Dominique Griffon

Dominique Griffon
Western University of Health Sciences · College of Veterinary Medicine

DMV, MS, PhD, DECVS, DACVS

About

107
Publications
12,295
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2,329
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Introduction
Skills and Expertise
Additional affiliations
January 2011 - present
Western University of Health Sciences
Position
  • Associate Dean For Research

Publications

Publications (107)
Article
Objective: To gather and evaluate veterinarians' perspectives about the impacts of the COVID-19 pandemic on the use of veterinary telehealth and on cat owners' versus dog owners' attitudes toward transmission of the SARS-CoV-2 virus from their pets. Sample: 93 respondent veterinarians (47 in primary care practice and 46 in specialty practice)....
Article
Three‐dimensional (3D) printing, also called rapid prototyping or additive manufacturing, transforms digital images into 3D printed objects, typically by layering consecutive thin films of material. This technology has become increasingly accessible to the public, prompting applications in veterinary surgery. Three‐dimensional prints provide direct...
Article
Full-text available
Objective To predict readiness for laparoscopic ovariectomy of live dogs on the basis of performance on a high‐fidelity laparoscopic abdominal simulator and to determine interrater reliability of the assessment. Study design Experimental study. Sample population Seventeen fourth‐year veterinary students. Methods After a standardized laparoscopic...
Article
Objective: To determine the influence of sampling methods on culture results and selection of antimicrobials for treating infected wounds in dogs. Design: Prospective study from January to July 2016. Setting: Three private multispecialty referral centers. Animals: Fifty-two client-owned dogs with infected wounds. Interventions: Each wound...
Article
Objective: To evaluate the biocompatibility of canine fascia lata (FL) in vitro and after FL allograft implantation in dogs with clinical disease. Study design: In vitro experiment and small case series. Sample population: Six dogs treated with allogenic freeze-dried FL. Methods: Fibroblasts were cultured on disks of FL, polypropylene mesh (...
Article
Osteoarthritis challenges traditional therapies and remains a leading cause of lameness in older dogs. Regenerative medicine offers new strategies, typically involving the injection of autologous adipose-derived mesenchymal stem cells (MSCs). Conversely, allogenic MSCs are appealing candidates to palliate patient morbidity and cell preparation time...
Article
Full-text available
The objective of this study was to investigate the effect of playing video games on the performance of basic laparoscopic skills. The study was an experimental pre-test-post-test comparison group design. Fifty-two students (31 from the Western University of Health Sciences College of Veterinary Medicine and 21 from the Colorado State University Col...
Article
Objective To determine the impact of obesity on postoperative recovery from thoracolumbar hemilaminectomy in dachshunds treated with rehabilitation. Study design Prospective observational trial. Animals Thirty‐two dachshunds with thoracolumbar intervertebral disk disease and pain perception. Methods Dachshunds were entered into the study after u...
Article
Objective: To determine repeatability of and correlation between 2 radiographic measurements of femoral anteversion angles (FAA) and to determine their influence on a score derived from tibial plateau angle (TPA) and FAA to predict the risk of cra-nial cruciate ligament disease (CCLD). Study Design: Prospective clinical study. Animals: Forty-eight...
Article
Regenerative medicine provides novel alternatives to conditions that challenge traditional treatments. The prevalence and morbidity of tendinopathy across species, combined with the limited healing properties of this tissue, have prompted the search for cellular therapies and propelled the development of experimental models to study their efficacy....
Article
Objective: To characterize radioulnar incongruence (RUI) in large dogs with medial coronoid disease (MCD) and determine the agreement between radiography, computed tomography (CT), and arthroscopy. Study design: Prospective observational case series. Animals: Twenty-four large-breed dogs under 3 years of age with confirmed MCD. Methods: MCD...
Article
Objective: To determine repeatability of and correlation between 2 radiographic measurements of femoral anteversion angles (FAA) and to determine their influence on a score derived from tibial plateau angle (TPA) and FAA to predict the risk of cranial cruciate ligament disease (CCLD). Study design: Prospective clinical study. Animals: Forty-ei...
