress and stress. Caring for a person with Alzheimer's disease (AD) is a difficult task, which can become overwhelming. Their caregivers need attention as well. Objectives The present study examines the socio-demographic c...

Elopement is frequently observed among older adults with AD. Little work has been done on this significant problem. Elopement can be dangerous. It puts both families and caregivers under a lot of stress. Physical restraints are sometimes used to prevent wandering and elopement. The problem for physicians, administrators and caregivers is working ou...

The relation between CI treatment and Pisa syndrome may be considered as likely because dystonia stopped with CI discontinuation in most cases which suggests that CI alone can induce reversible Pisa syndrome in Alzheimer’s disease patients. We believe that the widespread use of CI may cause an increasing number of Pisa syndrome cases and therefore...

GP are most frequently woman. Those women are described as the sandwich generation like a hamburger of ground meat with 2 levels (parents and grandchildren). Women-in the-middle (daughters and daughters-in-law) as helpers and caregivers for the elderly have to face care demands from two generations. They find themselves in a specific position, hel...

Background: Elopement is frequently observed among older adults with AD. Little work has been done on this significant problem. Objectives: to analyse the prevalence of the phenomenon, to define the profile of those who run away and to describe intervention strategies employed to prevent new intent to elope. Design and setting: Prospective study ov...

Background Because of a lack of efficacy of influenza vaccination in elderly population, there are still numerous outbreaks in geriatric health care settings. The health care workers (HCW) flu vaccination is known to get herd immunity and decrease the impact of influenza in elderly population living in geriatric health care settings. However, the...

Bien que les personnes âgées soient particulièrement vulnérables aux effets nocifs de l’alcool, très peu de travaux ont été consacrés à la consommation d’alcool en établissement d’hébergement pour personnes âgées dépendantes (EHPAD).

Although frail elderly people are particularly vulnerable to the adverse effects of alcohol, very little work on alcohol consumption patterns in older people living in nursing homes has been undertaken. To determine alcohol consumption patterns among the residents of 8 nursing homes of the Nord Pas-de-Calais in France, and the characteristics assoc...

In France, in 2010, about one million people developed Alzheimer’s disease (AD) or other forms of dementia. AD mainly affects old or very old people, namely grandparents or great-grandparents. Studies estimate that more than three million people (patients and relatives) are directly affected by the phenomenon. AD affects both the patient and his fa...

The Pisa syndrome (or pleurothotonus) is anacquired, persistent truncal dystonia that appears to be re-versible and is characterized by an involuntary side flexion(on either side) of the body and head and is associated witha backward axial rotation, so that the person seems to beleaning like the leaning tower of Pisa.Ekbom et al.1have attributed th...

Contexte : Depuis 20 ans se sont ouverts en France des Consultations Mémoire avec comme objectifs le diagnostic précoce et la prise en charge globale des patients atteints de démence. Objectif : Comparer l'activité en 2002, des deux Consultations Mémoire de Lille ; celle de l'hôpital de jour de neurologie, siège du Centre Mémoire de Ressource et de...

Context: Twenty years ago, opened in France, the first Memory clinics. Their aim, the early diagnosis of dementia and the management of patients with dementia. Objective: At the university hospital of Lille, there are two memory clinics. The first one (CMRR) is located in the day-hospital of neurology department and the other is located in the geri...

Background: Falls are common among elderly hospitalised patients. Preventive measures include identification of high-risk patients. Objectives: The aim of this study was to assess the ability of the STRATIFY score to predict fallers in a geriatric rehabilitation care unit. Tool which takes into account five clinical factors associated with falling,...

Pain management of elderly in institution is a real challenge facing contingencies of the nursing personnel and also, elderly with communication disorders unable to express their suffering. In order to bypass these difficulties, it is important that the whole of the institution be aware of this frequent symptom expressed daily during cares provided...

Nous avons élaboré un guide local de prescription contenant des recommandations pour l’antibiothérapie initiale empirique des pneumonies communautaires ou nosocomiales. Le but de notre étude était d’évaluer l’impact de cette mesure.

Objective We developed a prescribing guideline containing recommendations for the initial empirical antibiotic therapy in community or nosocomial pneumonia. The aim of the present study was to examine the impact of this measure. Method The prescribing guideline was implemented in May 1999. We retrospectively reviewed the charts of all patients > 6...

We developed a prescribing guideline containing recommendations for the initial empirical antibiotic therapy in community or nosocomial pneumonia. The aim of the present study was to examine the impact of this measure. The prescribing guideline was implemented in May 1999. We retrospectively reviewed the charts of all patients>65 years with communi...