Article
Full-text available
Background We recently reported that a conformation score derived from the tibial plateau angle (TPA) and the femoral anteversion angle (FAA), best discriminates limbs predisposed to, or affected by cranial cruciate ligament disease (CCLD), from those that are at low risk for CCLD. The specificity and sensitivity of this score were high enough to s...
Book
Complications in Small Animal Surgery provides a complete reference to diagnosing, managing, and treating surgical complications, with information following a standardized format for ease of use. Presents comprehensive information on diagnosing, managing, and preventing surgical complications using an accessible format. Offers a well-defined, thoro...
Chapter
Bone resorption results from an imbalance in bone homeostasis leading to predominant osteoclastic activity. This chapter focuses primarily on the mechanical conditions that favor bone resorption. The diagnosis of bone resorption is made based on radiographic evidence of radiolucency within the fracture site. Early detection of bone resorption as a...
Chapter
Ulnar osteotomies and ostectomies are indicated in the management of elbow incongruity and premature closure of the distal ulnar growth plate. The location and configuration of the osteotomies vary with the indication. Dynamic proximal ulna osteotomies (DPUOs) are performed in dogs with radioulnar incongruity, generally associated with other compon...
Chapter
Arthrodeses are most commonly performed on the carpus and tarsus to manage severe traumatic injuries such as intraarticular fractures, luxations, ligament injuries, and shearing injuries. Based on a review of the literature covering all types of arthrodeses, the most common complications seem to consist of soft tissue lesions caused by external coa...
Chapter
Degenerative joint disease (DJD) results from both mechanical and biologic events that destabilize the normal coupling of degradation and synthesis of articular cartilage and subchondral bone. Although articular cartilage resurfacing procedures have reached clinical applications, DJD remains a common postoperative complication. Fracture disease enc...
Chapter
Cranial cruciate ligament disease (CCLD) is the leading cause of stifle-associated lameness in dogs and is the primary cause of degenerative joint disease (DJD) in that joint. Fibular head transposition (FHT) relies on the lateral collateral ligament of the stifle to prevent excessive internal rotation and cranial translation of the tibia. Retinacu...
Chapter
External coaptation includes the use of casts, splints, bandages, slings, or hobbles to help stabilize fractures or luxations, reduce postoperative swelling, or help to protect wounds. Edema secondary to external coaptation most commonly involves the digits or distal limbs. It may be considered as the milder and earlier stage of soft tissue disease...
Chapter
Osteomyelitis can be classified, based on its origin, as hematogenous or posttraumatic. Posttraumatic osteomyelitis is more common in small animals and results from direct inoculation of infectious agents during trauma or surgery. Bone is naturally resistant to infection, and adjuvants play a crucial role in shifting surgical contamination toward b...
Chapter
Avascular necrosis of the femoral head occurs spontaneously in small breed dogs and is often referred to as Legg-Calve-Perthes disease. This chapter focuses on avascular necrosis as a complication of fracture repair. As a surgical complication, avascular necrosis is most commonly reported after repair of traumatic femoral capital physeal fractures....
Article
Chitosan is attractive as a substrate for stem cell expansion because it improves stemness through formation of spheroids. Hypoxia has also been proposed as a strategy to enhance stemness and survival of stem cells after in vivo implantation. This study was therefore designed to evaluate the influence of hypoxia on chitosan-induced behavior of stem...
Article
Objective: To determine the association of a radiographic score derived from tibial plateau angle (TPA) and femoral anteversion (FAA) with an outcome of cranial cruciate ligament deficiency (CCLD) in large dogs. Study design: Cross-sectional study. Animals: 167 Labrador Retrievers. Methods: Hind limbs of sound Labrador Retrievers over 6 year...
Article
Full-text available
The objective of this study was to subjectively evaluate the harvest of two areas of adipose collection and three areas of bone marrow collection as potential sites for clinical harvest of adipose stromal vascular fraction (SVF) and bone marrow concentrate for clinical use by quantifying the amount of tissue harvested, subjective ease of harvest, t...
Article
The objective of this study was to compare the effectiveness of two different laparoscopic training models in preparing veterinary students to perform basic laparoscopic skills. Sixteen first- and second-year veterinary students were randomly assigned to a box trainer (group B) or tablet trainer (group T). Training and assessment for both groups in...
Article
Full-text available
Chitosan opens new perspectives in regenerative medicine as it enhances the properties of mesenchymal stem cells (MSCs) through formation of spheroids. Hypoxia has also been proposed to enhance stemness and survival of MSCs after in vivo implantation. These characteristics are relevant to the development of an off-the-shelf source of allogenic cell...
Data
Full-text available
Supplemental data include tables listing means, standard deviations, and statistical differences corresponding to the graphs in Figures 3, 4, 6, and 7.
Article
Full-text available
Objective-To compare the feasibility of training veterinary medicine students to perform laparoscopic versus conventional open ovariectomy in live dogs. Design-Randomized prospective parallel-group experiment. Population-25 students completing the second year of their veterinary curriculum. Procedures-Students were randomly assigned to 2 groups to...
Article
Full-text available
Objective: To characterize the gait of small-breed dogs walked on a pressure walkway by handlers moving at a metronome-set tempo and to determine the influence of handler and leash side on gait characteristics. Design: Prospective study. Animals: 5 healthy adult small-breed dogs weighing < 11.4 kg (25 lb). Procedures: Dogs were walked by eac...
Article
Objectives To report short- and long-term outcomes after arthroscopic treatment in young large breed dogs affected by medial coronoid process disease (MCPD) and identify variables affecting outcome.Study DesignProspective observational case series.AnimalsLarge breed dogs <3 years old (n = 15; 23 elbows).MethodsMCPD was confirmed by radiography, com...
Article
To determine the risk factors for meniscal disease and diagnostic accuracy of physical examination in dogs with cranial cruciate ligament (CCL) deficiency. Prospective cohort study. Stifles (n = 80) of dogs with CCL deficiency. Each dog was evaluated preoperatively for factors that may increase the risk of, or aid in the diagnosis of meniscal disea...
Article
Objectives To (1) develop a technique to determine the anteversion angle (AA) of the femur on a single radiograph; (2) determine the correlation between this technique and other published radiographic and computed tomographic (CT) methods; and (3) compare the diagnostic outcome of these methods in determining the level at which femoral torsion occu...
Article
To compare the ability of the Tightrope® (TR) cranial cruciate ligament (CCL) technique, percutaneous lateral fabella suture (pLFS) technique, and normal CCL to control cranial tibial translation (CTT). In vitro biomechanical study. Cadaveric canine pelvic limbs (n = 18 pairs). Six small animal surgical residents (1 pair each) and a Diplomate of th...
Article
To compare level of difficulty, deviations from technical description and postoperative assessment during the training of veterinary students, small animal surgical residents, and a board certified surgeon for Tightrope® (TR) and percutaneous lateral fabella suture (pLFS) techniques for cranial cruciate ligament (CCL) repair. Prospective study. Cad...
Article
To describe 2 minimally invasive approaches to the spinal canal for treatment of intervertebral disc disease and compare their efficacy to conventional hemilaminectomy. Experimental; randomized, controlled design. Canine cadavers (n = 10; 5 small and 5 large dogs). Barium-impregnated agarose gel (BA-gel) was injected into the spinal canal at 3 inte...
Article
Objective: To compare 1-year outcomes after lateral fabellar suture stabilization (LFS) and tibial plateau leveling osteotomy (TPLO) for the treatment of dogs with cranial cruciate ligament disease. Design: Randomized blinded controlled clinical trial. Animals: 80 dogs with naturally occurring unilateral cranial cruciate ligament disease. Pro...
Article
To compare kinematics, net moments, powers, ground and joint reaction forces (GRF, JRF) across the hock, stifle and hip joints in Labrador Retrievers at low risk or predisposed to cranial cruciate ligament disease (CCLD). Cross-sectional clinical study. Clinically normal Labradors predisposed (n = 11) or at low risk for CCLD (n = 9). Right pelvic l...
Article
Full-text available
To identify gait characteristics during trotting on a treadmill in nonlame Labrador Retrievers presumed predisposed or not predisposed to cranial cruciate ligament disease (CCLD). Clinically normal Labrador Retrievers presumed predisposed (n = 10) or not predisposed (7) to CCLD. The right hind limb of each dog was classified by use of a predictive...
Article
To compare the ability of N-terminal telopeptide (NTx) assays and dual-energy x-ray absorptiometry (DEXA) to detect bone resorption in dogs with nonneoplastic bone lysis and evaluate the correlation between these diagnostic tools. Prospective, cross-sectional clinical study. Dogs (n = 35; 39 femoral heads) that had femoral head and neck ostectomy a...
Article
Full-text available
The regions of deviation method has been proposed as a technique for identifying regions of the gait cycle where joint motion deviates from normal (Shorter et al., 2008). The original statistical analysis distinguished only peak values during stance and swing. In the current article, we extend the approach by examining deviations from normal throug...
Article
To evaluate strategies for increasing the axial stiffness of a hybrid external bone fixator. Type Ia hybrid fixators, consisting of a uniplanar linear component connected to a circular ring, were tested in displacement controlled loading in axial compression. The basic hybrid construct was modified to explore strategies considered to increase fixat...
Article
To quantify humeroulnar incongruity on elbow radiographs in Labrador Retrievers with or without medial coronoid disease (MCD). Retrospective study of 92 elbows. Radiographic projections of elbow joints from Labrador Retrievers with MCD (n = 42 elbows; 26 dogs) and without MCD (n = 50 elbows; 25 dogs). The congruity of the humeroulnar joint was meas...
Article
To identify a method of composite application for maxillomandibular fixation (MMF) in cats that ensures the material will remain bonded during convalescence but be easy to remove with a low complication rate. Experimental study. Feline cadavers (n=88). MMF was applied using composite to 4 groups of 22 feline cadaver heads each. The protocols were:...
Article
Mesenchymal stem cells (MSCs) offer significant potential as a cell source in tissue-engineering applications because of their multipotent ability. The objective of this study was to evaluate the behaviour of MSCs during the seeding phase, using four different seeding techniques (spinner flask, custom vacuum system combined with a perfused bioreact...
Article
To evaluate the efficacy of S-adenosyl l-methionine (SAMe) in the treatment of clinically inferred canine osteoarthritis (OA). Six weeks, double-blinded, placebo-controlled, clinical trial. Dogs (n=33) with clinical signs, history, and orthopedic exams consistent with OA. Dogs were block randomized by body condition score (<6/9, or ≥6/9) into eithe...
Article
To determine the combination of conformation characteristics of the pelvic limbs of Labrador Retrievers that best discriminates between limb at risk to develop cranial cruciate ligament (CCL) disease and limbs at low risk using radiographs, computerized tomography (CT) images, and dual-energy X-ray absorptiometry (DEXA). Cross-sectional clinical st...
Article
Autograft is considered ideal for grafting procedures, providing osteoinductive growth factors, osteogenic cells, and an osteoconductive scaffold. Limitations, however, exist regarding donor site morbidity and graft availability. Although allograft provides an osteoconductive matrix with some osteoinductivity, its availability is limited. To achiev...
Article
To establish the dose-dependent effects of high-molecular-weight hyaluronic acid (HA) supplementation on chondrogenesis by mesenchymal stem cells (MSCs) cultured on chitosan sponges and to determine the extent to which MSC matrix production (chondrogenesis) can be influenced by incorporation of high-molecular-weight HA into chitosan scaffolds. Muri...
Article
The biocompatibility of chitosan and its similarity to glycosaminoglycans (GAG) make it attractive for cartilage tissue engineering. We have previously reported improved chondrogenesis but limited cell adhesion on chitosan scaffolds. Our objectives were to produce chitosan scaffolds coated with different densities of type II collagen and to evaluat...
Article
The biocompatibility and biomimetic properties of chitosan make it attractive for tissue engineering but its use is limited by its cell adhesion properties. Our objectives were to produce and characterize chitosan and reacetylated-chitosan fibrous scaffolds coated with type II collagen and to evaluate the effect of these chemical modifications on m...
Article
Objective: To identify morphometric characteristics of the pelvic limb musculature associated with the development of cranial cruciate ligament (CCL) deficiency in Labrador Retrievers. Study design: Cross-sectional clinical study. Animals: Pure-bred female (n=18) and male (n=12) Labrador Retrievers with (n=16) and without (n=14) CCL deficiency...
Article
Objectives: To quantify net joint moments, joint powers, and joint reaction forces (JRF) across the hock, stifle, and hip joints in Labrador Retrievers with and without cranial cruciate ligament (CCL) disease. To investigate differences in joint mechanics between normal, CCL deficient, and contralateral pelvic limbs. Study design: Cross-sectiona...
Article
Cranial cruciate ligament (CCL) deficiency is the leading cause of lameness of the canine stifle and has important consequences in terms of morbidity and cost associated with its management. In spite of this impact, development of preventive strategies remains in its infancy, largely because of gaps in our understanding of the complex and likely mu...
Article
To compare short- and long-term functional and radiographic outcome of cranial cruciate ligament (CrCL) injury in dogs treated with postoperative physical rehabilitation and either tibial plateau leveling osteotomy (TPLO) or lateral fabellar suture stabilization (LFS). Prospective observational clinical study. Medium to large breed dogs with natura...
Article
To compare the intra- and interobserver variability occurring when observers with differing experience levels measure tibial plateau angles (TPAs) with a novel digital radiographic projection program (tibial plateau leveling osteotomy [TPLO] planning program), the Kodak Picture Archiving and Communications System (PACS), and standard sized printed...
Article
Objective— To report diagnosis and treatment of bilateral iliopsoas muscle contracture in a dog with spinous process impingement. Study design— Case report. Animals— German Shepherd dog. Methods— A dog with chronic progressive lameness, flexion contracture of the coxofemoral joints, severe pain, and decreased femoral reflexes had severe spondylosis...
Article
Although numerous biomaterials have been investigated as scaffolds for cartilage tissue engineering, the effect of their microstructure on final construct characteristics remains unclear. The biocompatibility of chitosan and its similarity with glycosaminoglycans make it attractive as a scaffold for cartilage engineering. Our objective was to evalu...
Article
A 4-year-old, spayed female, mixed-breed dog was presented for evaluation of chronic left hind-limb lameness. Lytic lesions were observed in the left patella on radiographs of the stifle. A biopsy of the patella led to a histopathological diagnosis of blastomycosis. Surgical debridement followed by a 90-day course of itraconazole and physical rehab...
Article
OBJECTIVE-To evaluate skeletal characteristics of pelvic limbs with and without cranial cruciate ligament (CCL) deficiency in Labrador Retrievers. ANIMALS-30 adult purebred Labrador Retrievers. PROCEDURES-Pelvic limbs (n = 28) of 14 dogs without CCL deficiency were classified as control limbs, whereas the limbs of 16 dogs with CCL deficiency were c...
Article
Nonrigid external fixation of a joint is designed to restrict abnormal joint movement and facilitate healing of traumatized ligaments and capsule tissue with minimizing the impact of immobilization on articular homeostasis and cartilage metabolism. Weight bearing and joint motion minimize muscle atrophy and loss of bone mineral and allow controlled...
Article
Full-text available
Canine osteosarcoma (OSA) causes focal malignant osteolysis leading to severe pain. Despite the documented efficacy of radiotherapy or IV aminobisphosphonates for managing cancer bone pain, their potential combined therapeutic value has not been reported in OSA-bearing dogs. Pamidronate combined with standardized palliative therapy will improve pai...
Article
The biocompatibility of chitosan and its similarity with glycosaminoglycans make it attractive as a scaffold for cartilage engineering. Fibrous scaffolds may simulate cartilage extracellular matrix structure and promote chondrocyte functions. Our objectives were to produce chitosan fibers of different size and evaluate their potential for chondroge...
Article
Full-text available
Medical records for six dogs treated with tobramycin-impregnated calcium sulfate beads were reviewed for indications, duration of disease, number of beads implanted, complications, radiographic appearance of the beads, and outcomes. Beads were no longer visible on radiographs made 5 weeks after implantation. Osteomyelitis resolved in five of five d...
Article
To evaluate the outcome in dogs treated with demineralized bone matrix (DBM) as an adjunct to orthopedic procedures. Retrospective and case-match study. Dogs (n=75). Medical records (1999-2006) and radiographs of dogs that had orthopedic procedures (comminuted fractures, tibial plateau leveling osteotomy [TPLO] where correction for tibial rotation...
Article
To determine mass, center of mass (COM), and moment of inertia (ie, body segment parameters [BSPs]) of hind limb segments by use of a noninvasive method based on computerized tomography (CT) in Labrador Retrievers with and without cranial cruciate ligament (CCL) disease and to provide regression equations to estimate BSPs of normal, CCL-deficient,...
Article
Various bone resorption markers in humans are useful for supporting the diagnosis of malignant skeletal pathology, with certain bone resorption markers appearing to be more discriminatory for detecting cancer-induced osteolysis than others. Canine osteosarcoma (OSA) is characterized by focal bone destruction, but a systematic investigation for dete...
Article
To evaluate the contribution of proximodistal alignment of the patella to patellar luxation, and to evaluate the structures contributing to proximodistal alignment of the patella relative to the femoral trochlea. Retrospective study using a convenience sample. Medium to giant breed dogs (n=106). Medical records and stifle radiographs of 106 dogs we...
Article
Chondrocytes were collected from the stifle joints of four pigs to study the effect of cryopreservation on the chondrogenic potential of chondrocytes. Half of the cells were cryopreserved for 3months. Polyglycolic acid scaffolds were cultured with fresh or cryopreserved chondrocytes for 4weeks. Cell morphology and the quality of engineered tissue w...
Article
Cartilage engineering benefits from the fabrication of random fibrous constructs, mimicking the structures found in the extracellular matrix of natural tissue, to support the attachment and proliferation of cells. Here, a novel approach is demonstrated for the production of fibers with controlled dimensions in the micron regime from the naturally d...
Article
Objective: To compare the diagnostic value of arthroscopy, computed tomography (CT), and radiography for evaluation of radio-ulnar incongruence (RUI). Study design: Experimental evaluation of induced progressive RUI. Sample population: Cadaveric Labrador forelimbs (n=11). Methods: The radius was shortened by 1, 2, and 3 mm with a surgical mo...
Article
Full-text available
The main goal of this study is to evaluate potential applications of two zirconia-hydroxyapatite composites, Z4H6 and Z6H4, as bone substitutes. Composite plugs were implanted into the distal femoral metaphysis and also onto the longissimus dorsi of 18 adult mixed-breed dogs in order to assess in vivo biocompatibility by immediate clinical and radi...
Article
Full-text available
To evaluate effects of small intestinal submucosa (SIS) on elution properties of plaster of Paris (POP). 27 POP cylinders, 27 POP spheres, and 9 polymethylmethacrylate (PMMA) spheres. Pellets were loaded with gentamicin (50 mg/g) and divided into 7 groups of 9 beads each: PMMA spheres; POP cylinders coated with 0, 4, or 8 layers of SIS; and POP sph...
Article
Full-text available
The main goal of this study is to evaluate potential applications of two zirconia-hydroxyapatite composites, Z4H6 and Z6H4, as bone substitutes. Composite plugs were implanted into the distal femoral metaphysis and also onto the longissimus dorsi of 18 adult mixed-breed dogs in order to assess in vivo biocompatibility by immediate clinical and radi...